Dihydrotestosterone (BioDeep_00000004016)

 

Secondary id: BioDeep_00000398250

human metabolite Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one

化学式: C19H30O2 (290.2246)
中文名称: 二氢睾酮, 双氢睾酮
谱图信息: 最多检出来源 Homo sapiens(blood) 5.56%

分子结构信息

SMILES: CC12CCC(=O)CC1CCC3C2CCC4(C3CCC4O)C
InChI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3

描述信息

Dihydrotestosterone is a potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. -- Pubchem; Dihydrotestosterone (DHT) (INN: androstanolone) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5-alpha-reductase by means of reducing the alpha 4,5 double-bond. Dihydrotestosterone belongs to the class of compounds called androgens, also commonly called androgenic hormones or testoids. DHT is thought to be approximately 30 times more potent than testosterone because of increased affinity to the androgen receptor.
A potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. -- Pubchem; Dihydrotestosterone (DHT) (INN: androstanolone) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5-alpha-reductase by means of reducing the alpha 4,5 double-bond. Dihydrotestosterone belongs to the class of compounds called androgens, also commonly called androgenic hormones or testoids. DHT is thought to be approximately 30 times more potent than testosterone because of increased affinity to the androgen receptor. -- Wikipedia [HMDB]
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03B - Androgens > G03BB - 5-androstanon (3) derivatives
A - Alimentary tract and metabolism > A14 - Anabolic agents for systemic use > A14A - Anabolic steroids > A14AA - Androstan derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D000728 - Androgens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone

同义名列表

70 个代谢物同义名

(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one; Berenguer infale brand OF androstanolone; Besins-iscovesco brand OF androstanolone; Besins iscovesco brand OF androstanolone; 17beta-Hydroxy-3-oxo-5alpha-androstanone; beta-Hydroxy-5 beta-androstan-3-one, 17; 17 beta-Hydroxy-5 beta-androstan-3-one; 17 beta Hydroxy 5 beta androstan 3 one; 17beta-Hydroxy-5alpha-androstan-3-one; 17beta Hydroxy 5alpha androstan 3 one; 17b-Hydroxy-3-oxo-5a-androstanone; 17Β-hydroxy-3-oxo-5α-androstanone; 17β-hydroxy-androstan-3-one; 5alpha-Androstan-17beta-ol-3-one; 17Β-hydroxy-5α-androstan-3-one; 17b-Hydroxy-5a-androstan-3-one; Cuxson brand OF androstanolone; 17beta-Hydroxyandrostan-3-one; Dihydrotestosterone, 5-alpha; 4,5alpha-Dihydrotestosterone; 5α-dihydrotestosterone; 5 alpha-Dihydrotestosterone; 5-alpha Dihydrotestosterone; 5 alpha Dihydrotestosterone; 5alpha-Dihydrotestosterone; 5 beta-Dihydrotestosterone; 17b-Hydroxy-3-androstanone; 5 beta Dihydrotestosterone; 17Β-hydroxyandrostan-3-one; 17-Hydroxy-androstan-3-one; 17b-Hydroxyandrostan-3-one; 5a-Androstan-17b-ol-3-one; 17-Hydroxyandrostan-3-one; 5a-Androstan-3-on-17b-ol; 4,5a-Dihydrotestosterone; 4,5Α-dihydrotestosterone; 5b-Androstan-3-on-17b-ol; 5a-Dihydrotestosterone; 5Α-dihydrotestosterone; 5-alpha-Androstanolone; Dihydroepitestosterone; 4-Dihydrotestosterone; Dihydrotestosterone; Dihydrotestosteron; 5-a-Androstanolone; Androstanolonum; Androstanolona; Androstanolone; Cristerona MB; Androstalone; 5 alpha DHT; 5-alpha-DHT; 5alpha-DHT; Anaboleen; Anaprotin; Stanorone; Androlone; Stanaprol; Stanolone; Andractim; Anabolex; Proteina; Neodrol; Drolban; Gelovit; Protona; 5Α-DHT; 5a-DHT; DHT; Dihydrotestosterone



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(3)

PlantCyc(0)

代谢反应

108 个相关的代谢反应过程信息。

Reactome(90)

BioCyc(3)

  • androgen biosynthesis: NAD+ + dehydroepiandrosterone ⟶ 5-androstene-3,17-dione + H+ + NADH
  • androgen biosynthesis: 17-α-hydroxypregnenolone + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ 3-β-hydroxyandrost-5-en-17-one + H+ + H2O + acetate + an oxidized [NADPH-hemoprotein reductase]
  • androgen biosynthesis: NADP+ + testosterone ⟶ H+ + NADPH + androst-4-ene-3,17-dione

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(12)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, ALB, BGLAP, CASP3, CCND1, CDKN1A, EGFR, MAPK14, NR3C1, PIK3CA, POMC, PRL
Peripheral membrane protein 1 CYP11A1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 EGFR, SRD5A1, SRD5A2
Mitochondrion membrane 1 CYP11A1
Nucleus 9 AKT1, ALB, CASP3, CCND1, CDKN1A, EGFR, MAPK14, NR3C1, PRL
cytosol 10 AKR1C2, AKT1, ALB, CASP3, CCND1, CDKN1A, LEP, MAPK14, NR3C1, PIK3CA
dendrite 1 BGLAP
nuclear body 1 CDKN1A
centrosome 3 ALB, CCND1, NR3C1
nucleoplasm 7 AKT1, CASP3, CCND1, CDKN1A, MAPK14, NR3C1, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 2 AKT1, EGFR
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 SRD5A1, SRD5A2
Synapse 1 NR3C1
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 4 AKT1, CASP3, EGFR, MAPK14
Golgi apparatus 1 ALB
Golgi membrane 1 EGFR
lysosomal membrane 1 EGF
mitochondrial inner membrane 1 CYP11A1
neuronal cell body 3 CASP3, SRD5A1, SRD5A2
postsynapse 1 AKT1
Cytoplasm, cytosol 1 AKR1C2
endosome 1 EGFR
plasma membrane 4 AKT1, EGF, EGFR, PIK3CA
Membrane 6 AKT1, CYP11A1, EGF, EGFR, NR3C1, SRD5A1
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 3 ALB, EGF, SHBG
endoplasmic reticulum 1 ALB
extracellular space 8 ALB, BGLAP, EGF, EGFR, GNRH1, LEP, POMC, PRL
perinuclear region of cytoplasm 4 CDKN1A, EGFR, PIK3CA, SRD5A1
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 3 CYP11A1, MAPK14, NR3C1
protein-containing complex 5 AKT1, ALB, CDKN1A, EGFR, NR3C1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 6 ALB, BGLAP, LEP, POMC, PRL, SHBG
extracellular region 9 ALB, BGLAP, EGF, GNRH1, LEP, MAPK14, POMC, PRL, SHBG
mitochondrial matrix 2 CYP11A1, NR3C1
anchoring junction 1 ALB
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, EGFR
perikaryon 1 BGLAP
microtubule cytoskeleton 1 AKT1
nucleolus 1 CDKN1A
cell-cell junction 1 AKT1
vesicle 2 AKT1, BGLAP
Mitochondrion inner membrane 1 CYP11A1
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton, spindle 1 NR3C1
focal adhesion 1 EGFR
spindle 2 AKT1, NR3C1
intracellular vesicle 1 EGFR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 POMC
nuclear speck 2 MAPK14, NR3C1
receptor complex 1 EGFR
ciliary basal body 2 AKT1, ALB
chromatin 2 NR3C1, PRL
Chromosome 1 NR3C1
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 1 ALB
endosome lumen 1 PRL
cell body fiber 2 SRD5A1, SRD5A2
Nucleus, nucleoplasm 1 NR3C1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 MAPK14, POMC
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 2 ALB, BGLAP
transcription repressor complex 1 CCND1
platelet alpha granule lumen 2 ALB, EGF
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
death-inducing signaling complex 1 CASP3
[Isoform Alpha]: Cytoplasm 1 NR3C1
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDKN1A
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
cyclin D1-CDK4 complex 1 CCND1
PCNA-p21 complex 1 CDKN1A
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB


文献列表

  • Hangjie Fu, Wenxia Li, Jinyuan Liu, Qiehao Tang, Zhiwei Weng, Lijian Zhu, Bin Ding. Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway. Journal of ethnopharmacology. 2024 Aug; 330(?):118227. doi: 10.1016/j.jep.2024.118227. [PMID: 38685364]
  • Seong Min Lee, Sang Mok Lee, Jungbin Song. Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081189. [PMID: 38674879]
  • R Z Huang, Y W Wang, H Y Huang, R H Jiang, N N Xue, S P Yin, H Y Zhao. [Application effect of a dual release system of androgen and its antagonist in the repair of full-thickness burn wounds in mice]. Zhonghua shao shang yu chuang mian xiu fu za zhi. 2024 Feb; 40(2):180-189. doi: 10.3760/cma.j.cn501225-20230802-00033. [PMID: 38418180]
  • Rui-Rong Zheng, Qian-Xi Ouyang, Zi-Yao Liu, Lin-Nan Li, Li Yang, Zheng-Tao Wang. [Natural 5α-reductase inhibitors in treatment of benign prostatic hyperplasia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Feb; 49(4):858-867. doi: 10.19540/j.cnki.cjcmm.20231113.601. [PMID: 38621893]
  • Jiarui Wei, Tao Li, Shengyuan Lin, Bin Zhang, Xing Li. Dihydrotestosterone reduces neuroinflammation in spinal cord injury through NF-κB and MAPK pathway. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Jan; 70(1):213-218. doi: 10.14715/cmb/2024.70.1.29. [PMID: 38372091]
  • Y Y Han, Q H Zhang, W S Chen, Z L Li, D Xie, S L Zhang, H Lu, L W Wang, Z H Xu, L Z Zhang. Fermented rape pollen powder can alleviate benign prostatic hyperplasia in rats by reducing hormone content and changing gut microbiota. Beneficial microbes. 2023 Nov; 14(5):503-524. doi: 10.1163/18762891-20230039. [PMID: 38656098]
  • Min Hu, Yuehui Zhang, Xu Zhang, XiuYing Zhang, Xinyue Huang, Yaxing Lu, Yijia Li, Mats Brännström, Amanda Nancy Sferruzzi-Perri, Linus R Shao, Håkan Billig. Defective uterine spiral artery remodelling and placental senescence in a pregnant rat model of polycystic ovary syndrome. The American journal of pathology. 2023 Sep; ?(?):. doi: 10.1016/j.ajpath.2023.08.008. [PMID: 37689383]
  • Glendis Shiko, Max-Jonas Paulmann, Felix Feistel, Maria Ntefidou, Vanessa Hermann-Ene, Walter Vetter, Benedikt Kost, Grit Kunert, Julie A Z Zedler, Michael Reichelt, Ralf Oelmüller, Jan Klein. Occurrence and conversion of progestogens and androgens are conserved in land plants. The New phytologist. 2023 Aug; ?(?):. doi: 10.1111/nph.19163. [PMID: 37559351]
  • Rami M Mosaoa, Taha A Kumosani, Soonham S Yaghmoor, Shaimaa Rihan, Said S Moselhy. Rhus tripartite methanolic extract alleviates propylparaben-induced reproductive toxicity via anti-inflammatory, antioxidant, 5-α reductase in male rats. Environmental science and pollution research international. 2023 May; ?(?):. doi: 10.1007/s11356-023-27802-8. [PMID: 37249771]
  • V A Filatova, R V Rozhivanov, I Z Bondarenko, V A Ioutsi, E N Andreeva, G A Mel'nichenko, N G Mokrysheva. [Features of steroidogenesis and arterial hypertension in men in different types of "physiological" male hyperandrogenism]. Problemy endokrinologii. 2023 May; 69(2):80-91. doi: 10.14341/probl13226. [PMID: 37448275]
  • Mauricio D Dorfman, Thomas Monfeuga, Susan J Melhorn, Jenny E Kanter, Jeremy M Frey, Rachael D Fasnacht, Anandhakumar Chandran, Emaad Lala, Inmaculada Velasco, Katya B Rubinow, Thomas H Meek, Ellen A Schur, Karin E Bornfeldt, Joshua P Thaler. Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice. American journal of physiology. Endocrinology and metabolism. 2023 Apr; ?(?):. doi: 10.1152/ajpendo.00059.2023. [PMID: 37053049]
  • Biao Liu, Tian Fang, Lei Liang, Wen-Juan Hu, Min Dong, Li Chen, Wei Wu, Shi-Feng Yun. [Rauwolfia extract inhibits the proliferation of prostate cells in rats with benign prostatic hyperplasia]. Zhonghua nan ke xue = National journal of andrology. 2023 Mar; 29(3):195-201. doi: ". [PMID: 38597699]
  • April K Binder, Danielle L Peecher, Amanda J Qvigstad, Silvia D Gutierrez, Jennifer Magaña, David B Banks, Kenneth S Korach. Differential Strain-dependent Ovarian and Metabolic Responses in a Mouse Model of PCOS. Endocrinology. 2023 02; 164(4):. doi: 10.1210/endocr/bqad024. [PMID: 36718579]
  • You-Jee Jang, Hye-Yeon Jung, Ju-Yeong Myeong, Kwang Hoon Song, Joseph Kwon, Duwoon Kim, Jae-Il Park. Effects of Alginate Oligosaccharide on Testosterone-Induced Benign Prostatic Hyperplasia in Orchiectomized Rats. Nutrients. 2023 Jan; 15(3):. doi: 10.3390/nu15030682. [PMID: 36771389]
  • Rabab Ahmed Rasheed, A S Sadek, R T Khattab, Fatma Alzahraa A Elkhamisy, Heba Abdelrazak Abdelfattah, Mohamed M A Elshaer, Saeedah Musaed Almutairi, Dina S Hussein, Azza Saleh Embaby, Mai A M Almoatasem. Diacerein provokes apoptosis, improves redox balance, and downregulates PCNA and TNF-α in a rat model of testosterone-induced benign prostatic hyperplasia: A new non-invasive approach. PloS one. 2023; 18(11):e0293682. doi: 10.1371/journal.pone.0293682. [PMID: 37943844]
  • Ruan Pimenta, Juliana A Camargo, Patrícia Candido, Vitória Ghazarian, Guilherme L Gonçalves, Vanessa R Guimarães, Poliana Romão, Caroline Chiovatto, Carolina M Mioshi, Gabriel A Dos Santos, Iran A Silva, Alexander Birbrair, Miguel Srougi, William C Nahas, Kátia R Leite, Nayara I Viana, Sabrina T Reis. Cholesterol Triggers Nuclear Co-Association of Androgen Receptor, p160 Steroid Coactivators, and p300/CBP-Associated Factor Leading to Androgenic Axis Transactivation in Castration-Resistant Prostate Cancer. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2022 Dec; 56(S4):1-15. doi: 10.33594/000000592. [PMID: 36458578]
  • Henrique J Cardoso, Marília I Figueira, Tiago M A Carvalho, Catarina D M Serra, Cátia V Vaz, Patrícia A Madureira, Sílvia Socorro. Androgens and low density lipoprotein-cholesterol interplay in modulating prostate cancer cell fate and metabolism. Pathology, research and practice. 2022 Dec; 240(?):154181. doi: 10.1016/j.prp.2022.154181. [PMID: 36327818]
  • Inês L Pereira, Célia Lopes, Eduardo Rocha, Tânia V Madureira. Establishing brown trout primary hepatocyte spheroids as a new alternative experimental model-Testing the effects of 5α-dihydrotestosterone on lipid pathways. Aquatic toxicology (Amsterdam, Netherlands). 2022 Dec; 253(?):106331. doi: 10.1016/j.aquatox.2022.106331. [PMID: 36327687]
  • Jiyoung You, Jieun Woo, Kyung-Baeg Roh, Dehun Ryu, Youngsu Jang, Eunae Cho, Deokhoon Park, Eunsun Jung. Assessment of the anti-hair loss potential of Camellia japonica fruit shell extract in vitro. International journal of cosmetic science. 2022 Nov; ?(?):. doi: 10.1111/ics.12827. [PMID: 36411959]
  • Ali Aflatounian, Valentina Rodriguez Paris, Dulama Richani, Melissa C Edwards, Blake J Cochran, William L Ledger, Robert B Gilchrist, Michael J Bertoldo, Lindsay E Wu, Kirsty A Walters. Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation. Molecular metabolism. 2022 11; 65(?):101583. doi: 10.1016/j.molmet.2022.101583. [PMID: 36096453]
  • Young-Jin Choi, Meiqi Fan, Nishala Erandi Wedamulla, Yujiao Tang, Sung Mun Bae, Ji-Young Hwang, Eun-Kyung Kim. Inhibitory effects of Centella asiatica (L.) Urban on enlarged prostate through androgen receptor and PI3K/Akt signaling pathways. Food & function. 2022 Oct; 13(19):10235-10247. doi: 10.1039/d2fo00841f. [PMID: 36124918]
  • Ling Ma, Huchi Shen, Chengge Fang, Timson Chen, Jing Wang. Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196443. [PMID: 36234980]
  • Menglu Yang, Haakon K Fjærvoll, Ketil A Fjærvoll, Nicholas H Wang, Tor P Utheim, Charles N Serhan, Darlene A Dartt. Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators. Scientific reports. 2022 09; 12(1):16305. doi: 10.1038/s41598-022-20177-9. [PMID: 36175572]
  • Ting Xiong, Valentina Rodriguez Paris, Melissa C Edwards, Ying Hu, Blake J Cochran, Kerry-Anne Rye, William L Ledger, Vasantha Padmanabhan, David J Handelsman, Robert B Gilchrist, Kirsty A Walters. Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model. American journal of physiology. Endocrinology and metabolism. 2022 08; 323(2):E145-E158. doi: 10.1152/ajpendo.00418.2021. [PMID: 35658542]
  • Feifei Zhang, Tong Ma, Xiaoyu Tong, Yanjun Liu, Peng Cui, Xiaoqing Xu, Jiemei Shi, Wei Hu, Wenhan Lu, Zhenle Pei, Minzhen Xu, Xin Li, Congjian Xu, Yi Feng. Electroacupuncture improves metabolic and ovarian function in a rat model of polycystic ovary syndrome by decreasing white adipose tissue, increasing brown adipose tissue, and modulating the gut microbiota. Acupuncture in medicine : journal of the British Medical Acupuncture Society. 2022 08; 40(4):347-359. doi: 10.1177/09645284211056663. [PMID: 34892981]
  • Andrew J McGovern, Janneth González, David Ramírez, George E Barreto. Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology. International immunopharmacology. 2022 Jul; 108(?):108721. doi: 10.1016/j.intimp.2022.108721. [PMID: 35344815]
  • Taratorn Fainanta, Sukanya Jaroenporn, Patteera Wititsuwankul, Suchinda Malaivijitnond. Comparison of neuroprotective effects of dihydrotestosterone, 17β-estradiol, and Pueraria mirifica herb extract on cognitive impairment in androgen deficient male rats. Hormones and behavior. 2022 07; 143(?):105198. doi: 10.1016/j.yhbeh.2022.105198. [PMID: 35609404]
  • Bo Wang, Di Pan, Yong Ban, Zhaolin Sun, Ye Tian, Guangheng Luo. The relationship between prostatic microvessel density and different concentrations of oestrogen/androgen in Sprague-Dawley rats. European journal of medical research. 2022 Jun; 27(1):87. doi: 10.1186/s40001-022-00719-7. [PMID: 35672771]
  • Liuxi Chu, Xin Shu, Yao Huang, Tong Chu, Meina Ge, Qin Lu. Sex steroid hormones in urinary exosomes as biomarkers for the prediction of prostate cancer. Clinica chimica acta; international journal of clinical chemistry. 2022 Jun; 531(?):389-398. doi: 10.1016/j.cca.2022.04.995. [PMID: 35487250]
  • Romy W P M de Kroon, Martin den Heijer, Annemieke C Heijboer. Is idiopathic hirsutism idiopathic?. Clinica chimica acta; international journal of clinical chemistry. 2022 Jun; 531(?):17-24. doi: 10.1016/j.cca.2022.03.011. [PMID: 35292252]
  • Krystyna A Rybka, Kassandra L Sturm, Rose M De Guzman, Saoudatou Bah, Jason S Jacobskind, Zachary J Rosinger, Ed Zandro M Taroc, Paolo E Forni, Damian G Zuloaga. Androgen Regulation of Corticotropin Releasing Factor Receptor 1 in the Mouse Brain. Neuroscience. 2022 05; 491(?):185-199. doi: 10.1016/j.neuroscience.2022.04.005. [PMID: 35398506]
  • Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An. Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis. Journal of agricultural and food chemistry. 2022 May; 70(18):5561-5569. doi: 10.1021/acs.jafc.1c07955. [PMID: 35466676]
  • Olivier Salamin, Raul Nicoli, Tobias Langer, Julien Boccard, Carine Schweizer Grundisch, Cheng Xu, Serge Rudaz, Tiia Kuuranne, Nelly Pitteloud, Martial Saugy. Longitudinal evaluation of multiple biomarkers for the detection of testosterone gel administration in women with normal menstrual cycle. Drug testing and analysis. 2022 May; 14(5):833-850. doi: 10.1002/dta.3040. [PMID: 33817997]
  • Sasha Savkovic, Lam P Ly, Reena Desai, John Howa, Vinod Nair, Daniel Eichner, David J Handelsman. Detection of testosterone microdosing in healthy females. Drug testing and analysis. 2022 Apr; 14(4):653-666. doi: 10.1002/dta.3202. [PMID: 34811948]
  • Claes Ohlsson, Marcus Langenskiöld, Kristian Smidfelt, Matti Poutanen, Henrik Ryberg, Anna-Karin Norlén, Joakim Nordanstig, Göran Bergström, Åsa Tivesten. Low Progesterone and Low Estradiol Levels Associate With Abdominal Aortic Aneurysms in Men. The Journal of clinical endocrinology and metabolism. 2022 03; 107(4):e1413-e1425. doi: 10.1210/clinem/dgab867. [PMID: 34865072]
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