pyrilamine (BioDeep_00000398453)

   

Volatile Flavor Compounds


代谢物信息卡片


PYR_286.1915_11.5

化学式: C17H23N3O (285.1841028)
中文名称: 美吡拉敏
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)CCN(Cc(c2)ccc(OC)c2)c(c1)nccc1
InChI: InChI=1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3

描述信息

D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
CONFIDENCE Parent Substance with Reference Standard (Level 1); INTERNAL_ID 1700

同义名列表

4 个代谢物同义名

pyrilamine; Mepyramine; PYR_286.1915_11.5; Mepyramine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Shigeru Hishinuma, Hiroshi Komazaki, Hayato Tsukamoto, Hirokazu Hatahara, Hiroyuki Fukui, Masaru Shoji. Ca2+ -dependent down-regulation of human histamine H1 receptors in Chinese hamster ovary cells. Journal of neurochemistry. 2018 01; 144(1):68-80. doi: 10.1111/jnc.14245. [PMID: 29063596]
  • Luke R Odell, Mohammed K Abdel-Hamid, Timothy A Hill, Ngoc Chau, Kelly A Young, Fiona M Deane, Jennette A Sakoff, Sofia Andersson, James A Daniel, Phillip J Robinson, Adam McCluskey. Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. Journal of medicinal chemistry. 2017 01; 60(1):349-361. doi: 10.1021/acs.jmedchem.6b01422. [PMID: 27997171]
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  • John Wilton, Elena Kurenova, Laura Pitzonka, Allison Gaudy, Leslie Curtin, Sandra Sexton, William Cance, Gerald Fetterly. Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogs. European journal of drug metabolism and pharmacokinetics. 2016 Feb; 41(1):55-67. doi: 10.1007/s13318-014-0233-6. [PMID: 25377246]
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  • Lais Moraes de Oliveira, Aline Gabriela Rodrigues, Elaine Fernanda da Silva, Letícia Bonancio Cerqueira, Carlos Henrique Castro, Gustavo Rodrigues Pedrino, Maria Helena Catelli de Carvalho, Roberto Pontarolo, Elson Alves Costa, Francinete Ramos Campos, Fernando Paranaiba Filgueira, Paulo César Ghedini. Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):934142. doi: 10.1155/2012/934142. [PMID: 22927883]
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  • Fernanda da Rocha Lapa, Kelly Cristina Soares, Yanna Dantas Rattmann, Sandra Crestani, Fabiana Cristina Missau, Moacir Geraldo Pizzolatti, Maria Consuelo Andrade Marques, Lia Rieck, Adair Roberto Soares Santos. Vasorelaxant and hypotensive effects of the extract and the isolated flavonoid rutin obtained from Polygala paniculata L. The Journal of pharmacy and pharmacology. 2011 Jun; 63(6):875-81. doi: 10.1111/j.2042-7158.2010.01240.x. [PMID: 21585387]
  • Joanne Yap, Caroline F H Foo, Ming Yee Lee, Peter G Stanton, Evdokia Dimitriadis. Proteomic analysis identifies interleukin 11 regulated plasma membrane proteins in human endometrial epithelial cells in vitro. Reproductive biology and endocrinology : RB&E. 2011 May; 9(?):73. doi: 10.1186/1477-7827-9-73. [PMID: 21619711]
  • Renata Frazão, Douglas G McMahon, Walter Schunack, Proleta Datta, Ruth Heidelberger, David W Marshak. Histamine elevates free intracellular calcium in mouse retinal dopaminergic cells via H1-receptors. Investigative ophthalmology & visual science. 2011 May; 52(6):3083-8. doi: 10.1167/iovs.10-6160. [PMID: 21310914]
  • Guglielmina Froldi, Riccardo Bertin, Enrico Secchi, Giuseppe Zagotto, Mariano Martínez-Vázquez, Aída García-Argaéz. Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms. Journal of ethnopharmacology. 2011 Apr; 134(3):637-43. doi: 10.1016/j.jep.2011.01.008. [PMID: 21236328]
  • Najeeb-Ur-Rehman, Malik Hassan Mehmood, Khalid M Alkharfy, Anwarul-Hassan Gilani. Prokinetic and laxative activities of Lepidium sativum seed extract with species and tissue selective gut stimulatory actions. Journal of ethnopharmacology. 2011 Apr; 134(3):878-83. doi: 10.1016/j.jep.2011.01.047. [PMID: 21296647]
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  • Anwarul Hassan Gilani, Aslam Khan, Arif-Ullah Khan, Samra Bashir, Najeeb-Ur Rehman, Saf-Ur-Rehman Mandukhail. Pharmacological basis for the medicinal use of Holarrhena antidysenterica in gut motility disorders. Pharmaceutical biology. 2010 Nov; 48(11):1240-6. doi: 10.3109/13880201003727960. [PMID: 20822397]
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  • Tianxiu Qian, Zongwei Cai. Biotransformation of ginsenosides Rb1, Rg3 and Rh2 in rat gastrointestinal tracts. Chinese medicine. 2010 May; 5(?):19. doi: 10.1186/1749-8546-5-19. [PMID: 20504301]
  • Yi-Liang Zhu, Shui-Jun Zhang, Yang-Mei Deng, Xin-Wei Dong, Jun-Xia Jiang, Qiang-Min Xie. Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs. Journal of neuroinflammation. 2010 Feb; 7(?):12. doi: 10.1186/1742-2094-7-12. [PMID: 20146826]
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  • Mamoru Kakino, Hiroshi Izuta, Tetsuro Ito, Kazuhiro Tsuruma, Yoko Araki, Masamitsu Shimazawa, Masayoshi Oyama, Munekazu Iinuma, Hideaki Hara. Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. Bioscience, biotechnology, and biochemistry. 2010; 74(8):1550-5. doi: 10.1271/bbb.100122. [PMID: 20699592]
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