Didanosine (BioDeep_00000408801)

Main id: BioDeep_00000002366

 


代谢物信息卡片


2,3-Dideoxyinosine

化学式: C10H12N4O3 (236.0909362)
中文名称: 2,3-二脱氧肌苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(OC1CO)N2C=NC3=C2N=CNC3=O
InChI: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1

描述信息

J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV[1][2][3].

同义名列表

4 个代谢物同义名

2,3-Dideoxyinosine; Didanosine; 2',3'-Dideoxyinosine; ddI



数据库引用编号

20 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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COVID-19 Disease Map(0)

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Julie Høgh, Malene Hove-Skovsgaard, Marco Gelpi, Anne Marie Reimer Jensen, Jan Gerstoft, Thomas Benfield, Heidi Storgaard, Susanne Dam Nielsen. Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency. BMC infectious diseases. 2022 May; 22(1):503. doi: 10.1186/s12879-022-07485-1. [PMID: 35643429]
  • Marco Gelpi, Andreas Dehlbæk Knudsen, Karoline Brostrup Larsen, Amanda Mocroft, Anne-Mette Lebech, Birgitte Lindegaard, Jens Lundgren, Klaus Fuglsang Kofoed, Susanne Dam Nielsen. Long-lasting alterations in adipose tissue density and adiponectin production in people living with HIV after thymidine analogues exposure. BMC infectious diseases. 2019 Aug; 19(1):708. doi: 10.1186/s12879-019-4347-y. [PMID: 31399063]
  • Nongodo Firmin Kaboré, Armel Poda, Jacques Zoungrana, Ollo Da, Laura Ciaffi, Aoua Semdé, Issouf Yaméogo, Adrien B Sawadogo, Eric Delaporte, Nicolas Meda, Sophie Limou, Amandine Cournil. Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting. BMC nephrology. 2019 05; 20(1):155. doi: 10.1186/s12882-019-1335-9. [PMID: 31064340]
  • Hongxiang Chen, Gang Wang, Lanzhen Sun, Huicong Zhang, Mengchi Sun, Jin Sun, Lei Shang, Cong Luo. Regulating the alky chain length of fatty acid-didanosine prodrugs and evaluating its role in albumin binding. Drug delivery and translational research. 2018 02; 8(1):21-31. doi: 10.1007/s13346-017-0428-x. [PMID: 28944416]
  • Aylin B Unsal, Aviva S Mattingly, Sara E Jones, Julia B Purdy, James C Reynolds, Jeffrey B Kopp, Rohan Hazra, Colleen M Hadigan. Effect of Antiretroviral Therapy on Bone and Renal Health in Young Adults Infected With HIV in Early Life. The Journal of clinical endocrinology and metabolism. 2017 08; 102(8):2896-2904. doi: 10.1210/jc.2017-00197. [PMID: 28531309]
  • Opass Putcharoen, Lalita Wattanachanya, Jiratchaya Sophonphan, Sarawut Siwamogsatham, Vorapot Sapsirisavat, Sivaporn Gatechompol, Supalak Phonphithak, Stephen J Kerr, Pairoj Chattranukulchai, Yingyos Avihingsanon, Kiat Ruxrungtham, Anchalee Avihingsanon. New-onset diabetes in HIV-treated adults: predictors, long-term renal and cardiovascular outcomes. AIDS (London, England). 2017 07; 31(11):1535-1543. doi: 10.1097/qad.0000000000001496. [PMID: 28398958]
  • Alexander N Geisman, Vladimir T Valuev-Elliston, Alexander A Ozerov, Anastasia L Khandazhinskaya, Alexander O Chizhov, Sergey N Kochetkov, Christophe Pannecouque, Lieve Naesens, Katherine L Seley-Radtke, Mikhail S Novikov. 1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus. Bioorganic & medicinal chemistry. 2016 06; 24(11):2476-85. doi: 10.1016/j.bmc.2016.04.010. [PMID: 27112451]
  • Karanam Anandan Suresh, Venkata Subbaiah C Kadiam, Thaslim S K Basha, Naga Raju Chamarti, Suresh M Kumar, Rajendra Wudayagiri, Lokanatha Valluru. Synthesis and Antiviral Activity of Novel Phosphorylated Derivatives of Didanosine Against Newcastle Disease Virus in Chicken. Archiv der Pharmazie. 2016 Jun; 349(6):442-55. doi: 10.1002/ardp.201600038. [PMID: 27128998]
  • Noris Pavia-Ruz, Magdel Rossouw, Xavier Sáez-Llorens, Torsak Bunupuradah, Mathew Taylor, Rong Yang, Heather Sevinsky, Mark Krystal, Max Lataillade, Daniel Seekins, Sophie Biguenet. Efavirenz Capsule Sprinkle and Liquid Formulations With Didanosine and Emtricitabine in HIV-1-infected Infants and Children 3 Months to 6 Years of Age: Study AI266-922. The Pediatric infectious disease journal. 2015 Dec; 34(12):1355-60. doi: 10.1097/inf.0000000000000913. [PMID: 26379163]
  • Xu Lan, Lei Mingdao, Guo Huilin, Gan Wei, Hu Lvjiang, Zhou Yan, Li Gang. Simultaneous determination of 2',3'-dideoxyinosine and the active metabolite, 2',3'-dideoxyadenosine-5'-triphosphate in human peripheral-blood mononuclear cell by HPLC-MS/MS and the application to cell pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Oct; 1002(?):337-42. doi: 10.1016/j.jchromb.2015.08.039. [PMID: 26350426]
  • Rupak Shivakoti, Nikhil Gupte, Wei-Teng Yang, Noluthando Mwelase, Cecilia Kanyama, Alice M Tang, Sandy Pillay, Wadzanai Samaneka, Cynthia Riviere, Sima Berendes, Javier R Lama, Sandra W Cardoso, Patcharaphan Sugandhavesa, Richard D Semba, Parul Christian, Thomas B Campbell, Amita Gupta. Pre-antiretroviral therapy serum selenium concentrations predict WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy. Nutrients. 2014 Nov; 6(11):5061-78. doi: 10.3390/nu6115061. [PMID: 25401501]
  • Keishiro Yajima, Tomoko Uehira, Hiroshi Otera, Yusuke Koizumi, Dai Watanabe, Yoshinori Kodama, Noriyoshi Kuzushita, Yasuharu Nishida, Eiji Mita, Masayuki Mano, Takuma Shirasaka. A case of non-cirrhotic portal hypertension associated with anti-retroviral therapy in a Japanese patient with human immunodeficiency virus infection. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2014 Sep; 20(9):582-5. doi: 10.1016/j.jiac.2014.06.005. [PMID: 25034388]
  • Louis-Félix Nothias-Scaglia, Pascal Retailleau, Julien Paolini, Christophe Pannecouque, Johan Neyts, Vincent Dumontet, Fanny Roussi, Pieter Leyssen, Jean Costa, Marc Litaudon. Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead. Journal of natural products. 2014 Jun; 77(6):1505-12. doi: 10.1021/np500271u. [PMID: 24926807]
  • Elsabé Jones, Elizabeth Ojewole, Rahul Kalhapure, Thirumala Govender. In vitro comparative evaluation of monolayered multipolymeric films embedded with didanosine-loaded solid lipid nanoparticles: a potential buccal drug delivery system for ARV therapy. Drug development and industrial pharmacy. 2014 May; 40(5):669-79. doi: 10.3109/03639045.2014.892957. [PMID: 24576267]
  • Hervé Hillaireau, Nathalie Dereuddre-Bosquet, Rym Skanji, Fawzia Bekkara-Aounallah, Joachim Caron, Sinda Lepêtre, Sébastien Argote, Laurent Bauduin, Rahima Yousfi, Christine Rogez-Kreuz, Didier Desmaële, Bernard Rousseau, Ruxandra Gref, Karine Andrieux, Pascal Clayette, Patrick Couvreur. Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies. Biomaterials. 2013 Jul; 34(20):4831-8. doi: 10.1016/j.biomaterials.2013.03.022. [PMID: 23562054]
  • Linda Barlow-Mosha, Allison Ross Eckard, Grace A McComsey, Philippa M Musoke. Metabolic complications and treatment of perinatally HIV-infected children and adolescents. Journal of the International AIDS Society. 2013 Jun; 16(?):18600. doi: 10.7448/ias.16.1.18600. [PMID: 23782481]
  • H Hien, N Meda, S Diagbouga, E Zoure, S Yaméogo, H Tamboura, J Somé, A Ouiminga, F Rouet, A Drabo, A Hien, J Nicolas, H Chappuy, P Van de Perre, P Msellati, B Nacro. 24-Month adherence, tolerance and efficacy of once-a-day antiretroviral therapy with didanosine, lamivudine, and efavirenz in African HIV-1 infected children: ANRS 12103/12167. African health sciences. 2013 Jun; 13(2):287-94. doi: 10.4314/ahs.v13i2.13. [PMID: 24235926]
  • Eugenia Vispo, Muge Cevik, Juergen K Rockstroh, Pablo Barreiro, Mark Nelson, Andrew Scourfield, Christoph Boesecke, Jan-Christian Wasmuth, Vincent Soriano. Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013 Apr; 56(8):1117-22. doi: 10.1093/cid/cit001. [PMID: 23315321]
  • Naïm Bouazza, Jean-Marc Tréluyer, Philippe Msellati, Philippe Van de Perre, Serge Diagbouga, Boubacar Nacro, Hervé Hien, Emmanuelle Zoure, François Rouet, Adama Ouiminga, Stephane Blanche, Déborah Hirt, Saik Urien. A novel pharmacokinetic approach to predict virologic failure in HIV-1-infected paediatric patients. AIDS (London, England). 2013 Mar; 27(5):761-8. doi: 10.1097/qad.0b013e32835caad1. [PMID: 23719348]
  • N N Guimarães, C J Silva, H H R de Andrade, R R Dihl, M Lehmann, K S Cunha. Comparative analysis of genetic toxicity of antiretroviral combinations in somatic cells of Drosophila melanogaster. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Mar; 53(?):299-309. doi: 10.1016/j.fct.2012.12.005. [PMID: 23261680]
  • T C S Martin, A Scourfield, N Rockwood, N K Martin, N Patel, M Nelson, B G Gazzard. Pancreatic insufficiency in patients with HIV infection: role of didanosine questioned. HIV medicine. 2013 Mar; 14(3):161-6. doi: 10.1111/j.1468-1293.2012.01047.x. [PMID: 22994793]
  • T Suárez-Zarracina, E Valle-Garay, J Collazos, A H Montes, V Cárcaba, J A Carton, V Asensi. Didanosine (ddI) associates with increased liver fibrosis in adult HIV-HCV coinfected patients. Journal of viral hepatitis. 2012 Oct; 19(10):685-93. doi: 10.1111/j.1365-2893.2012.01596.x. [PMID: 22967099]
  • Didier Desmaële, Ruxandra Gref, Patrick Couvreur. Squalenoylation: a generic platform for nanoparticular drug delivery. Journal of controlled release : official journal of the Controlled Release Society. 2012 Jul; 161(2):609-18. doi: 10.1016/j.jconrel.2011.07.038. [PMID: 21840355]
  • Laia Tolosa, Sandra Pinto, M Teresa Donato, Agustín Lahoz, José V Castell, J Enrique O'Connor, M José Gómez-Lechón. Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs. Toxicological sciences : an official journal of the Society of Toxicology. 2012 May; 127(1):187-98. doi: 10.1093/toxsci/kfs083. [PMID: 22331495]
  • Kasongo Wa Kasongo, Rainer H Müller, Roderick B Walker. The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients. Pharmaceutical development and technology. 2012 May; 17(3):353-62. doi: 10.3109/10837450.2010.542163. [PMID: 21241166]
  • Alberto Diez-Torrubia, Silvia Cabrera, Anne-Marie Lambeir, Jan Balzarini, María-José Camarasa, Sonsoles Velázquez. Dipeptidyl peptidase IV (DPPIV/CD26)-based prodrugs of hydroxy-containing drugs. ChemMedChem. 2012 Apr; 7(4):618-28. doi: 10.1002/cmdc.201100504. [PMID: 22307932]
  • Raveen Parboosing, Glenn E M Maguire, Patrick Govender, Hendrik G Kruger. Nanotechnology and the treatment of HIV infection. Viruses. 2012 04; 4(4):488-520. doi: 10.3390/v4040488. [PMID: 22590683]
  • Johannes Vermehren, Annika Vermehren, Axel Mueller, Amina Carlebach, Thomas Lutz, Peter Gute, Gaby Knecht, Christoph Sarrazin, Mireen Friedrich-Rust, Nicole Forestier, Thierry Poynard, Stefan Zeuzem, Eva Herrmann, Wolf Peter Hofmann. Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers. BMC gastroenterology. 2012 Mar; 12(?):27. doi: 10.1186/1471-230x-12-27. [PMID: 22453133]
  • Elizabeth Ojewole, Irene Mackraj, Kamil Akhundov, Josias Hamman, Alvaro Viljoen, Eugene Olivier, James Wesley-Smith, Thirumala Govender. Investigating the effect of Aloe vera gel on the buccal permeability of didanosine. Planta medica. 2012 Mar; 78(4):354-61. doi: 10.1055/s-0031-1280431. [PMID: 22161764]
  • Enrico Girardi, Paola Scognamiglio, Claudio Angeletti, Andrea Gori, Dora Buonfrate, Massimo Arlotti, Giovanni Mazzarello, Antonella Castagna, Massimo Andreoni, Antonella d'Arminio Monforte, Andrea Antinori, Giuseppe Ippolito. Determinants of access to experimental antiretroviral drugs in an Italian cohort of patients with HIV: a multilevel analysis. BMC health services research. 2012 Feb; 12(?):38. doi: 10.1186/1472-6963-12-38. [PMID: 22336471]
  • Giuseppe Pontrelli, Nicola Cotugno, Donato Amodio, Paola Zangari, Hyppolite K Tchidjou, Stefania Baldassari, Paolo Palma, Stefania Bernardi. Renal function in HIV-infected children and adolescents treated with tenofovir disoproxil fumarate and protease inhibitors. BMC infectious diseases. 2012 Jan; 12(?):18. doi: 10.1186/1471-2334-12-18. [PMID: 22269183]
  • Marilia Rita Pinzone, Michelino Di Rosa, Bruno Cacopardo, Giuseppe Nunnari. HIV RNA suppression and immune restoration: can we do better?. Clinical & developmental immunology. 2012; 2012(?):515962. doi: 10.1155/2012/515962. [PMID: 22489250]
  • Julie H Levison, Catherine Orrell, Sébastien Gallien, Daniel R Kuritzkes, Naishin Fu, Elena Losina, Kenneth A Freedberg, Robin Wood. Virologic failure of protease inhibitor-based second-line antiretroviral therapy without resistance in a large HIV treatment program in South Africa. PloS one. 2012; 7(3):e32144. doi: 10.1371/journal.pone.0032144. [PMID: 22427821]
  • Bernhard Setzer, Ulrich A Walker. Antiretroviral nucleoside analogues suppress antibody synthesis in human B-lymphocytes. Antiviral therapy. 2012; 17(4):729-35. doi: 10.3851/imp2086. [PMID: 22414568]
  • Robert Balikuddembe, Joshua Kayiwa, David Musoke, Muhammad Ntale, Steven Baveewo, Paul Waako, Celestino Obua. Plasma drug level validates self-reported adherence but predicts limited specificity for nonadherence to antiretroviral therapy. ISRN pharmacology. 2012; 2012(?):274978. doi: 10.5402/2012/274978. [PMID: 22530137]
  • Thomas Aschacher, Sandra Sampl, Lisa Käser, David Bernhard, Andreas Spittler, Klaus Holzmann, Michael Bergmann. The combined use of known antiviral reverse transcriptase inhibitors AZT and DDI induce anticancer effects at low concentrations. Neoplasia (New York, N.Y.). 2012 Jan; 14(1):44-53. doi: 10.1593/neo.11426. [PMID: 22355273]
  • Slim Fourati, Isabelle Malet, Carolin A Guenzel, Cathia Soulie, Priscilla Maidou-Peindara, Laurence Morand-Joubert, Marc Wirden, Sophie Sayon, Gilles Peytavin, Anne Simon, Christine Katlama, Serge Benichou, Vincent Calvez, Anne-Geneviève Marcelin. E17A mutation in HIV-1 Vpr confers resistance to didanosine in association with thymidine analog mutations. Antiviral research. 2012 Jan; 93(1):167-74. doi: 10.1016/j.antiviral.2011.11.008. [PMID: 22138483]
  • Patrícia Severino, Tatiana Andreani, Ana Sofia Macedo, Joana F Fangueiro, Maria Helena A Santana, Amélia M Silva, Eliana B Souto. Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. Journal of drug delivery. 2012; 2012(?):750891. doi: 10.1155/2012/750891. [PMID: 22175030]
  • Kasongo Wa Kasongo, Jana Pardeike, Rainer H Müller, Roderick B Walker. Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers. Journal of pharmaceutical sciences. 2011 Dec; 100(12):5185-96. doi: 10.1002/jps.22711. [PMID: 22020815]
  • L Ene, D Duiculescu, S M Ruta. How much do antiretroviral drugs penetrate into the central nervous system?. Journal of medicine and life. 2011 Nov; 4(4):432-9. doi: NULL. [PMID: 22514580]
  • Andrea Costantini, Katia Marinelli, Giulia Biagioni, Alessia Monachetti, Monica L Ferreri, Luca Butini, Maria Montroni, Aldo Manzin, Patrizia Bagnarelli. Molecular analysis of hepatitis B virus (HBV) in an HIV co-infected patient with reactivation of occult HBV infection following discontinuation of lamivudine-including antiretroviral therapy. BMC infectious diseases. 2011 Nov; 11(?):310. doi: 10.1186/1471-2334-11-310. [PMID: 22054111]
  • Thomas A Rasmussen, Martin Tolstrup, Jesper Melchjorsen, Christian A Frederiksen, Ulla S Nielsen, Bente L Langdahl, Lars Østergaard, Alex L Laursen. Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy. BMC infectious diseases. 2011 Oct; 11(?):267. doi: 10.1186/1471-2334-11-267. [PMID: 21970555]
  • Kasongo Wa Kasongo, Mirko Jansch, Rainer H Müller, Roderick B Walker. Evaluation of the in vitro differential protein adsorption patterns of didanosine-loaded nanostructured lipid carriers (NLCs) for potential targeting to the brain. Journal of liposome research. 2011 Sep; 21(3):245-54. doi: 10.3109/08982104.2010.539186. [PMID: 21174528]
  • Rym Skanji, Karine Andrieux, Muriel Lalanne, Joachim Caron, Claudie Bourgaux, Jéril Degrouard, François Brisset, Claire Gueutin, Hélène Chacun, Nathalie Dereuddre-Bosquet, Angelo Paci, Gilles Vassal, Laurent Bauduin, Sébastien Garcia-Argote, Bernard Rousseau, Pascal Clayette, Didier Desmaële, Patrick Couvreur. A new nanomedicine based on didanosine glycerolipidic prodrug enhances the long term accumulation of drug in a HIV sanctuary. International journal of pharmaceutics. 2011 Jul; 414(1-2):285-97. doi: 10.1016/j.ijpharm.2011.05.005. [PMID: 21596125]
  • Laurence Ahoua, Gunar Guenther, Christine Rouzioux, Loretxu Pinoges, Paul Anguzu, Anne-Marie Taburet, Suna Balkan, David M Olson, Charles Olaro, Mar Pujades-Rodríguez. Immunovirological response to combined antiretroviral therapy and drug resistance patterns in children: 1- and 2-year outcomes in rural Uganda. BMC pediatrics. 2011 Jul; 11(?):67. doi: 10.1186/1471-2431-11-67. [PMID: 21791095]
  • Makoura Barro, Jérôme Some, Vincent Foulongne, Yaya Diasso, Emmanuelle Zouré, Hervé Hien, Rouet François, Segondy Michel, Aly Drabo, Hassane Tamboura, Adama Ouiminga, Serge Diagbouga, Alain Hien, Souleymane Yaméogo, Philippe Van De Perre, Boubacar Nacro, Philippe Msellati. Short-term virological efficacy, immune reconstitution, tolerance, and adherence of once-daily dosing of didanosine, lamivudine, and efavirenz in HIV-1-infected African children: ANRS 12103 Burkiname. Journal of acquired immune deficiency syndromes (1999). 2011 Jul; 57 Suppl 1(?):S44-9. doi: 10.1097/qai.0b013e31821fd64f. [PMID: 21857286]
  • B Prabhakar, Asima Banu, H B Pavithra, P Chandrashekhara, Suresh Sasthri. Immunological failure despite virological suppression in HIV seropositive individuals on antiretroviral therapy. Indian journal of sexually transmitted diseases and AIDS. 2011 Jul; 32(2):94-8. doi: 10.4103/0253-7184.85412. [PMID: 22021970]
  • Luis Mérida, Javier de la Torre, Julián Olalla, Mariam Noureddine, Alfonso del Arco, José Luis Prada, Ana Aguilar, Javier García-Alegría. [Protective role of antiretroviral treatment in the impairment of renal function in a cohort of human immunodeficiency virus patients]. Medicina clinica. 2011 Jun; 137(3):104-7. doi: 10.1016/j.medcli.2010.09.049. [PMID: 21397277]
  • Yiguang Jin, Rui Xin, Li Tong, Lina Du, Miao Li. Combination anti-HIV therapy with the self-assemblies of an asymmetric bolaamphiphilic zidovudine/didanosine prodrug. Molecular pharmaceutics. 2011 Jun; 8(3):867-76. doi: 10.1021/mp100457d. [PMID: 21553876]
  • James J Kohler, Seyed H Hosseini, Elgin Green, Allison Abuin, Tomika Ludaway, Rodney Russ, Robert Santoianni, William Lewis. Tenofovir renal proximal tubular toxicity is regulated by OAT1 and MRP4 transporters. Laboratory investigation; a journal of technical methods and pathology. 2011 Jun; 91(6):852-8. doi: 10.1038/labinvest.2011.48. [PMID: 21403643]
  • Boubacar Nacro, Emmanuelle Zoure, Hervé Hien, Hassane Tamboura, François Rouet, Adama Ouiminga, Ali Drabo, Souleymane Yameogo, Alain Hien, Hélène Peyriere, Olivier Mathieu, Deborah Hirt, Jean-Marc Treluyer, Joëlle Nicolas, Vincent Foulongne, Michel Segondy, Philippe van de Perre, Serge Diagbouga, Philippe Msellati. Pharmacology and immuno-virologic efficacy of once-a-day HAART in African HIV-infected children: ANRS 12103 phase II trial. Bulletin of the World Health Organization. 2011 Jun; 89(6):451-8. doi: 10.2471/blt.10.081646. [PMID: 21673861]
  • Usman A Ashfaq, Tariq Javed, Sidra Rehman, Zafar Nawaz, Sheikh Riazuddin. Lysosomotropic agents as HCV entry inhibitors. Virology journal. 2011 Apr; 8(?):163. doi: 10.1186/1743-422x-8-163. [PMID: 21481279]
  • Zhongtian Yan, Jin Sun, Yannan Chang, Yanhua Liu, Qiang Fu, Youjun Xu, Yongbing Sun, Xiaohui Pu, Youxi Zhang, Yongkui Jing, Shiliang Yin, Meng Zhu, Yongjun Wang, Zhonggui He. Bifunctional peptidomimetic prodrugs of didanosine for improved intestinal permeability and enhanced acidic stability: synthesis, transepithelial transport, chemical stability and pharmacokinetics. Molecular pharmaceutics. 2011 Apr; 8(2):319-29. doi: 10.1021/mp100376q. [PMID: 21280612]
  • Kasongo Wa Kasongo, Ranjita Shegokar, Rainer H Müller, Roderick B Walker. Formulation development and in vitro evaluation of didanosine-loaded nanostructured lipid carriers for the potential treatment of AIDS dementia complex. Drug development and industrial pharmacy. 2011 Apr; 37(4):396-407. doi: 10.3109/03639045.2010.516264. [PMID: 20923388]
  • K J Wadher, R B Kakde, M J Umekar. Formulation and evaluation of a sustained-release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers. Indian journal of pharmaceutical sciences. 2011 Mar; 73(2):208-15. doi: 10.4103/0250-474x.91579. [PMID: 22303065]
  • Eva A Operskalski, Andrea Kovacs. HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies. Current HIV/AIDS reports. 2011 Mar; 8(1):12-22. doi: 10.1007/s11904-010-0071-3. [PMID: 21221855]
  • Luke C Swenson, Graham Pollock, Brian Wynhoven, Theresa Mo, Winnie Dong, Robert S Hogg, Julio S G Montaner, P Richard Harrigan. 'Dynamic range' of inferred phenotypic HIV drug resistance values in clinical practice. PloS one. 2011 Feb; 6(2):e17402. doi: 10.1371/journal.pone.0017402. [PMID: 21390218]
  • Chandrasekaran Padmapriyadarsini, S Ramesh Kumar, Norma Terrin, Gopalan Narendran, Pradeep A Menon, Geetha Ramachandran, Sudha Subramanyan, Perumal Venkatesan, Christine Wanke, Soumya Swaminathan. Dyslipidemia among HIV-infected Patients with tuberculosis taking once-daily nonnucleoside reverse-transcriptase inhibitor-based antiretroviral therapy in India. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2011 Feb; 52(4):540-6. doi: 10.1093/cid/ciq195. [PMID: 21252141]
  • Linos Vandekerckhove, Chris Verhofstede, Els Demecheleer, Stephane De Wit, Eric Florence, Katrien Fransen, Michel Moutschen, Wendy Mostmans, Kabamba Kabeya, Nicola Mackie, Jean Plum, Dolores Vaira, Kurt Van Baelen, Ina Vandenbroucke, Veerle Van Eygen, Herwig Van Marck, Dirk Vogelaers, Anna Maria Geretti, Lieven J Stuyver. Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment. The Journal of antimicrobial chemotherapy. 2011 Feb; 66(2):265-72. doi: 10.1093/jac/dkq458. [PMID: 21196489]
  • Christine L Clouser, Colleen M Holtz, Mary Mullett, Duane L Crankshaw, Jacquie E Briggs, Jay Chauhan, Ilze Matise VanHoutan, Steven E Patterson, Louis M Mansky. Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine. PloS one. 2011 Jan; 6(1):e15840. doi: 10.1371/journal.pone.0015840. [PMID: 21264291]
  • Heidi M Crane, Carl Grunfeld, James H Willig, Michael J Mugavero, Stephen Van Rompaey, Richard Moore, Benigno Rodriguez, Betsy J Feldman, Michael M Lederman, Michael S Saag, Mari M Kitahata. Impact of NRTIs on lipid levels among a large HIV-infected cohort initiating antiretroviral therapy in clinical care. AIDS (London, England). 2011 Jan; 25(2):185-95. doi: 10.1097/qad.0b013e328341f925. [PMID: 21150555]
  • Sébastien Gallien, Valérie Journot, Willy Rozenbaum, Patrick Yéni, Philippe Morlat, Isabelle Poizot-Martin, Jacques Reynes, Véronique Reliquet, Pascale Leclercq, François Simon, Geneviève Chêne, Jean-Michel Molina. Four year follow-up of simplification therapy with once-daily emtricitabine, didanosine and efavirenz in HIV-infected patients (ALIZE ANRS 099 trial). The Journal of antimicrobial chemotherapy. 2011 Jan; 66(1):184-91. doi: 10.1093/jac/dkq395. [PMID: 21036772]
  • Jacques Gasnault, Dominique Costagliola, Houria Hendel-Chavez, Anne Dulioust, Sophie Pakianather, Anne-Aurélie Mazet, Marie-Ghislaine de Goer de Herve, Rémi Lancar, Anne-Sophie Lascaux, Lydie Porte, Jean-François Delfraissy, Yassine Taoufik. Improved survival of HIV-1-infected patients with progressive multifocal leukoencephalopathy receiving early 5-drug combination antiretroviral therapy. PloS one. 2011; 6(6):e20967. doi: 10.1371/journal.pone.0020967. [PMID: 21738597]
  • Carolina Gutiérrez, Laura Díaz, Alejandro Vallejo, Beatriz Hernández-Novoa, María Abad, Nadia Madrid, Viktor Dahl, Rafael Rubio, Ana M Moreno, Fernando Dronda, José Luis Casado, Enrique Navas, María Jesús Pérez-Elías, Javier Zamora, Sarah Palmer, Eduardo Muñoz, María Ángeles Muñoz-Fernández, Santiago Moreno. Intensification of antiretroviral therapy with a CCR5 antagonist in patients with chronic HIV-1 infection: effect on T cells latently infected. PloS one. 2011; 6(12):e27864. doi: 10.1371/journal.pone.0027864. [PMID: 22174752]
  • Robert Kalyesubula, Mark A Perazella. Nephrotoxicity of HAART. AIDS research and treatment. 2011; 2011(?):562790. doi: 10.1155/2011/562790. [PMID: 21860787]
  • Pedro Cahn, Julio Montaner, Patrice Junod, Patricia Patterson, Alejandro Krolewiecki, Jaime Andrade-Villanueva, Isabel Cassetti, Juan Sierra-Madero, Arnaldo David Casiró, Raul Bortolozzi, Sergio Horacio Lupo, Nadia Longo, Emmanouil Rampakakis, Nabil Ackad, John S Sampalis. Pilot, randomized study assessing safety, tolerability and efficacy of simplified LPV/r maintenance therapy in HIV patients on the 1 PI-based regimen. PloS one. 2011; 6(8):e23726. doi: 10.1371/journal.pone.0023726. [PMID: 21886816]
  • Pierre Delobel, Adrien Saliou, Florence Nicot, Martine Dubois, Stéphanie Trancart, Philippe Tangre, Jean-Pierre Aboulker, Anne-Marie Taburet, Jean-Michel Molina, Patrice Massip, Bruno Marchou, Jacques Izopet. Minor HIV-1 variants with the K103N resistance mutation during intermittent efavirenz-containing antiretroviral therapy and virological failure. PloS one. 2011; 6(6):e21655. doi: 10.1371/journal.pone.0021655. [PMID: 21738752]
  • Katherine A Barraclough, Nicole M Isbel, Christine E Staatz, David W Johnson. BK Virus in Kidney Transplant Recipients: The Influence of Immunosuppression. Journal of transplantation. 2011; 2011(?):750836. doi: 10.1155/2011/750836. [PMID: 21766009]
  • Christa Kasang, Samuel Kalluvya, Charles Majinge, August Stich, Jochen Bodem, Gilbert Kongola, Graeme B Jacobs, Mathias Mlewa, Miriam Mildner, Irina Hensel, Anne Horn, Wolfgang Preiser, Gert van Zyl, Hartwig Klinker, Eleni Koutsilieri, Axel Rethwilm, Carsten Scheller, Benedikt Weissbrich. HIV drug resistance (HIVDR) in antiretroviral therapy-naïve patients in Tanzania not eligible for WHO threshold HIVDR survey is dramatically high. PloS one. 2011; 6(8):e23091. doi: 10.1371/journal.pone.0023091. [PMID: 21886779]
  • Karin J Metzner, Christine Leemann, Francesca Di Giallonardo, Christina Grube, Alexandra U Scherrer, Dominique Braun, Herbert Kuster, Rainer Weber, Huldrych F Guenthard. Reappearance of minority K103N HIV-1 variants after interruption of ART initiated during primary HIV-1 infection. PloS one. 2011; 6(7):e21734. doi: 10.1371/journal.pone.0021734. [PMID: 21754996]
  • Jia Wang, Huijuan Kou, Qiang Fu, Yang Han, Zhifeng Qiu, Lingyan Zuo, Yanling Li, Zhu Zhu, Min Ye, Qing Ma, Taisheng Li. Nevirapine plasma concentrations are associated with virologic response and hepatotoxicity in Chinese patients with HIV infection. PloS one. 2011; 6(10):e26739. doi: 10.1371/journal.pone.0026739. [PMID: 22066007]
  • Yong Chang Seo, Woon Yong Choi, Choon Geun Lee, Seon Woo Cha, Young Ock Kim, Jin-Chul Kim, Gregor P C Drummen, Hyeon Yong Lee. Enhanced immunomodulatory activity of gelatin-encapsulated Rubus coreanus Miquel nanoparticles. International journal of molecular sciences. 2011; 12(12):9031-56. doi: 10.3390/ijms12129031. [PMID: 22272118]
  • Beatriz Fernandez-Fernandez, Ana Montoya-Ferrer, Ana B Sanz, Maria D Sanchez-Niño, Maria C Izquierdo, Jonay Poveda, Valeria Sainz-Prestel, Natalia Ortiz-Martin, Alejandro Parra-Rodriguez, Rafael Selgas, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz. Tenofovir nephrotoxicity: 2011 update. AIDS research and treatment. 2011; 2011(?):354908. doi: 10.1155/2011/354908. [PMID: 21716719]
  • Tudor J C Phillips, Catherine L Cherry, Sarah Cox, Sarah J Marshall, Andrew S C Rice. Pharmacological treatment of painful HIV-associated sensory neuropathy: a systematic review and meta-analysis of randomised controlled trials. PloS one. 2010 Dec; 5(12):e14433. doi: 10.1371/journal.pone.0014433. [PMID: 21203440]
  • Juan Manuel Tiraboschi, Jordi Niubo, Jordi Curto, Daniel Podzamczer. Maraviroc concentrations in cerebrospinal fluid in HIV-infected patients. Journal of acquired immune deficiency syndromes (1999). 2010 Dec; 55(5):606-9. doi: 10.1097/qai.0b013e3181ef70fe. [PMID: 20706127]
  • Zhihui Dou, Ray Y Chen, Jiahong Xu, Ye Ma, Jin Hua Jiao, Stephen Durako, Yan Zhao, Decai Zhao, Hua Fang, Fujie Zhang. Changing baseline characteristics among patients in the China National Free Antiretroviral Treatment Program, 2002-09. International journal of epidemiology. 2010 Dec; 39 Suppl 2(?):ii56-64. doi: 10.1093/ije/dyq215. [PMID: 21113038]
  • Pere Domingo, Javier Torres-Torronteras, Virginia Pomar, Marta Giralt, Joan Carles Domingo, Maria Del Mar Gutierrez, José M Gallego-Escuredo, Maria Gracia Mateo, Pedro Cano-Soldado, Irene Fernandez, Marçal Pastor-Anglada, Francesc Vidal, Francesc Villarroya, Antoni Andreu, Ramon Marti. Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome. PloS one. 2010 Nov; 5(11):e13896. doi: 10.1371/journal.pone.0013896. [PMID: 21085568]
  • Zhihui Dou, Ray Y Chen, Zhe Wang, Guoping Ji, Guoping Peng, Xiaochun Qiao, Jihua Fu, Xiangdong Meng, Marc Bulterys, Ye Ma, Yan Zhao, Ning Wang, Fujie Zhang. HIV-infected former plasma donors in rural Central China: from infection to survival outcomes, 1985-2008. PloS one. 2010 Oct; 5(10):e13737. doi: 10.1371/journal.pone.0013737. [PMID: 21060835]
  • Weerawat Manosuthi, Wiroj Mankatitham, Aroon Lueangniyomkul, Wisit Prasithsirikul, Preecha Tantanathip, Busakorn Suntisuklappon, Anongnuch Narkksoksung, Samruay Nilkamhang, Somnuek Sungkanuparph. Renal impairment after switching from stavudine/lamivudine to tenofovir/lamivudine in NNRTI-based antiretroviral regimens. AIDS research and therapy. 2010 Oct; 7(?):37. doi: 10.1186/1742-6405-7-37. [PMID: 20937122]
  • C Stephan, B Dauer, M Bickel, A Haberl, L Locher, A Müller, S Klauke, A Berger, H-W Doerr, M Stürmer, S Staszewski. Intensification of a failing regimen with zidovudine may cause sustained virologic suppression in the presence of resensitising mutations including K65R. The Journal of infection. 2010 Oct; 61(4):346-50. doi: 10.1016/j.jinf.2010.06.008. [PMID: 20600301]
  • D De Forni, M R Stevens, F Lori. Strategies to improve efficacy and safety of a novel class of antiviral hyper-activation-limiting therapeutic agents: the VS411 model in [corrected] HIV/AIDS. British journal of pharmacology. 2010 Oct; 161(4):830-43. doi: 10.1111/j.1476-5381.2010.00940.x. [PMID: 20860662]
  • Livio Azzoni, Nigel J Crowther, Cynthia Firnhaber, Andrea S Foulkes, Xiangfan Yin, Deborah Glencross, Robert Gross, Mitch D Kaplan, Emmanouil Papasavvas, Doreen Schulze, Wendy Stevens, Tessa van der Merwe, Rita Waisberg, Ian Sanne, Luis J Montaner. Association between HIV replication and serum leptin levels: an observational study of a cohort of HIV-1-infected South African women. Journal of the International AIDS Society. 2010 Sep; 13(?):33. doi: 10.1186/1758-2652-13-33. [PMID: 20822522]
  • Rama Mallipeddi, Lisa Cencia Rohan. Progress in antiretroviral drug delivery using nanotechnology. International journal of nanomedicine. 2010 Aug; 5(?):533-47. doi: 10.2147/ijn.s7681. [PMID: 20957115]
  • Naïm Bouazza, Déborah Hirt, Christophe Bardin, Serge Diagbouga, Boubacar Nacro, Hervé Hien, Emmanuelle Zoure, François Rouet, Adama Ouiminga, Stephane Blanche, Philippe Van De Perre, Jean-Marc Tréluyer, Philippe Msellati, Saik Urien. Is the recommended once-daily dose of lamivudine optimal in West African HIV-infected children?. Antimicrobial agents and chemotherapy. 2010 Aug; 54(8):3280-6. doi: 10.1128/aac.00306-10. [PMID: 20516271]
  • Lakshmi N Ramana, Swaminathan Sethuraman, Udaykumar Ranga, Uma M Krishnan. Development of a liposomal nanodelivery system for nevirapine. Journal of biomedical science. 2010 Jul; 17(?):57. doi: 10.1186/1423-0127-17-57. [PMID: 20624325]
  • Charlotte Hedskog, Mattias Mild, Johanna Jernberg, Ellen Sherwood, Göran Bratt, Thomas Leitner, Joakim Lundeberg, Björn Andersson, Jan Albert. Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing. PloS one. 2010 Jul; 5(7):e11345. doi: 10.1371/journal.pone.0011345. [PMID: 20628644]
  • E Randall Lanier, Roger G Ptak, Bernhard M Lampert, Laurie Keilholz, Tracy Hartman, Robert W Buckheit, Marie K Mankowski, Mark C Osterling, Merrick R Almond, George R Painter. Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV. Antimicrobial agents and chemotherapy. 2010 Jul; 54(7):2901-9. doi: 10.1128/aac.00068-10. [PMID: 20439609]
  • Amitabh Sagar, Ambika P Mohanty, Ashish Bahal. Zidovudine-induced myopathy: A study in Indian patients. Journal of neurosciences in rural practice. 2010 Jul; 1(2):63-6. doi: 10.4103/0976-3147.71717. [PMID: 21808505]
  • Reshmie Ramautarsing, Jintanat Ananworanich. Generic and low dose antiretroviral therapy in adults and children: implication for scaling up treatment in resource limited settings. AIDS research and therapy. 2010 Jun; 7(?):18. doi: 10.1186/1742-6405-7-18. [PMID: 20569473]
  • Vici Varghese, Elijah Wang, Farbod Babrzadeh, Michael H Bachmann, Rajin Shahriar, Tommy Liu, Svetlana Jean M Mappala, Baback Gharizadeh, W Jeffrey Fessel, David Katzenstein, Seble Kassaye, Robert W Shafer. Nucleic acid template and the risk of a PCR-Induced HIV-1 drug resistance mutation. PloS one. 2010 Jun; 5(6):e10992. doi: 10.1371/journal.pone.0010992. [PMID: 20539818]
  • Abeer M Al-Ghananeem, Hayder Saeed, Rebecca Florence, Robert A Yokel, Ahmad H Malkawi. Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses. Journal of drug targeting. 2010 Jun; 18(5):381-8. doi: 10.3109/10611860903483396. [PMID: 20001275]
  • Philippe Halfon, Claude Giorgetti, Hacène Khiri, Guillaume Pénaranda, Philippe Terriou, Géraldine Porcu-Buisson, Véronique Chabert-Orsini. Semen may harbor HIV despite effective HAART: another piece in the puzzle. PloS one. 2010 May; 5(5):e10569. doi: 10.1371/journal.pone.0010569. [PMID: 20485526]
  • Roland Landman, M B Diallo, N F Ngom Gueye, C Toure Kane, S Mboup, M B Koita Fall, B Ndiaye, G Peytavin, Y Bennai, A Benalycherif, P M Girard, P S Sow. Efficacy and safety of unboosted atazanavir in combination with lamivudine and didanosine in naive HIV type 1 patients in Senegal. AIDS research and human retroviruses. 2010 May; 26(5):519-25. doi: 10.1089/aid.2009.0123. [PMID: 20455760]
  • Ofelia A Olivero, Irma L Vazquez, Catherine C Cooch, Jessica Ming, Emily Keller, Mia Yu, Jennifer P Borojerdi, Hannan M Braun, Edward McKee, Miriam C Poirier. Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells. Toxicological sciences : an official journal of the Society of Toxicology. 2010 May; 115(1):109-17. doi: 10.1093/toxsci/kfq023. [PMID: 20106944]
  • Mariam Sampson, Anthony E Archibong, Adriane Powell, Brandon Strange, Shannon Roberson, Edward R Hills, Phillip Bourne. Perturbation of the developmental potential of preimplantation mouse embryos by hydroxyurea. International journal of environmental research and public health. 2010 05; 7(5):2033-44. doi: 10.3390/ijerph7052033. [PMID: 20623009]
  • Steven J Reynolds, Cissy Kityo, Claire W Hallahan, Geoffrey Kabuye, Diana Atwiine, Frank Mbamanya, Francis Ssali, Robin Dewar, Marybeth Daucher, Richard T Davey, Peter Mugyenyi, Anthony S Fauci, Thomas C Quinn, Mark R Dybul. A randomized, controlled, trial of short cycle intermittent compared to continuous antiretroviral therapy for the treatment of HIV infection in Uganda. PloS one. 2010 Apr; 5(4):e10307. doi: 10.1371/journal.pone.0010307. [PMID: 20442758]
  • Eefje Jong, Joost C M Meijers, Eric C M van Gorp, C Arnold Spek, Jan W Mulder. Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir. AIDS research and therapy. 2010 Apr; 7(?):9. doi: 10.1186/1742-6405-7-9. [PMID: 20398387]
  • Bambang S Adiwijaya, Eva Herrmann, Brian Hare, Tara Kieffer, Chao Lin, Ann D Kwong, Varun Garg, John C R Randle, Christoph Sarrazin, Stefan Zeuzem, Paul R Caron. A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants. PLoS computational biology. 2010 Apr; 6(4):e1000745. doi: 10.1371/journal.pcbi.1000745. [PMID: 20419154]
  • Luis F López-Cortés, Pompeyo Viciana, Rosa Ruiz-Valderas, Juan Pasquau, Josefa Ruiz, Fernando Lozano, Dolores Merino, Antonio Vergara, Alberto Terrón, Luis González, Antonio Rivero, Agustin Muñoz-Sanz. Efficacy, safety and pharmacokinetic of once-daily boosted saquinavir (1500/100 mg) together with 2 nucleos(t)ide reverse transcriptase inhibitors in real life: a multicentre prospective study. AIDS research and therapy. 2010 Mar; 7(?):5. doi: 10.1186/1742-6405-7-5. [PMID: 20236544]