Sphondin (BioDeep_00000407827)

Main id: BioDeep_00000000879

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2H-Furo(2,3-h)-1-benzopyran-2-one, 6-methoxy-

化学式: C12H8O4 (216.0423)
中文名称: 6-甲氧基当归素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C2C(=C3C(=C1)C=CC(=O)O3)C=CO2
InChI: InChI=1S/C12H8O4/c1-14-9-6-7-2-3-10(13)16-11(7)8-4-5-15-12(8)9/h2-6H,1H3

描述信息

D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].
Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].

同义名列表

31 个代谢物同义名

2H-Furo(2,3-h)-1-benzopyran-2-one, 6-methoxy-; 6-Methoxy-2H-furo(2,3-h)-1-benzopyran-2-one; 6-Methoxy-2H-furo[2,3-H]chromen-2-one; 6-methoxy-2-furo[2,3-h]chromenone; 6-Methoxyfuro[2,3-h]chromen-2-one; SDCCGMLS-0066509.P001; Spectrum2_001759; Spectrum4_001600; Spectrum3_001238; Spectrum5_000320; NCGC00095567-01; SpecPlus_000144; Spectrum_000598; SPECTRUM300005; BSPBio_002716; A4338\0184974; KBioSS_001078; KBioGR_002220; DivK1c_006240; MLS000574845; SPBio_001898; KBio3_002216; KBio2_006214; SMR000156215; KBio2_001078; KBio2_003646; KBio1_001184; 483-66-9; Sphondin; Sphondin; Sphondin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

63 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CYP2A6, CYP2B6, MAPK14, MAPK8, NFKB1, PRPF19, PTGS2, TYR
Peripheral membrane protein 4 CYP1B1, CYP2B6, GORASP1, PTGS2
Endoplasmic reticulum membrane 4 CYP1B1, CYP2A6, CYP2B6, PTGS2
Nucleus 4 MAPK14, MAPK8, NFKB1, PRPF19
cytosol 3 MAPK14, MAPK8, NFKB1
nucleoplasm 4 MAPK14, MAPK8, NFKB1, PRPF19
Cytoplasmic side 1 GORASP1
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
glutamatergic synapse 1 MAPK14
Golgi apparatus 1 GORASP1
Golgi membrane 1 GORASP1
lysosomal membrane 1 GAA
Lysosome 2 GAA, TYR
plasma membrane 1 GAA
Membrane 4 CYP1B1, CYP2A6, GAA, PRPF19
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 1 GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 1 PTGS2
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 TYR
mitochondrion 3 CYP1B1, MAPK14, NFKB1
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 5 CYP1B1, CYP2A6, CYP2B6, GAA, TYR
Microsome membrane 3 CYP1B1, CYP2B6, PTGS2
Single-pass type I membrane protein 1 TYR
Secreted 1 GAA
extracellular region 3 GAA, MAPK14, NFKB1
transcription regulator complex 1 NFKB1
Melanosome membrane 1 TYR
Golgi-associated vesicle 1 TYR
Cytoplasm, cytoskeleton, spindle 1 PRPF19
spindle 1 PRPF19
cis-Golgi network 1 GORASP1
nuclear speck 2 MAPK14, PRPF19
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 1 NFKB1
spindle pole 1 MAPK14
spliceosomal complex 1 PRPF19
site of double-strand break 1 PRPF19
Lipid droplet 1 PRPF19
Nucleus, nucleoplasm 1 PRPF19
tertiary granule membrane 1 GAA
Melanosome 1 TYR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 MAPK14, NFKB1
endoplasmic reticulum lumen 1 PTGS2
specific granule lumen 1 NFKB1
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
cytoplasmic microtubule 1 CYP2A6
U2-type catalytic step 1 spliceosome 1 PRPF19
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
catalytic step 2 spliceosome 1 PRPF19
Prp19 complex 1 PRPF19
U2-type catalytic step 2 spliceosome 1 PRPF19
autolysosome lumen 1 GAA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1


文献列表

  • Fang Ren, Junchi Hu, Yongjun Dang, Haijun Deng, Jihua Ren, Shengtao Cheng, Ming Tan, Hui Zhang, Xin He, Haibo Yu, Juan Zhang, Zhenzhen Zhang, Weixian Chen, Jieli Hu, Xuefei Cai, Yuan Hu, Ailong Huang, Juan Chen. Sphondin efficiently blocks HBsAg production and cccDNA transcription through promoting HBx degradation. Journal of medical virology. 2023 Feb; ?(?):. doi: 10.1002/jmv.28578. [PMID: 36846971]
  • Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
  • Taryn O'Neill, John A Johnson, Duncan Webster, Christopher A Gray. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. Journal of ethnopharmacology. 2013 May; 147(1):232-7. doi: 10.1016/j.jep.2013.03.009. [PMID: 23501157]
  • Yu Fu, Yang Bai, Zhuoma Dawa, Bingru Bai, Lisheng Ding. [Chemical constituents of Incarvillea younghusbandii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jan; 35(1):58-62. doi: 10.4268/cjcmm20100112. [PMID: 20349717]
  • Ya-li Zong, Yu-ping Lin, Qiong-e Ding, Hui He, Gao-xiong Rao. [Studies on the chemical constituents of the aerial parts of Seseli mairei]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 Jan; 30(1):42-4. doi: . [PMID: 17539301]
  • Anna Bogucka-Kocka, Tadeusz Krzaczek. The furanocoumarins in the roots of Heracleum sibiricum L. Acta poloniae pharmaceutica. 2003 Sep; 60(5):391-3. doi: ". [PMID: 15005423]
  • N F KOMISSARENKO, V T CHERNOBAI, D G KOLESNIKOV. [Isolation of sphondin from the roots of the cow parsnip Heracleum dissectum LDB. II]. Meditsinskaia promyshlennost' SSSR. 1962 Oct; 10(?):25-6. doi: . [PMID: 14034501]