Ac-Phe-OH (BioDeep_00000405292)

Main id: BioDeep_00000001294

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


N-Acetyl-L-phenylalanine

化学式: C11H13NO3 (207.0895)
中文名称: N-乙酰-L-苯丙氨酸, N-乙酰基-L苯丙氨酸, N-乙酰基-L-苯丙氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(CC1=CC=CC=C1)C(=O)O
InChI: InChI=1S/C11H13NO3/c1-8(13)12-10(11(14)15)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1

描述信息

The N-acetyl derivative of L-phenylalanine.
N-Acetyl-L-phenylalanine (N-Acetylphenylalanine), the principal acylamino acid in Escherichia coli, is synthesized from L-phenylalanine and acetyl-CoA[1].

同义名列表

5 个代谢物同义名

N-Acetyl-L-phenylalanine; Ac-Phe-OH; N-Acetylphenylalanine; N-Acetyl-L-phenylalanine; N-Acetyl-L-phenylalanine



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, CHUK, ELANE, MYLK, MYLK3, PMP2
Nucleus 4 ALB, CHUK, JUND, PMP2
cytosol 9 ALB, CHUK, ELANE, GPT, LIPE, MYLK, MYLK3, PMP2, RND1
phagocytic vesicle 1 ELANE
centrosome 1 ALB
nucleoplasm 2 CHUK, JUND
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 4 LIPE, RND1, TNF, TNFRSF1A
Lipid-anchor 1 RND1
Cytoplasmic side 1 RND1
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Golgi apparatus membrane 1 TNFRSF1A
Synapse 1 MYLK
cell surface 3 ELANE, TNF, TNFRSF1A
Golgi apparatus 1 ALB
Golgi membrane 1 TNFRSF1A
neuronal cell body 2 TNF, TNFRSF1B
Cytoplasm, cytosol 1 LIPE
plasma membrane 6 KNG1, MYLK, RND1, TNF, TNFRSF1A, TNFRSF1B
Membrane 4 LIPE, MMP13, TNFRSF1A, TNFRSF1B
caveola 1 LIPE
extracellular exosome 7 ALB, ELANE, GPT, KNG1, LYZ, PGA4, PMP2
endoplasmic reticulum 1 ALB
extracellular space 10 ADAMTS5, ALB, CTRL, ELANE, KNG1, LYZ, MMP10, MMP13, TNF, TNFRSF1A
perinuclear region of cytoplasm 1 TNFRSF1B
adherens junction 1 RND1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 1 RND1
Single-pass type I membrane protein 1 TNFRSF1A
Secreted 3 ALB, MMP13, TNFRSF1A
extracellular region 10 ADAMTS5, ALB, ELANE, KNG1, LYZ, MMP10, MMP13, TNF, TNFRSF1A, TNFRSF1B
cytoplasmic side of plasma membrane 1 CHUK
anchoring junction 1 ALB
transcription regulator complex 1 JUND
CD40 receptor complex 1 CHUK
external side of plasma membrane 1 TNF
varicosity 1 TNFRSF1B
Secreted, extracellular space, extracellular matrix 3 ADAMTS5, MMP10, MMP13
actin cytoskeleton 3 MYLK, MYLK3, RND1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 MYLK
Membrane raft 3 TNF, TNFRSF1A, TNFRSF1B
Cytoplasm, cytoskeleton 1 RND1
extracellular matrix 3 ADAMTS5, MMP10, MMP13
collagen-containing extracellular matrix 3 ADAMTS5, ELANE, KNG1
secretory granule 1 ELANE
receptor complex 1 TNFRSF1A
ciliary basal body 1 ALB
chromatin 1 JUND
phagocytic cup 1 TNF
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
specific granule membrane 1 TNFRSF1B
myelin sheath 1 PMP2
stress fiber 1 MYLK
endoplasmic reticulum lumen 3 ADAMTS5, ALB, KNG1
transcription repressor complex 2 ELANE, JUND
platelet alpha granule lumen 2 ALB, KNG1
specific granule lumen 2 ELANE, LYZ
tertiary granule lumen 1 LYZ
azurophil granule lumen 2 ELANE, LYZ
IkappaB kinase complex 1 CHUK
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
Cytoplasmic vesicle, phagosome 1 ELANE
multivesicular body lumen 1 PGA4
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
tumor necrosis factor receptor superfamily complex 2 TNFRSF1A, TNFRSF1B
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Prabhakar Sripadi, Bindesh Shrestha, Rebecca L Easley, Lawrence Carpio, Kylene Kehn-Hall, Sebastien Chevalier, Renaud Mahieux, Fatah Kashanchi, Akos Vertes. Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry. PloS one. 2010 Sep; 5(9):e12590. doi: 10.1371/journal.pone.0012590. [PMID: 20830293]
  • Vera A Stupina, Arturas Meskauskas, John C McCormack, Yaroslava G Yingling, Bruce A Shapiro, Jonathan D Dinman, Anne E Simon. The 3' proximal translational enhancer of Turnip crinkle virus binds to 60S ribosomal subunits. RNA (New York, N.Y.). 2008 Nov; 14(11):2379-93. doi: 10.1261/rna.1227808. [PMID: 18824512]
  • Jana Frýdlová, Zdenka Kucerová, Marie Tichá. Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Feb; 863(1):135-40. doi: 10.1016/j.jchromb.2008.01.021. [PMID: 18255363]
  • Magnus Stödeman, Frederick P Schwarz. Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry. Analytical biochemistry. 2002 Sep; 308(2):285-93. doi: 10.1016/s0003-2697(02)00339-1. [PMID: 12419341]
  • Do Kyung Kim, Yoshikatsu Kanai, Hirotaka Matsuo, Ju Young Kim, Arthit Chairoungdua, Yukari Kobayashi, Atsushi Enomoto, Seok Ho Cha, Tomoyuki Goya, Hitoshi Endou. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan; 79(1):95-103. doi: 10.1006/geno.2001.6678. [PMID: 11827462]
  • K Y Xu. Acid dissociation constant and apparent nucleophilicity of lysine-501 of the alpha-polypeptide of sodium and potassium ion activated adenosinetriphosphatase. Biochemistry. 1989 Aug; 28(17):6894-9. doi: 10.1021/bi00443a018. [PMID: 2554957]
  • E Jellum, L Horn, O Thoresen, E A Kvittingen, O Stokke. Urinary excretion of N-acetyl amino acids in patients with some inborn errors of amino acid metabolism. Scandinavian journal of clinical and laboratory investigation. Supplementum. 1986; 184(?):21-6. doi: . [PMID: 3473611]
  • K Okajima, M Inoue, Y Morino. Studies on the mechanism for renal elimination of N-acetylphenylalanine: its pathophysiologic significance in phenylketonuria. The Journal of laboratory and clinical medicine. 1985 Jan; 105(1):132-8. doi: . [PMID: 4038506]