Indometacin (BioDeep_00000398955)

Main id: BioDeep_00000001358

 

natural product Chemicals and Drugs


代谢物信息卡片


"Indomethacin (Indocid, Indocin)"

化学式: C19H16ClNO4 (357.0768)
中文名称: 吲哚美辛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C=C2C(=C1)N(C(=C2CC(O)=O)C)C(C3=CC=C(C=C3)Cl)=O)OC
InChI: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

描述信息

A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
S - Sensory organs > S01 - Ophthalmologicals > S01B - Antiinflammatory agents > S01BC - Antiinflammatory agents, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
C - Cardiovascular system > C01 - Cardiac therapy
D000893 - Anti-Inflammatory Agents
D002317 - Cardiovascular Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

4 个代谢物同义名

Indometacin; indomethacin; "Indomethacin (Indocid, Indocin)"; Indomethacin



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE, CALCA, POMC, XDH
Peripheral membrane protein 1 AP1S2
Nucleus 1 PLCZ1
cytosol 5 AP1S2, AVP, PLCZ1, PRKCQ, XDH
dendrite 1 AVP
nucleoplasm 1 PLCZ1
Cell membrane 7 ACE, ADRB3, AGTR1, AGTR2, PTGER1, PTGER3, PTGER4
Cytoplasmic side 1 AP1S2
Multi-pass membrane protein 8 ADRB3, AGTR1, AGTR2, CACNA1I, KCNA3, PTGER1, PTGER3, PTGER4
glutamatergic synapse 1 KCNA3
Golgi apparatus 1 AP1S2
Golgi membrane 1 AP1S2
lysosomal membrane 1 AP1S2
neuronal cell body 1 CALCA
presynaptic membrane 1 KCNA3
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 14 ACE, ADRB3, AGTR1, AGTR2, CACNA1I, F2, GCG, KCNA3, KNG1, PRKCQ, PTGER1, PTGER3, PTGER4, REN
terminal bouton 1 CALCA
Membrane 7 ACE, AGTR1, CACNA1I, KCNA3, PTGER3, PTGER4, REN
axon 1 KCNA3
extracellular exosome 3 ACE, F2, KNG1
extracellular space 9 ACE, AVP, CALCA, F2, GCG, KNG1, POMC, REN, XDH
perinuclear region of cytoplasm 2 KCNA3, PLCZ1
intracellular membrane-bounded organelle 1 AP1S2
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 ACE
Secreted 7 ACE, AVP, CALCA, F2, GCG, POMC, REN
extracellular region 8 ACE, AVP, CALCA, F2, GCG, KNG1, POMC, REN
hippocampal mossy fiber to CA3 synapse 1 CALCA
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 ACE
nucleolus 1 PLCZ1
Early endosome 1 AP1S2
Membrane, clathrin-coated pit 1 AP1S2
apical part of cell 1 REN
clathrin-coated pit 1 AP1S2
postsynaptic membrane 1 KCNA3
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 KCNA3
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
collagen-containing extracellular matrix 2 F2, KNG1
secretory granule 2 AVP, POMC
receptor complex 1 ADRB3
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
blood microparticle 2 F2, KNG1
sperm midpiece 1 ACE
[Isoform 2]: Cell membrane 1 KCNA3
nuclear envelope 1 PTGER3
Endomembrane system 1 AP1S2
Cytoplasmic vesicle membrane 1 AP1S2
basal plasma membrane 1 ACE
voltage-gated potassium channel complex 1 KCNA3
trans-Golgi network membrane 1 AP1S2
secretory granule lumen 2 GCG, POMC
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 F2, GCG, KNG1
platelet alpha granule lumen 1 KNG1
voltage-gated calcium channel complex 1 CACNA1I
immunological synapse 1 PRKCQ
neuronal dense core vesicle 2 AVP, CALCA
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 AVP
[Isoform 1]: Cell membrane 1 KCNA3
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
AP-1 adaptor complex 1 AP1S2
[Glucagon-like peptide 1]: Secreted 1 GCG
sperm head 1 PLCZ1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3


文献列表

  • Sangmin Lee, Jeongbok Lee, Soomi Choi, Eunhyung Kim, Hyunseok Kwon, Jinkyu Lee, Sung Min Kim, Heungsoo Shin. Biofabrication of 3D adipose tissue via assembly of composite stem cell spheroids containing adipo-inductive dual-signal delivery nanofibers. Biofabrication. 2024 May; 16(3):. doi: 10.1088/1758-5090/ad4a67. [PMID: 38739412]
  • Bao-Ping Xu, Xiao-Tao Wang. Rare blue-green urine due to excess indomethacin: A case report. Nephrology (Carlton, Vic.). 2024 Mar; 29(3):168-169. doi: 10.1111/nep.14256. [PMID: 37963604]
  • Dalia H Abu-Baih, Alshymaa Abdel-Rahman Gomaa, Nada Mohamed Abdel-Wahab, Enas Reda Abdelaleem, Azza M Abdel Zaher, Noha F Hassan, Gerhard Bringmann, Usama Ramadan Abdelmohsen, Faisal H Altemani, Naseh A Algehainy, Fatma Alzahraa Mokhtar, Miada F Abdelwahab. Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations. BMC complementary medicine and therapies. 2024 Feb; 24(1):88. doi: 10.1186/s12906-023-04333-w. [PMID: 38355510]
  • Yong Wang, Benjamin Buer, Cynthia L Goodman, David Kang, Tamra Reall, Susanne Dohn, Joseph Ringbauer, Yaofa Li, Sven Geibel, David Stanley. Indomethacin and 20-hydroxyecdysone influence protein expression in a Spodoptera frugiperda nervous system cell line. Archives of insect biochemistry and physiology. 2024 Feb; 115(2):e22089. doi: 10.1002/arch.22089. [PMID: 38409869]
  • Hyo-Jung Kim, Bo-Ram Jin, Chang-Dae Lee, Doyun Kim, Ah Young Lee, Sanghyun Lee, Hyo-Jin An. Anti-Inflammatory Effect of Chestnut Honey and Cabbage Mixtures Alleviates Gastric Mucosal Damage. Nutrients. 2024 Jan; 16(3):. doi: 10.3390/nu16030389. [PMID: 38337674]
  • Karem Fouda, Ahmed M Mabrouk, Sherein S Abdelgayed, Rasha S Mohamed. Protective effect of tomato pomace extract encapsulated in combination with probiotics against indomethacin induced enterocolitis. Scientific reports. 2024 01; 14(1):2275. doi: 10.1038/s41598-024-52642-y. [PMID: 38280919]
  • Jonathan Saúl Piñón-Simental, Luis Alberto Ayala-Ruiz, Luis Gerardo Ortega-Pérez, Oliver Rafid Magaña-Rodríguez, Esperanza Meléndez-Herrera, Asdrubal Aguilera-Méndez, Patricia Rios-Chavez. Use of Callistemon citrinus as a gastroprotective and anti-inflammatory agent on indomethacin-induced gastric ulcers in obese rats. PeerJ. 2024; 12(?):e17062. doi: 10.7717/peerj.17062. [PMID: 38435992]
  • F Rafique, M N Mushtaq, H Ahmed, W Younis. Evaluation and estimation of diuretic activity of the linalyl acetate in the rats. Brazilian journal of biology = Revista brasleira de biologia. 2024; 83(?):e277354. doi: 10.1590/1519-6984.277354. [PMID: 38452187]
  • Faisal H Altemani, Abeer H Elmaidomy, Dalia H Abu-Baih, Azza M Abdel Zaher, Fatma Alzahraa Mokhtar, Naseh A Algehainy, Hussain T Bakhsh, Gerhard Bringmann, Usama Ramadan Abdelmohsen, Omnia Hesham Abdelhafez. Tamarix aphylla derived metabolites ameliorate indomethacin-induced gastric ulcers in rats by modulating the MAPK signaling pathway, alleviating oxidative stress and inflammation: In vivo study supported by pharmacological network analysis. PloS one. 2024; 19(5):e0302015. doi: 10.1371/journal.pone.0302015. [PMID: 38728332]
  • Monika Singh, Shreshtha Singh, Dinesh Puri, Shalini Kapoor Sawhney, Nitin Kumar, Mohd Yasir, Pankaj Nainwal. The Anti-ulcer Potential of Weissella cibaria Assisted Bio-fermented Product of Citrus limetta Waste Peel in Wistar Albino Rats. Recent patents on biotechnology. 2024; 18(4):344-357. doi: 10.2174/0118722083278152231121173605. [PMID: 38566382]
  • Yifei Xu, Linsun Lin, Huantian Zheng, Siyuan Xu, Xinxin Hong, Tiantian Cai, Jianqu Xu, Weijian Zhang, Yanzhen Mai, Jingwei Li, Bin Huang, Zhu Liu, Shaoju Guo. Protective effect of Amauroderma rugosum ethanol extract and its primary bioactive compound, ergosterol, against acute gastric ulcers based on LXR-mediated gastric mucus secretions. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155236. doi: 10.1016/j.phymed.2023.155236. [PMID: 38016383]
  • Leandro Gastón Parra, Luciana Cecilia Erjavec, Cecilia Irene Casali, Andrea Zerpa Velazquez, Karen Weber, Clara Patricia Setton-Avruj, María Del Carmen Fernández Tome. Cytosolic phospholipase A2 regulates lipid homeostasis under osmotic stress through PPARγ. The FEBS journal. 2023 Nov; ?(?):. doi: 10.1111/febs.16998. [PMID: 37947039]
  • Mariana Garrido-Valdes, Leonor Díaz-Velis, Marisela Valdes-Gonzalez, Barbara B Garrido-Suárez, Gabino Garrido. Gastroprotective Role of Fruit Extracts in Gastric Damage Induced by Non-Steroidal Anti-Inflammatory Drugs: A Systematic Review. Journal of medicinal food. 2023 Nov; 26(11):777-798. doi: 10.1089/jmf.2023.0005. [PMID: 37902784]
  • Albina Uka, Donjeta Krasniqi, Giangiacomo Beretta, Armond Daci. Assessment of In Vitro Airway Smooth Muscle Relaxant Activity of Rhus coriaria L. Fruit Ethanolic Extract and Its Possible Mechanisms. Journal of medicinal food. 2023 Nov; 26(11):820-830. doi: 10.1089/jmf.2022.0126. [PMID: 37902984]
  • Zhiqun Zhang, Xinrui Lou, Luyi Hua, Xinhui Jia, Lili Xu, Min Zhao. Cardiopulmonary Ultrasound-Guided Treatment of Premature Infants with Respiratory Failure and Patent Ductus Arteriosus: A Randomized, Controlled Trial. Indian journal of pediatrics. 2023 11; 90(11):1103-1109. doi: 10.1007/s12098-023-04489-w. [PMID: 36952111]
  • Houpan Song, Meng Xiong, Chang Yu, Baoping Ren, Meiqi Zhong, Shunhua Zhou, Qing Gao, Chen Ou, Xiaojuan Wang, Jing Lu, Meiyan Zeng, Xiong Cai, Qinghua Peng. Huang-Qi-Jian-Zhong-Tang accelerates healing of indomethacin-induced gastric ulceration in rats via anti-inflammatory and antioxidant mechanisms. Journal of ethnopharmacology. 2023 Oct; 319(Pt 2):117264. doi: 10.1016/j.jep.2023.117264. [PMID: 37783407]
  • Chang Yu, Jingyue Qiu, Meng Xiong, Baoping Ren, Meiqi Zhong, Sainan Zhou, Yuejun Li, Meiyan Zeng, Houpan Song. Protective effect of Lizhong Pill on nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rats: Possible involvement of TNF and IL-17 signaling pathways. Journal of ethnopharmacology. 2023 Aug; ?(?):116991. doi: 10.1016/j.jep.2023.116991. [PMID: 37536648]
  • Claudio Luis Venturini, Amilcar Sabino Damazo, Marcelo José Dias Silva, Jessica de Araujo Isaias Muller, Darley Maria Oliveira, Fabiana de Freitas Figueiredo, Bruna Fioravante Di Serio, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins. Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models. Journal of ethnopharmacology. 2023 Jul; 318(Pt B):116972. doi: 10.1016/j.jep.2023.116972. [PMID: 37517568]
  • Karelle Kouam Yacine Madjo, Marius Mbiantcha, Linda Zenab Njoya Fagni, Vanessa Mba Matah Marthe, Elvira Azanze Ngoufack, Gonzal Eric Tsafack, Stephanie Flore Djuichou Nguemnang, Carine Flore Adjouzem, Gilbert Ateufack. Gastroprotective and ulcer healing effects of Nauclea pobeguinii (Rubiaceae) on experimentally induced gastric ulcers in male Wistar rats. Journal of complementary & integrative medicine. 2023 Jun; ?(?):. doi: 10.1515/jcim-2023-0024. [PMID: 37382892]
  • Yasin Bayir, Nermin Tagiyeva, Abdulmecit Albayrak, Abbas Ismayilov, Erol Akpinar, Erdem Toktay, Esen Sezen Karaoglan, Kushver Memmedova, Zekai Halici, Nilufar Rustemova. Effects of Polygonum cognatum Meissn. extract on indomethacin induced gastric damage in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023 Jun; ?(?):1-8. doi: 10.1080/10520295.2023.2221040. [PMID: 37291906]
  • Saira Siddique, Khawaja Raees Ahmad, Syed Kashif Nawaz, Syeda Nadia Ahmad, Rabiyah Ali, Iram Inayat, Sadia Suleman, Muhammad Ali Kanwal, Muhammad Usman. Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives. Scientific reports. 2023 May; 13(1):8639. doi: 10.1038/s41598-023-35640-4. [PMID: 37244979]
  • Lan Feng, Terigele Bao, Laxinamujila Bai, Xiyele Mu, Na Ta, Minglan Bao, Yonghui Li, Junqing Zhang, Minghai Fu, Yongsheng Chen. Mongolian medicine formulae Ruda-6 alleviates indomethacin-induced gastric ulcer by regulating gut microbiome and serum metabolomics in rats. Journal of ethnopharmacology. 2023 May; 314(?):116545. doi: 10.1016/j.jep.2023.116545. [PMID: 37196816]
  • Zahra Sadeghi, Antonietta Cerulli, Stefania Marzocco, Mahdi Moridi Farimani, Milena Masullo, Sonia Piacente. Anti-inflammatory Activity of Tanshinone-Related Diterpenes from Perovskia artemisioides Roots. Journal of natural products. 2023 04; 86(4):812-821. doi: 10.1021/acs.jnatprod.2c01004. [PMID: 37040078]
  • Sahar Idris, Anuradha Mishra, Mohammad Khushtar. Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis. Chinese journal of integrative medicine. 2023 Apr; ?(?):. doi: 10.1007/s11655-023-3734-9. [PMID: 37079159]
  • E Prakash, S Pavithra, D G Kishor Kumar, Manjit Panigrahi, Thakur Uttam Singh, Dinesh Kumar, Subhashree Parida. TXA2 mediates LPA1-stimulated uterine contraction in late pregnant mouse. Prostaglandins & other lipid mediators. 2023 Apr; 167(?):106736. doi: 10.1016/j.prostaglandins.2023.106736. [PMID: 37062326]
  • Serdar Sahinturk. Elabela relaxes rat pulmonary artery and trachea via BKCa, KV, and KATP channels. Prostaglandins & other lipid mediators. 2023 Apr; 167(?):106735. doi: 10.1016/j.prostaglandins.2023.106735. [PMID: 37059294]
  • Elizabeth Arlen Pineda-Peña, David Capistran-Amezcua, Adelfo Reyes-Ramírez, Santiago Xolalpa-Molina, Aracely Evangelina Chávez-Piña, Mario Figueroa, Andrés Navarrete. Gastroprotective effect methanol extract of Caesalpinia coriaria pods against indomethacin- and ethanol-induced gastric lesions in Wistar rats. Journal of ethnopharmacology. 2023 Apr; 305(?):116057. doi: 10.1016/j.jep.2022.116057. [PMID: 36574790]
  • Elaine Cristine Souza da Silva, Gerlane Coelho Bernardo Guerra, Edilane Rodrigues Dantas de Araújo, Jade Schlamb, Valéria Costa da Silva, Emanuella de Aragão Tavares, Renato Dantas-Medeiros, Lucas Silva Abreu, Josean Fechine Tavares, Raimundo Fernandes de Araújo Júnior, Debora Esposito, Marvin Moncada, Silvana Maria Zucolotto. Phenolic-rich extract of Nopalea cochenillifera attenuates gastric lesions induced in experimental models through inhibiting oxidative stress, modulating inflammatory markers and a cytoprotective effect. Food & function. 2023 Apr; 14(7):3242-3258. doi: 10.1039/d2fo03735a. [PMID: 36928439]
  • Ivana Predarska, Mohamad Saoud, Ibrahim Morgan, Peter Lönnecke, Goran N Kaluđerović, Evamarie Hey-Hawkins. Triphenyltin(IV) Carboxylates with Exceptionally High Cytotoxicity against Different Breast Cancer Cell Lines. Biomolecules. 2023 Mar; 13(4):. doi: 10.3390/biom13040595. [PMID: 37189343]
  • Petar Šušnjara, Zrinka Mihaljević, Ana Stupin, Nikolina Kolobarić, Anita Matić, Ivana Jukić, Zlata Kralik, Gordana Kralik, Anđelina Miloloža, Tihana Pavošević, Vatroslav Šerić, Zdenko Lončarić, Darko Kerovec, Olivera Galović, Ines Drenjančević. Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study. Nutrients. 2023 Mar; 15(7):. doi: 10.3390/nu15071599. [PMID: 37049437]
  • Fabiana de Freitas Figueiredo, Amilcar Sabino Damazoa, Karuppusamy Arunachalam, Marcelo José Dias Silva, Eduarda Pavan, Joaquim Corsino da Silva Lima, Domingos Tabajara de Oliveira Martins. Evaluation of the gastroprotective and ulcer healing properties by Fridericia chica (Bonpl.) L.G. Lohmann hydroethanolic extract of leaves. Journal of ethnopharmacology. 2023 Mar; ?(?):116338. doi: 10.1016/j.jep.2023.116338. [PMID: 36870462]
  • Momita Rani Baro, Manas Das, Anuradha Kalita, Bhabajyoti Das, Kishore Sarma. Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation. Journal of ethnopharmacology. 2023 Mar; 303(?):116021. doi: 10.1016/j.jep.2022.116021. [PMID: 36516907]
  • Adedotun A Adefolalu, Bamidele V Owoyele, Ayoade A Adesokan. Comparative study of antipyretic potency of extracts of morinda lucida leaves and fruits of capsicum frutescens in albino rats. African health sciences. 2023 Mar; 23(1):213-217. doi: 10.4314/ahs.v23i1.23. [PMID: 37545963]
  • Cristina Salinas-Nolasco, Gabriela Soledad Barragán-Zarate, Luicita Lagunez-Rivera, Rodolfo Solano, Liliana Favari, Juan Miguel Jiménez-Andrade, Aracely Evangelina Chávez-Piña. Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat. Natural product research. 2023 Mar; 37(5):819-822. doi: 10.1080/14786419.2022.2089880. [PMID: 35722687]
  • Mona F Mahmoud, Walied Abdo, Mohamed Nabil, Badreddine Drissi, Assem M El-Shazly, Mohamed A O Abdelfattah, Mansour Sobeh. Apple (Malus domestica Borkh) leaves attenuate indomethacin-induced gastric ulcer in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Feb; 160(?):114331. doi: 10.1016/j.biopha.2023.114331. [PMID: 36736281]
  • Bo Jia, Leyi Zhao, Pengpeng Liu, Meng Li, Zhilei Tian. Limonin ameliorates indomethacin-induced intestinal damage and ulcers through Nrf2/ARE pathway. Immunity, inflammation and disease. 2023 Feb; 11(2):e787. doi: 10.1002/iid3.787. [PMID: 36840501]
  • Angelina Subeska, Jan Althaus, Theresa Hake, Walburga Hanekamp, Dominik Bettenworth, Dennis Mulac, Klaus Langer, Matthias Lehr. Synthesis and pharmacokinetic properties of novel cPLA2α inhibitors with 1-(carboxyalkylpyrrolyl)-3-aryloxypropan-2-one structure. Bioorganic & medicinal chemistry. 2023 01; 77(?):117110. doi: 10.1016/j.bmc.2022.117110. [PMID: 36495814]
  • Kuo-Shyang Jeng, Po-Yu Cheng, Yueh-Hsien Lin, Po-Chun Liu, Ping-Hui Tseng, Yu-Chao Wang, Chiung-Fang Chang, Chuen-Miin Leu. Aldo-keto reductase family member C3 (AKR1C3) promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α. Oncology research. 2023; 32(1):163-174. doi: 10.32604/or.2023.030975. [PMID: 38188684]
  • Mariane Meurer, Fabiula Felisbino, Fabiana B Müller, Lincon B Somensi, Benhur J Cury, Daniele T Jerônimo, Larissa Venzon, Tauani C S França, Marihá Mariott, Ana C Santos, Ruan Kaio S Nunes, Thaise Boeing, Alexandre Bella-Cruz, Priscila DE Souza, Walter A Roman-Junior, Karuppusamy Arunachalam, Ruberlei G Oliveira, Luisa M Silva. Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds' medicinal and edible flowers (Tagetes erecta L.). Anais da Academia Brasileira de Ciencias. 2023; 95(suppl 1):e20220427. doi: 10.1590/0001-3765202320220427. [PMID: 37556712]
  • Muryam Abdul Razzaq, Waqas Younis, Muhammad Nasir Hayat Malik, Tariq G Alsahli, Alamgeer, Shah Jahan, Roma Ehsan, Arquimedes Gasparotto Junior, Asifa Bashir. Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats. Cardiovascular therapeutics. 2023; 2023(?):8166840. doi: 10.1155/2023/8166840. [PMID: 37214130]
  • Houpan Song, Jingyue Qiu, Chang Yu, Meng Xiong, Chen Ou, Baoping Ren, Meiqi Zhong, Meiyan Zeng, Qinghua Peng. Traditional Chinese Medicine prescription Huang-Qi-Jian-Zhong-Tang ameliorates indomethacin-induced duodenal ulcers in rats by affecting NF-κB and STAT signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Dec; 156(?):113866. doi: 10.1016/j.biopha.2022.113866. [PMID: 36228371]
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