zafirlukast (BioDeep_00000398936)
Main id: BioDeep_00000003192
natural product Volatile Flavor Compounds
代谢物信息卡片
Zafirlukast (Accolate)
化学式: C31H33N3O6S (575.2089958000001)
中文名称: 扎鲁斯特
谱图信息:
最多检出来源 Homo sapiens(urine) 33.33%
分子结构信息
SMILES: C12=C(C=C(C=C1)NC(OC3CCCC3)=O)C(=CN2C)CC4=CC=C(C=C4OC)C(=O)NS(C5=CC=CC=C5C)(=O)=O
InChI: InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DC - Leukotriene receptor antagonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D020024 - Leukotriene Antagonists
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent
同义名列表
3 个代谢物同义名
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:10100
- KEGG: C07206
- KEGGdrug: D92802
- KEGGdrug: D00411
- PubChem: 5717
- DrugBank: DB00549
- ChEMBL: CHEMBL603
- CAS: 107753-78-6
- MoNA: FiehnHILIC003057
- MoNA: FiehnHILIC002423
- MoNA: FiehnHILIC001584
- MoNA: FiehnHILIC000864
- MoNA: CCMSLIB00000078216
- MoNA: CCMSLIB00000078215
- PubChem: 9415
- PDB-CCD: ZLK
- NIKKAJI: J322.324H
- RefMet: Zafirlukast
- KNApSAcK: 10100
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenxin Huang, Jia-Xi Wang, Xiaofei Shen, Yuqin Lei, Xueqin Chen, Da Jia, Xia Zhang, Qingxiang Sun. Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach.
Journal of medicinal chemistry.
2023 01; 66(2):1574-1582. doi:
10.1021/acs.jmedchem.2c01772. [PMID: 36622814] - Christopher Wolf, Sonja Smith, Sjoerd J L van Wijk. Zafirlukast Induces VHL- and HIF-2α-Dependent Oxidative Cell Death in 786-O Clear Cell Renal Carcinoma Cells.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073567. [PMID: 35408930] - Yuanying Fang, Lamees Hegazy, Brian N Finck, Bahaa Elgendy. Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor.
Journal of medicinal chemistry.
2021 12; 64(24):17545-17571. doi:
10.1021/acs.jmedchem.1c01017. [PMID: 34889100] - N Mehyar, A Mashhour, I Islam, H A Alhadrami, A M Tolah, B Alghanem, S Alkhaldi, B A Somaie, M Al Ghobain, Y Alobaida, A S Alaskar, M Boudjelal. Discovery of Zafirlukast as a novel SARS-CoV-2 helicase inhibitor using in silico modelling and a FRET-based assay.
SAR and QSAR in environmental research.
2021 Dec; 32(12):963-983. doi:
10.1080/1062936x.2021.1993995. [PMID: 34818959] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Qiang Song, Zhi Hu, Xinming Xie, Hui Cai. Zafirlukast prevented ox-LDL-induced formation of foam cells.
Toxicology and applied pharmacology.
2020 12; 409(?):115295. doi:
10.1016/j.taap.2020.115295. [PMID: 33096109] - Nosayba Al-Azzam, Lina Elsalem. Leukotriene D4 role in allergic asthma pathogenesis from cellular and therapeutic perspectives.
Life sciences.
2020 Nov; 260(?):118452. doi:
10.1016/j.lfs.2020.118452. [PMID: 32956660] - Francesca Citron, Luigi Perelli, Angela K Deem, Giannicola Genovese, Andrea Viale. Leukotrienes, a potential target for Covid-19.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 10; 161(?):102174. doi:
10.1016/j.plefa.2020.102174. [PMID: 32977289] - Pranesh Kumar, Aakriti Agarwal, Ashok K Singh, Anurag Kumar Gautam, Sreemoyee Chakraborti, Umesh Kumar, Dinesh Kumar, Bolay Bhattacharya, Parthasarathi Panda, Biswajit Saha, Tabish Qidwai, Biswanath Maity, Sudipta Saha. Antineoplastic properties of zafirlukast against hepatocellular carcinoma via activation of mitochondrial mediated apoptosis.
Regulatory toxicology and pharmacology : RTP.
2019 Dec; 109(?):104489. doi:
10.1016/j.yrtph.2019.104489. [PMID: 31605713] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Eric E Figueroa, Meghan Kramer, Kevin Strange, Jerod S Denton. CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.
American journal of physiology. Cell physiology.
2019 10; 317(4):C857-C866. doi:
10.1152/ajpcell.00281.2019. [PMID: 31390227] - Changjiang Lei, Shixing Wu, Chong Wen, Yuan Li, Ning Liu, Jianbin Huang, Lei Li, Meixia Fu, Jiani Liu. Zafirlukast attenuates advanced glycation end-products (AGEs)-induced degradation of articular extracellular matrix (ECM).
International immunopharmacology.
2019 Mar; 68(?):68-73. doi:
10.1016/j.intimp.2018.12.056. [PMID: 30612086] - Joanne M Donkers, Benno Zehnder, Gerard J P van Westen, Mark J Kwakkenbos, Adriaan P IJzerman, Ronald P J Oude Elferink, Ulrich Beuers, Stephan Urban, Stan F J van de Graaf. Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP.
Scientific reports.
2017 11; 7(1):15307. doi:
10.1038/s41598-017-15338-0. [PMID: 29127322] - Evelien Gerits, Isolde Van der Massen, Katleen Vandamme, Kaat De Cremer, Katrijn De Brucker, Karin Thevissen, Bruno P A Cammue, Serge Beullens, Maarten Fauvart, Natalie Verstraeten, Jan Michiels. In vitro activity of the antiasthmatic drug zafirlukast against the oral pathogens Porphyromonas gingivalis and Streptococcus mutans.
FEMS microbiology letters.
2017 01; 364(2):. doi:
10.1093/femsle/fnx005. [PMID: 28087617] - Hyun-Jee Lee, Young-Hoon Kim, Se-Hyung Kim, Choong-Min Lee, Ae-Yun Yang, Choon-Gon Jang, Seok-Yong Lee, Jung-Woo Bae, Chang-Ik Choi. Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of zafirlukast.
Archives of pharmacal research.
2016 Jul; 39(7):1013-9. doi:
10.1007/s12272-016-0785-x. [PMID: 27377818] - Valérie Capra, Chiara Carnini, Maria Rosa Accomazzo, Antonio Di Gennaro, Marco Fiumicelli, Emanuele Borroni, Ivan Brivio, Carola Buccellati, Paolo Mangano, Silvia Carnevali, Gianenrico Rovati, Angelo Sala. Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT₂ receptor.
Prostaglandins & other lipid mediators.
2015 Jul; 120(?):115-25. doi:
10.1016/j.prostaglandins.2015.03.007. [PMID: 25839425] - Muzaffar Iqbal, Essam Ezzeldin, Khalid A Al-Rashood, Yousif A Asiri, Naser L Rezk. Rapid determination of canagliflozin in rat plasma by UHPLC-MS/MS using negative ionization mode to avoid adduct-ions formation.
Talanta.
2015 Jan; 132(?):29-36. doi:
10.1016/j.talanta.2014.08.041. [PMID: 25476275] - M Iqbal, E Ezzeldin, K A Al-Rashood, K I Al-Khamees, R M A Khan, M Raish, T Anwer. Simple and rapid determination of zafirlukast in plasma by ultra-performance liquid chromatography tandem mass spectrometric method: application into pharmacokinetic study in rabbits.
Drug research.
2014 Aug; 64(8):412-9. doi:
10.1055/s-0033-1358748. [PMID: 24258705] - Hanan H Hagar, Raeesa Abd El Tawab. Cysteinyl leukotriene receptor antagonism alleviates renal injury induced by ischemia-reperfusion in rats.
The Journal of surgical research.
2012 Nov; 178(1):e25-34. doi:
10.1016/j.jss.2012.02.022. [PMID: 22487384] - Tiina Karonen, Jouko Laitila, Mikko Niemi, Pertti J Neuvonen, Janne T Backman. Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations.
European journal of clinical pharmacology.
2012 May; 68(5):681-8. doi:
10.1007/s00228-011-1158-5. [PMID: 22108774] - Susanna L Lundström, Jun Yang, Henrik J Källberg, Sarah Thunberg, Guro Gafvelin, Jesper Z Haeggström, Reidar Grönneberg, Johan Grunewald, Marianne van Hage, Bruce D Hammock, Anders Eklund, Åsa M Wheelock, Craig E Wheelock. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation.
PloS one.
2012; 7(3):e33780. doi:
10.1371/journal.pone.0033780. [PMID: 22438998] - Alexandre P Rogerio, Fernanda F Anibal. Role of leukotrienes on protozoan and helminth infections.
Mediators of inflammation.
2012; 2012(?):595694. doi:
10.1155/2012/595694. [PMID: 22577251] - Amin Kanani, Robert Schellenberg, Richard Warrington. Urticaria and angioedema.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology.
2011 Nov; 7 Suppl 1(?):S9. doi:
10.1186/1710-1492-7-s1-s9. [PMID: 22165855] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Tiina Karonen, Pertti J Neuvonen, Janne T Backman. The CYP2C8 inhibitor gemfibrozil does not affect the pharmacokinetics of zafirlukast.
European journal of clinical pharmacology.
2011 Feb; 67(2):151-5. doi:
10.1007/s00228-010-0908-0. [PMID: 20931329] - Zeinab Mohamed Radwan, Gamal Abdel Nasser Yamamah, Hala Hamdy Shaaban, Azza Mohamed Omar Abdel-Rahman, Amany Abdel-Ghany Ismaeil, Elham Mohamed Mostafa. Effect of different monotherapies on serum nitric oxide and pulmonary functions in children with mild persistent asthma.
Archives of medical science : AMS.
2010 Dec; 6(6):919-25. doi:
10.5114/aoms.2010.19302. [PMID: 22427767] - Amy E DeClue, Claire R Sharp, Rachael L Cohen, Elizabeth F Leverenz, Carol R Reinero. Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats.
Journal of feline medicine and surgery.
2010 Oct; 12(10):754-9. doi:
10.1016/j.jfms.2010.05.012. [PMID: 20719552] - T Kezeli, N Gongadze, Z Chapichadze, K Bakuridze, K Chirakadze. Effect of combination of zafirlukast and quercetin on baroreflex sensitivity and endothelin production in rats with myocardial infarction.
International journal of clinical pharmacology and therapeutics.
2010 May; 48(5):335-41. doi:
10.5414/cpp48335. [PMID: 20420790] - Upal Roy, Geetika Chakravarty, Kerstin Honer Zu Bentrup, Debasis Mondal. Montelukast is a potent and durable inhibitor of multidrug resistance protein 2-mediated efflux of taxol and saquinavir.
Biological & pharmaceutical bulletin.
2009 Dec; 32(12):2002-9. doi:
10.1248/bpb.32.2002. [PMID: 19952419] - Sudha Yadav, A K Bajaj. Management of difficult urticaria.
Indian journal of dermatology.
2009 Jul; 54(3):275-9. doi:
10.4103/0019-5154.55641. [PMID: 20161863] - Graziano Riccioni, Alessandra Zanasi, Nicola Vitulano, Barbara Mancini, Nicolantonio D'Orazio. Leukotrienes in atherosclerosis: new target insights and future therapy perspectives.
Mediators of inflammation.
2009; 2009(?):737282. doi:
10.1155/2009/737282. [PMID: 20150962] - Gabriele Di Lorenzo, Alberto D'Alcamo, Manfredi Rizzo, Maria Stefania Leto-Barone, Claudia Lo Bianco, Vito Ditta, Donatella Politi, Francesco Castello, Ilenia Pepe, Gaetana Di Fede, Giovambattista Rini. Leukotriene receptor antagonists in monotherapy or in combination with antihistamines in the treatment of chronic urticaria: a systematic review.
Journal of asthma and allergy.
2008 Dec; 2(?):9-16. doi:
10.2147/jaa.s3236. [PMID: 21437139] - D Vijaya Bharathi, A Naidu, B Jagadeesh, K N K Maha Laxmi, P Revathi Naga Laxmi, Pandu Ranga Reddy, Ramesh Mullangi. Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of zafirlukast, a selective leukotriene antagonist in human plasma: application to a clinical pharmacokinetic study.
Biomedical chromatography : BMC.
2008 Jun; 22(6):645-53. doi:
10.1002/bmc.983. [PMID: 18254142] - Tina Little, Bruce D Butler. Pharmacological intervention to the inflammatory response from decompression sickness in rats.
Aviation, space, and environmental medicine.
2008 Feb; 79(2):87-93. doi:
10.3357/asem.2118.2008. [PMID: 18309904] - Incilay Süslü, Sacide Altinöz. A reversed-phase high-performance liquid chromatographic method for the determination of zafirlukast in pharmaceutical formulations and human plasma.
Journal of AOAC International.
2006 Nov; 89(6):1557-64. doi:
10.1093/jaoac/89.6.1557. [PMID: 17225602] - Fumiaki Yamashita, Hisakazu Ohtani, Noriko Koyabu, Fumihiko Ushigome, Hiroki Satoh, Hideyasu Murakami, Takeshi Uchiumi, Takanori Nakamura, Michihiko Kuwano, Masayuki Tsujimoto, Yasufumi Sawada. Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.
The Journal of pharmacy and pharmacology.
2006 Nov; 58(11):1499-505. doi:
10.1211/jpp.58.11.0011. [PMID: 17132213] - Tiina Jaakkola, Janne T Backman, Mikko Neuvonen, Mikko Niemi, Pertti J Neuvonen. Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone.
European journal of clinical pharmacology.
2006 Jul; 62(7):503-9. doi:
10.1007/s00228-006-0136-9. [PMID: 16670899] - M Peters-Golden, M M Gleason, A Togias. Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2006 Jun; 36(6):689-703. doi:
10.1111/j.1365-2222.2006.02498.x. [PMID: 16776669] - G Di Lorenzo, M L Pacor, P Mansueto, M Esposito-Pellitteri, V Ditta, C Lo Bianco, M S Leto-Barone, G Di Fede, G B Rini. Is there a role for antileukotrienes in urticaria?.
Clinical and experimental dermatology.
2006 May; 31(3):327-34. doi:
10.1111/j.1365-2230.2006.02127.x. [PMID: 16681569] - J N Sharma, L A Mohammed. The role of leukotrienes in the pathophysiology of inflammatory disorders: is there a case for revisiting leukotrienes as therapeutic targets?.
Inflammopharmacology.
2006 Mar; 14(1-2):10-6. doi:
10.1007/s10787-006-1496-6. [PMID: 16835707] - Ergul Belge Kurutas, Ali Cetinkaya, Ertan Bulbuloglu, Bulent Kantarceken. Effects of antioxidant therapy on leukocyte myeloperoxidase and Cu/Zn-superoxide dismutase and plasma malondialdehyde levels in experimental colitis.
Mediators of inflammation.
2005 Dec; 2005(6):390-4. doi:
10.1155/mi.2005.390. [PMID: 16489261] - Dermot F McGinnity, James Tucker, Steve Trigg, Robert J Riley. Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Nov; 33(11):1700-7. doi:
10.1124/dmd.105.005884. [PMID: 16081671] - Carol R Reinero, Kendra C Decile, Jenni R Byerly, Roy D Berghaus, William E Walby, Londa J Berghaus, Dallas M Hyde, Edward S Schelegle, Laurel J Gershwin. Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.
American journal of veterinary research.
2005 Jul; 66(7):1121-7. doi:
10.2460/ajvr.2005.66.1121. [PMID: 16111148] - Marc Peters-Golden, William R Henderson. The role of leukotrienes in allergic rhinitis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2005 Jun; 94(6):609-18; quiz 618. doi:
10.1016/s1081-1206(10)61317-8. [PMID: 15984591] - Josiane S Neves, Lídia M Lima, Carlos A M Fraga, Eliezer J Barreiro, Ana L P Miranda, Bruno L Diaz, Alex Balduino, Rodrigo de Azeredo Siqueira, Patrícia M R e Silva, Marco A Martins. Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats.
European journal of pharmacology.
2005 Mar; 511(2-3):219-27. doi:
10.1016/j.ejphar.2005.02.011. [PMID: 15792791] - David Goldmeier, Peter Madden, Michael McKenna, Norbert Tamm. Treatment of category III A prostatitis with zafirlukast: a randomized controlled feasibility study.
International journal of STD & AIDS.
2005 Mar; 16(3):196-200. doi:
10.1258/0956462053420239. [PMID: 15829018] - Gulfidan Cakmak, Tuncalp Demir, Bilun Gemicioglu, Akin Aydemir, Emel Serdaroglu, Orkide Donma. The effects of add-on zafirlukast treatment to budesonide on bronchial hyperresponsiveness and serum levels of eosinophilic cationic protein and total antioxidant capacity in asthmatic patients.
The Tohoku journal of experimental medicine.
2004 Dec; 204(4):249-56. doi:
10.1620/tjem.204.249. [PMID: 15572850] - María Magdalena Cuevas Hernández, Rosa María Arias Hernández. [Therapeutic effects of an antileukotriene in children with moderate-severe persistent asthma].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993).
2004 Nov; 51(6):206-9. doi:
. [PMID: 15794412] - Ilknur Basyigit, Fusun Yildiz, Sevgiye Kacar Ozkara, Hasim Boyaci, Ahmet Ilgazli, Oktay Ozkarakas. Effects of different anti-asthmatic agents on induced sputum and eosinophil cationic protein in mild asthmatics.
Respirology (Carlton, Vic.).
2004 Nov; 9(4):514-20. doi:
10.1111/j.1440-1843.2004.00631.x. [PMID: 15612964] - Nevin Oruc, Vahit Yukselen, A Omer Ozutemiz, Gul Yuce, Handan Ak Celik, Ahmet Musoglu, Yucel Batur. Leukotriene receptor antagonism in experimental acute pancreatitis in rats.
European journal of gastroenterology & hepatology.
2004 Apr; 16(4):383-8. doi:
10.1097/00042737-200404000-00003. [PMID: 15028970] - Scott E Bagenstose, Linda Levin, Jonathan A Bernstein. The addition of zafirlukast to cetirizine improves the treatment of chronic urticaria in patients with positive autologous serum skin test results.
The Journal of allergy and clinical immunology.
2004 Jan; 113(1):134-40. doi:
10.1016/j.jaci.2003.10.002. [PMID: 14713918] - Benjamin H S Lau, Sharon K Riesen, Kim P Truong, Esther W Lau, Peter Rohdewald, Ray A Barreta. Pycnogenol as an adjunct in the management of childhood asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2004; 41(8):825-32. doi:
10.1081/jas-200038433. [PMID: 15641632] - Takanori Kumagai, Yuichi Hori, Yukiko Kishida, Kazuhiro Yakumaru, Takeshi Takahashi, Takashi Itou. Acute renal failure and nephrotic syndrome associated with zafirlukast therapy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2003 Oct; 18(10):2202-3. doi:
10.1093/ndt/gfg334. [PMID: 13679508] - Thiruma V Arumugam, Naomi Arnold, Lavinia M Proctor, Michelle Newman, Robert C Reid, Karl A Hansford, David P Fairlie, Ian A Shiels, Stephen M Taylor. Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist.
British journal of pharmacology.
2003 Sep; 140(1):71-80. doi:
10.1038/sj.bjp.0705402. [PMID: 12967936] - Chung-Jen Huang, Chun-Hua Wang, Wen-Te Liu, Mei-Chen Yang, Horng-Chyuan Lin, Chih-Teng Yu, Chia-Jung Shiao, Chia-Chun Tan, Chao-Kai Yang, Han Pin Kuo. Zafirlukast improves pulmonary function in patients with moderate persistent asthma receiving regular inhaled steroids: a prospective randomized control study.
Chang Gung medical journal.
2003 Aug; 26(8):554-60. doi:
. [PMID: 14609035] - Xiaoning Bu, Chen Wang, Baosen Pang. Effects of leukotriene receptor antagonist on chronic obstructive [correction of obstractive] pulmonary disease induced pulmonary hypertension.
Chinese medical journal.
2003 Mar; 116(3):459-61. doi:
. [PMID: 12781059] - James P Kemp. Recent advances in the management of asthma using leukotriene modifiers.
American journal of respiratory medicine : drugs, devices, and other interventions.
2003; 2(2):139-56. doi:
10.1007/bf03256645. [PMID: 14720013] - Alberto Tedeschi, Lorena Airaghi, Maurizio Lorini, Riccardo Asero. Chronic urticaria: a role for newer immunomodulatory drugs?.
American journal of clinical dermatology.
2003; 4(5):297-305. doi:
10.2165/00128071-200304050-00001. [PMID: 12688835] - Blaithin McMahon, Derick Mitchell, Richard Shattock, Finian Martin, Hugh R Brady, Catherine Godson. Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2002 Nov; 16(13):1817-9. doi:
10.1096/fj.02-0416fje. [PMID: 12223454] - Chien-Wei Su, Jaw-Ching Wu, Yi-Hsiang Huang, Yi-Shin Huang, Full-Young Chang, Shou-Dong Lee. Zafirlukast-induced acute hepatitis.
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed.
2002 Nov; 65(11):553-6. doi:
. [PMID: 12583521] - Owen J Dempsey, Stephen J Fowler, Andrew Wilson, Gwen Kennedy, Brian J Lipworth. Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma.
Chest.
2002 Jul; 122(1):151-9. doi:
10.1378/chest.122.1.151. [PMID: 12114351] - Modesto Orea Solano, Graciela Flores Sandoval, Fidel Machado C, Humberto Romero, Leopoldo Santos Argumedo. [Aspirin induced asthma, urinary leukotriene E4 and zafirlukast].
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993).
2002 Mar; 49(2):52-6. doi:
. [PMID: 12092526] - Carola Buccellati, Francesca Fumagalli, Serena Viappiani, Giancarlo Folco. Leukotriene modifiers: novel therapeutic opportunities in asthma.
Farmaco (Societa chimica italiana : 1989).
2002 Mar; 57(3):235-42. doi:
10.1016/s0014-827x(02)01209-0. [PMID: 11989802] - Tieying Sun, Yanfei Guo, Hongsheng Zhang. [Study on relationship between leukotrienes and exercise-induced asthma].
Zhonghua yi xue za zhi.
2002 Jan; 82(1):54-6. doi:
NULL. [PMID: 11953129] - P N Richard Dekhuijzen, Peter P Koopmans. Pharmacokinetic profile of zafirlukast.
Clinical pharmacokinetics.
2002; 41(2):105-14. doi:
10.2165/00003088-200241020-00003. [PMID: 11888331] - Y Guo, T Sun, H Zhang. [The relationship between eosinophils, activated T lymphocyte, leukotreine and the exercise-induced asthma].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2001 Jun; 24(6):360-4. doi:
. [PMID: 11802990] - J J Tsai, Y C Su, S C Chan, C K Ho, T C Feng. Enhanced prostaglandin E2 secretion in sputum from asthmatic patients after zafirlukast therapy.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2001 Apr; 100(4):241-3. doi:
. [PMID: 11393122] - S Wang, E Gustafson, L Pang, X Qiao, J Behan, M Maguire, M Bayne, T Laz. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.
The Journal of biological chemistry.
2000 Dec; 275(52):40686-94. doi:
10.1074/jbc.m004512200. [PMID: 11006272] - J F Reinus, S Persky, J S Burkiewicz, D Quan, N M Bass, T J Davern. Severe liver injury after treatment with the leukotriene receptor antagonist zafirlukast.
Annals of internal medicine.
2000 Dec; 133(12):964-8. doi:
10.7326/0003-4819-133-12-200012190-00011. [PMID: 11119397] - B Pang, C Wang, J Zhou. [A study of influence of zafirlukast to anoxic pulmonary hypertension in rats].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2000 Mar; 23(3):144-6. doi:
. [PMID: 11778485] - J D Fischer, M H Song, A B Suttle, W D Heizer, C B Burns, D L Vargo, K L Brouwer. Comparison of zafirlukast (Accolate) absorption after oral and colonic administration in humans.
Pharmaceutical research.
2000 Feb; 17(2):154-9. doi:
10.1023/a:1007509112383. [PMID: 10751029] - R I Shader, B W Granda, L L von Moltke, G M Giancarlo, D J Greenblatt. Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast.
Biopharmaceutics & drug disposition.
1999 Nov; 20(8):385-8. doi:
10.1002/1099-081x(199911)20:8<385::aid-bdd203>3.0.co;2-7. [PMID: 10870095] - H M Sarau, R S Ames, J Chambers, C Ellis, N Elshourbagy, J J Foley, D B Schmidt, R M Muccitelli, O Jenkins, P R Murdock, N C Herrity, W Halsey, G Sathe, A I Muir, P Nuthulaganti, G M Dytko, P T Buckley, S Wilson, D J Bergsma, D W Hay. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
Molecular pharmacology.
1999 Sep; 56(3):657-63. doi:
10.1124/mol.56.3.657. [PMID: 10462554] - M Kupczyk, P Kuna. [The role of leukotrienes in inflammation and leukotriene inhibitors].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
1999 Sep; 7(39):85-93. doi:
. [PMID: 10598480] - K W Garey, C A Peloquin, P G Godo, A N Nafziger, G W Amsden. Lack of effect of zafirlukast on the pharmacokinetics of azithromycin, clarithromycin, and 14-hydroxyclarithromycin in healthy volunteers.
Antimicrobial agents and chemotherapy.
1999 May; 43(5):1152-5. doi:
10.1128/aac.43.5.1152. [PMID: 10223928] - S E Wenzel. Leukotriene receptor antagonists and related compounds.
Canadian respiratory journal.
1999 Mar; 6(2):189-93. doi:
10.1155/1999/676798. [PMID: 10322101] - R D Savidge, K H Bui, B K Birmingham, J L Morse, R C Spreen. Metabolism and excretion of zafirlukast in dogs, rats, and mice.
Drug metabolism and disposition: the biological fate of chemicals.
1998 Nov; 26(11):1069-76. doi:
NULL. [PMID: 9806948] - R K Katial, R C Stelzle, M W Bonner, M Marino, L R Cantilena, L J Smith. A drug interaction between zafirlukast and theophylline.
Archives of internal medicine.
1998 Aug; 158(15):1713-5. doi:
10.1001/archinte.158.15.1713. [PMID: 9701106] - L J Smith, L A Hanby, B J Lavins, S G Simonson. A single dose of zafirlukast reduces LTD4-induced bronchoconstriction in patients on maintenance inhaled corticosteroid therapy.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
1998 Jul; 81(1):43-9. doi:
10.1016/s1081-1206(10)63108-0. [PMID: 9690572] - V Capra, M Bolla, P A Belloni, M Mezzetti, G C Folco, S Nicosia, G E Rovati. Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro.
British journal of pharmacology.
1998 Feb; 123(3):590-8. doi:
10.1038/sj.bjp.0701636. [PMID: 9504401] - S C Lazarus, H H Wong, M J Watts, H A Boushey, B J Lavins, M C Minkwitz. The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide-induced bronchoconstriction in patients with asthma.
American journal of respiratory and critical care medicine.
1997 Dec; 156(6):1725-30. doi:
10.1164/ajrccm.156.6.9608006. [PMID: 9412547] - K H Bui, C M Kennedy, C T Azumaya, B K Birmingham. Determination of zafirlukast, a selective leukotriene antagonist, human plasma by normal-phase high-performance liquid chromatography with fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Aug; 696(1):131-6. doi:
10.1016/s0378-4347(97)00092-3. [PMID: 9300917] - K E Pedersen, B S Bochner, B J Undem. Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism.
The Journal of pharmacology and experimental therapeutics.
1997 May; 281(2):655-62. doi:
. [PMID: 9152370] - A L Donnelly, M Glass, M C Minkwitz, T B Casale. The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis.
American journal of respiratory and critical care medicine.
1995 Jun; 151(6):1734-9. doi:
10.1164/ajrccm.151.6.7767514. [PMID: 7767514] - L J Smith, M Glass, M C Minkwitz. Inhibition of leukotriene D4-induced bronchoconstriction in subjects with asthma: a concentration-effect study of ICI 204,219.
Clinical pharmacology and therapeutics.
1993 Oct; 54(4):430-6. doi:
10.1038/clpt.1993.170. [PMID: 8222486] - K M O'Shaughnessy, I K Taylor, B O'Connor, F O'Connell, H Thomson, C T Dollery. Potent leukotriene D4 receptor antagonist ICI 204,219 given by the inhaled route inhibits the early but not the late phase of allergen-induced bronchoconstriction.
The American review of respiratory disease.
1993 Jun; 147(6 Pt 1):1431-5. doi:
10.1164/ajrccm/147.6_pt_1.1431. [PMID: 8389105] - J C Kidney, S M Ridge, K F Chung, P J Barnes. Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219.
The American review of respiratory disease.
1993 Jan; 147(1):215-7. doi:
10.1164/ajrccm/147.1.215. [PMID: 8420421] - S E Dahlén, B Dahlén, E Eliasson, H Johansson, T Björck, M Kumlin, K Boo, J Whitney, S Binks, B King. Inhibition of allergic bronchoconstriction in asthmatics by the leukotriene-antagonist ICI-204,219.
Advances in prostaglandin, thromboxane, and leukotriene research.
1991; 21A(?):461-4. doi:
NULL. [PMID: 1847783] - J W Watson, M Conklyn, H J Showell. IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators.
The American review of respiratory disease.
1990 Nov; 142(5):1093-8. doi:
10.1164/ajrccm/142.5.1093. [PMID: 2240832] - L J Smith, S Geller, L Ebright, M Glass, P T Thyrum. Inhibition of leukotriene D4-induced bronchoconstriction in normal subjects by the oral LTD4 receptor antagonist ICI 204,219.
The American review of respiratory disease.
1990 Apr; 141(4 Pt 1):988-92. doi:
10.1164/ajrccm/141.4_pt_1.988. [PMID: 2158260]