Cortodoxone (BioDeep_00000405788)

Main id: BioDeep_00000003114

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


"17A,21-DIHYDROXY-4-PREGNENE-3,20-DIONE"

化学式: C21H30O4 (346.214398)
中文名称: 可托多松, 脱氧可的松
谱图信息: 最多检出来源 Homo sapiens(blood) 1.87%

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C(=O)CO)O)C
InChI: InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Cortodoxone is a glucocorticoid that can be oxidized to cortisone (Hydrocortisone).

同义名列表

5 个代谢物同义名

Cortodoxone; "17A,21-DIHYDROXY-4-PREGNENE-3,20-DIONE"; 11-Deoxycortisol; cortexolone; Reichstein's substance S



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(13)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kandaswamy Kalaivani, Sengottayan Senthil-Nathan, Vethamonickam Stanley-Raja, Prabhakaran Vasantha-Srinivasan. Physiological and biochemical alterations in Vigna rdiate L. triggered by sesame derived elicitors as defense mechanism against Rhizoctonia and Macrophomina infestation. Scientific reports. 2023 08; 13(1):13884. doi: 10.1038/s41598-023-39660-y. [PMID: 37620354]
  • Hannah Peterson, Leon Kircik, April W Armstrong. Individual Article: Clascoterone Cream 1\%: Mechanism of Action, Efficacy, and Safety of a Novel, First-in-Class Topical Antiandrogen Therapy for Acne. Journal of drugs in dermatology : JDD. 2023 Jun; 22(6):SF350992s7-SF350992s14. doi: . [PMID: 37276168]
  • Yu Song, Luting Nie, Dandan Wei, Pengling Liu, Keliang Fan, Li Zhang, Mian Wang, Lulu Wang, Wei Liao, Ning Kang, Qingqing Xu, Juan Wang, Zhenxing Mao, Chongjian Wang, Wenqian Huo. Serum cortisol-to-cortisone ratio and 11-deoxycortisol are associated with hypertension and blood pressure in Chinese rural population: a cross sectional study. Journal of hypertension. 2022 03; 40(3):432-440. doi: 10.1097/hjh.0000000000003028. [PMID: 34670995]
  • Parvathy Santhosh, Mamatha George. Clascoterone: a new topical anti-androgen for acne management. International journal of dermatology. 2021 Dec; 60(12):1561-1565. doi: 10.1111/ijd.15752. [PMID: 34242398]
  • Flávia A Costa-Barbosa, Valdemir M Carvalho, Kelly C Oliveira, José Gilberto H Vieira, Claudio E Kater. Reassessment of predictive values of ACTH-stimulated serum 21-deoxycortisol and 17-hydroxyprogesterone to identify CYP21A2 heterozygote carriers and nonclassic subjects. Clinical endocrinology. 2021 10; 95(4):677-685. doi: 10.1111/cen.14550. [PMID: 34231242]
  • Silvia M Albillos, Olimpio Montero, Sara Calvo, Berta Solano-Vila, José M Trejo, Esther Cubo. Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study. Parkinsonism & related disorders. 2021 10; 91(?):167-172. doi: 10.1016/j.parkreldis.2021.09.014. [PMID: 34649109]
  • Ciaran A Shaughnessy, Stephen D McCormick. 11-Deoxycortisol is a stress responsive and gluconeogenic hormone in a jawless vertebrate, the sea lamprey (Petromyzon marinus). The Journal of experimental biology. 2021 06; 224(11):. doi: 10.1242/jeb.241943. [PMID: 34086050]
  • Simon Travers, Claire Bouvattier, Jérôme Fagart, Laetitia Martinerie, Say Viengchareun, Eric Pussard, Marc Lombès. Interaction between accumulated 21-deoxysteroids and mineralocorticoid signaling in 21-hydroxylase deficiency. American journal of physiology. Endocrinology and metabolism. 2020 02; 318(2):E102-E110. doi: 10.1152/ajpendo.00368.2019. [PMID: 31821037]
  • L I Velikanova, Z R Shafigullina, N V Vorokhobina, E V Malevanaya. Gas Chromatography-Mass Spectrometry Analysis of Urinary Steroid Metabolomics for Detection of Early Signs of Adrenal Neoplasm Malignancy in Patients with Cushing's Syndrome. Bulletin of experimental biology and medicine. 2019 Sep; 167(5):676-680. doi: 10.1007/s10517-019-04597-8. [PMID: 31630306]
  • Alessandro Mazzetti, Luigi Moro, Mara Gerloni, Martina Cartwright. Pharmacokinetic Profile, Safety, and Tolerability of Clascoterone (Cortexolone 17-alpha propionate, CB-03-01) Topical Cream, 1\% in Subjects With Acne Vulgaris: An Open-Label Phase 2a Study. Journal of drugs in dermatology : JDD. 2019 Jun; 18(6):563. doi: . [PMID: 31251549]
  • Xiao Yang, Zhenru Wang, Qian Zhang, Ran Liu, Huarong Xu, Kaishun Bi, Qing Li. The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers?. Journal of separation science. 2019 May; 42(10):1833-1841. doi: 10.1002/jssc.201801298. [PMID: 30848087]
  • Caridad Rosette, Frances J. Agan, Alessandro Mazzetti, Luigi Moro, Mara Gerloni. Cortexolone 17α-propionate (Clascoterone) Is a Novel Androgen Receptor Antagonist that Inhibits Production of Lipids and Inflammatory Cytokines from Sebocytes In Vitro. Journal of drugs in dermatology : JDD. 2019 May; 18(5):412-418. doi: ". [PMID: 31141847]
  • Xue Liu, Jingjing Jiang, Xiaotian Liu, Zhicheng Luo, Yan Wang, Xiaokang Dong, Dandan Wei, Wenqian Huo, Songcheng Yu, Linlin Li, Shuna Jin, Chongjian Wang, Zhenxing Mao. Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study. Journal of diabetes research. 2019; 2019(?):4693817. doi: 10.1155/2019/4693817. [PMID: 31281850]
  • Joanne Sloan-Lancaster, Eyas Raddad, Amy Flynt, Yan Jin, James Voelker, Jeffrey W Miller. LY3045697: Results from two randomized clinical trials of a novel inhibitor of aldosterone synthase. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2017 Jul; 18(3):1470320317717883. doi: 10.1177/1470320317717883. [PMID: 28814143]
  • Christopher M Jones, Ashwini Mallappa, Nicole Reisch, Nikolaos Nikolaou, Nils Krone, Beverly A Hughes, Donna M O'Neil, Martin J Whitaker, Jeremy W Tomlinson, Karl-Heinz Storbeck, Deborah P Merke, Richard J Ross, Wiebke Arlt. Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia. The Journal of clinical endocrinology and metabolism. 2017 06; 102(6):1797-1806. doi: 10.1210/jc.2016-2855. [PMID: 27845856]
  • Alexander M Clifford, Nicolas R Bury, Aaron G Schultz, James D Ede, Brendan L Goss, Greg G Goss. Regulation of plasma glucose and sulfate excretion in Pacific hagfish, Eptatretus stoutii is not mediated by 11-deoxycortisol. General and comparative endocrinology. 2017 06; 247(?):107-115. doi: 10.1016/j.ygcen.2017.01.022. [PMID: 28126345]
  • D H Abbott, B H Rayome, D A Dumesic, K C Lewis, A K Edwards, K Wallen, M E Wilson, S E Appt, J E Levine. Clustering of PCOS-like traits in naturally hyperandrogenic female rhesus monkeys. Human reproduction (Oxford, England). 2017 04; 32(4):923-936. doi: 10.1093/humrep/dex036. [PMID: 28333238]
  • Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller, Philipp Schuetz. Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study. Critical care (London, England). 2017 03; 21(1):72. doi: 10.1186/s13054-017-1656-7. [PMID: 28335807]
  • L I Velikanova, Z R Shafigullina, A A Lisitsin, N V Vorokhobina, K Grigoryan, E A Kukhianidze, E G Strelnikova, N S Krivokhizhina, L M Krasnov, E A Fedorov, I V Sablin, A L Moskvin, E A Bessonova. Different Types of Urinary Steroid Profiling Obtained by High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectrometry in Patients with Adrenocortical Carcinoma. Hormones & cancer. 2016 12; 7(5-6):327-335. doi: 10.1007/s12672-016-0267-0. [PMID: 27370636]
  • A E Kulle, F G Riepe, J Hedderich, W G Sippell, J Schmitz, L Niermeyer, P M Holterhus. LC-MS/MS based determination of basal- and ACTH-stimulated plasma concentrations of 11 steroid hormones: implications for detecting heterozygote CYP21A2 mutation carriers. European journal of endocrinology. 2015 Oct; 173(4):517-24. doi: 10.1530/eje-14-1084. [PMID: 26315375]
  • T M A Kerkhofs, M N Kerstens, I P Kema, T P Willems, H R Haak. Diagnostic Value of Urinary Steroid Profiling in the Evaluation of Adrenal Tumors. Hormones & cancer. 2015 Aug; 6(4):168-75. doi: 10.1007/s12672-015-0224-3. [PMID: 25985881]
  • Satbir Rai, András Szeitz, Brent W Roberts, Quill Christie, Wesley Didier, Junho Eom, Sang-Seon Yun, David A Close. A putative corticosteroid hormone in Pacific lamprey, Entosphenus tridentatus. General and comparative endocrinology. 2015 Feb; 212(?):178-84. doi: 10.1016/j.ygcen.2014.06.019. [PMID: 24971804]
  • Julie A Ray, Mark M Kushnir, Richard A Yost, Alan L Rockwood, A Wayne Meikle. Performance enhancement in the measurement of 5 endogenous steroids by LC-MS/MS combined with differential ion mobility spectrometry. Clinica chimica acta; international journal of clinical chemistry. 2015 Jan; 438(?):330-6. doi: 10.1016/j.cca.2014.07.036. [PMID: 25110813]
  • Diane Dufour-Rainfray, Valérie Moal, Lucie Cloix, Elisabeth Mathieu, Anne-Sophie Gauchez, Julie Brossaud, Jean-Benoît Corcuff, François Fraissinet, Christine Collet, Florence Boux de Casson, Denis Guilloteau, Patrick Emond, Pascal Reynier. [Mass spectrometry for steroid assays]. Annales de biologie clinique. 2015 Jan; 73(1):70-8. doi: 10.1684/abc.2014.0988. [PMID: 25582724]
  • Clemens Kamrath, Michaela F Hartmann, Claudia Boettcher, Stefan A Wudy. Reduced activity of 11β-hydroxylase accounts for elevated 17α-hydroxyprogesterone in preterms. The Journal of pediatrics. 2014 Aug; 165(2):280-4. doi: 10.1016/j.jpeds.2014.04.011. [PMID: 24862381]
  • Wenxian Tan, Joseph Aizen, Peter Thomas. Membrane progestin receptor alpha mediates progestin-induced sperm hypermotility and increased fertilization success in southern flounder (Paralichthys lethostigma). General and comparative endocrinology. 2014 May; 200(?):18-26. doi: 10.1016/j.ygcen.2014.02.003. [PMID: 24530629]
  • Brent W Roberts, Wes Didier, Satbir Rai, Nicholas S Johnson, Scot Libants, Sang-Seon Yun, David A Close. Regulation of a putative corticosteroid, 17,21-dihydroxypregn-4-ene,3,20-one, in sea lamprey, Petromyzon marinus. General and comparative endocrinology. 2014 Jan; 196(?):17-25. doi: 10.1016/j.ygcen.2013.11.008. [PMID: 24287339]
  • Amir Kalani, Gul Bahtiyar, Alan Sacerdote. Ashwagandha root in the treatment of non-classical adrenal hyperplasia. BMJ case reports. 2012 Sep; 2012(?):. doi: 10.1136/bcr-2012-006989. [PMID: 22987912]
  • Rachel M Genova, Margaret A Marchaterre, Rosemary Knapp, Daniel Fergus, Andrew H Bass. Glucocorticoid and androgen signaling pathways diverge between advertisement calling and non-calling fish. Hormones and behavior. 2012 Sep; 62(4):426-32. doi: 10.1016/j.yhbeh.2012.07.010. [PMID: 22884426]
  • Yasuhiro Nakamura, Juilee Rege, Fumitoshi Satoh, Ryo Morimoto, Michael R Kennedy, Clarence N Ahlem, Seijiro Honma, Hironobu Sasano, William E Rainey. Liquid chromatography-tandem mass spectrometry analysis of human adrenal vein corticosteroids before and after adrenocorticotropic hormone stimulation. Clinical endocrinology. 2012 Jun; 76(6):778-84. doi: 10.1111/j.1365-2265.2011.04316.x. [PMID: 22150161]
  • Therese Koal, Diane Schmiederer, Hai Pham-Tuan, Cornelia Röhring, Manfred Rauh. Standardized LC-MS/MS based steroid hormone profile-analysis. The Journal of steroid biochemistry and molecular biology. 2012 Apr; 129(3-5):129-38. doi: 10.1016/j.jsbmb.2011.12.001. [PMID: 22210511]
  • Gerhardt Attard, Alison H M Reid, Richard J Auchus, Beverly A Hughes, Amy Mulick Cassidy, Emilda Thompson, Nikhil Babu Oommen, Elizabeth Folkerd, Mitch Dowsett, Wiebke Arlt, Johann S de Bono. Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer. The Journal of clinical endocrinology and metabolism. 2012 Feb; 97(2):507-16. doi: 10.1210/jc.2011-2189. [PMID: 22170708]
  • Andrea Hirsch, Dagmar Hahn, Petra Kempná, Gaby Hofer, Primus E Mullis, Jean-Marc Nuoffer, Christa E Flück. Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells. PloS one. 2012; 7(1):e30956. doi: 10.1371/journal.pone.0030956. [PMID: 22295121]
  • Lee Koren, Ella S M Ng, Kiran K Soma, Katherine E Wynne-Edwards. Sample preparation and liquid chromatography-tandem mass spectrometry for multiple steroids in mammalian and avian circulation. PloS one. 2012; 7(2):e32496. doi: 10.1371/journal.pone.0032496. [PMID: 22384262]
  • Nils Janzen, Stefanie Sander, Michael Terhardt, Ulrike Steuerwald, Michael Peter, Anibh M Das, Johannes Sander. Rapid steroid hormone quantification for congenital adrenal hyperplasia (CAH) in dried blood spots using UPLC liquid chromatography-tandem mass spectrometry. Steroids. 2011 Dec; 76(13):1437-42. doi: 10.1016/j.steroids.2011.07.013. [PMID: 21839763]
  • Wiebke Arlt, Michael Biehl, Angela E Taylor, Stefanie Hahner, Rossella Libé, Beverly A Hughes, Petra Schneider, David J Smith, Han Stiekema, Nils Krone, Emilio Porfiri, Giuseppe Opocher, Jerôme Bertherat, Franco Mantero, Bruno Allolio, Massimo Terzolo, Peter Nightingale, Cedric H L Shackleton, Xavier Bertagna, Martin Fassnacht, Paul M Stewart. Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors. The Journal of clinical endocrinology and metabolism. 2011 Dec; 96(12):3775-84. doi: 10.1210/jc.2011-1565. [PMID: 21917861]
  • Shou-yue Sun, Man-na Zhang, Jun Yang, Hui-jie Zhang, Jian-min Liu, Jie Hong, Guang Ning, Xiao-ying Li. [Clinical and genetic analysis of 11β-hydroxylase deficiency]. Zhonghua yi xue za zhi. 2011 Nov; 91(42):2999-3002. doi: NULL. [PMID: 22333028]
  • Min Jae Kang, Shin Mi Kim, Young Ah Lee, Choong Ho Shin, Sei Won Yang. Relationships of basal level of serum 17-hydroxyprogesterone with that of serum androstenedione and their stimulated responses to a low dose of ACTH in young adult patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Journal of Korean medical science. 2011 Nov; 26(11):1454-60. doi: 10.3346/jkms.2011.26.11.1454. [PMID: 22065901]
  • Vishal Gupta. Mineralocorticoid hypertension. Indian journal of endocrinology and metabolism. 2011 Oct; 15 Suppl 4(?):S298-312. doi: 10.4103/2230-8210.86972. [PMID: 22145132]
  • Phillip J Monaghan, Laura J Owen, Peter J Trainer, Georg Brabant, Brian G Keevil, Denise Darby. Comparison of serum cortisol measurement by immunoassay and liquid chromatography-tandem mass spectrometry in patients receiving the 11β-hydroxylase inhibitor metyrapone. Annals of clinical biochemistry. 2011 Sep; 48(Pt 5):441-6. doi: 10.1258/acb.2011.011014. [PMID: 21813575]
  • Rafal M Kaminski, Michael A Rogawski. 11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis. Neuropharmacology. 2011 Jul; 61(1-2):133-7. doi: 10.1016/j.neuropharm.2011.03.019. [PMID: 21458468]
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  • Kodzue Kinoshita, Sayaka Inada, Kazuya Seki, Aiko Sasaki, Natsuki Hama, Hiroshi Kusunoki. Long-term monitoring of fecal steroid hormones in female snow leopards (Panthera uncia) during pregnancy or pseudopregnancy. PloS one. 2011 May; 6(5):e19314. doi: 10.1371/journal.pone.0019314. [PMID: 21559303]
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