medroxyprogesterone (BioDeep_00000402585)

Main id: BioDeep_00000409800

 


代谢物信息卡片


medroxyprogesterone

化学式: C22H32O3 (344.23513219999995)
中文名称: 甲羟孕酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C
InChI: InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3

描述信息

G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DA - Pregnen (4) derivatives
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AB - Progestogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
CONFIDENCE standard compound; INTERNAL_ID 8739

同义名列表

1 个代谢物同义名

medroxyprogesterone



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Jessica Venugopal, Jintao Wang, Chiao Guo, Daniel T Eitzman. Amiodarone improves anemia in a murine model of sickle cell disease and is associated with increased erythrocyte bis(monoacylglycerol) phosphate. Scientific reports. 2022 09; 12(1):16437. doi: 10.1038/s41598-022-20955-5. [PMID: 36180774]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Marta Jerez-Peña, Borja Salvador-Culla, María F de la Paz, Rafael I Barraquer. Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer. European journal of ophthalmology. 2021 Mar; 31(2):NP33-NP38. doi: 10.1177/1120672120909768. [PMID: 32141311]
  • Margaret A Zimmerman, Benard O Ogola, Mary M Wilkinson, Bruna Visniauskas, Carmen De Miguel, Jill M Daniel, Sarah H Lindsey. Medroxyprogesterone opposes estradiol-induced renal damage in midlife ovariectomized Long Evans rats. Menopause (New York, N.Y.). 2020 12; 27(12):1411-1419. doi: 10.1097/gme.0000000000001675. [PMID: 33109993]
  • Kenneth Omollo, Julie Lajoie, Julius Oyugi, Jocelyn M Wessels, Dufton Mwaengo, Joshua Kimani, Charu Kaushic, Keith R Fowke. Differential Elevation of Inflammation and CD4+ T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate. Frontiers in immunology. 2020; 11(?):598307. doi: 10.3389/fimmu.2020.598307. [PMID: 33717049]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Daniel Molano Franco, Víctor H Nieto Estrada, Alejandro G Gonzalez Garay, Arturo J Martí-Carvajal, Ingrid Arevalo-Rodriguez. Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions. The Cochrane database of systematic reviews. 2019 04; 4(?):CD013315. doi: 10.1002/14651858.cd013315. [PMID: 31012483]
  • S Rajaian, M Pragatheeswarane, K Krishnamurthy, S C Narasimhachar. Isolated intraluminal ureteral endometriosis mimicking tuberculosis. Journal of postgraduate medicine. 2019 Jan; 65(1):58-59. doi: 10.4103/jpgm.jpgm_458_18. [PMID: 30693876]
  • Pavel Šauer, Alžběta Stará, Oksana Golovko, Olga Valentová, Adam Bořík, Roman Grabic, Hana Kocour Kroupová. Two synthetic progestins and natural progesterone are responsible for most of the progestagenic activities in municipal wastewater treatment plant effluents in the Czech and Slovak republics. Water research. 2018 06; 137(?):64-71. doi: 10.1016/j.watres.2018.02.065. [PMID: 29544204]
  • Juana Serret-Montoya, Miguel A Villasís-Keever, Alejandra Aguilar-Kitsu, Iliana Del Moral-Estrada, Abigail Hernandez-Cabezza, Jessie N Zurita-Cruz. [Experiencia en el tratamiento de la hemorragia uterina anormal en adolescentes con enfermedad renal crónica]. Boletin medico del Hospital Infantil de Mexico. 2018; 75(5):295-302. doi: 10.24875/bmhim.18000006. [PMID: 30250312]
  • Ashraf H Ahmed, Richard D Gordon, Gregory Ward, Martin Wolley, Brett C McWhinney, Jacobus P Ungerer, Michael Stowasser. Effect of Combined Hormonal Replacement Therapy on the Aldosterone/Renin Ratio in Postmenopausal Women. The Journal of clinical endocrinology and metabolism. 2017 07; 102(7):2329-2334. doi: 10.1210/jc.2016-3851. [PMID: 28379474]
  • Joanna L Denbigh, David Perez-Guaita, Robbin R Vernooij, Mark J Tobin, Keith R Bambery, Yun Xu, Andrew D Southam, Farhat L Khanim, Mark T Drayson, Nicholas P Lockyer, Royston Goodacre, Bayden R Wood. Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques. Scientific reports. 2017 06; 7(1):2649. doi: 10.1038/s41598-017-02069-5. [PMID: 28572622]
  • Yousef Abdossalami Asl, Yadollah Yamini, Shahram Seidi. Development of a microfluidic-chip system for liquid-phase microextraction based on two immiscible organic solvents for the extraction and preconcentration of some hormonal drugs. Talanta. 2016 Nov; 160(?):592-599. doi: 10.1016/j.talanta.2016.07.063. [PMID: 27591655]
  • Martha A Sánchez-Rodríguez, Mariano Zacarías-Flores, Lizett Castrejón-Delgado, Ana Karen Ruiz-Rodríguez, Víctor Manuel Mendoza-Núñez. Effects of Hormone Therapy on Oxidative Stress in Postmenopausal Women with Metabolic Syndrome. International journal of molecular sciences. 2016 Aug; 17(9):. doi: 10.3390/ijms17091388. [PMID: 27563883]
  • Jiratti Thammasiri, Chainarong Navanukraw, Suthipong Uriyapongson, Vilaivan Khanthusaeng, Chuchat Kamollirt. Expression of cumulus-oocyte complex genes and embryonic development in goats subjected to progestogen-based estrus synchronization. Theriogenology. 2016 Jul; 86(2):612-8. doi: 10.1016/j.theriogenology.2016.02.011. [PMID: 27056418]
  • Huma Dilshad, Rabia Ismail, Safila Naveed, Khan Usmanghani, M Tanweer Alam, Ghulam Sarwar. Effect of hormonal contraceptives on serum lipids: A prospective study. Pakistan journal of pharmaceutical sciences. 2016 Jul; 29(4 Suppl):1379-82. doi: NULL. [PMID: 27592475]
  • Agnieszka Ociepka, Tomasz Milewicz, Marta Kialka, Magdalena Krzyczkowska-Sendrakowska. Vascular effects of simvastatin are similar to hormone replacement therapy in postmenopausal women. Przeglad lekarski. 2016 ; 73(5):280-6. doi: . [PMID: 29629740]
  • Manuela Menezes Máximo, Patrícia Silveira Silva, Carolina Sales Vieira, Thaís Mangetti Gonçalvez, Júlio Cesar Rosa-E-Silva, Francisco José Candido-Dos-Reis, Antonio Alberto Nogueira, Omero Benedicto Poli-Neto. Low-dose progestin-releasing contraceptives are associated with a higher pain threshold in healthy women. Fertility and sterility. 2015 Nov; 104(5):1182-9. doi: 10.1016/j.fertnstert.2015.07.1165. [PMID: 26341277]
  • Shan Liu, Guang-Guo Ying, Li-Jun Zhou, Rui-Quan Zhang, Zhi-Feng Chen, Hua-Jie Lai. Steroids in a typical swine farm and their release into the environment. Water research. 2012 Aug; 46(12):3754-68. doi: 10.1016/j.watres.2012.04.006. [PMID: 22591816]
  • Sharula, Chebib Chekir, Yayoi Emi, Fujimi Arai, Yukako Kikuchi, Aiko Sasaki, Miwa Matsuda, Keiko Shimizu, Kazuhiro Tabuchi, Yasuhiko Kamada, Yuji Hiramatsu, Mikiya Nakatsuka. Altered arterial stiffness in male-to-female transsexuals undergoing hormonal treatment. The journal of obstetrics and gynaecology research. 2012 Jun; 38(6):932-40. doi: 10.1111/j.1447-0756.2011.01815.x. [PMID: 22487218]
  • Christine Klipping, Ingrid Duijkers, Michel P Fortier, Joachim Marr, Dietmar Trummer, Jörg Elliesen. Long-term tolerability of ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen: results from a randomised, controlled, multicentre study. The journal of family planning and reproductive health care. 2012 Apr; 38(2):84-93. doi: 10.1136/jfprhc-2011-100214. [PMID: 22454004]
  • M F Martinez, G de Nava, K J Demmers, D Tutt, M Rodriguez Sabarrós, B Smaill, M Corti, J Juengel. Intravaginal progesterone devices in synchronization protocols for artificial insemination in beef heifers. Reproduction in domestic animals = Zuchthygiene. 2012 Apr; 47(2):230-7. doi: 10.1111/j.1439-0531.2011.01833.x. [PMID: 21883507]
  • J F S Mann, D Stieh, K Klein, D S Miranda de Stegmann, M P Cranage, R J Shattock, P F McKay. Transferrin conjugation confers mucosal molecular targeting to a model HIV-1 trimeric gp140 vaccine antigen. Journal of controlled release : official journal of the Controlled Release Society. 2012 Mar; 158(2):240-9. doi: 10.1016/j.jconrel.2011.11.009. [PMID: 22119743]
  • Ghazaleh Soleimany, Haleh Dadgostar, Sara Lotfian, Mazyar Moradi-Lakeh, Elham Dadgostar, Shafieh Movaseghi. Bone Mineral Changes and Cardiovascular Effects among Female Athletes with Chronic Menstrual Dysfunction. Asian journal of sports medicine. 2012 Mar; 3(1):53-8. doi: 10.5812/asjsm.34730. [PMID: 22461966]
  • Anna-Clara E Spetz Holm, Jessica Frisk, Mats L Hammar. Acupuncture as treatment of hot flashes and the possible role of calcitonin gene-related Peptide. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):579321. doi: 10.1155/2012/579321. [PMID: 22110545]
  • Alvaro Pulchinelli, Ana Maria Massad Costa, Cristina V de Carvalho, Naiara Correa Nogueira de Souza, Mauro A Haidar, Adagmar Andriolo, Ismael D C Guerreiro da Silva. Positive association of the hepatic lipase gene polymorphism c.514C > T with estrogen replacement therapy response. Lipids in health and disease. 2011 Nov; 10(?):197. doi: 10.1186/1476-511x-10-197. [PMID: 22047520]
  • Adarsh J Sai, J Christopher Gallagher, Xiang Fang. Effect of hormone therapy and calcitriol on serum lipid profile in postmenopausal older women: association with estrogen receptor-α genotypes. Menopause (New York, N.Y.). 2011 Oct; 18(10):1101-12. doi: 10.1097/gme.0b013e318217d41d. [PMID: 21712736]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Abdullah Foraih Al-Anazi, Viquar Fatima Qureshi, Khalida Javaid, Shoeb Qureshi. Preventive effects of phytoestrogens against postmenopausal osteoporosis as compared to the available therapeutic choices: An overview. Journal of natural science, biology, and medicine. 2011 Jul; 2(2):154-63. doi: 10.4103/0976-9668.92322. [PMID: 22346228]
  • Maple M Fung, Sameer Poddar, Ricki Bettencourt, Simerjot Kaur Jassal, Elizabeth Barrett-Connor. A cross-sectional and 10-year prospective study of postmenopausal estrogen therapy and blood pressure, renal function, and albuminuria: the Rancho Bernardo Study. Menopause (New York, N.Y.). 2011 Jun; 18(6):629-37. doi: 10.1097/gme.0b013e3181fca9c4. [PMID: 21326121]
  • Toshio Hayashi, Koichiro Ina, Morihiko Maeda, Hideki Nomura. The effects of selective estrogen receptor modulator treatment following hormone replacement therapy on elderly postmenopausal women with osteoporosis. Nitric oxide : biology and chemistry. 2011 May; 24(4):199-203. doi: 10.1016/j.niox.2011.04.002. [PMID: 21513812]
  • Tomasz Milewicz, Józef Krzysiek, Iwona Rogatko, Krystyna Sztefko, Ewa Stochmal, Alicja Hubalewska-Dydejczyk, Robert Jach, Stanisław Radowicki. The somatotropic axis in postmenopausal women during six month of transdermal continuous 17beta-estradiol administration combined with oral medroxyprogesterone. Ginekologia polska. 2011 Apr; 82(4):254-8. doi: . [PMID: 21721462]
  • Binod Kumar Yadav, Rajesh Kumar Gupta, Prajwal Gyawali, Rojeet Shrestha, Bibek Poudel, Manoj Sigdel, Bharat Jha. Effects of long-term use of depo-medroxyprogesterone acetate on lipid metabolism in Nepalese women. The Korean journal of laboratory medicine. 2011 Apr; 31(2):95-7. doi: 10.3343/kjlm.2011.31.2.95. [PMID: 21474983]
  • Nicholas A Tritos, Thomas N Byrne, Chin-Lee Wu, Anne Klibanski. A patient with diabetes insipidus, anterior hypopituitarism and pituitary stalk thickening. Nature reviews. Endocrinology. 2011 Jan; 7(1):54-9. doi: 10.1038/nrendo.2010.198. [PMID: 21102546]
  • Agata Bielecka-Dąbrowa, Simon Hannam, Jacek Rysz, Maciej Banach. Malignancy-associated dyslipidemia. The open cardiovascular medicine journal. 2011; 5(?):35-40. doi: 10.2174/1874192401105010035. [PMID: 21660223]
  • Whitney Wharton, Laura D Baker, Carey E Gleason, Maritza Dowling, Jodi H Barnet, Sterling Johnson, Cynthia Carlsson, Suzanne Craft, Sanjay Asthana. Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial. Journal of Alzheimer's disease : JAD. 2011; 26(3):495-505. doi: 10.3233/jad-2011-110341. [PMID: 21694454]
  • Agnieszka Rajtar-Ciosek, Hubert Huras, Józef Krzysiek, Alfred Reroń, Maciej Wilczak, Robert Jach. Beneficial influence of postmenopausal estrogen therapy on serum adhesion molecules is independent of the route and dose of administration. Neuro endocrinology letters. 2011; 32(3):340-4. doi: . [PMID: 21670727]
  • Wai-Hong Wu, Elizabeth Gersch, Kihyuck Kwak, Subhashini Jagu, Balasubramanyam Karanam, Warner K Huh, Robert L Garcea, Richard B S Roden. Capsomer vaccines protect mice from vaginal challenge with human papillomavirus. PloS one. 2011; 6(11):e27141. doi: 10.1371/journal.pone.0027141. [PMID: 22069498]
  • Hong-Yan Ge, Nan Xiao, Xiu-Li Yin, Song-Bin Fu, Jin-Ying Ge, Yan Shi, Ping Liu. Comparison of the antiangiogenic activity of modified RGDRGD-endostatin to endostatin delivered by gene transfer in vivo rabbit neovascularization model. Molecular vision. 2011; 17(?):1918-28. doi: . [PMID: 21850166]
  • Jue Zhou, Fan Qu, Xisheng Sang, Xiaotong Wang, Rui Nan. Acupuncture and auricular acupressure in relieving menopausal hot flashes of bilaterally ovariectomized chinese women: a randomized controlled trial. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):713274. doi: 10.1093/ecam/nep001. [PMID: 19189989]
  • Konrad Bork. Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 2010 Jul; 6(1):15. doi: 10.1186/1710-1492-6-15. [PMID: 20667118]
  • A N Jeppesen, H K Jensen, F Donskov, N Marcussen, H von der Maase. Hyponatremia as a prognostic and predictive factor in metastatic renal cell carcinoma. British journal of cancer. 2010 Mar; 102(5):867-72. doi: 10.1038/sj.bjc.6605563. [PMID: 20145619]
  • Martin E Gore, Clare L Griffin, Barry Hancock, Poulam M Patel, Lynda Pyle, Michael Aitchison, Nicholas James, Roderick T D Oliver, Jozef Mardiak, Tahera Hussain, Richard Sylvester, Mahesh K B Parmar, Patrick Royston, Peter F A Mulders. Interferon alfa-2a versus combination therapy with interferon alfa-2a, interleukin-2, and fluorouracil in patients with untreated metastatic renal cell carcinoma (MRC RE04/EORTC GU 30012): an open-label randomised trial. Lancet (London, England). 2010 Feb; 375(9715):641-8. doi: 10.1016/s0140-6736(09)61921-8. [PMID: 20153039]
  • María V Cavilla, Carolina P Bianchi, Marcelo A Aba. Oestradiol-17beta plasma concentrations after intramuscular injection of oestradiol benzoate or oestradiol cypionate in llamas (Lama glama). Acta veterinaria Scandinavica. 2010 Feb; 52(?):13. doi: 10.1186/1751-0147-52-13. [PMID: 20149242]
  • Paula Bernstein, Gerald Pohost. Progesterone, progestins, and the heart. Reviews in cardiovascular medicine. 2010; 11(3):e141-9. doi: 10.3909/ricm0557. [PMID: 21045766]
  • Anuradha Dogiparthi, Neelam Aggarwal, Vanita Suri, Radhika Srinivasan, Sarla Malhotra. Comparative evaluation of raloxifene versus estrogen: Progestin on symptomatology, endometrium, and lipid profile in postmenopausal women. Journal of mid-life health. 2010 Jan; 1(1):14-8. doi: 10.4103/0976-7800.66988. [PMID: 21799632]
  • Antonio Alberto Zuppa, Paola Sindico, Claudia Orchi, Chiara Carducci, Valentina Cardiello, Costantino Romagnoli. Safety and efficacy of galactogogues: substances that induce, maintain and increase breast milk production. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2010; 13(2):162-74. doi: 10.18433/j3ds3r. [PMID: 20816003]
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  • Paula Bernstein, Gerald Pohost. Progesterone, progestins, and the heart. Reviews in cardiovascular medicine. 2010; 11(4):228-36. doi: 10.3909/ricm0557. [PMID: 21389912]
  • Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He. Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry. 2009 Nov; 44(11):4455-60. doi: 10.1016/j.ejmech.2009.06.004. [PMID: 19586686]
  • Quanlin Wang, Aizhi Zhang, Liren Chen. [Study on simultaneous determination method for banded synthesis hormones residues in egg products]. Wei sheng yan jiu = Journal of hygiene research. 2009 Nov; 38(6):740-6. doi: . [PMID: 20047238]
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  • Sheng-Li Lin, Li-Ying Yan, Xing-Wei Liang, Zhen-Bo Wang, Zhao-Yi Wang, Jie Qiao, Heide Schatten, Qing-Yuan Sun. A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells. Reproductive biology and endocrinology : RB&E. 2009 Sep; 7(?):102. doi: 10.1186/1477-7827-7-102. [PMID: 19775474]
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  • Li Li, Zhong-Mian Pan, Xin-Qiu Chen, Kun Gao, Wei Zhang, Yuan Luo, Zhong-Qiang Yao, Xin-Qiang Liang, Wei Huang, De-Sheng Yao. [Relationship between hormone therapy in women with ovarian malignancy and prognosis]. Zhonghua fu chan ke za zhi. 2008 Nov; 43(11):843-8. doi: NULL. [PMID: 19087569]
  • Xiao-hong Xia, Ling Hu, Zheng-yu Qin, Jun Zhou, Li Meng, Wei-Li Li, Li-ying Tian, Yi-juan Zhang. [Multicentral randomized controlled clinical trials about treatment of perimenopausal syndrome with electroacupuncture of sanyinjiao (SP 6)]. Zhen ci yan jiu = Acupuncture research. 2008 Aug; 33(4):262-6. doi: NULL. [PMID: 18928120]
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