Danazol (BioDeep_00000405540)
Main id: BioDeep_00000001942
代谢物信息卡片
Danazol
化学式: C22H27NO2 (337.2042)
中文名称: 达那唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
InChI: InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1
描述信息
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03X - Other sex hormones and modulators of the genital system > G03XA - Antigonadotropins and similar agents
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C2092 - Gonadotropin Releasing Hormone Antagonist
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:4315
- KEGG: C06938
- KEGGdrug: D00289
- PubChem: 28417
- DrugBank: DB01406
- ChEMBL: CHEMBL1479
- MeSH: Danazol
- CAS: 17230-88-5
- MoNA: HMDB0002835_ms_ms_2148
- MoNA: HMDB0002835_ms_ms_2146
- MoNA: HMDB0002835_ms_ms_2147
- PubChem: 9153
- PDB-CCD: QA1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- John A Mackintosh, Maria Pietsch, Viviana Lutzky, Debra Enever, Sandra Bancroft, Simon H Apte, Maxine Tan, Stephanie T Yerkovich, Joanne L Dickinson, Hilda A Pickett, Hiran Selvadurai, Christopher Grainge, Nicole S Goh, Peter Hopkins, Ian Glaspole, Paul N Reynolds, Jeremy Wrobel, Adam Jaffe, Tamera J Corte, Daniel C Chambers. TELO-SCOPE study: a randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis.
BMJ open respiratory research.
2021 12; 8(1):. doi:
10.1136/bmjresp-2021-001127. [PMID: 34857525] - N Mete Gökmen, O Kuman Tunçel, G Boğatekin, G Bulut, S Demir, A Gelincik, C Tunakan Dalgıç, D Mungan. Psychiatric and Clinical Characteristics of Hereditary Angioedema Patients Who Experienced Attacks During COVID-19.
Journal of investigational allergology & clinical immunology.
2021 Jul; 31(4):356-357. doi:
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Cell reports.
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2021 Apr; 70(2):235-243. doi:
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Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
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The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2020 05; 39(5):498-500. doi:
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PloS one.
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2017 06; 89(6):953-963. doi:
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The New England journal of medicine.
2016 May; 374(20):1922-31. doi:
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2014 Dec; 36(6):828-9. doi:
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The AAPS journal.
2014 Nov; 16(6):1344-57. doi:
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2014 Mar; 26(3):414-20. doi:
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The Cochrane database of systematic reviews.
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Molecular pharmaceutics.
2012 May; 9(5):1189-98. doi:
10.1021/mp200479f. [PMID: 22482927] - Jonathan A Bernstein, Joseph J Moellman. Progress in the emergency management of hereditary angioedema: focus on new treatment options in the United States.
Postgraduate medicine.
2012 May; 124(3):91-100. doi:
10.3810/pgm.2012.05.2552. [PMID: 22691903] - Cornelia Fürstenberger, Anna Vuorinen, Thierry Da Cunha, Denise V Kratschmar, Martial Saugy, Daniela Schuster, Alex Odermatt. The anabolic androgenic steroid fluoxymesterone inhibits 11β-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Apr; 126(2):353-61. doi:
10.1093/toxsci/kfs022. [PMID: 22273746] - Michael Linn, Eva-Maria Collnot, Dejan Djuric, Katja Hempel, Eric Fabian, Karl Kolter, Claus-Michael Lehr. Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 Feb; 45(3):336-43. doi:
10.1016/j.ejps.2011.11.025. [PMID: 22172603] - Suresh Kumar, Punit Tiwari, Pramod Sharma, Amit Goel, Jitendra P Singh, Mukesh K Vijay, Sandeep Gupta, Malay K Bera, Anup K Kundu. Urinary tract endometriosis: Review of 19 cases.
Urology annals.
2012 Jan; 4(1):6-12. doi:
10.4103/0974-7796.91613. [PMID: 22346093] - Hetal N Prajapati, Damon M Dalrymple, Abu T M Serajuddin. A comparative evaluation of mono-, di- and triglyceride of medium chain fatty acids by lipid/surfactant/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development.
Pharmaceutical research.
2012 Jan; 29(1):285-305. doi:
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Medicina.
2012; 72(2):119-23. doi:
NULL. [PMID: 22522852] - Zan-Hua Zhou, Qing Weng, Jian-Hong Zhou, Jue Zhou. Extracts of Salvia miltiorrhiza Bunge on the cytokines of rat endometriosis models.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2012; 9(3):303-14. doi:
10.4314/ajtcam.v9i3.2. [PMID: 23983360] - Furquan Nazimuddin Khan, Mohamed Hassan G Dehghan. Enhanced Bioavailability and Dissolution of Atorvastatin Calcium from Floating Microcapsules using Minimum Additives.
Scientia pharmaceutica.
2012 Jan; 80(1):215-28. doi:
10.3797/scipharm.1104-26. [PMID: 22396916] - Amin Kanani, Robert Schellenberg, Richard Warrington. Urticaria and angioedema.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.
2011 Nov; 7 Suppl 1(?):S9. doi:
10.1186/1710-1492-7-s1-s9. [PMID: 22165855] - HeLi Liu, GuoQing Liao, ZhongShu Yan. Gynecomastia during imatinib mesylate treatment for gastrointestinal stromal tumor: a rare adverse event.
BMC gastroenterology.
2011 Nov; 11(?):116. doi:
10.1186/1471-230x-11-116. [PMID: 22047550] - Yu Chen, Chao Chen, Shufang Shi, Jie Han, Jiaqi Wang, Jingjing Hu, Yuhuan Liu, Zailong Cai, Chaoqin Yu. Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level.
Reproductive sciences (Thousand Oaks, Calif.).
2011 Sep; 18(9):886-91. doi:
10.1177/1933719111398500. [PMID: 21673282] - Seung Ah Choe, Seung-Yup Ku, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Jung Gu Kim, Shin Young Moon. Significance of the serum CA-125 level in intrauterine insemination cycles.
Clinical and experimental reproductive medicine.
2011 Sep; 38(3):164-7. doi:
10.5653/cerm.2011.38.3.164. [PMID: 22384437] - Paula Lehto, Hanna Kortejärvi, Anni Liimatainen, Krista Ojala, Heli Kangas, Jouni Hirvonen, Veli Pekka Tanninen, Leena Peltonen. Use of conventional surfactant media as surrogates for FaSSIF in simulating in vivo dissolution of BCS class II drugs.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Aug; 78(3):531-8. doi:
10.1016/j.ejpb.2011.02.007. [PMID: 21329757] - Jie Han, Qiao-ling Zhou, Dan-ying Zhang. [Adhesive and invasive effects and mechanism of neiyi recipe on the endometriosis].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2011 Aug; 31(8):1113-7. doi:
NULL. [PMID: 21910347] - Kanjaksha Ghosh, Shrimati Shetty. Epidemiology, diagnosis, and management of von Willebrand disease in India.
Seminars in thrombosis and hemostasis.
2011 Jul; 37(5):595-601. doi:
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Reproductive biology and endocrinology : RB&E.
2011 Jun; 9(?):80. doi:
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Haematologica.
2011 Jun; 96(6):814-9. doi:
10.3324/haematol.2010.035600. [PMID: 21422115] - René Holm, Erling Bonne Jørgensen, Michael Harborg, Rune Larsen, Per Holm, Anette Müllertz, Jette Jacobsen. A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2011 Mar; 42(4):416-22. doi:
10.1016/j.ejps.2011.01.007. [PMID: 21256961] - Asja Stipić Marković, Martina Janzeković. [Increasing incidence of angioedema without urticaria--clinical features].
Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti.
2011; 65(2):119-27. doi:
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International journal of molecular sciences.
2011; 12(8):4819-35. doi:
10.3390/ijms12084819. [PMID: 21954327] - Benjamin Davis, Jonathan A Bernstein. Conestat alfa for the treatment of angioedema attacks.
Therapeutics and clinical risk management.
2011; 7(?):265-73. doi:
10.2147/tcrm.s15544. [PMID: 21753889] - Henriette Farkas, Lilian Varga. Ecallantide is a novel treatment for attacks of hereditary angioedema due to C1 inhibitor deficiency.
Clinical, cosmetic and investigational dermatology.
2011; 4(?):61-8. doi:
10.2147/ccid.s10322. [PMID: 21760740] - Candis M Morello. Pharmacokinetics and pharmacodynamics of insulin analogs in special populations with type 2 diabetes mellitus.
International journal of general medicine.
2011; 4(?):827-35. doi:
10.2147/ijgm.s26889. [PMID: 22267935] - Michael M Frank. Update on preventive therapy (prophylaxis) of hereditary angioedema.
Allergy and asthma proceedings.
2011 Jan; 32(1):17-21. doi:
10.2500/aap.2011.32.3412. [PMID: 21262094] - C Perricone, N Agmon-Levin, N Shoenfeld, C de Carolis, M D Guarino, G Gigliucci, I Milana, L Novelli, G Valesini, R Perricone, Y Shoenfeld. Evidence of impaired sense of smell in hereditary angioedema.
Allergy.
2011 Jan; 66(1):149-54. doi:
10.1111/j.1398-9995.2010.02453.x. [PMID: 20649895] - Xing Sun, Lijue Chen, Fanbo Zeng. Effects of Chinese Materia Medica-Fubao Danggui Jiao on experimental endometriosis.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2011; 8(3):224-9. doi:
10.4314/ajtcam.v8i3.65283. [PMID: 22468001] - Rafael Firszt, Michael M Frank. An overview of novel therapies for acute hereditary angioedema.
American journal of clinical dermatology.
2010 Dec; 11(6):383-8. doi:
10.2165/11537030-000000000-00000. [PMID: 20866113] - Dallas B Warren, Hassan Benameur, Christopher J H Porter, Colin W Pouton. Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility.
Journal of drug targeting.
2010 Dec; 18(10):704-31. doi:
10.3109/1061186x.2010.525652. [PMID: 20973755] - Nitin Pandey, Alka Kriplani, Raj Kumar Yadav, Basil T Lyngdoh, Sushil Chandra Mahapatra. Peritoneal fluid leptin levels are increased but adiponectin levels are not changed in infertile patients with pelvic endometriosis.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2010 Nov; 26(11):843-9. doi:
10.3109/09513590.2010.487585. [PMID: 20504092] - Jonathan A Bernstein, Suzanne Coleman, Arturo J Bonnin. Successful C1 inhibitor short-term prophylaxis during redo mitral valve replacement in a patient with hereditary angioedema.
Journal of cardiothoracic surgery.
2010 Oct; 5(?):86. doi:
10.1186/1749-8090-5-86. [PMID: 20955596] - M Galesio, R Rial-Otero, J Simal-Gándara, X de la Torre, F Botrè, J L Capelo-Martínez. Improved ultrasonic-based sample treatment for the screening of anabolic steroids by gas chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2010 Aug; 24(16):2375-85. doi:
10.1002/rcm.4654. [PMID: 20635322] - Paolo G V Martini, Lynette C Cook, Scott Alderucci, Angela W Norton, Dianna M Lundberg, Susan M Fish, Knut Langsetmo, Göran Jönsson, Christian Lood, Birgitta Gullstrand, Kate J Zaleski, Nancy Savioli, Jason Lottherand, Charles Bedard, John Gill, Michael F Concino, Michael W Heartlein, Lennart Truedsson, Jan L Powell, Arthur O Tzianabos. Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases.
BMC immunology.
2010 Aug; 11(?):43. doi:
10.1186/1471-2172-11-43. [PMID: 20727163] - Hua Yi, Yue Lu, Jian-kun Chen, Biao-yan Du, Ai-jun Liu, Hui Luo. [Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2010 Aug; 30(8):1874-6. doi:
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Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.
2010 Jul; 6(1):15. doi:
10.1186/1710-1492-6-15. [PMID: 20667118] - Marco Cicardi, Andrea Zanichelli. Acquired angioedema.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.
2010 Jul; 6(1):14. doi:
10.1186/1710-1492-6-14. [PMID: 20667117] - Frank J Eidelman. Hereditary angioedema: New therapeutic options for a potentially deadly disorder.
BMC blood disorders.
2010 May; 10(?):3. doi:
10.1186/1471-2326-10-3. [PMID: 20470390] - Ivan Stankovic, Alja Vlahovic-Stipac, Biljana Putnikovic, Zorica Cvetkovic, Aleksandar N Neskovic. Concomitant administration of simvastatin and danazol associated with fatal rhabdomyolysis.
Clinical therapeutics.
2010 May; 32(5):909-14. doi:
10.1016/j.clinthera.2010.04.017. [PMID: 20685498] - Elizabeth A Price, Stanley L Schrier. Unexplained aspects of anemia of inflammation.
Advances in hematology.
2010; 2010(?):508739. doi:
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Journal of dentistry for children (Chicago, Ill.).
2010 Jan; 77(1):59-63. doi:
NULL. [PMID: 20359432] - Farzin Khorvash, Alireza Emami Naeini, Mohadesseh Behjati, Mohammad Jalali. HIV associated thrombocytopenia, misdiagnosed as thrombotic thrombocytopenic purpura: a case report.
Cases journal.
2009 Oct; 2(?):175. doi:
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