Norgestrel (BioDeep_00000402584)

Main id: BioDeep_00000002282

 


代谢物信息卡片


(±)-13-ethyl-17α-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one

化学式: C21H28O2 (312.2089188)
中文名称: D-(-)-炔诺孕酮, 炔诺孕酮
谱图信息: 最多检出来源 Homo sapiens(blood) 5.3%

分子结构信息

SMILES: CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
InChI: InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3

描述信息

G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AD - Emergency contraceptives
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4987; ORIGINAL_PRECURSOR_SCAN_NO 4984
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5650; ORIGINAL_PRECURSOR_SCAN_NO 5649
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4969; ORIGINAL_PRECURSOR_SCAN_NO 4965
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5035; ORIGINAL_PRECURSOR_SCAN_NO 5034
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5762; ORIGINAL_PRECURSOR_SCAN_NO 5761
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5116; ORIGINAL_PRECURSOR_SCAN_NO 5115
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9309; ORIGINAL_PRECURSOR_SCAN_NO 9307
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9321; ORIGINAL_PRECURSOR_SCAN_NO 9318
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9409; ORIGINAL_PRECURSOR_SCAN_NO 9405
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9359; ORIGINAL_PRECURSOR_SCAN_NO 9356
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9374; ORIGINAL_PRECURSOR_SCAN_NO 9371
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9442; ORIGINAL_PRECURSOR_SCAN_NO 9438
CONFIDENCE standard compound; INTERNAL_ID 2806
CONFIDENCE standard compound; INTERNAL_ID 8737

同义名列表

5 个代谢物同义名

Levonorgestrel; Norgestrel; (±)-13-ethyl-17α-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one; 13-ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one; ST 21:4;O2



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jing Liu, Feiyun Tu, Ming Liu, Jichao Wang, Zhibin Zhang. Antifertility effects of EP-1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans). Integrative zoology. 2023 Oct; ?(?):. doi: 10.1111/1749-4877.12774. [PMID: 37884475]
  • Andrea Flores-Rodriguez, Fernando Diaz Gonzalez-Colmenero, Mariana Garcia-Leal, Melissa Saenz-Flores, Erick Burciaga-Jimenez, Jorge A Zuñiga-Hernandez, Neri A Alvarez-Villalobos, Rene Rodríguez-Guajardo, Felipe A Morales-Martinez, Luis H Sordia-Hernandez, Rene Rodriguez-Gutierrez. Harms of third- and fourth-generation combined oral contraceptives in premenopausal women: A systematic review and meta-analysis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2023 Jul; ?(?):10815589231184227. doi: 10.1177/10815589231184227. [PMID: 37415461]
  • Zhiming Hu, Yanlin Zhang, Hanqing Jiang, Jiu-An Lv. Bioinspired helical-artificial fibrous muscle structured tubular soft actuators. Science advances. 2023 06; 9(25):eadh3350. doi: 10.1126/sciadv.adh3350. [PMID: 37352358]
  • Rubina Bunjun, Tanko F Ramla, Shameem Z Jaumdally, Laura Noël-Romas, Hossaena Ayele, Bryan P Brown, Hoyam Gamieldien, Rushil Harryparsad, Smritee Dabee, Gonasagrie Nair, Maricianah Onono, Thesla Palanee-Phillips, Catilin W Scoville, Kate B Heller, Jared M Baeten, Steven E Bosinger, Adam Burgener, Jo-Ann S Passmore, Heather Jaspan, Renee Heffron. Initiating Intramuscular Depot Medroxyprogesterone Acetate Increases Frequencies of Th17-like Human Immunodeficiency Virus Target Cells in the Genital Tract of Women in South Africa: A Randomized Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 11; 75(11):2000-2011. doi: 10.1093/cid/ciac284. [PMID: 35941737]
  • Chien-Ming Chen, Yun-Ning Tsai, Chien-Hsiun Chen, Yu-Hwei Tseng, Sunny Jui-Shan Lin, Yi-Chang Su. Levonorgestrel intrauterine devices improve body constitution deviations in the perspective of traditional Chinese medicine and quality of life in patients with chronic pelvic pain and heavy menstrual bleeding. Taiwanese journal of obstetrics & gynecology. 2022 Nov; 61(6):989-994. doi: 10.1016/j.tjog.2021.10.012. [PMID: 36428003]
  • Kristina Gemzell-Danielsson, Angelo Cagnacci, Nathalie Chabbert-Buffet, Jonathan Douxfils, Jean-Michel Foidart, Ali Kubba, Luis Ignacio Lete Lasa, Diana Mansour, Joseph Neulen, Jaoquim Neves, Fátima Palma, Thomas Römer, Robert Spaczyński, Vera Tóth. A novel estetrol-containing combined oral contraceptive: European expert panel review. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2022 Oct; 27(5):373-383. doi: 10.1080/13625187.2022.2093850. [PMID: 35862627]
  • Ramla F Tanko, Rubina Bunjun, Smritee Dabee, Shameem Z Jaumdally, Maricianah Onono, Gonasagrie Nair, Thesla Palanee-Phillips, Rushil Harryparsad, Anna Ursula Happel, Hoyam Gamieldien, Yamkela Qumbelo, Musalula Sinkala, Caitlin W Scoville, Kate Heller, Jared M Baeten, Steven E Bosinger, Adam Burgener, Renee Heffron, Heather B Jaspan, Jo Ann S Passmore. The Effect of Contraception on Genital Cytokines in Women Randomized to Copper Intrauterine Device, Depot Medroxyprogesterone Acetate, or Levonorgestrel Implant. The Journal of infectious diseases. 2022 09; 226(5):907-919. doi: 10.1093/infdis/jiac084. [PMID: 35263421]
  • Ting-Ting Zhao, Li-Li Pang, Lei-Lei Yang, Ruo-Nan Li, Ling-Xiu Fan, Yi Wen. Efficacy of high-intensity focused ultrasound combined with LNG-IUS for adenomyosis: a systematic review and meta-analysis. Archives of gynecology and obstetrics. 2022 Aug; ?(?):. doi: 10.1007/s00404-022-06720-z. [PMID: 35947146]
  • Jianghuan Hua, Biran Zhu, Wei Guo, Xianfeng Wang, Yongyong Guo, Lihua Yang, Jian Han, Bingsheng Zhou. Endocrine disrupting effects induced by levonorgestrel linked to altered DNA methylation in rare minnow (Gobiocypris rarus). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Jul; 257(?):109332. doi: 10.1016/j.cbpc.2022.109332. [PMID: 35351618]
  • Ganesh Cherala, Cara Nelson, Ying Guo, Anubhav Mathur, Thomas Tarnowski, Ahmed A Othman. Evaluation of the potential for pharmacokinetic interaction between tirabrutinib and levonorgestrel/ethinyl estradiol in healthy female volunteers. Clinical and translational science. 2022 06; 15(6):1492-1499. doi: 10.1111/cts.13265. [PMID: 35266297]
  • Noémie Roland, Jérôme Drouin, David Desplas, Lise Duranteau, François Cuenot, Rosemary Dray-Spira, Alain Weill, Mahmoud Zureik. Impact of Coronavirus disease 2019 (COVID-19) on contraception use in 2020 and up until the end of April 2021 in France. Contraception. 2022 04; 108(?):50-55. doi: 10.1016/j.contraception.2021.12.002. [PMID: 34971603]
  • Baorui Wang, Suohui Zhang, Xiaoyu Zhao, Jie Lian, Yunhua Gao. Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles. Drug delivery and translational research. 2022 04; 12(4):944-956. doi: 10.1007/s13346-021-01057-7. [PMID: 34515951]
  • Charles M'Poca Charles, Aline Munezero, Luis G Bahamondes, Rodolfo C Pacagnella. Comparison of contraceptive sales before and during the COVID-19 pandemic in Brazil. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2022 Apr; 27(2):115-120. doi: 10.1080/13625187.2022.2027364. [PMID: 35156489]
  • Matthias Teigeler, Dirk Schaudien, Walter Böhmer, Reinhard Länge, Christoph Schäfers. Effects of the Gestagen Levonorgestrel in a Life Cycle Test with Zebrafish (Danio rerio). Environmental toxicology and chemistry. 2022 03; 41(3):580-591. doi: 10.1002/etc.5008. [PMID: 33539028]
  • Karthik Lingineni, Ayyappa Chaturvedula, Brian Cicali, Rodrigo Cristofoletti, Thomas Wendl, Joachim Hoechel, Joshua D Brown, Valvanera Vozmediano, Stephan Schmidt. Determining the Exposure Threshold for Levonorgestrel Efficacy Using an Integrated Model Based Meta-Analysis Approach. Clinical pharmacology and therapeutics. 2022 02; 111(2):509-518. doi: 10.1002/cpt.2457. [PMID: 34674227]
  • Teodora Pene Dumitrescu, Thomas J Greene, Samit R Joshi, Jianfeng Xu, Mark Johnson, Fiona Halliday, Laurie Butcher, Eric Zimmerman, Lindsey Webster, Theresa T Pham, Max Lataillade, Sherene Min. Lack of pharmacokinetic interaction between the HIV-1 maturation inhibitor GSK3640254 and combination oral contraceptives in healthy women. British journal of clinical pharmacology. 2022 02; 88(4):1704-1712. doi: 10.1111/bcp.15051. [PMID: 34427938]
  • Madelon C Vonk, Alfredo Guillén-Del-Castillo, Michael Kreuter, Mandy Avis, Kristell Marzin, Salome R Mack, Sven Wind, Martina Gahlemann. A Drug-Drug Interaction Study to Investigate the Effect of Nintedanib on the Pharmacokinetics of Microgynon (Ethinylestradiol and Levonorgestrel) in Female Patients with Systemic Sclerosis-Associated Interstitial Lung Disease. European journal of drug metabolism and pharmacokinetics. 2022 Jan; 47(1):81-89. doi: 10.1007/s13318-021-00728-7. [PMID: 34664183]
  • Le-Kai Nie, Hong-Li Zou, Lei Cheng, Pei-Hai Zhang. Subcutaneous etonogestrel implant combined with endometrial ablation for the treatment of adenomyosis: two case reports. The journal of obstetrics and gynaecology research. 2022 Jan; 48(1):262-265. doi: 10.1111/jog.15084. [PMID: 34713941]
  • Wendy Ankrom, Deanne Jackson Rudd, Saijuan Zhang, Kerry L Fillgrove, Kezia N Gravesande, Randolph P Matthews, Darin Brimhall, S Aubrey Stoch, Marian N Iwamoto. A phase 1, open-label study to evaluate the drug interaction between islatravir (MK-8591) and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females. Journal of the International AIDS Society. 2021 12; 24(12):e25858. doi: 10.1002/jia2.25858. [PMID: 34935295]
  • Mingxiang Liao, Krzysztof G Jeziorski, Monika Tomaszewska-Kiecana, István Láng, Marek Jasiówka, Viera Skarbová, Piotr Centkowski, Rodryg Ramlau, Maria Górnaś, John Lee, Sarah Edwards, Jenn Habeck, Eileen Nash, Nikolay Grechko, Jim J Xiao. A phase 1, open-label, drug-drug interaction study of rucaparib with rosuvastatin and oral contraceptives in patients with advanced solid tumors. Cancer chemotherapy and pharmacology. 2021 11; 88(5):887-897. doi: 10.1007/s00280-021-04338-7. [PMID: 34370076]
  • Kathryn E Fay, Amelia C Clement, Alexandra Gero, Jennifer E Kaiser, Jessica N Sanders, Abena A BakenRa, David K Turok. Rates of pregnancy among levonorgestrel and copper intrauterine emergency contraception initiators: Implications for backup contraception recommendations. Contraception. 2021 11; 104(5):561-566. doi: 10.1016/j.contraception.2021.06.011. [PMID: 34166648]
  • Eka R Gunardi, Raymond Surya, Inayah Syafitri, Yogi Pasidri. Impact of one-rod levonorgestrel implant on the blood chemistry profile. Scientific reports. 2021 10; 11(1):20141. doi: 10.1038/s41598-021-99801-z. [PMID: 34635768]
  • Li Zhang, Cheng Li, Danni Yang, Yuhua Wang, Yongping Yang, Xudong Sun. Genome-Wide Analysis of the TCP Transcription Factor Genes in Dendrobium catenatum Lindl. International journal of molecular sciences. 2021 Sep; 22(19):. doi: 10.3390/ijms221910269. [PMID: 34638610]
  • Andreas B Jordy, Muna Albayaty, Astrid Breitschaft, Thomas W Anderson, Erik Christiansen, Azadeh Houshmand-Øregaard, Easwaran Manigandan, Tine A Bækdal. Effect of Oral Semaglutide on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol in Healthy Postmenopausal Women and Furosemide and Rosuvastatin in Healthy Subjects. Clinical pharmacokinetics. 2021 09; 60(9):1171-1185. doi: 10.1007/s40262-020-00976-x. [PMID: 33782832]
  • Kristina Gemzell-Danielsson, Ali Kubba, Cecilia Caetano, Thomas Faustmann, Eeva Lukkari-Lax, Oskari Heikinheimo. More than just contraception: the impact of the levonorgestrel-releasing intrauterine system on public health over 30 years. BMJ sexual & reproductive health. 2021 07; 47(3):228-230. doi: 10.1136/bmjsrh-2020-200962. [PMID: 33514606]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Claudia Moreira de Brito, Maria Edna de Melo, Marcio C Mancini, Marco Aurelio Santo, Cintia Cercato. Pharmacokinetics of oral levonorgestrel and ethinylestradiol in women after Roux-en-Y gastric bypass surgery. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 2021 Apr; 17(4):673-681. doi: 10.1016/j.soard.2020.12.007. [PMID: 33547015]
  • Christine Klipping, Ingrid Duijkers, Marie Mawet, Catherine Maillard, Adriana Bastidas, Maud Jost, Jean-Michel Foidart. Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone. Contraception. 2021 04; 103(4):213-221. doi: 10.1016/j.contraception.2021.01.001. [PMID: 33428907]
  • Giovanni Grandi, Maria Chiara Del Savio, Fabio Facchinetti. The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism. Expert review of clinical pharmacology. 2021 Feb; 14(2):211-224. doi: 10.1080/17512433.2021.1878876. [PMID: 33464138]
  • David K Turok, Alexandra Gero, Rebecca G Simmons, Jennifer E Kaiser, Gregory J Stoddard, Corinne D Sexsmith, Lori M Gawron, Jessica N Sanders. Levonorgestrel vs. Copper Intrauterine Devices for Emergency Contraception. The New England journal of medicine. 2021 01; 384(4):335-344. doi: 10.1056/nejmoa2022141. [PMID: 33503342]
  • Niaree G Hopelian, Rebecca G Simmons, Jessica N Sanders, Katherine Ward, Sabrina Malone Jenkins, Eve Espey, David K Turok. Comparison of levonorgestrel level and creamatocrit in milk following immediate versus delayed postpartum placement of the levonorgestrel IUD. BMC women's health. 2021 01; 21(1):33. doi: 10.1186/s12905-021-01179-7. [PMID: 33478494]
  • Andrea Henkel, Lisa M Goldthwaite. Management of bothersome bleeding associated with progestin-based long-acting reversible contraception: a review. Current opinion in obstetrics & gynecology. 2020 12; 32(6):408-415. doi: 10.1097/gco.0000000000000664. [PMID: 32889971]
  • Birte Maria Hofmann, Dan Apter, Johannes Bitzer, Isabel Reinecke, Marco Serrani, Joachim Höchel, Martin Merz. Comparative pharmacokinetic analysis of levonorgestrel-releasing intrauterine systems and levonorgestrel-containing contraceptives with oral or subdermal administration route. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2020 Dec; 25(6):417-426. doi: 10.1080/13625187.2020.1815008. [PMID: 33006493]
  • Alaa E A Moubasher, Hisham A Abdel Basset, Asmaa A M Khalil, Eman M K Youssef. Levonorgestrel vs combined oral contraceptive pills in treatment of female acne and hirsutism. Dermatologic therapy. 2020 11; 33(6):e13700. doi: 10.1111/dth.13700. [PMID: 32713062]
  • R Nave, J Höchel, U Mellinger, A Kohnke, J Elliesen, H Schmitz. Pearl Index study with levonorgestrel-releasing intravaginal rings: using pharmacokinetic results to investigate treatment compliance as a potential contributor for contraceptive failure. Human reproduction (Oxford, England). 2020 11; 35(11):2515-2523. doi: 10.1093/humrep/deaa195. [PMID: 32914172]
  • Jan de Jong, Anna Mitselos, Wojciech Jurczak, Raul Cordoba, Carlos Panizo, Tomasz Wrobel, Monika Dlugosz-Danecka, James Jiao, Juthamas Sukbuntherng, Daniele Ouellet, Peter Hellemans. Ibrutinib does not have clinically relevant interactions with oral contraceptives or substrates of CYP3A and CYP2B6. Pharmacology research & perspectives. 2020 10; 8(5):e00649. doi: 10.1002/prp2.649. [PMID: 32945596]
  • R R Campos, T Baêta, A Silva-Filho, S M Rezende, A L L Rocha. Use of a levonorgestrel 52-mg intrauterine system in the control of abnormal uterine bleeding in women with inherited bleeding disorders. Contraception. 2020 10; 102(4):254-258. doi: 10.1016/j.contraception.2020.05.009. [PMID: 32470465]
  • Wendy Ankrom, Jialin Xu, Marie-Helene Vallee, Marissa F Dockendorf, Danielle Armas, Ramesh Boinpally, K Chris Min. Atogepant Has No Clinically Relevant Effects on the Pharmacokinetics of an Ethinyl Estradiol/Levonorgestrel Oral Contraceptive in Healthy Female Participants. Journal of clinical pharmacology. 2020 09; 60(9):1157-1165. doi: 10.1002/jcph.1610. [PMID: 32297990]
  • O S Michael, C L Dibia, O A Adeyanju, K S Olaniyi, E D Areola, L A Olatunji. Estrogen-progestin oral contraceptive and nicotine exposure synergistically confers cardio-renoprotection in female Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110387. doi: 10.1016/j.biopha.2020.110387. [PMID: 32540646]
  • Eva Lundström, Ivana Virijevic, Gunnar Söderqvist. Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate. Hormone molecular biology and clinical investigation. 2020 Jul; 41(3):. doi: 10.1515/hmbci-2019-0051. [PMID: 32735552]
  • Charlotte Ginstman, Helena Kopp Kallner, Johanna Fagerberg-Silwer, Björn Carlsson, Andreas Ärlemalm, Ylva Böttiger, Jan Brynhildsen. Pharmacokinetics of Oral Levonorgestrel in Women After Roux-en-Y Gastric Bypass Surgery and in BMI-Matched Controls. Obesity surgery. 2020 06; 30(6):2217-2224. doi: 10.1007/s11695-020-04447-x. [PMID: 32030619]
  • Peng Yu, Zhuo Chen, Haochi Zhao, Ruidong Cao, Lingyun Chen, Junhu Su, Yingzhi Ning. Exposure to quinestrol and levonorgestrel affects maternal behavior and offspring development in midday gerbil (Meriones meridianus). Physiology & behavior. 2020 05; 219(?):112848. doi: 10.1016/j.physbeh.2020.112848. [PMID: 32088172]
  • Catherine S Todd, Heidi E Jones, Nontokozo Langwenya, Donald R Hoover, Pai-Lien Chen, Gregory Petro, Landon Myer. Safety and continued use of the levonorgestrel intrauterine system as compared with the copper intrauterine device among women living with HIV in South Africa: A randomized controlled trial. PLoS medicine. 2020 05; 17(5):e1003110. doi: 10.1371/journal.pmed.1003110. [PMID: 32442189]
  • Paula M Castaño, Carolyn L Westhoff. Experience with same-day placement of the 52 mg levonorgestrel-releasing intrauterine system. American journal of obstetrics and gynecology. 2020 04; 222(4S):S883.e1-S883.e6. doi: 10.1016/j.ajog.2019.12.268. [PMID: 31945336]
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