Oxalacetic acid (BioDeep_00000405222)

Main id: BioDeep_00000001679

 

PANOMIX_OTCML-2023 natural product Endogenous human metabolite BioNovoGene_Lab2019


代谢物信息卡片


2-oxobutanedioic acid

化学式: C4H4O5 (132.0059)
中文名称: 草乙酸, 草酰乙酸
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-10-17.

Cite this Page

Oxalacetic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/oxalacetic_acid (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000405222). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(=O)C(=O)O)C(=O)O
InChI: InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)

描述信息

C274 - Antineoplastic Agent > C177430 - Agent Targeting Cancer Metabolism
C26170 - Protective Agent > C1509 - Neuroprotective Agent
Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2].
Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2].

同义名列表

5 个代谢物同义名

Oxaloacetic acid; oxalacetic acid; 2-Oxosuccinic acid; Oxaloacetate; Oxalacetic acid



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ACLY, ALB, FH, G6PD, GOT1, LDHA, MDH1, MDH2, ME1, PC, PKM, TXN
Peripheral membrane protein 2 G6PD, HSD17B6
Nucleus 8 ALB, CS, FH, GOT1, LDHA, MDH2, PKM, TXN
cytosol 12 ACLY, ALB, FH, G6PD, GOT1, GPT, LDHA, MDH1, ME1, PC, PKM, TXN
centrosome 2 ALB, MDH1
nucleoplasm 2 ACLY, TXN
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 UCP1
Golgi apparatus 1 ALB
Golgi membrane 1 INS
mitochondrial inner membrane 1 UCP1
Cytoplasm, cytosol 3 ACLY, G6PD, MDH1
plasma membrane 2 GCG, ME1
Membrane 6 ACLY, CS, G6PD, LDHA, MDH2, ME1
extracellular exosome 12 ACLY, ALB, CS, FH, G6PD, GOT1, GPT, LDHA, MDH1, MDH2, PKM, TXN
Lumenal side 1 HSD17B6
endoplasmic reticulum 2 ALB, HSD17B6
extracellular space 4 ALB, GCG, INS, MDH1
mitochondrion 9 CS, FH, LDHA, MDH2, ME1, PC, PCK2, PKM, UCP1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 2 G6PD, HSD17B6
Microsome membrane 1 HSD17B6
Secreted 4 ALB, GCG, INS, TXN
extracellular region 6 ACLY, ALB, GCG, INS, PKM, TXN
cytoplasmic side of plasma membrane 1 G6PD
Single-pass membrane protein 1 ME1
Mitochondrion matrix 3 CS, MDH2, PC
mitochondrial matrix 5 CS, FH, MDH2, PC, PCK2
anchoring junction 1 ALB
centriolar satellite 1 G6PD
Extracellular vesicle 1 PKM
vesicle 1 PKM
Mitochondrion inner membrane 1 UCP1
collagen-containing extracellular matrix 1 PKM
ciliary basal body 1 ALB
cilium 1 PKM
Chromosome 1 FH
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
site of double-strand break 1 FH
endosome lumen 1 INS
ficolin-1-rich granule lumen 2 ACLY, PKM
secretory granule lumen 3 GCG, INS, PKM
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, GCG, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
azurophil granule lumen 1 ACLY
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Rough endoplasmic reticulum 1 PKM
oxidoreductase complex 1 LDHA
[Glucagon-like peptide 1]: Secreted 1 GCG
[Isoform Mitochondrial]: Mitochondrion 1 FH
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 FH
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
ciliary transition fiber 1 ALB


文献列表

  • Erika Greipel, Krisztina Nagy, Eszter Csákvári, László Dér, Peter Galajda, József Kutasi. Chemotactic Interactions of Scenedesmus sp. and Azospirillum brasilense Investigated by Microfluidic Methods. Microbial ecology. 2024 Mar; 87(1):52. doi: 10.1007/s00248-024-02366-3. [PMID: 38498218]
  • Cong Yin, Rui Qin, Zewei Ma, Fan Li, Jiao Liu, Hong Liu, Gang Shu, Hairong Xiong, Qingyan Jiang. Oxaloacetic acid induces muscle energy substrate depletion and fatigue by JNK-mediated mitochondrial uncoupling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024 02; 38(2):e23373. doi: 10.1096/fj.202301796r. [PMID: 38217376]
  • Anthony J Zmuda, Xiaojun Kang, Katie B Wissbroecker, Katrina Freund Saxhaug, Kyle C Costa, Adrian D Hegeman, Thomas D Niehaus. A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle. Nature communications. 2024 Jan; 15(1):846. doi: 10.1038/s41467-024-45134-0. [PMID: 38287013]
  • Maki Nishii, Shoki Ito, Takashi Osanai. Citrate synthase from Cyanidioschyzon merolae exhibits high oxaloacetate and acetyl-CoA catalytic efficiency. Plant molecular biology. 2023 Mar; ?(?):. doi: 10.1007/s11103-023-01335-7. [PMID: 36884198]
  • Alan Cash, David Lyons Kaufman. Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial. Journal of translational medicine. 2022 06; 20(1):295. doi: 10.1186/s12967-022-03488-3. [PMID: 35764955]
  • Kusum Rana, Junhu Yuan, Hongmei Liao, Surinder S Banga, Rahul Kumar, Wei Qian, Yijuan Ding. Host-induced gene silencing reveals the role of Sclerotinia sclerotiorum oxaloacetate acetylhydrolase gene in fungal oxalic acid accumulation and virulence. Microbiological research. 2022 May; 258(?):126981. doi: 10.1016/j.micres.2022.126981. [PMID: 35183041]
  • Arthur J L Cooper, Thambi Dorai, John T Pinto, Travis T Denton. The metabolic importance of the overlooked asparaginase II pathway. Analytical biochemistry. 2022 05; 644(?):114084. doi: 10.1016/j.ab.2020.114084. [PMID: 33347861]
  • Yona Goldshmit, Rita Perelroizen, Alex Yakovchuk, Evgeni Banyas, Lior Mayo, Sari David, Amit Benbenishty, Pablo Blinder, Moshe Shalom, Angela Ruban. Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo. Scientific reports. 2021 07; 11(1):14644. doi: 10.1038/s41598-021-94183-8. [PMID: 34282238]
  • Shoki Ito, Takumi Hakamada, Tatsumi Ogino, Takashi Osanai. Reconstitution of oxaloacetate metabolism in the tricarboxylic acid cycle in Synechocystis sp. PCC 6803: discovery of important factors that directly affect the conversion of oxaloacetate. The Plant journal : for cell and molecular biology. 2021 03; 105(6):1449-1458. doi: 10.1111/tpj.15120. [PMID: 33280178]
  • Eric D Vidoni, In-Young Choi, Phil Lee, Gregory Reed, Na Zhang, Joseph Pleen, Jonathan D Mahnken, Jonathan Clutton, Annette Becker, Erica Sherry, Rebecca Bothwell, Heidi Anderson, Robert A Harris, William Brooks, Heather M Wilkins, Lisa Mosconi, Jeffrey M Burns, Russell H Swerdlow. Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021 01; 17(1):7-17. doi: 10.1002/alz.12156. [PMID: 32715609]
  • Philippe Icard, Zherui Wu, Ludovic Fournel, Antoine Coquerel, Hubert Lincet, Marco Alifano. ATP citrate lyase: A central metabolic enzyme in cancer. Cancer letters. 2020 02; 471(?):125-134. doi: 10.1016/j.canlet.2019.12.010. [PMID: 31830561]
  • Jeffrey D Kiiskila, Kefeng Li, Dibyendu Sarkar, Rupali Datta. Metabolic response of vetiver grass (Chrysopogon zizanioides) to acid mine drainage. Chemosphere. 2020 Feb; 240(?):124961. doi: 10.1016/j.chemosphere.2019.124961. [PMID: 31574433]
  • Bruno E Rojas, Matías D Hartman, Carlos M Figueroa, Laura Leaden, Florencio E Podestá, Alberto A Iglesias. Biochemical characterization of phosphoenolpyruvate carboxykinases from Arabidopsis thaliana. The Biochemical journal. 2019 10; 476(20):2939-2952. doi: 10.1042/bcj20190523. [PMID: 31548269]
  • Yana Shaulov, Chikako Shimokawa, Meirav Trebicz-Geffen, Shruti Nagaraja, Karen Methling, Michael Lalk, Lea Weiss-Cerem, Ayelet T Lamm, Hajime Hisaeda, Serge Ankri. Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate. PLoS pathogens. 2018 10; 14(10):e1007295. doi: 10.1371/journal.ppat.1007295. [PMID: 30308066]
  • Cun Wang, Jingbo Zhang, Juyou Wu, Dennis E Brodsky, Julian I Schroeder. Cytosolic malate and oxaloacetate activate S-type anion channels in Arabidopsis guard cells. The New phytologist. 2018 10; 220(1):178-186. doi: 10.1111/nph.15292. [PMID: 29971803]
  • Juan P Zubimendi, Andrea Martinatto, Maria P Valacco, Silvia Moreno, Carlos S Andreo, María F Drincovich, Marcos A Tronconi. The complex allosteric and redox regulation of the fumarate hydratase and malate dehydratase reactions of Arabidopsis thaliana Fumarase 1 and 2 gives clues for understanding the massive accumulation of fumarate. The FEBS journal. 2018 06; 285(12):2205-2224. doi: 10.1111/febs.14483. [PMID: 29688630]
  • Ye Kuang, Xiaoyun Han, Mu Xu, Yue Wang, Yuxiang Zhao, Qing Yang. Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes. International journal of molecular sciences. 2018 May; 19(6):. doi: 10.3390/ijms19061626. [PMID: 29857490]
  • Jennifer Selinski, Andreas Hartmann, Gabriele Deckers-Hebestreit, David A Day, James Whelan, Renate Scheibe. Alternative Oxidase Isoforms Are Differentially Activated by Tricarboxylic Acid Cycle Intermediates. Plant physiology. 2018 02; 176(2):1423-1432. doi: 10.1104/pp.17.01331. [PMID: 29208641]
  • Jaime Abrego, Venugopal Gunda, Enza Vernucci, Surendra K Shukla, Ryan J King, Aneesha Dasgupta, Gennifer Goode, Divya Murthy, Fang Yu, Pankaj K Singh. GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells. Cancer letters. 2017 08; 400(?):37-46. doi: 10.1016/j.canlet.2017.04.029. [PMID: 28455244]
  • Qingpeng Liu, Gang Zhao, Changwei Zhou, Martin R Farlow, Yansheng Du, Guangxu Xu, Huiying Gu. Oxaloacetate and adipose stromal cells-conditional medium synergistically protected potassium/serum deprivation-induced neuronal apoptosis. Brain research bulletin. 2017 01; 128(?):7-12. doi: 10.1016/j.brainresbull.2016.11.002. [PMID: 27816553]
  • Nanette R Boyle, Neelanjan Sengupta, John A Morgan. Metabolic flux analysis of heterotrophic growth in Chlamydomonas reinhardtii. PloS one. 2017; 12(5):e0177292. doi: 10.1371/journal.pone.0177292. [PMID: 28542252]
  • Katsumi Shibata, Chifumi Nakata, Tsutomu Fukuwatari. High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats. Bioscience, biotechnology, and biochemistry. 2016; 80(2):304-12. doi: 10.1080/09168451.2015.1083395. [PMID: 26745680]
  • Howbeer Muhamadali, Yun Xu, David I Ellis, J William Allwood, Nicholas J W Rattray, Elon Correa, Haitham Alrabiah, Jonathan R Lloyd, Royston Goodacre. Metabolic Profiling of Geobacter sulfurreducens during Industrial Bioprocess Scale-Up. Applied and environmental microbiology. 2015 May; 81(10):3288-98. doi: 10.1128/aem.00294-15. [PMID: 25746987]
  • Christopher G Poggi, Kristin M Slade. Macromolecular crowding and the steady-state kinetics of malate dehydrogenase. Biochemistry. 2015 Jan; 54(2):260-7. doi: 10.1021/bi5011255. [PMID: 25478785]
  • Heather M Wilkins, Janna L Harris, Steven M Carl, Lezi E, Jianghua Lu, J Eva Selfridge, Nairita Roy, Lewis Hutfles, Scott Koppel, Jill Morris, Jeffrey M Burns, Mary L Michaelis, Elias K Michaelis, William M Brooks, Russell H Swerdlow. Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. Human molecular genetics. 2014 Dec; 23(24):6528-41. doi: 10.1093/hmg/ddu371. [PMID: 25027327]
  • Abhaypratap Vishwakarma, Leena Bashyam, Balasubramanian Senthilkumaran, Renate Scheibe, Kollipara Padmasree. Physiological role of AOX1a in photosynthesis and maintenance of cellular redox homeostasis under high light in Arabidopsis thaliana. Plant physiology and biochemistry : PPB. 2014 Aug; 81(?):44-53. doi: 10.1016/j.plaphy.2014.01.019. [PMID: 24560882]
  • Angelo Vozza, Giovanni Parisi, Francesco De Leonardis, Francesco M Lasorsa, Alessandra Castegna, Daniela Amorese, Raffaele Marmo, Valeria M Calcagnile, Luigi Palmieri, Daniel Ricquier, Eleonora Paradies, Pasquale Scarcia, Ferdinando Palmieri, Frédéric Bouillaud, Giuseppe Fiermonte. UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation. Proceedings of the National Academy of Sciences of the United States of America. 2014 Jan; 111(3):960-5. doi: 10.1073/pnas.1317400111. [PMID: 24395786]
  • M Pérez-Mato, P Ramos-Cabrer, T Sobrino, M Blanco, A Ruban, D Mirelman, P Menendez, J Castillo, F Campos. Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia. Cell death & disease. 2014 Jan; 5(?):e992. doi: 10.1038/cddis.2013.507. [PMID: 24407245]
  • Jian-jun Chen, Hua Huang, Li-bo Zhao, De-zhi Zhou, Yong-tao Yang, Peng Zheng, De-yu Yang, Peng He, Jing-jing Zhou, Liang Fang, Peng Xie. Sex-specific urinary biomarkers for diagnosing bipolar disorder. PloS one. 2014; 9(12):e115221. doi: 10.1371/journal.pone.0115221. [PMID: 25531985]
  • Anja Bienholz, Ahmad Al-Taweel, Nancy F Roeser, Andreas Kribben, Thorsten Feldkamp, Joel M Weinberg. Substrate modulation of fatty acid effects on energization and respiration of kidney proximal tubules during hypoxia/reoxygenation. PloS one. 2014; 9(4):e94584. doi: 10.1371/journal.pone.0094584. [PMID: 24728405]
  • Sirisha Ghanta, Ruth E Grossmann, Charles Brenner. Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Critical reviews in biochemistry and molecular biology. 2013 Nov; 48(6):561-74. doi: 10.3109/10409238.2013.838204. [PMID: 24050258]
  • Ilias Zafiriadis, Spyridon Ntougias, Anastasios G Kapagiannidis, Alexander Aivasidis. Metabolic behavior and enzymatic aspects of denitrifying EBPR sludge in a continuous-flow anaerobic-anoxic system. Applied biochemistry and biotechnology. 2013 Oct; 171(4):939-53. doi: 10.1007/s12010-013-0390-0. [PMID: 23912208]
  • Katsumi Shibata, Kasumi Inomoto, Chifumi Nakata, Tsutomu Fukuwatari. Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats. Journal of nutritional science and vitaminology. 2013; 59(6):509-15. doi: 10.3177/jnsv.59.509. [PMID: 24477247]
  • Stephen M G Duff, Timothy J Rydel, Amanda L McClerren, Wenlan Zhang, Jimmy Y Li, Eric J Sturman, Coralie Halls, Songyang Chen, Jiamin Zeng, Jiexin Peng, Crystal N Kretzler, Artem Evdokimov. The enzymology of alanine aminotransferase (AlaAT) isoforms from Hordeum vulgare and other organisms, and the HvAlaAT crystal structure. Archives of biochemistry and biophysics. 2012 Dec; 528(1):90-101. doi: 10.1016/j.abb.2012.06.006. [PMID: 22750542]
  • Angela Ruban, Tamara Berkutzki, Itzik Cooper, Boaz Mohar, Vivian I Teichberg. Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas. Investigational new drugs. 2012 Dec; 30(6):2226-35. doi: 10.1007/s10637-012-9799-5. [PMID: 22392507]
  • Paolo Dell' Antone. Energy metabolism in cancer cells: how to explain the Warburg and Crabtree effects?. Medical hypotheses. 2012 Sep; 79(3):388-92. doi: 10.1016/j.mehy.2012.06.002. [PMID: 22770870]
  • Anthony Gandin, Claire Duffes, David A Day, Asaph B Cousins. The absence of alternative oxidase AOX1A results in altered response of photosynthetic carbon assimilation to increasing CO(2) in Arabidopsis thaliana. Plant & cell physiology. 2012 Sep; 53(9):1627-37. doi: 10.1093/pcp/pcs107. [PMID: 22848123]
  • A Pérez-Jiménez, G Cardenete, M C Hidalgo, A García-Alcázar, E Abellán, A E Morales. Metabolic adjustments of Dentex dentex to prolonged starvation and refeeding. Fish physiology and biochemistry. 2012 Aug; 38(4):1145-1157. doi: 10.1007/s10695-011-9600-2. [PMID: 22228074]
  • Yoshinori Tsuji, Iwane Suzuki, Yoshihiro Shiraiwa. Enzymological evidence for the function of a plastid-located pyruvate carboxylase in the Haptophyte alga Emiliania huxleyi: a novel pathway for the production of C4 compounds. Plant & cell physiology. 2012 Jun; 53(6):1043-52. doi: 10.1093/pcp/pcs045. [PMID: 22492231]
  • Arghya Biswas, Syed Imam Rabbani, Kshama Devi. Influence of pioglitazone on experimental heart failure and hyperlipidemia in rats. Indian journal of pharmacology. 2012 May; 44(3):333-9. doi: 10.4103/0253-7613.96305. [PMID: 22701242]
  • Xu-Yu Zu, Qing-Hai Zhang, Jiang-Hua Liu, Ren-Xian Cao, Jing Zhong, Guang-Hui Yi, Zhi-Hua Quan, Giuseppe Pizzorno. ATP citrate lyase inhibitors as novel cancer therapeutic agents. Recent patents on anti-cancer drug discovery. 2012 May; 7(2):154-67. doi: 10.2174/157489212799972954. [PMID: 22339355]
  • Sudhakar Pandurangan, Agnieszka Pajak, Stephen J Molnar, Elroy R Cober, Sangeeta Dhaubhadel, Cinta Hernández-Sebastià, Werner M Kaiser, Randall L Nelson, Steven C Huber, Frédéric Marsolais. Relationship between asparagine metabolism and protein concentration in soybean seed. Journal of experimental botany. 2012 May; 63(8):3173-84. doi: 10.1093/jxb/ers039. [PMID: 22357599]
  • Jun-ichi Hanai, Nathaniel Doro, Atsuo T Sasaki, Susumu Kobayashi, Lewis C Cantley, Pankaj Seth, Vikas P Sukhatme. Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. Journal of cellular physiology. 2012 Apr; 227(4):1709-20. doi: 10.1002/jcp.22895. [PMID: 21688263]
  • Li-Tao Zhang, Zi-Shan Zhang, Hui-Yuan Gao, Xiang-Long Meng, Cheng Yang, Jian-Guo Liu, Qing-Wei Meng. The mitochondrial alternative oxidase pathway protects the photosynthetic apparatus against photodamage in Rumex K-1 leaves. BMC plant biology. 2012 Mar; 12(?):40. doi: 10.1186/1471-2229-12-40. [PMID: 22429403]
  • Constance Schmelzer, Mitsuaki Kitano, Kazunori Hosoe, Frank Döring. Ubiquinol affects the expression of genes involved in PPARα signalling and lipid metabolism without changes in methylation of CpG promoter islands in the liver of mice. Journal of clinical biochemistry and nutrition. 2012 Mar; 50(2):119-26. doi: 10.3164/jcbn.11-19. [PMID: 22448092]
  • O Micle, M Muresan, L Antal, F Bodog, A Bodog. The influence of homocysteine and oxidative stress on pregnancy outcome. Journal of medicine and life. 2012 Feb; 5(1):68-73. doi: NULL. [PMID: 22574089]
  • Randor Radakovits, Robert E Jinkerson, Susan I Fuerstenberg, Hongseok Tae, Robert E Settlage, Jeffrey L Boore, Matthew C Posewitz. Draft genome sequence and genetic transformation of the oleaginous alga Nannochloropis gaditana. Nature communications. 2012 Feb; 3(?):686. doi: 10.1038/ncomms1688. [PMID: 22353717]
  • Inga Hebbelmann, Jennifer Selinski, Corinna Wehmeyer, Tatjana Goss, Ingo Voss, Paula Mulo, Saijaliisa Kangasjärvi, Eva-Mari Aro, Marie-Luise Oelze, Karl-Josef Dietz, Adriano Nunes-Nesi, Phuc T Do, Alisdair R Fernie, Sai K Talla, Agepati S Raghavendra, Vera Linke, Renate Scheibe. Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase. Journal of experimental botany. 2012 Feb; 63(3):1445-59. doi: 10.1093/jxb/err386. [PMID: 22140244]
  • Francisco Campos, Tomás Sobrino, Pedro Ramos-Cabrer, José Castillo. Oxaloacetate: a novel neuroprotective for acute ischemic stroke. The international journal of biochemistry & cell biology. 2012 Feb; 44(2):262-5. doi: 10.1016/j.biocel.2011.11.003. [PMID: 22085530]
  • Darren M Soanes, Apratim Chakrabarti, Konrad H Paszkiewicz, Angus L Dawe, Nicholas J Talbot. Genome-wide transcriptional profiling of appressorium development by the rice blast fungus Magnaporthe oryzae. PLoS pathogens. 2012 Feb; 8(2):e1002514. doi: 10.1371/journal.ppat.1002514. [PMID: 22346750]
  • Djédoux Maxime Angaman, Rocco Petrizzo, Francesc Hernández-Gras, Carmen Romero-Segura, Irene Pateraki, Montserrat Busquets, Albert Boronat. Precursor uptake assays and metabolic analyses in isolated tomato fruit chromoplasts. Plant methods. 2012 Jan; 8(1):1. doi: 10.1186/1746-4811-8-1. [PMID: 22243738]
  • Carine Guillet, Mourad A M Aboul-Soud, Aline Le Menn, Nicolas Viron, Anne Pribat, Véronique Germain, Daniel Just, Pierre Baldet, Patrick Rousselle, Martine Lemaire-Chamley, Christophe Rothan. Regulation of the fruit-specific PEP carboxylase SlPPC2 promoter at early stages of tomato fruit development. PloS one. 2012; 7(5):e36795. doi: 10.1371/journal.pone.0036795. [PMID: 22615815]
  • Saskia Floerl, Andrzej Majcherczyk, Mareike Possienke, Kirstin Feussner, Hella Tappe, Christiane Gatz, Ivo Feussner, Ursula Kües, Andrea Polle. Verticillium longisporum infection affects the leaf apoplastic proteome, metabolome, and cell wall properties in Arabidopsis thaliana. PloS one. 2012; 7(2):e31435. doi: 10.1371/journal.pone.0031435. [PMID: 22363647]
  • Huawu Jiang, Pingzhi Wu, Sheng Zhang, Chi Song, Yaping Chen, Meiru Li, Yongxia Jia, Xiaohua Fang, Fan Chen, Guojiang Wu. Global analysis of gene expression profiles in developing physic nut (Jatropha curcas L.) seeds. PloS one. 2012; 7(5):e36522. doi: 10.1371/journal.pone.0036522. [PMID: 22574177]
  • Nancy Nader, Sinnie Sin Man Ng, Yonghong Wang, Brent S Abel, George P Chrousos, Tomoshige Kino. Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism. PloS one. 2012; 7(3):e26751. doi: 10.1371/journal.pone.0026751. [PMID: 22457708]
  • Jessie Fernandez, Janet D Wright, David Hartline, Cristian F Quispe, Nandakumar Madayiputhiya, Richard A Wilson. Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection. PLoS genetics. 2012; 8(5):e1002673. doi: 10.1371/journal.pgen.1002673. [PMID: 22570632]
  • Fabiola Márquez, Nancy Babio, Mònica Bulló, J Salas-Salvadó. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Critical reviews in food science and nutrition. 2012; 52(7):585-94. doi: 10.1080/10408398.2010.500551. [PMID: 22530711]
  • Meike J Ochs, Bernd L Sorg, Laura Pufahl, Manuel Grez, Beatrix Suess, Dieter Steinhilber. Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay. PloS one. 2012; 7(2):e31363. doi: 10.1371/journal.pone.0031363. [PMID: 22363630]
  • Johanna L Barclay, Jana Husse, Brid Bode, Nadine Naujokat, Judit Meyer-Kovac, Sebastian M Schmid, Hendrik Lehnert, Henrik Oster. Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork. PloS one. 2012; 7(5):e37150. doi: 10.1371/journal.pone.0037150. [PMID: 22629359]
  • Philippe Icard, Laurent Poulain, Hubert Lincet. Understanding the central role of citrate in the metabolism of cancer cells. Biochimica et biophysica acta. 2012 Jan; 1825(1):111-6. doi: 10.1016/j.bbcan.2011.10.007. [PMID: 22101401]
  • Hiroshi Nishimura, Kyoko Murayama, Takahito Watanabe, Yoichi Honda, Takashi Watanabe. Diverse rare lipid-related metabolites including ω-7 and ω-9 alkenylitaconic acids (ceriporic acids) secreted by a selective white rot fungus, Ceriporiopsis subvermispora. Chemistry and physics of lipids. 2012 Jan; 165(1):97-104. doi: 10.1016/j.chemphyslip.2011.10.007. [PMID: 22074880]
  • Ryan S Streeper, Carrie A Grueter, Nathan Salomonis, Sylvaine Cases, Malin C Levin, Suneil K Koliwad, Ping Zhou, Mattew D Hirschey, Eric Verdin, Robert V Farese. Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. Aging. 2012 Jan; 4(1):13-27. doi: 10.18632/aging.100424. [PMID: 22291164]
  • Marion Andrew, Reeta Barua, Steven M Short, Linda M Kohn. Evidence for a common toolbox based on necrotrophy in a fungal lineage spanning necrotrophs, biotrophs, endophytes, host generalists and specialists. PloS one. 2012; 7(1):e29943. doi: 10.1371/journal.pone.0029943. [PMID: 22253834]
  • Adrian P Brown, Johan T M Kroon, David Swarbreck, Melanie Febrer, Tony R Larson, Ian A Graham, Mario Caccamo, Antoni R Slabas. Tissue-specific whole transcriptome sequencing in castor, directed at understanding triacylglycerol lipid biosynthetic pathways. PloS one. 2012; 7(2):e30100. doi: 10.1371/journal.pone.0030100. [PMID: 22319559]
  • Jun Tian, Xiaoquan Ban, Hong Zeng, Jingsheng He, Yuxin Chen, Youwei Wang. The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus. PloS one. 2012; 7(1):e30147. doi: 10.1371/journal.pone.0030147. [PMID: 22272289]
  • Christine Crumbley, Yongjun Wang, Subhashis Banerjee, Thomas P Burris. Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PloS one. 2012; 7(4):e33804. doi: 10.1371/journal.pone.0033804. [PMID: 22485150]
  • Marcus Thein, Mari Bonde, Ignas Bunikis, Katrin Denker, Albert Sickmann, Sven Bergström, Roland Benz. DipA, a pore-forming protein in the outer membrane of Lyme disease spirochetes exhibits specificity for the permeation of dicarboxylates. PloS one. 2012; 7(5):e36523. doi: 10.1371/journal.pone.0036523. [PMID: 22590556]
  • Nicole Linka, Christian Esser. Transport proteins regulate the flux of metabolites and cofactors across the membrane of plant peroxisomes. Frontiers in plant science. 2012; 3(?):3. doi: 10.3389/fpls.2012.00003. [PMID: 22645564]
  • Ana Carolina Ariza, Peter Meinardus T Deen, Joris Hubertus Robben. The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditions. Frontiers in endocrinology. 2012; 3(?):22. doi: 10.3389/fendo.2012.00022. [PMID: 22649411]
  • Carolin A Kolmeder, Mark de Been, Janne Nikkilä, Ilja Ritamo, Jaana Mättö, Leena Valmu, Jarkko Salojärvi, Airi Palva, Anne Salonen, Willem M de Vos. Comparative metaproteomics and diversity analysis of human intestinal microbiota testifies for its temporal stability and expression of core functions. PloS one. 2012; 7(1):e29913. doi: 10.1371/journal.pone.0029913. [PMID: 22279554]
  • Alexandra Maier, Holger Fahnenstich, Susanne von Caemmerer, Martin K M Engqvist, Andreas P M Weber, Ulf-Ingo Flügge, Veronica G Maurino. Transgenic Introduction of a Glycolate Oxidative Cycle into A. thaliana Chloroplasts Leads to Growth Improvement. Frontiers in plant science. 2012; 3(?):38. doi: 10.3389/fpls.2012.00038. [PMID: 22639647]
  • Young-Man Kim, Sung-Eun Lee, Byeoung-Soo Park, Mi-Kyung Son, Young-Mi Jung, Seung-Ok Yang, Hyung-Kyoon Choi, Sung-Ho Hur, Jong Hwa Yum. Proteomic analysis on acetate metabolism in Citrobacter sp. BL-4. International journal of biological sciences. 2012; 8(1):66-78. doi: 10.7150/ijbs.8.66. [PMID: 22211106]
  • Ilka Haferkamp, Stephan Schmitz-Esser. The plant mitochondrial carrier family: functional and evolutionary aspects. Frontiers in plant science. 2012; 3(?):2. doi: 10.3389/fpls.2012.00002. [PMID: 22639632]
  • Wei Guo, Li-fang Zou, Yu-rong Li, Yi-ping Cui, Zhi-yuan Ji, Lu-lu Cai, Hua-song Zou, William C Hutchins, Ching-hong Yang, Gong-you Chen. Fructose-bisphophate aldolase exhibits functional roles between carbon metabolism and the hrp system in rice pathogen Xanthomonas oryzae pv. oryzicola. PloS one. 2012; 7(2):e31855. doi: 10.1371/journal.pone.0031855. [PMID: 22384086]
  • D A Spratt, M Daglia, A Papetti, M Stauder, D O'Donnell, L Ciric, A Tymon, B Repetto, C Signoretto, Y Houri-Haddad, M Feldman, D Steinberg, S Lawton, P Lingström, J Pratten, E Zaura, G Gazzani, C Pruzzo, M Wilson. Evaluation of plant and fungal extracts for their potential antigingivitis and anticaries activity. Journal of biomedicine & biotechnology. 2012; 2012(?):510198. doi: 10.1155/2012/510198. [PMID: 22500094]
  • Stewart Frankel, Blanka Rogina. Indy mutants: live long and prosper. Frontiers in genetics. 2012; 3(?):13. doi: 10.3389/fgene.2012.00013. [PMID: 22363340]
  • Ki-Hwan Han. Mechanisms of the effects of acidosis and hypokalemia on renal ammonia metabolism. Electrolyte & blood pressure : E & BP. 2011 Dec; 9(2):45-9. doi: 10.5049/ebp.2011.9.2.45. [PMID: 22438855]
  • Victor Romanov, Terry Whyard, Radha Bonala, Francis Johnson, Arthur Grollman. Glutamate dehydrogenase requirement for apoptosis induced by aristolochic acid in renal tubular epithelial cells. Apoptosis : an international journal on programmed cell death. 2011 Dec; 16(12):1217-28. doi: 10.1007/s10495-011-0646-5. [PMID: 21901531]
  • Gang Wang, Xiaoliang Sun, Guifeng Wang, Fei Wang, Qiang Gao, Xin Sun, Yuanping Tang, Chong Chang, Jinsheng Lai, Lihuang Zhu, Zhengkai Xu, Rentao Song. Opaque7 encodes an acyl-activating enzyme-like protein that affects storage protein synthesis in maize endosperm. Genetics. 2011 Dec; 189(4):1281-95. doi: 10.1534/genetics.111.133967. [PMID: 21954158]
  • Shaowei Wei, Yin Li. [Functions of plant phosphoenolpyruvate carboxylase and its applications for genetic engineering]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2011 Dec; 27(12):1702-10. doi: . [PMID: 22506410]
  • Josirley de F C Carvalho, Pippa J Madgwick, Stephen J Powers, Alfred J Keys, Peter J Lea, Martin A J Parry. An engineered pathway for glyoxylate metabolism in tobacco plants aimed to avoid the release of ammonia in photorespiration. BMC biotechnology. 2011 Nov; 11(?):111. doi: 10.1186/1472-6750-11-111. [PMID: 22104170]
  • Tom Grunert, Nicole R Leitner, Martina Marchetti-Deschmann, Ingrid Miller, Barbara Wallner, Marta Radwan, Claus Vogl, Thomas Kolbe, Dagmar Kratky, Manfred Gemeiner, Günter Allmaier, Mathias Müller, Birgit Strobl. A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C). Journal of proteomics. 2011 Nov; 74(12):2866-80. doi: 10.1016/j.jprot.2011.07.006. [PMID: 21787891]
  • Ana M Fortes, Patricia Agudelo-Romero, Marta S Silva, Kashif Ali, Lisete Sousa, Federica Maltese, Young H Choi, Jerome Grimplet, José M Martinez-Zapater, Robert Verpoorte, Maria S Pais. Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. BMC plant biology. 2011 Nov; 11(?):149. doi: 10.1186/1471-2229-11-149. [PMID: 22047180]
  • Ehud Katz, Kyung Hwan Boo, Ho Youn Kim, Richard A Eigenheer, Brett S Phinney, Vladimir Shulaev, Florence Negre-Zakharov, Avi Sadka, Eduardo Blumwald. Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. Journal of experimental botany. 2011 Nov; 62(15):5367-84. doi: 10.1093/jxb/err197. [PMID: 21841177]
  • Brendan O'Leary, Eric T Fedosejevs, Allyson T Hill, James Bettridge, Joonho Park, Srinath K Rao, Craig A Leach, William C Plaxton. Tissue-specific expression and post-translational modifications of plant- and bacterial-type phosphoenolpyruvate carboxylase isozymes of the castor oil plant, Ricinus communis L. Journal of experimental botany. 2011 Nov; 62(15):5485-95. doi: 10.1093/jxb/err225. [PMID: 21841182]
  • Yizhou Wang, Michael R Blatt. Anion channel sensitivity to cytosolic organic acids implicates a central role for oxaloacetate in integrating ion flux with metabolism in stomatal guard cells. The Biochemical journal. 2011 Oct; 439(1):161-70. doi: 10.1042/bj20110845. [PMID: 21745184]
  • Jennifer R Hall, Kathy A Clow, Matthew L Rise, William R Driedzic. Identification and validation of differentially expressed transcripts in a hepatocyte model of cold-induced glycerol production in rainbow smelt (Osmerus mordax). American journal of physiology. Regulatory, integrative and comparative physiology. 2011 Oct; 301(4):R995-R1010. doi: 10.1152/ajpregu.00210.2011. [PMID: 21734021]
  • Vesna Hadži-Tašković Šukalović, Mirjana Vuletić, Ksenija Marković, Zeljko Vučinić. Cell wall-associated malate dehydrogenase activity from maize roots. Plant science : an international journal of experimental plant biology. 2011 Oct; 181(4):465-70. doi: 10.1016/j.plantsci.2011.07.007. [PMID: 21889053]
  • Ozgür Fırat, Hikmet Y Cogun, Tüzin A Yüzereroğlu, Gülbin Gök, Ozge Fırat, Ferit Kargin, Yasemin Kötemen. A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus. Fish physiology and biochemistry. 2011 Sep; 37(3):657-66. doi: 10.1007/s10695-011-9466-3. [PMID: 21229307]
  • Rami Abu Fanne, Taher Nassar, Samuel N Heyman, Nuha Hijazi, Abd Al-Roof Higazi. Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. American journal of physiology. Regulatory, integrative and comparative physiology. 2011 Sep; 301(3):R668-73. doi: 10.1152/ajpregu.00058.2011. [PMID: 21677268]
  • Timo Mühlhaus, Julia Weiss, Dorothea Hemme, Frederik Sommer, Michael Schroda. Quantitative shotgun proteomics using a uniform ¹⁵N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii. Molecular & cellular proteomics : MCP. 2011 Sep; 10(9):M110.004739. doi: 10.1074/mcp.m110.004739. [PMID: 21610104]
  • Joelle Amselem, Christina A Cuomo, Jan A L van Kan, Muriel Viaud, Ernesto P Benito, Arnaud Couloux, Pedro M Coutinho, Ronald P de Vries, Paul S Dyer, Sabine Fillinger, Elisabeth Fournier, Lilian Gout, Matthias Hahn, Linda Kohn, Nicolas Lapalu, Kim M Plummer, Jean-Marc Pradier, Emmanuel Quévillon, Amir Sharon, Adeline Simon, Arjen ten Have, Bettina Tudzynski, Paul Tudzynski, Patrick Wincker, Marion Andrew, Véronique Anthouard, Ross E Beever, Rolland Beffa, Isabelle Benoit, Ourdia Bouzid, Baptiste Brault, Zehua Chen, Mathias Choquer, Jérome Collémare, Pascale Cotton, Etienne G Danchin, Corinne Da Silva, Angélique Gautier, Corinne Giraud, Tatiana Giraud, Celedonio Gonzalez, Sandrine Grossetete, Ulrich Güldener, Bernard Henrissat, Barbara J Howlett, Chinnappa Kodira, Matthias Kretschmer, Anne Lappartient, Michaela Leroch, Caroline Levis, Evan Mauceli, Cécile Neuvéglise, Birgitt Oeser, Matthew Pearson, Julie Poulain, Nathalie Poussereau, Hadi Quesneville, Christine Rascle, Julia Schumacher, Béatrice Ségurens, Adrienne Sexton, Evelyn Silva, Catherine Sirven, Darren M Soanes, Nicholas J Talbot, Matt Templeton, Chandri Yandava, Oded Yarden, Qiandong Zeng, Jeffrey A Rollins, Marc-Henri Lebrun, Marty Dickman. Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea. PLoS genetics. 2011 Aug; 7(8):e1002230. doi: 10.1371/journal.pgen.1002230. [PMID: 21876677]
  • Haytham Eloqayli, Torun M Melø, Anne Haukvik, Ursula Sonnewald. [2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells. Neurochemical research. 2011 Aug; 36(8):1566-73. doi: 10.1007/s11064-011-0485-3. [PMID: 21538079]
  • Dillon Chung, Graham P Lloyd, Raymond H Thomas, Chrisopher G Guglielmo, James F Staples. Mitochondrial respiration and succinate dehydrogenase are suppressed early during entrance into a hibernation bout, but membrane remodeling is only transient. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2011 Jul; 181(5):699-711. doi: 10.1007/s00360-010-0547-x. [PMID: 21207037]
  • Mariana Martín, Sebastián Pablo Rius, Florencio Esteban Podestá. Two phosphoenolpyruvate carboxykinases coexist in the Crassulacean Acid Metabolism plant Ananas comosus. Isolation and characterization of the smaller 65 kDa form. Plant physiology and biochemistry : PPB. 2011 Jun; 49(6):646-53. doi: 10.1016/j.plaphy.2011.02.015. [PMID: 21398135]
  • Yujin Cao, Yugang Cao, Xiangzhi Lin. Metabolically engineered Escherichia coli for biotechnological production of four-carbon 1,4-dicarboxylic acids. Journal of industrial microbiology & biotechnology. 2011 Jun; 38(6):649-56. doi: 10.1007/s10295-010-0913-4. [PMID: 21113642]
  • Brendan O'Leary, Joonho Park, William C Plaxton. The remarkable diversity of plant PEPC (phosphoenolpyruvate carboxylase): recent insights into the physiological functions and post-translational controls of non-photosynthetic PEPCs. The Biochemical journal. 2011 May; 436(1):15-34. doi: 10.1042/bj20110078. [PMID: 21524275]
  • Xianping Fang, Huasheng Ma, Dezhao Lu, Hong Yu, Wenguo Lai, Songlin Ruan. Comparative proteomics analysis of proteins expressed in the I-1 and I-2 internodes of strawberry stolons. Proteome science. 2011 May; 9(?):26. doi: 10.1186/1477-5956-9-26. [PMID: 21569547]
  • Kamal A Amin, Hamdy H Kamel, Mohamed A Abd Eltawab. The relation of high fat diet, metabolic disturbances and brain oxidative dysfunction: modulation by hydroxy citric acid. Lipids in health and disease. 2011 May; 10(?):74. doi: 10.1186/1476-511x-10-74. [PMID: 21569551]