Uridine monophosphate (BioDeep_00000400029)

Main id: BioDeep_00000001701

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


Uridine 5_-monophosphate

化学式: C9H13N2O9P (324.0359)
中文名称: 5-尿苷酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O
InChI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

描述信息

A pyrimidine ribonucleoside 5-monophosphate having uracil as the nucleobase.
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk[1].
Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk[1].
Uridine 5'-monophosphate (5'-?Uridylic acid), a monophosphate form of UTP, can be acquired either from a de novo pathway or degradation products of nucleotides and nucleic acids in vivo and is a major nucleotide analogue in mammalian milk[1].

同义名列表

8 个代谢物同义名

Uridine 5-monophosphate; Uridine monophosphate; Uridine 5_-monophosphate; URIDINE-5-MONOPHOSPHATE; URIDINE-5-monophosphATE; 5'-?Uridylic acid; Uridine 5'-monophosphate; UMP



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(4)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

81 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 CMPK2, ELAVL1, GAPDH, MAPK14, RBMS3, RRM2, TUT4, UPRT, ZFP36
Nucleus 10 ELAVL1, FOS, GAPDH, MAPK14, OMP, RBMS3, RRM2, TUT4, UPRT, ZFP36
cytosol 13 DHODH, ELAVL1, FOS, GALE, GAPDH, MAPK14, OMP, RBMS3, RRM2, TUT1, TUT4, UPP1, ZFP36
nucleoplasm 8 CMPK2, DHODH, ELAVL1, FOS, MAPK14, TUT1, UPP1, UPRT
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 1 TNF
Cytoplasmic granule 1 ZFP36
Multi-pass membrane protein 1 MT-CYB
Synapse 1 OMP
cell surface 1 TNF
glutamatergic synapse 2 ELAVL1, MAPK14
Golgi membrane 1 INS
mitochondrial inner membrane 2 DHODH, MT-CYB
neuronal cell body 2 OMP, TNF
postsynapse 1 ELAVL1
Cytoplasm, cytosol 1 GAPDH
plasma membrane 3 GAPDH, IFNLR1, TNF
Membrane 5 DHODH, ELAVL1, GAPDH, IFNLR1, MT-CYB
axon 1 OMP
extracellular exosome 2 GAPDH, TUT4
endoplasmic reticulum 2 ELAVL1, FOS
extracellular space 3 INS, TNF, TUT4
perinuclear region of cytoplasm 1 GAPDH
mitochondrion 5 CMPK2, DHODH, MAPK14, MT-CYB, TUT1
intracellular membrane-bounded organelle 2 GAPDH, UPRT
Single-pass type I membrane protein 1 IFNLR1
Secreted 1 INS
extracellular region 3 INS, MAPK14, TNF
Single-pass membrane protein 1 DHODH
nuclear membrane 1 GAPDH
external side of plasma membrane 1 TNF
cytoplasmic vesicle 1 ELAVL1
microtubule cytoskeleton 1 GAPDH
nucleolus 2 TUT1, TUT4
sarcoplasm 1 ELAVL1
Cytoplasm, P-body 2 ELAVL1, ZFP36
P-body 2 ELAVL1, ZFP36
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 GAPDH
Cytoplasm, perinuclear region 1 GAPDH
Mitochondrion inner membrane 2 DHODH, MT-CYB
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 GAPDH
nuclear speck 2 MAPK14, TUT1
chromatin 1 FOS
phagocytic cup 1 TNF
cytoskeleton 1 GAPDH
cytoplasmic ribonucleoprotein granule 1 TUT4
Nucleus, nucleolus 1 TUT1
spindle pole 1 MAPK14
CCR4-NOT complex 1 ZFP36
endosome lumen 1 INS
Lipid droplet 1 GAPDH
Cytoplasm, Stress granule 1 ELAVL1
cytoplasmic stress granule 2 ELAVL1, ZFP36
Nucleus speckle 1 TUT1
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 FOS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
respiratory chain complex III 1 MT-CYB
ribonucleoprotein complex 4 ELAVL1, GAPDH, RBMS3, ZFP36
Cytoplasm, Cytoplasmic ribonucleoprotein granule 1 TUT4
protein-DNA complex 1 FOS
mRNA cleavage and polyadenylation specificity factor complex 1 TUT1
GAIT complex 1 GAPDH
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
ribonucleoside-diphosphate reductase complex 1 RRM2
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Alexis Hinojosa-Cruz, Ángel G Díaz-Sánchez, Adelaida Díaz-Vilchis, Lilian González-Segura. Structural and functional properties of uridine 5'-monophosphate synthase from Coffea arabica. International journal of biological macromolecules. 2024 Jan; 259(Pt 1):129226. doi: 10.1016/j.ijbiomac.2024.129226. [PMID: 38184030]
  • Raffaela M Abbriano, Jestin George, Tim Kahlke, Audrey S Commault, Michele Fabris. Mobilization of a diatom mutator-like element (MULE) transposon inactivates the uridine monophosphate synthase (UMPS) locus in Phaeodactylum tricornutum. The Plant journal : for cell and molecular biology. 2023 08; 115(4):926-936. doi: 10.1111/tpj.16271. [PMID: 37147901]
  • Soumendra N Datta, Ramandeep S Chalokia, K W Wing, K Patel, R Solanki, Janak Desai. Ultramini-percutaneous nephrolithotomy versus retrograde intrarenal surgery in the treatment of 10-30 mm calculi: a randomized controlled trial. Urolithiasis. 2022 Jun; 50(3):361-367. doi: 10.1007/s00240-022-01304-7. [PMID: 35107612]
  • Baihua Zhao, Lieming Wen, Dan Liu, Shanya Huang. The Visualized Urethral Mobility Profile in Stress Urinary Incontinence Described by Four-Dimensional Transperineal Ultrasound. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2022 Jun; 41(6):1439-1445. doi: 10.1002/jum.15828. [PMID: 34515354]
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  • Du Qiao, Luo Cheng, Tian Xiaomei, Shi Baolei, Li Yingyi, Zhang Hui, Bian Shaohua, Liu Wei, Dai Y U, Deng Fangqiong, Liu Jie, Liu Shuangning. Effect of ultra-mini percutaneous nephrolithotomy and ShuoTong ureteroscopy on the stress response, inflammatory indices, and urokinase level in patients with polycystic kidney disease complicated with renal calculus. Cellular and molecular biology (Noisy-le-Grand, France). 2022 Feb; 67(5):309-316. doi: 10.14715/cmb/2021.67.5.42. [PMID: 35818238]
  • Karl-Frédéric Vieux, Katherine P Prothro, Leanne H Kelley, Cameron Palmer, Eleanor M Maine, Isana Veksler-Lublinsky, Katherine McJunkin. Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans. Nucleic acids research. 2021 11; 49(19):11167-11180. doi: 10.1093/nar/gkab840. [PMID: 34586415]
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  • Nanxiang Xiong, Xiaofei Gao, Hongyang Zhao, Feng Cai, Fang-Cheng Zhang, Ye Yuan, Weichao Liu, Fangping He, Lauren G Zacharias, Hong Lin, Hieu S Vu, Chao Xing, Dong-Xiao Yao, Fei Chen, Benyan Luo, Wenzhi Sun, Ralph J DeBerardinis, Hao Xu, Woo-Ping Ge. Using arterial-venous analysis to characterize cancer metabolic consumption in patients. Nature communications. 2020 06; 11(1):3169. doi: 10.1038/s41467-020-16810-8. [PMID: 32576825]
  • Mark H Eckman, E Steve Woodle, Charuhas V Thakar, Rita R Alloway, Kenneth E Sherman. Cost-effectiveness of Using Kidneys From HCV-Viremic Donors for Transplantation Into HCV-Uninfected Recipients. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2020 06; 75(6):857-867. doi: 10.1053/j.ajkd.2019.11.005. [PMID: 32081494]
  • Sandip K Zalawadiya, JoAnn Lindenfeld, Ashish Shah, Mark Wigger, Matthew Danter, D Marshall Brinkley, Jonathan Menachem, Lynn Punnoose, Keki Balsara, Suzanne Brown Sacks, Henry Ooi, Roman Perri, Joseph Awad, Sarah Smith, Rachel Fowler, Heather O'Dell, Callie Darragh, Shelly Ruzevich-Scholl, Kelly Schlendorf. Trends in Renal Function Among Heart Transplant Recipients of Donor-Derived Hepatitis C Virus. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2020 05; 66(5):553-558. doi: 10.1097/mat.0000000000001034. [PMID: 31425256]
  • Johannes Wiegand, Peter Buggisch, Stefan Mauss, Klaus H W Boeker, Hartwig Klinker, Tobias Müller, Rainer Günther, Yvonne Serfert, Michael P Manns, Stefan Zeuzem, Thomas Berg, Holger Hinrichsen, German Hepatitis C-Registry. Hepatitis C therapy with direct antiviral agents in patients with advanced chronic kidney disease: real-world experience of the German Hepatitis C-Registry (Deutsches Hepatitis C-Register). European journal of gastroenterology & hepatology. 2019 Nov; 31(11):1424-1431. doi: 10.1097/meg.0000000000001426. [PMID: 31589184]
  • Shinjiro Inomata, Akira Anan, Eri Yamauchi, Ryo Yamauchi, Hideo Kunimoto, Kazuhide Takata, Takashi Tanaka, Keiji Yokoyama, Daisuke Morihara, Yasuaki Takeyama, Makoto Irie, Satoshi Shakado, Tetsuro Sohda, Shotaro Sakisaka. Changes in the Serum Hepcidin-to-ferritin Ratio with Erythroferrone after Hepatitis C Virus Eradication Using Direct-acting Antiviral Agents. Internal medicine (Tokyo, Japan). 2019 Oct; 58(20):2915-2922. doi: 10.2169/internalmedicine.2909-19. [PMID: 31243222]
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  • Chun-Yan Xie, Qinhua Wang, Guanya Li, Zhiyong Fan, Hong Wang, Xin Wu. Dietary supplement with nucleotides in the form of uridine monophosphate or uridine stimulate intestinal development and promote nucleotide transport in weaned piglets. Journal of the science of food and agriculture. 2019 Oct; 99(13):6108-6113. doi: 10.1002/jsfa.9850. [PMID: 31177538]
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  • Ramazan Idilman, Mehmet Demir, Murat Aladag, Cihan Erol, Bilger Cavus, Raim Iliaz, Hayrettin Koklu, Yilmaz Cakaloglu, Memduh Sahin, Galip Ersoz, İftihar Koksal, Zeki Karasu, Meric Ozgenel, İlker Turan, Feyza Gunduz, Huseyin Ataseven, Meral Akdogan, Murat Kiyici, Aydın Seref Koksal, Sila Akhan, Fulya Gunsar, Fehmi Tabak, Sabahattin Kaymakoglu, Ulus S Akarca. Low recurrence rate of hepatocellular carcinoma following ledipasvir and sofosbuvir treatment in a real-world chronic hepatitis C patients cohort. Journal of viral hepatitis. 2019 06; 26(6):666-674. doi: 10.1111/jvh.13075. [PMID: 30740820]
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  • Samia M El-Gizawy, Salwa R El-Shaboury, Noha N Atia, Mohammad Nabil Abo-Zeid. New, simple and sensitive HPTLC method for simultaneous determination of anti-hepatitis C sofosbuvir and ledipasvir in rabbit plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Aug; 1092(?):432-439. doi: 10.1016/j.jchromb.2018.06.033. [PMID: 29945107]
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  • Qili Fei, Yu Yu, Li Liu, Yu Zhang, Patricia Baldrich, Qing Dai, Xuemei Chen, Blake C Meyers. Biogenesis of a 22-nt microRNA in Phaseoleae species by precursor-programmed uridylation. Proceedings of the National Academy of Sciences of the United States of America. 2018 07; 115(31):8037-8042. doi: 10.1073/pnas.1807403115. [PMID: 30012624]
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  • Hung-Yu Sun, Pin-Nan Cheng, Chiung-Ying Tseng, Wei-Jen Tsai, Yen-Cheng Chiu, Kung-Chia Young. Favouring modulation of circulating lipoproteins and lipid loading capacity by direct antiviral agents grazoprevir/elbasvir or ledipasvir/sofosbuvir treatment against chronic HCV infection. Gut. 2018 07; 67(7):1342-1350. doi: 10.1136/gutjnl-2017-313832. [PMID: 28615303]
  • Rebeca García-Agudo, Sami Aoufi-Rabih, Mercedes Salgueira-Lazo, Carmen González-Corvillo, Fabrizio Fabrizi. 'Real-life' experience with direct-acting antiviral agents for hepatitis C virus in end-stage renal disease. The International journal of artificial organs. 2018 Jul; 41(7):363-370. doi: 10.1177/0391398818763478. [PMID: 29582685]
  • Akira Kawano, Hirohisa Shigematsu, Koichiro Miki, Yasunori Ichiki, Chie Morita, Kimihiko Yanagita, Kazuhiro Takahashi, Kazufumi Dohmen, Hideyuki Nomura, Hiromi Ishibashi, Shinji Shimoda. Diabetes Mellitus Prevents an Improvement in the Serum Albumin Level During Interferon-free Sofosbuvir-based Therapy for Chronic Hepatitis C Patients: A Multi-institutional Joint Study. Internal medicine (Tokyo, Japan). 2018 Jun; 57(11):1533-1542. doi: 10.2169/internalmedicine.9857-17. [PMID: 29321441]
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  • Chun-Jen Liu, Wan-Long Chuang, I-Shyan Sheen, Horng-Yuan Wang, Chi-Yi Chen, Kuo-Chih Tseng, Ting-Tsung Chang, Benedetta Massetto, Jenny C Yang, Chohee Yun, Steven J Knox, Anu Osinusi, Gregory Camus, Deyuan Jiang, Diana M Brainard, John G McHutchison, Tsung-Hui Hu, You-Chun Hsu, Gin-Ho Lo, Chi-Jen Chu, Jyh-Jou Chen, Cheng-Yuan Peng, Ron-Nan Chien, Pei-Jer Chen. Efficacy of Ledipasvir and Sofosbuvir Treatment of HCV Infection in Patients Coinfected With HBV. Gastroenterology. 2018 03; 154(4):989-997. doi: 10.1053/j.gastro.2017.11.011. [PMID: 29174546]
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