CYPROHEPTADINE (BioDeep_00000405791)
Main id: BioDeep_00000001940
代谢物信息卡片
CYPROHEPTADINE
化学式: C21H21N (287.1674)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=1C=CC2=C(C1)C=CC=3C=CC=CC3C2=C4CCN(C)CC4
InChI: InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
描述信息
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D005765 - Gastrointestinal Agents
D018926 - Anti-Allergic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:4046
- KEGG: C06935
- KEGGdrug: D07765
- PubChem: 2913
- DrugBank: DB00434
- ChEMBL: CHEMBL516
- MeSH: Cyproheptadine
- MoNA: FiehnHILIC001860
- MoNA: FiehnHILIC000287
- PubChem: 9151
- CAS: 129-03-3
- PDB-CCD: C7H
- NIKKAJI: J5.419D
- medchemexpress: HY-B1622
- KNApSAcK: 4046
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hanaa Mohamed Khalaf, Sara Mohamed Naguib Abdel Hafez, Ahlam Mohamed Abdalla, Nermeen N Welson, Walaa Yehia Abdelzaher, Fatma Alzhraa Fouad Abdelbaky. Role of Platelet-activating factor and HO-1 in mediating the protective effect of rupatadine against 5-fluorouracil-induced hepatotoxicity in rats.
Environmental science and pollution research international.
2022 Jun; 29(26):40190-40203. doi:
10.1007/s11356-022-18899-4. [PMID: 35119631] - Benoit Banga N'guessan, Jessica Sarpongmaa Twumasi-Ankrah, Seth Kwabena Amponsah, Ismaila Adams, Albert Kyei-Kankam Poakwah, Charles Brown, Michael Buenor Adinortey, Joseph Adusei Sarkodie, Ofosua Adi-Dako, Isaac Julius Asiedu-Gyekye, Regina Appiah-Opong. Effect of Metaswitch® dietary supplement on anthropometric parameters, serum lipids, glucose level, oxidative stress and in vivo antioxidant properties in high fat diet-induced overweight Sprague Dawley rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 May; 149(?):112892. doi:
10.1016/j.biopha.2022.112892. [PMID: 35358796] - Yu Liu, Pengjun Jiang, Xuqing Chen, Wen Zhang, Jun Shi. Efficacy and Safety of Rupatadine Fumarate Combined with Acupoint Application in Allergic Rhinitis Complicated with Diabetes.
Computational intelligence and neuroscience.
2022; 2022(?):6935758. doi:
10.1155/2022/6935758. [PMID: 35747720] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Theoharis C Theoharides. Potential association of mast cells with coronavirus disease 2019.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2021 03; 126(3):217-218. doi:
10.1016/j.anai.2020.11.003. [PMID: 33161155] - Constantinos Demopoulos, Smaragdi Antonopoulou, Theoharis C Theoharides. COVID-19, microthromboses, inflammation, and platelet activating factor.
BioFactors (Oxford, England).
2020 Nov; 46(6):927-933. doi:
10.1002/biof.1696. [PMID: 33296106] - Suguru Kato, Abhi Shah, Mihaela Plesescu, Yoshinari Miyata, Jayaprakasam Bolleddula, Swapan Chowdhury, Xiaochun Zhu. Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver.
Drug metabolism and disposition: the biological fate of chemicals.
2020 10; 48(10):934-943. doi:
10.1124/dmd.120.000128. [PMID: 32665417] - T C Theoharides, P Conti. COVID-19 and Multisystem Inflammatory Syndrome, or is it Mast Cell Activation Syndrome?.
Journal of biological regulators and homeostatic agents.
2020 Sep; 34(5):1633-1636. doi:
10.23812/20-edit3. [PMID: 33023287] - Heba M Hafez, Elshymaa A Abdel-Hakeem, Hanaa Hassanein. Rupatadine, a dual antagonist of histamine and platelet-activating factor (PAF), attenuates experimentally induced diabetic nephropathy in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 08; 393(8):1487-1500. doi:
10.1007/s00210-020-01856-8. [PMID: 32200462] - Nisha Sharma, Himanshu Sankrityayan, Ajinath Kale, Anil Bhanudas Gaikwad. Role of SET7/9 in the progression of ischemic renal injury in diabetic and non-diabetic rats.
Biochemical and biophysical research communications.
2020 07; 528(1):14-20. doi:
10.1016/j.bbrc.2020.05.075. [PMID: 32448511] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Aruna Sharma, Rudy J Castellani, Mark A Smith, Dafin Fior Muresanu, Prasanta Kumar Dey, Hari Shanker Sharma. 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.
International review of neurobiology.
2019; 146(?):1-44. doi:
10.1016/bs.irn.2019.06.005. [PMID: 31349924] - Selvakumar Kanthiah, Valliappan Kannappan. D-Optimal mixture design optimization of an HPLC method for simultaneous determination of commonly used antihistaminic parent molecules and their active metabolites in human serum and urine.
Biomedical chromatography : BMC.
2017 Aug; 31(8):. doi:
10.1002/bmc.3932. [PMID: 28058761] - R Munoz-Cano, E Ainsua-Enrich, I Torres-Atencio, M Martin, J Sánchez-Lopez, J Bartra, C Picado, J Mullol, A Valero. Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study).
Journal of investigational allergology & clinical immunology.
2017 ; 27(3):161-168. doi:
10.18176/jiaci.0117. [PMID: 27758758] - Yuqing Xiong, Zhao Yuan, Jingzhi Yang, Chunhua Xia, Xinhua Li, Shibo Huang, Hong Zhang, Mingyi Liu. CYP3A5*3 and MDR1 C3435T are influencing factors of inter-subject variability in rupatadine pharmacokinetics in healthy Chinese volunteers.
European journal of drug metabolism and pharmacokinetics.
2016 Apr; 41(2):117-24. doi:
10.1007/s13318-014-0236-3. [PMID: 25427746] - Thomaz A A Rocha-E-Silva, Alessandra Linardi, Edson Antunes, Stephen Hyslop. Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats.
The Journal of pharmacology and experimental therapeutics.
2016 Jan; 356(1):13-9. doi:
10.1124/jpet.115.226787. [PMID: 26607257] - I O Ishola, S O Olayemi, O K Yemitan, E A Umeh. Antidepressant and anxiolytic effects of the methanol root extract of Capparis thonningii: involvement of monoaminergic, cholinergic and GABAergic systems.
Drug research.
2015 Apr; 65(4):205-13. doi:
10.1055/s-0034-1376963. [PMID: 24886981] - Chenglong Sun, Qian Li, Liping Pan, Bing Liu, Pan Gu, Junying Zhang, Li Ding, Chungyong Wu. Development of a highly sensitive LC-MS/MS method for simultaneous determination of rupatadine and its two active metabolites in human plasma: Application to a clinical pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2015; 111(?):163-8. doi:
10.1016/j.jpba.2015.03.025. [PMID: 25890211] - Hua Jiang, Rongrong Chen, Hongcui Wang, Hanlin Pu. Interaction of cyproheptadine hydrochloride with human serum albumin using spectroscopy and molecular modeling methods.
Luminescence : the journal of biological and chemical luminescence.
2013 Mar; 28(2):244-52. doi:
10.1002/bio.2374. [PMID: 22605685] - M Mutseura, D Tagwireyi, L L Gadaga. Pre-treatment of BALB/c mice with a centrally acting serotonin antagonist (cyproheptadine) reduces mortality from Boophone disticha poisoning.
Clinical toxicology (Philadelphia, Pa.).
2013 Jan; 51(1):16-22. doi:
10.3109/15563650.2012.748194. [PMID: 23194021] - Sébastien Beaune, Jacques Callebert, Frédéric J Baud, Patricia Risède, Philippe Juvin, Bruno Mégarbane. Mechanisms of high-dose citalopram-induced death in a rat model.
Toxicology.
2012 Dec; 302(2-3):248-54. doi:
10.1016/j.tox.2012.08.006. [PMID: 22951378] - Bruno Campos, Benjamín Piña, Carlos Barata C. Mechanisms of action of selective serotonin reuptake inhibitors in Daphnia magna.
Environmental science & technology.
2012 Mar; 46(5):2943-50. doi:
10.1021/es203157f. [PMID: 22324381] - Derong Zhu, Xia Li, Jinying Sun, Tianyan You. Chemometrics optimization of six antihistamines separations by capillary electrophoresis with electrochemiluminescence detection.
Talanta.
2012 Jan; 88(?):265-71. doi:
10.1016/j.talanta.2011.10.040. [PMID: 22265497] - Gustavo Duarte Mendes, André Arruda, Lu Shi Chen, José Cássio de Almeida Magalhães, Khalid M Alkharfy, Gilberto De Nucci. Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study.
Biomedical chromatography : BMC.
2012 Jan; 26(1):129-36. doi:
10.1002/bmc.1618. [PMID: 21432861] - Luis A Zarazaga, Irma Celi, José Luis Guzmán, Benoît Malpaux. The effect of nutrition on the neural mechanisms potentially involved in melatonin-stimulated LH secretion in female Mediterranean goats.
The Journal of endocrinology.
2011 Dec; 211(3):263-72. doi:
10.1530/joe-11-0225. [PMID: 21903864] - Rituparna Maiti, Jyothirmai Jaida, B N Raghavendra, Prakash Goud, Idris Ahmed, Anuradha Palani. Rupatadine and levocetirizine in chronic idiopathic urticaria: a comparative study of efficacy and safety.
Journal of drugs in dermatology : JDD.
2011 Dec; 10(12):1444-50. doi:
NULL. [PMID: 22134570] - Yan-Rong Zhu, Yan-Yan Jia, Ling Jiang, Chao Wang, Li-Kun Ding, Jing Yang, Liang Li, Pei-Xi Zhao, Wen-Xin Liu, Yi-Ding, Li Wang, Ai-Dong Wen. Determination of azatadine in human plasma by liquid chromatography/tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Aug; 879(23):2189-93. doi:
10.1016/j.jchromb.2011.05.050. [PMID: 21737359] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - M K Church. Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males.
The British journal of dermatology.
2010 Dec; 163(6):1330-2. doi:
10.1111/j.1365-2133.2010.10029.x. [PMID: 20819087] - Ellen E Codd, Judith Baker, Michael R Brandt, Stewart Bryant, Chaozhong Cai, John R Carson, Kristen M Chevalier, Raymond W Colburn, Timothy P Coogan, Scott L Dax, Bart Decorte, Michael Kemmerer, Edmund K Legrand, James M Lenhard, Angelique M Leone, Ling Lin, John R Mabus, Mark E McDonnell, Michael K McMillian, James J McNally, Dennis J Stone, Charles Y Wang, Sui-Po Zhang, Christopher M Flores. Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.
Toxicological sciences : an official journal of the Society of Toxicology.
2010 Oct; 117(2):493-504. doi:
10.1093/toxsci/kfq200. [PMID: 20616206] - Consuelo García-Gea, Maria Rosa Ballester, Juan Martínez, Rosa Maria Antonijoan, Esther Donado, Iñaki Izquierdo, Manuel-José Barbanoj. Rupatadine does not potentiate the CNS depressant effects of lorazepam: randomized, double-blind, crossover, repeated dose, placebo-controlled study.
British journal of clinical pharmacology.
2010 Jun; 69(6):663-74. doi:
10.1111/j.1365-2125.2010.03648.x. [PMID: 20565458] - Sayaka Kato, Yukio Kato, Tadakatsu Nakamura, Tomoko Sugiura, Yoshiyuki Kubo, Yoshiharu Deguchi, Akira Tsuji. Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice.
Biopharmaceutics & drug disposition.
2009 Dec; 30(9):495-507. doi:
10.1002/bdd.681. [PMID: 19821448] - Veronica Hargrove, D Kimberley Molina. A fatality due to cyproheptadine and citalopram.
Journal of analytical toxicology.
2009 Oct; 33(8):564-7. doi:
10.1093/jat/33.8.564. [PMID: 19874671] - Damanpreet Singh, Rajesh Kumar Goel. Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.
Journal of ethnopharmacology.
2009 Jun; 123(2):330-4. doi:
10.1016/j.jep.2009.02.042. [PMID: 19429380] - Pat Mahachoklertwattana, Santhira Wanasuwankul, Preamrudee Poomthavorn, Lulin Choubtum, Arporn Sriphrapradang. Short-term cyproheptadine therapy in underweight children: effects on growth and serum insulin-like growth factor-I.
Journal of pediatric endocrinology & metabolism : JPEM.
2009 May; 22(5):425-32. doi:
10.1515/jpem.2009.22.5.425. [PMID: 19618661] - Xesús Feás, Lei Ye, Patricia Regal, Cristina A Fente, Seyed V Hosseini, Alberto Cepeda. Application of dummy molecularly imprinted solid-phase extraction in the analysis of cyproheptadine in bovine urine.
Journal of separation science.
2009 May; 32(10):1740-7. doi:
10.1002/jssc.200800726. [PMID: 19472275] - Vijay L Kumar, Abhishek Singhal. Germinating seeds of the mung bean, Vigna radiata (Fabaceae), as a model for the preliminary evaluation of cytotoxic effects of drugs.
Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al.
2009 Apr; 33(1):19-24. doi:
10.32604/biocell.2009.33.019. [PMID: 19499882] - Cristina A Fente, Patricia Regal, Beatriz I Vázquez, Xexús Feás, Carlos M Franco, Alberto Cepeda. Development and validation of an LC-MS/MS confirmatory method for residue analysis of cyproheptadine in urine of food-producing animals.
Journal of agricultural and food chemistry.
2009 Mar; 57(6):2595-8. doi:
10.1021/jf803395r. [PMID: 19231896] - Jun Wen, Zhanying Hong, Yiwen Wu, Hua Wei, Guorong Fan, Yutian Wu. Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers.
Journal of pharmaceutical and biomedical analysis.
2009 Feb; 49(2):347-53. doi:
10.1016/j.jpba.2008.10.014. [PMID: 19059745] - Anna Solans, Iñaki Izquierdo, Esther Donado, Rosa Antonijoan, Juana Peña, Teresa Nadal, Marcel-Lí Carbó, Manuel Merlos, Manel Barbanoj. Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study.
Clinical therapeutics.
2008 Sep; 30(9):1639-50. doi:
10.1016/j.clinthera.2008.09.002. [PMID: 18840369] - Elke Ericson, Marinella Gebbia, Lawrence E Heisler, Jan Wildenhain, Mike Tyers, Guri Giaever, Corey Nislow. Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.
PLoS genetics.
2008 Aug; 4(8):e1000151. doi:
10.1371/journal.pgen.1000151. [PMID: 18688276] - Yuan Tian, Jingjing Zhang, Hui Lin, Jiabi Liang, Zunjian Zhang, Yun Chen. High performance liquid chromatography-tandem mass spectrometric determination of rupatadine in human plasma and its pharmacokinetics.
Journal of pharmaceutical and biomedical analysis.
2008 Aug; 47(4-5):899-906. doi:
10.1016/j.jpba.2008.03.015. [PMID: 18472381] - Elizabeth K Schooley, Joseph B McGee Turner, Renee D Jiji, Christine M Spinka, Carol R Reinero. Effects of cyproheptadine and cetirizine on eosinophilic airway inflammation in cats with experimentally induced asthma.
American journal of veterinary research.
2007 Nov; 68(11):1265-71. doi:
10.2460/ajvr.68.11.1265. [PMID: 17975984] - P Mercy, A Ghorpade, M N Das, A Soud, S Puttoo, D Sharma, A Jain. Acquired Blaschkoid dermatitis.
Indian journal of dermatology, venereology and leprology.
2007 Nov; 73(6):415-6. doi:
10.4103/0378-6323.37062. [PMID: 18032863] - Vijay L Kumar, Raman Sehgal. Calotropis procera latex-induced inflammatory hyperalgesia - effect of bradyzide and morphine.
Autonomic & autacoid pharmacology.
2007 Jul; 27(3):143-9. doi:
10.1111/j.1474-8673.2007.00405.x. [PMID: 17584444] - Anna Solans, Marcel Lí Carbó, Juana Peña, Teresa Nadal, Iñaki Izquierdo, Manuel Merlos. Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.
Clinical therapeutics.
2007 May; 29(5):900-908. doi:
10.1016/j.clinthera.2007.05.004. [PMID: 17697908] - Manuel J Barbanoj, Consuelo García-Gea, Rosa Antonijoan, Iñaki Izquierdo, Ester Donado, Iñaki Pérez, Anna Solans, Francesc Jané. Evaluation of the cognitive, psychomotor and pharmacokinetic profiles of rupatadine, hydroxyzine and cetirizine, in combination with alcohol, in healthy volunteers.
Human psychopharmacology.
2006 Jan; 21(1):13-26. doi:
10.1002/hup.741. [PMID: 16389668] - Petra Stuebner, Friedrich Horak, René Zieglmayer, Eva Arnáiz, Chiara Leuratti, Iñaki Pérez, Iñaki Izquierdo. Effects of rupatadine vs placebo on allergen-induced symptoms in patients exposed to aeroallergens in the Vienna Challenge Chamber.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2006 Jan; 96(1):37-44. doi:
10.1016/s1081-1206(10)61038-1. [PMID: 16440531] - Omer Calka, Ahmet Metin, Haluk Dülger, Reha Erkoç. Effect of cyproheptadine on serum leptin levels.
Advances in therapy.
2005 Sep; 22(5):424-8. doi:
10.1007/bf02849860. [PMID: 16418149] - Carol R Reinero, Kendra C Decile, Jenni R Byerly, Roy D Berghaus, William E Walby, Londa J Berghaus, Dallas M Hyde, Edward S Schelegle, Laurel J Gershwin. Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.
American journal of veterinary research.
2005 Jul; 66(7):1121-7. doi:
10.2460/ajvr.2005.66.1121. [PMID: 16111148] - Stefen A Boehme, Francisco M Lio, Lyudmila Sikora, Terlika S Pandit, Karine Lavrador, Savita P Rao, P Sriramarao. Cutting edge: serotonin is a chemotactic factor for eosinophils and functions additively with eotaxin.
Journal of immunology (Baltimore, Md. : 1950).
2004 Sep; 173(6):3599-603. doi:
10.4049/jimmunol.173.6.3599. [PMID: 15356103] - Francisco A Oliveira, Roberto C P Lima-Junior, Wilcare M Cordeiro, Gerardo M Vieira-Júnior, Mariana H Chaves, Fernanda R C Almeida, Regilane M Silva, Flavia A Santos, Vietla S N Rao. Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus.
Pharmacology, biochemistry, and behavior.
2004 Aug; 78(4):719-25. doi:
10.1016/j.pbb.2004.05.013. [PMID: 15301927] - S Karmakar, D C Muhuri, S C Dasgupta, A K Nagchaudhuri, A Gomes. Isolation of a haemorrhagic protein toxin (SA-HT) from the Indian venomous butterfish (Scatophagus argus, Linn) sting extract.
Indian journal of experimental biology.
2004 May; 42(5):452-60. doi:
. [PMID: 15233468] - Luiz Augusto Casulari, Luciana A Naves, Paulo A Mello, Aldo Pereira Neto, Carla Papadia. Nelson's syndrome: complete remission with cabergoline but not with bromocriptine or cyproheptadine treatment.
Hormone research.
2004; 62(6):300-5. doi:
10.1159/000082235. [PMID: 15557761] - Narendra Gunja, Michael Collins, Andis Graudins. A comparison of the pharmacokinetics of oral and sublingual cyproheptadine.
Journal of toxicology. Clinical toxicology.
2004; 42(1):79-83. doi:
10.1081/clt-120028749. [PMID: 15083941] - Sheikh Arshad Saeed, Huma Rasheed, Anwar-ul-Hassan Gilani. Synergism interaction between arachidonic acid by 5-hydroxytryptamine in human platelet aggregation is mediated through multiple signalling pathways.
Acta pharmacologica Sinica.
2003 Oct; 24(10):958-64. doi:
. [PMID: 14531936] - Emmanuel Yankep, Dieudonné Njamen, Maurice Tagatsing Fotsing, Zacharias Tanee Fomum, Jean-Claude Mbanya, Rosa M Giner, M Carmen Recio, Salvador Máñez, José Luis Ríos. Griffonianone D, an isoflavone with anti-inflammatory activity from the root bark of Millettia griffoniana.
Journal of natural products.
2003 Sep; 66(9):1288-90. doi:
10.1021/np0205912. [PMID: 14510620] - Constance M Yuan, Phillip R Spandorfer, Samuel L Miller, Fred M Henretig, Leslie M Shaw. Evaluation of tricyclic antidepressant false positivity in a pediatric case of cyproheptadine (periactin) overdose.
Therapeutic drug monitoring.
2003 Jun; 25(3):299-304. doi:
10.1097/00007691-200306000-00009. [PMID: 12766557] - Emmanuel Talla, Dieudonné Njamen, Joseph Tanyi Mbafor, Zacharias Tanee Fomum, Albert Kamanyi, Jean-Claude Mbanya, Rosa M Giner, M Carmen Recio, Salvador Máñez, José Luis Ríos. Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
Journal of natural products.
2003 Jun; 66(6):891-3. doi:
10.1021/np020599b. [PMID: 12828487] - H Kojima, T Terao, M Iwakawa, A Soya, N Inoue, Y Shiraishi, Y Son, S Soeda, N Ueda, R Yoshimura, J Nakamura. Paroxetine as a 5-HT neuroendocrine probe.
Psychopharmacology.
2003 Apr; 167(1):97-102. doi:
10.1007/s00213-003-1406-1. [PMID: 12601506] - Dyane Auclair, John J Hopwood, Douglas A Brooks, Jeffrey F Lemontt, Allison C Crawley. Replacement therapy in Mucopolysaccharidosis type VI: advantages of early onset of therapy.
Molecular genetics and metabolism.
2003 Mar; 78(3):163-74. doi:
10.1016/s1096-7192(03)00007-6. [PMID: 12649061] - Tatiana R Lavich, Renato S B Cordeiro, João B Calixto, Patrícia M R e Silva, Marco A Martins. Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.
European journal of pharmacology.
2003 Feb; 462(1-3):185-92. doi:
10.1016/s0014-2999(02)02947-3. [PMID: 12591112] - Teruaki Imada, Naruyasu Komorita, Fujio Kobayashi, Koji Naito, Tsutomu Yoshikawa, Mizuo Miyazaki, Norifumi Nakamura, Takao Kondo. Therapeutic potential of a specific chymase inhibitor in atopic dermatitis.
Japanese journal of pharmacology.
2002 Nov; 90(3):214-7. doi:
10.1254/jjp.90.214. [PMID: 12499574] - Mark T Donaldson, Bernadette H LaMonte, Peter Morresey, Gary Smith, Jill Beech. Treatment with pergolide or cyproheptadine of pituitary pars intermedia dysfunction (equine Cushing's disease).
Journal of veterinary internal medicine.
2002 Nov; 16(6):742-6. doi:
10.1892/0891-6640(2002)016<0742:twpoco>2.3.co;2. [PMID: 12465775] - G A Perkins, S Lamb, H N Erb, B Schanbacher, D V Nydam, T J Divers. Plasma adrenocorticotropin (ACTH) concentrations and clinical response in horses treated for equine Cushing's disease with cyproheptadine or pergolide.
Equine veterinary journal.
2002 Nov; 34(7):679-85. doi:
10.2746/042516402776250333. [PMID: 12455838] - F A Santos, V S N Rao. Possible role of mast cells in cineole-induced scratching behavior in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2002 Oct; 40(10):1453-7. doi:
10.1016/s0278-6915(02)00088-1. [PMID: 12387308] - Nina K Popova, Tamara G Amstislavskaya. 5-HT2A and 5-HT2C serotonin receptors differentially modulate mouse sexual arousal and the hypothalamo-pituitary-testicular response to the presence of a female.
Neuroendocrinology.
2002 Jul; 76(1):28-34. doi:
10.1159/000063681. [PMID: 12097814] - Eva M Giner-Larza, Salvador Máñez, Rosa M Giner, M Carmen Recio, José M Prieto, Miguel Cerdá-Nicolás, José Luis Ríos. Anti-inflammatory triterpenes from Pistacia terebinthus galls.
Planta medica.
2002 Apr; 68(4):311-5. doi:
10.1055/s-2002-26749. [PMID: 11988853] - Lizan Wang, Qingzhu Zhang, Xiuzhou Hu, Ning Lun, Baosheng Wang, Fanhe Zhu. Anti-endotoxic shock effects of cyproheptadine in rats.
Chinese medical journal.
2002 Mar; 115(3):443-5. doi:
. [PMID: 11940385] - A D Genazzani, C Strucchi, B Malavasi, F Tortolani, F Vecchi, S Luisi, F Petraglia. Effects of cyproheptadine clorhydrate, a serotonin receptor antagonist, on endocrine parameters in weight-loss related amenorrhea.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2001 Aug; 15(4):279-85. doi:
10.1080/gye.15.4.279.285. [PMID: 11560101] - S Zhou, P Kestell, M D Tingle, L M Ching, J W Paxton. A difference between the rat and mouse in the pharmacokinetic interaction of 5,6-dimethylxanthenone-4-acetic acid with thalidomide.
Cancer chemotherapy and pharmacology.
2001 Jun; 47(6):541-4. doi:
10.1007/s002800100285. [PMID: 11459209] - L Zhao, P Kestell, M Philpott, L M Ching, L Zhuang, B C Baguley. Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
Cancer chemotherapy and pharmacology.
2001 Jun; 47(6):491-7. doi:
10.1007/s002800000267. [PMID: 11459201] - M J Attenburrow, P R Mitter, R Whale, T Terao, P J Cowen. Low-dose citalopram as a 5-HT neuroendocrine probe.
Psychopharmacology.
2001 May; 155(3):323-6. doi:
10.1007/s002130100729. [PMID: 11432696] - J C Dreixler, J Bian, Y Cao, M T Roberts, J D Roizen, K M Houamed. Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds.
European journal of pharmacology.
2000 Jul; 401(1):1-7. doi:
10.1016/s0014-2999(00)00401-5. [PMID: 10915830] - D Katerere, O Parry. Pharmacological actions of Heteromorpha trifoliata ('dombwe') on rat isolated muscle preparations.
The Central African journal of medicine.
2000 Jan; 46(1):9-13. doi:
10.4314/cajm.v46i1.8515. [PMID: 14674200] - R Caballero, C Valenzuela, M Longobardo, J Tamargo, E Delpón. Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac kv1.5 channels.
British journal of pharmacology.
1999 Nov; 128(5):1071-81. doi:
10.1038/sj.bjp.0702890. [PMID: 10556945] - S Schwartz. Use of cyproheptadine to control urine spraying in a castrated male domestic cat.
Journal of the American Veterinary Medical Association.
1999 Aug; 215(4):501-2, 482. doi:
NULL. [PMID: 10461633] - Y Ohta, T Kobayashi, I Ishiguro. Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanaesthetised rats with a single treatment of compound 48/80, a mast cell degranulator.
Pharmacological research.
1999 Apr; 39(4):261-7. doi:
10.1006/phrs.1998.0403. [PMID: 10208755] - S Schwartz. Use of cyproheptadine to control urine spraying and masturbation in a cat.
Journal of the American Veterinary Medical Association.
1999 Feb; 214(3):369-71, 351. doi:
NULL. [PMID: 10023399] - L Z Wang, Y Q Liu, Y H Cui, F H Zhu, B S Wang, N Lun. Effects of dexamethasone, cyproheptadine, anisodamine, and dinoprostone on TNF alpha production in endotoxic shock.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1999 Feb; 20(2):171-4. doi:
NULL. [PMID: 10437167] - L G Villa-Diaz, G K Barrell. Involvement of serotoninergic pathways in the control of luteinizing hormone secretion in red deer hinds.
Reproduction, fertility, and development.
1999; 11(2):95-103. doi:
10.1071/rd99032. [PMID: 10735553] - S Kimura, A Watanabe, M Takeuchi, M Nagata, M Harada. Suppressive effects of antihistaminic and/or anti-PAF agents on passive anaphylactic shock in mice sensitized with allogeneic monoclonal IgE and IgG1 antibodies and hyperimmune serum.
Immunological investigations.
1998 Dec; 27(6):379-93. doi:
10.3109/08820139809022711. [PMID: 9845423] - B Kang, G Z Li, G Dai, Y Huang. Inhibitory effects of cyproheptadine on pituitary-thyroid axis and pancreatic beta cells in rats.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1998 Nov; 19(6):554-6. doi:
NULL. [PMID: 10437145] - S Kimura, A Watanabe, M Takeuchi, M Nagata, K Nakamura, M Harada. Drug susceptibility of PCA in WBB6F1-W/Wv mice.
Cellular and molecular life sciences : CMLS.
1998 May; 54(5):456-60. doi:
10.1007/s000180050173. [PMID: 9645225] - Y Miyazawa, H Tsutsui, H Mizuhara, H Fujiwara, K Kaneda. Involvement of intrasinusoidal hemostasis in the development of concanavalin A-induced hepatic injury in mice.
Hepatology (Baltimore, Md.).
1998 Feb; 27(2):497-506. doi:
10.1002/hep.510270225. [PMID: 9462649] - B Levine, D Green-Johnson, S Hogan, J E Smialek. A cyproheptadine fatality.
Journal of analytical toxicology.
1998 Jan; 22(1):72-4. doi:
10.1093/jat/22.1.72. [PMID: 9491973] - C R Norris, D M Boothe, T Esparza, C Gray, M Ragsdale. Disposition of cyproheptadine in cats after intravenous or oral administration of a single dose.
American journal of veterinary research.
1998 Jan; 59(1):79-81. doi:
NULL. [PMID: 9442249] - T Yoshino, I Yamaguchi. Possible involvement of 5-HT2 receptor activation in aggravation of diet-induced acute pancreatitis in mice.
The Journal of pharmacology and experimental therapeutics.
1997 Dec; 283(3):1495-502. doi:
NULL. [PMID: 9400026] - J J Reeves, C A Jones, M J Sheehan, C J Vardey, C J Whelan. Adenosine A3 receptors promote degranulation of rat mast cells both in vitro and in vivo.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
1997 May; 46(5):180-4. doi:
10.1007/s000110050169. [PMID: 9197988] - L B Mercado-Asis, J A Yanovski, H L Tracer, C L Chik, G B Cutler. Acute effects of bromocriptine, cyproheptadine, and valproic acid on plasma adrenocorticotropin secretion in Nelson's syndrome.
The Journal of clinical endocrinology and metabolism.
1997 Feb; 82(2):514-7. doi:
10.1210/jcem.82.2.3742. [PMID: 9024246] - C Küçükhüseyin, C Silan, N Akbaş, M Payat, H Oncel, A Barlas. On the mechanisms of adenosine induced pulmonary vasoconstriction in rats.
Journal of basic and clinical physiology and pharmacology.
1997; 8(4):287-99. doi:
10.1515/jbcpp.1997.8.4.287. [PMID: 9651801] - M Merlos, M Giral, D Balsa, R Ferrando, M Queralt, A Puigdemont, J García-Rafanell, J Forn. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).
The Journal of pharmacology and experimental therapeutics.
1997 Jan; 280(1):114-21. doi:
NULL. [PMID: 8996188] - J C Branum, R S Kline, C S Whisnant. The effects of neurotransmitter antagonists and glucose on luteinizing hormone secretion in growth-restricted wethers.
Animal reproduction science.
1997 Jan; 45(4):263-72. doi:
10.1016/s0378-4320(96)01592-8. [PMID: 9231237] - M Konstandi, A Kolijianni, A D Sfikakis. Effect of cyproheptadine treatment on conditioned avoidance response in female rats.
General pharmacology.
1996 Dec; 27(8):1401-3. doi:
10.1016/s0306-3623(96)00066-3. [PMID: 9304415] - S Kimura, A Watanabe, M Nagata, Y Niinomi, M Harada. Heterogeneity of drug susceptibility of mouse active anaphylactic shock.
Immunological investigations.
1996 Sep; 25(5-6):425-34. doi:
10.3109/08820139609055732. [PMID: 8915680] - T Yanase, K Nishizawa, O Inoue, T Sukamoto, Y Saito. [Antinociceptive effects of Kami-kihi-to in mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1996 Aug; 108(2):77-83. doi:
10.1254/fpj.108.77. [PMID: 8827725] - T H Schürmeyer, G Brademann, A Von Zur Mühlen. Effect of cyproheptadine on episodic ACTH and cortisol secretion.
European journal of clinical investigation.
1996 May; 26(5):397-403. doi:
10.1046/j.1365-2362.1996.143305.x. [PMID: 8796367] - M Kikuchi, K Tsuzurahara, T Suzuki, N Yato, K Naito. Involvement of leukotrienes in allergic pleurisy in actively sensitized rats: inhibition by the lipoxygenase inhibitor T-0757 of the increase in vascular permeability and leukotriene E4 production.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
1996 Apr; 45(4):192-7. doi:
10.1007/bf02285160. [PMID: 8741009] - C O van Waveren Hogervorst, H P Koppeschaar, P M Zelissen, C J Lips, B M Garcia. Cortisol secretory patterns in Cushing's disease and response to cyproheptadine treatment.
The Journal of clinical endocrinology and metabolism.
1996 Feb; 81(2):652-5. doi:
10.1210/jcem.81.2.8636284. [PMID: 8636284]
