N8-Acetylspermidine (BioDeep_00000405952)

Main id: BioDeep_00000001387

 


代谢物信息卡片


N8-Acetylspermidine

化学式: C9H21N3O (187.1685)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NCCCCNCCCN
InChI: InChI=1S/C9H21N3O/c1-9(13)12-8-3-2-6-11-7-4-5-10/h11H,2-8,10H2,1H3,(H,12,13)

描述信息

同义名列表

2 个代谢物同义名

N8-Acetylspermidine; N8-Acetylspermidine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AFP, ARG1, ASPM, HDAC10, HDAC6, HDAC8, HDAC9, ODC1, PAOX, SAT1
Nucleus 8 ARG1, ASPM, CS, HDAC10, HDAC6, HDAC8, HDAC9, SPEG
cytosol 9 ARG1, HDAC10, HDAC6, NGF, ODC1, PAOX, SAT1, SMS, SRM
dendrite 2 HDAC6, NGF
centrosome 2 ASPM, HDAC6
nucleoplasm 4 HDAC10, HDAC6, HDAC8, HDAC9
Cell membrane 3 CD19, CHRNA7, SAT1
Cell projection, axon 1 HDAC6
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 2 CHRNA7, SAT1
Synapse 1 CHRNA7
mitochondrial inner membrane 1 SIRT4
neuronal cell body 1 SAT1
postsynapse 1 CHRNA7
synaptic vesicle 1 NGF
Cytoplasm, cytosol 1 SAT1
plasma membrane 3 CD19, CHRNA7, SAT1
Membrane 4 CD19, CHRNA7, CS, SAT1
apical plasma membrane 1 ASPM
axon 3 HDAC6, NGF, SAT1
basolateral plasma membrane 1 SAT1
caveola 1 HDAC6
extracellular exosome 4 CD19, CS, SAT1, SMS
extracellular space 5 AFP, ARG1, CRP, NGF, TG
perinuclear region of cytoplasm 1 HDAC6
mitochondrion 2 CS, SIRT4
protein-containing complex 1 CD19
intracellular membrane-bounded organelle 1 HDAC10
Single-pass type I membrane protein 1 CD19
Secreted 4 AFP, CRP, NGF, TG
extracellular region 4 ARG1, CRP, NGF, TG
Mitochondrion matrix 2 CS, SIRT4
mitochondrial matrix 2 CS, SIRT4
transcription regulator complex 1 HDAC9
Cell projection, cilium 1 HDAC6
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 HDAC6
external side of plasma membrane 1 CD19
multivesicular body 1 HDAC6
perikaryon 1 HDAC6
axon cytoplasm 1 HDAC6
midbody 1 ASPM
postsynaptic membrane 1 CHRNA7
Membrane raft 1 CD19
Cytoplasm, cytoskeleton 1 HDAC6
Cytoplasm, cytoskeleton, spindle 1 ASPM
microtubule 1 HDAC6
spindle 1 ASPM
Peroxisome 1 PAOX
peroxisomal matrix 1 PAOX
Postsynaptic cell membrane 1 CHRNA7
neuron projection 1 CHRNA7
ciliary basal body 1 HDAC6
cell leading edge 1 HDAC6
microtubule associated complex 1 HDAC6
Chromosome 1 HDAC8
Cytoplasm, cytoskeleton, cilium basal body 1 HDAC6
nuclear chromosome 1 HDAC8
Basolateral cell membrane 1 SAT1
endosome lumen 1 NGF
Cell projection, dendrite 1 HDAC6
plasma membrane raft 1 CHRNA7
Golgi lumen 1 NGF
endoplasmic reticulum lumen 1 AFP
histone methyltransferase complex 1 HDAC9
specific granule lumen 1 ARG1
histone deacetylase complex 4 HDAC10, HDAC6, HDAC8, HDAC9
mitotic spindle pole 1 ASPM
azurophil granule lumen 1 ARG1
aggresome 1 HDAC6
meiotic spindle 1 ASPM
external side of apical plasma membrane 1 SAT1
microtubule minus-end 1 ASPM
acetylcholine-gated channel complex 1 CHRNA7
inclusion body 1 HDAC6


文献列表

  • Lucia Abela, Luke Simmons, Katharina Steindl, Bernhard Schmitt, Massimo Mastrangelo, Pascal Joset, Mihaela Papuc, Heinrich Sticht, Alessandra Baumer, Lisa M Crowther, Déborah Mathis, Anita Rauch, Barbara Plecko. N(8)-acetylspermidine as a potential plasma biomarker for Snyder-Robinson syndrome identified by clinical metabolomics. Journal of inherited metabolic disease. 2016 Jan; 39(1):131-7. doi: 10.1007/s10545-015-9876-y. [PMID: 26174906]
  • Ashley J Vargas, Erin L Ashbeck, Cynthia A Thomson, Eugene W Gerner, Patricia A Thompson. Dietary polyamine intake and polyamines measured in urine. Nutrition and cancer. 2014; 66(7):1144-53. doi: 10.1080/01635581.2014.949801. [PMID: 25204413]
  • B L O'Brien, M Hankewych, D McCormick, R Jacoby, T A Brasitus, A G Halline. Urinary N1-acetylspermidine and N8-acetylspermidine excretion in normal humans and in patients with colorectal cancer. Digestive diseases and sciences. 1995 Jun; 40(6):1269-74. doi: 10.1007/bf02065536. [PMID: 7781445]
  • C Löser, U R Fölsch, C Paprotny, W Creutzfeldt. Polyamines in colorectal cancer. Evaluation of polyamine concentrations in the colon tissue, serum, and urine of 50 patients with colorectal cancer. Cancer. 1990 Feb; 65(4):958-66. doi: 10.1002/1097-0142(19900215)65:4<958::aid-cncr2820650423>3.0.co;2-z. [PMID: 2297664]
  • A G Halline, P K Dudeja, B A Lashner, T A Brasitus. Urinary excretion of N1-acetylspermidine and other acetylated and free polyamines in the 1,2-dimethylhydrazine model of experimental rat colon cancer. Cancer research. 1989 Sep; 49(17):4721-3. doi: . [PMID: 2758407]
  • J Blankenship, P E Marchant. Metabolism of N1-acetylspermidine and N8-acetylspermidine in rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1984 Oct; 177(1):180-7. doi: 10.3181/00379727-177-41930. [PMID: 6473353]
  • S Yamamoto, T Kobayashi, Y Suemoto, M Makita. An improved gas chromatographic method for the determination of urinary acetylpolyamines. Chemical & pharmaceutical bulletin. 1984 May; 32(5):1878-84. doi: 10.1248/cpb.32.1878. [PMID: 6467469]
  • W J Hrushesky, J Merdink, M M Abdel-Monem. Circadian rhythmicity of polyamine urinary excretion. Cancer research. 1983 Aug; 43(8):3944-7. doi: NULL. [PMID: 6861156]
  • D H Russell, J D Ellingson, T P Davis. Analysis of polyamines and acetyl derivatives by a single automated amino acid analyzer technique. Journal of chromatography. 1983 Apr; 273(2):263-74. doi: 10.1016/s0378-4347(00)80948-2. [PMID: 6863443]
  • C E Prussak, K Brendel. The formation of radiolabeled N1- and N8-acetylspermidine in various rat organs following [14C]spermidine administration. The International journal of biochemistry. 1983; 15(7):899-905. doi: 10.1016/0020-711x(83)90165-9. [PMID: 6884566]
  • S Yamamoto, M Yokogawa, K Wakamatsu, H Kataoka, M Makita. Gas chromatographic method for the determination of urinary acetylpolyamines. Journal of chromatography. 1982 Dec; 233(?):29-38. doi: 10.1016/s0378-4347(00)81728-4. [PMID: 7161341]
  • M M Abdel-Monem, J L Merdink, A Theologides. Urinary excretion of monoacetyl polyamines in patients with non-Hodgkin's lymphoma. Cancer research. 1982 May; 42(5):2097-8. doi: . [PMID: 7066912]
  • M M Abdel-Monem, J L Merdink. Determination of monoacetyldiamines and -polyamines in urine by high-performance liquid chromatography. Journal of chromatography. 1981 Mar; 222(3):363-70. doi: 10.1016/s0378-4347(00)84136-5. [PMID: 7228946]