Enalaprilat (BioDeep_00000398427)
代谢物信息卡片
Enalaprilat
化学式: C18H24N2O5 (348.1685)
中文名称: 依那普利拉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)N1CCCC1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O
InChI: InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14+,15+/m0/s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
2 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:4786
- PubChem: 5462501
- DrugBank: DB09477
- ChEMBL: CHEMBL577
- MeSH: Enalaprilat
- CAS: 76420-72-9
- MoNA: FiehnHILIC001911
- MoNA: FiehnHILIC001171
- MoNA: FiehnHILIC000331
- MoNA: CO000165
- MoNA: CO000164
- MoNA: CO000163
- MoNA: CO000162
- MoNA: CO000161
- KEGG: C11720
- PubChem: 13885
- KNApSAcK: 4786
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ekaterina Popova, Victoria Tikhomirova, Olga Beznos, Natalia Chesnokova, Yuri Grigoriev, Michael Taliansky, Olga Kost. A Direct Comparison of Peptide Drug Delivery Systems Based on the Use of Hybrid Calcium Phosphate/Chitosan Nanoparticles versus Unmixed Calcium Phosphate or Chitosan Nanoparticles In Vitro and In Vivo.
International journal of molecular sciences.
2023 Oct; 24(21):. doi:
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PloS one.
2022 ; 17(1):e0261000. doi:
10.1371/journal.pone.0261000. [PMID: 35085251] - Lucy H Her, Xinwen Wang, Jian Shi, Hee Jae Choi, Sun Min Jung, Logan S Smith, Audrey H Wu, Barry E Bleske, Hao-Jie Zhu. Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.
British journal of clinical pharmacology.
2021 12; 87(12):4691-4700. doi:
10.1111/bcp.14888. [PMID: 33963573] - Cindy Gueguen, Kristy L Jackson, Francine Z Marques, Nina Eikelis, Sarah Phillips, Emily R Stevenson, Fadi J Charchar, Gavin W Lambert, Pamela J Davern, Geoffrey A Head. Renal nerves contribute to hypertension in Schlager BPH/2J mice.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 03; 42(3):306-318. doi:
10.1038/s41440-018-0147-9. [PMID: 30531841] - David Dahlgren, Carl Roos, Pernilla Johansson, Anders Lundqvist, Christer Tannergren, Bertil Abrahamsson, Erik Sjögren, Hans Lennernäs. Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms.
Molecular pharmaceutics.
2016 09; 13(9):3022-33. doi:
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British journal of clinical pharmacology.
2015 Nov; 80(5):1131-8. doi:
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Journal of hypertension.
2015 Sep; 33(9):1931-8; discussion 1938. doi:
10.1097/hjh.0000000000000635. [PMID: 26147389] - Bjoern B Burckhardt, Jutta Tins, Stephanie Laeer. Simultaneous quantitative and qualitative analysis of aliskiren, enalapril and its active metabolite enalaprilat in undiluted human urine utilizing LC-ESI-MS/MS.
Biomedical chromatography : BMC.
2014 Dec; 28(12):1679-91. doi:
10.1002/bmc.3201. [PMID: 24788577] - Manuel Gómez-Díez, Ana Muñoz, Juan Manuel Serrano Caballero, Cristina Riber, Francisco Castejón, Juan Manuel Serrano-Rodríguez. Pharmacokinetics and pharmacodynamics of enalapril and its active metabolite, enalaprilat, at four different doses in healthy horses.
Research in veterinary science.
2014 Aug; 97(1):105-10. doi:
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Toxicology and applied pharmacology.
2014 Feb; 274(3):436-44. doi:
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American journal of nephrology.
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2013 May; 927(?):124-32. doi:
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Cardiovascular drugs and therapy.
2012 Dec; 26(6):511-9. doi:
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European review for medical and pharmacological sciences.
2012 Dec; 16(15):2162-70. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
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Biomedical chromatography : BMC.
2012 Jun; 26(6):697-702. doi:
10.1002/bmc.1716. [PMID: 21953651] - Feng Qin, Dan Wang, Shuyan Yang, Lijuan Jing, Zhili Xiong, Famei Li. Quantitative determination of lisinopril in human plasma by high performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Jun; 26(6):691-6. doi:
10.1002/bmc.1715. [PMID: 21932385] - Ingrid A-L Persson. The pharmacological mechanism of angiotensin-converting enzyme inhibition by green tea, Rooibos and enalaprilat - a study on enzyme kinetics.
Phytotherapy research : PTR.
2012 Apr; 26(4):517-21. doi:
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BMC gastroenterology.
2012 Mar; 12(?):26. doi:
10.1186/1471-230x-12-26. [PMID: 22453061] - Min Yu, Yang Zheng, Hong-Xia Sun, Du-Juan Yu. Inhibitory effects of enalaprilat on rat cardiac fibroblast proliferation via ROS/P38MAPK/TGF-β1 signaling pathway.
Molecules (Basel, Switzerland).
2012 Mar; 17(3):2738-51. doi:
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Drug testing and analysis.
2012 Feb; 4(2):94-103. doi:
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PloS one.
2012; 7(11):e49290. doi:
10.1371/journal.pone.0049290. [PMID: 23166630] - Syed Ahmed Zaki, Swapnil Bhongade, Preeti Shanbag. Enalapril induced severe hyponatremia and altered sensorium in a child.
Indian journal of pharmacology.
2011 Sep; 43(5):605-6. doi:
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The Journal of trauma.
2011 Sep; 71(3):663-71; discussion 672. doi:
10.1097/ta.0b013e31822175f6. [PMID: 21909000] - Fawzi Elsebaei, Yan Zhu. Fast gradient high performance liquid chromatography method with UV detection for simultaneous determination of seven angiotensin converting enzyme inhibitors together with hydrochlorothiazide in pharmaceutical dosage forms and spiked human plasma and urine.
Talanta.
2011 Jul; 85(1):123-9. doi:
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Shock (Augusta, Ga.).
2011 Jun; 35(6):542-9. doi:
10.1097/shk.0b013e3182115e6a. [PMID: 21283060] - K K Tripathi. Very low frequency oscillations in the power spectra of heart rate variability during dry supine immersion and exposure to non-hypoxic hypobaria.
Physiological measurement.
2011 Jun; 32(6):717-29. doi:
10.1088/0967-3334/32/6/008. [PMID: 21606562] - Lei Tian, Hong Liu, Shuang Xie, Juanjuan Jiang, Lulu Han, Yiling Huang, Yishi Li. Effect of organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphism on the single- and multiple-dose pharmacokinetics of enalapril in healthy Chinese adult men.
Clinical therapeutics.
2011 May; 33(5):655-63. doi:
10.1016/j.clinthera.2011.04.018. [PMID: 21665049] - Maria Fernanda de M Costa, Adriana K Carmona, Marcio F M Alves, Timothy M Ryan, Helen M Davies, Garry A Anderson, Ron F Slocombe. Determination of angiotensin I-converting enzyme activity in equine blood: lack of agreement between methods of analysis.
Journal of veterinary science.
2011 Mar; 12(1):21-5. doi:
10.4142/jvs.2011.12.1.21. [PMID: 21368559] - Rocio Bautista-Pérez, Abraham Arellano, Martha Franco, Horacio Osorio, Israel Coronel. Enalaprilat-mediated activation of kinin b(1) receptors and vasodilation in the rat isolated perfused kidney.
Pharmacology.
2011; 87(3-4):195-203. doi:
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Journal of biomedicine & biotechnology.
2011; 2011(?):290874. doi:
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Nutrition journal.
2010 Nov; 9(?):52. doi:
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2010 Oct; 878(28):2685-92. doi:
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Vascular health and risk management.
2010 Aug; 6(?):457-64. doi:
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PloS one.
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Hypertension (Dallas, Tex. : 1979).
2010 Feb; 55(2):298-304. doi:
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American journal of physiology. Renal physiology.
2010 Feb; 298(2):F401-7. doi:
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Critical care (London, England).
2010; 14(1):R24. doi:
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Therapeutic drug monitoring.
2009 Dec; 31(6):710-6. doi:
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Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.
2009 Oct; 95(10):1151-9. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Ze-Yuan Lei, Yue-Sheng Huang, Rong Xiao, Bing-Qian Zhang, Qiong Zhang. [Effects of angiotensin (1-7) and enalaprilat on function of isolated rat heart perfused by burn serum].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2009 Jun; 25(3):180-3. doi:
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Journal of pharmaceutical and biomedical analysis.
2009 Jan; 49(1):163-7. doi:
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PloS one.
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Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2008 Dec; 24(6):428-31. doi:
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Journal of chromatographic science.
2008 Nov; 46(10):848-53. doi:
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Biomedical chromatography : BMC.
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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La Clinica terapeutica.
2008 May; 159(3):151-4. doi:
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Hypertension (Dallas, Tex. : 1979).
2008 Feb; 51(2):345-51. doi:
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International immunopharmacology.
2008 Feb; 8(2):254-60. doi:
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Gender medicine.
2008; 5 Suppl A(?):S114-20. doi:
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Inflammation.
2007 Dec; 30(6):205-12. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
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Clinical and experimental pharmacology & physiology.
2007 Apr; 34(4):290-5. doi:
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Journal of internal medicine.
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Pediatrics.
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Acta physiologica (Oxford, England).
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American journal of hypertension.
2006 Jul; 19(7):756-63. doi:
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The Journal of pharmacology and experimental therapeutics.
2006 Jul; 318(1):395-402. doi:
10.1124/jpet.106.103390. [PMID: 16627748] - Hein A van Onzenoort, Michiel Bussink, Paul P Menheere, Walther N van Mook, Paul-Hugo M van der Kuy. The effect of sublingual captopril versus intravenous enalaprilat on angiotensin II plasma levels.
Pharmacy world & science : PWS.
2006 Jun; 28(3):131-4. doi:
10.1007/s11096-006-9024-8. [PMID: 17004021] - Ingrid A-L Persson, Linda Dong, Karin Persson. Effect of Panax ginseng extract (G115) on angiotensin-converting enzyme (ACE) activity and nitric oxide (NO) production.
Journal of ethnopharmacology.
2006 May; 105(3):321-5. doi:
10.1016/j.jep.2005.10.030. [PMID: 16387458] - J Schumacher, M R Puchakayala, K Binkowski, W Eichler, A Dendorfer, K-F Klotz. Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats.
British journal of anaesthesia.
2006 Apr; 96(4):437-43. doi:
10.1093/bja/ael030. [PMID: 16490762] - Sinisa Stanisavljevic, Tatjana Ignjatovic, Peter A Deddish, Viktor Brovkovych, Kai Zhang, Ervin G Erdös, Randal A Skidgel. Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells.
The Journal of pharmacology and experimental therapeutics.
2006 Mar; 316(3):1153-8. doi:
10.1124/jpet.105.093849. [PMID: 16282523] - Rene M Oliveira, Antonio A Oliveira Neto, Luiz C Miranda. Interference of enalaprilat on glomerular permeability to macromolecules (IgG) in acute unilateral ureteral obstruction in rats.
International braz j urol : official journal of the Brazilian Society of Urology.
2006 Mar; 32(2):216-21. doi:
10.1590/s1677-55382006000200016. [PMID: 16650303] - Dauren Biyashev, Fulong Tan, Zhenlong Chen, Kai Zhang, Peter A Deddish, Ervin G Erdös, Claudie Hecquet. Kallikrein activates bradykinin B2 receptors in absence of kininogen.
American journal of physiology. Heart and circulatory physiology.
2006 Mar; 290(3):H1244-50. doi:
10.1152/ajpheart.00934.2005. [PMID: 16272198] - Maria Claudina Camargo de Andrade, Giovana Seno Di Marco, Vicente de Paulo Castro Teixeira, Renato Arruda Mortara, Regiane Angélica Sabatini, João Bosco Pesquero, Miriam Aparecida Boim, Adriana Karaoglanovic Carmona, Nestor Schor, Dulce Elena Casarini. Expression and localization of N-domain ANG I-converting enzymes in mesangial cells in culture from spontaneously hypertensive rats.
American journal of physiology. Renal physiology.
2006 Feb; 290(2):F364-75. doi:
10.1152/ajprenal.00110.2005. [PMID: 16106038] - David G Levitt, Rik C Schoemaker. Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.
BMC clinical pharmacology.
2006 Jan; 6(?):1. doi:
10.1186/1472-6904-6-1. [PMID: 16398929] - Javid Sadjadi, Gerald L Kramer, Chun-Hua Yu, M Burress Welborn, J Gregory Modrall. Angiotensin II exerts positive feedback on the intrarenal renin-angiotensin system by an angiotensin converting enzyme-dependent mechanism.
The Journal of surgical research.
2005 Dec; 129(2):272-7. doi:
10.1016/j.jss.2005.04.044. [PMID: 15992826] - Farid Nakhoul, Rawi Ramadan, Eliyahu Khankin, Afif Yaccob, Zoya Kositch, Moshe Lewin, Suheir Assady, Zaid Abassi. Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies.
American journal of physiology. Renal physiology.
2005 Oct; 289(4):F880-90. doi:
10.1152/ajprenal.00451.2004. [PMID: 15942045] - Marcelo Rodrigues Borba, Roberto Iglesias Lopes, Murilo Carmona, Boulangier Mioto Neto, Sérgio Carlos Nahas, Paulo Roberto Bueno Pereira. Effects of enalaprilat on the renin-angiotensin-aldosterone system and on renal function during CO2 pneumoperitoneum.
Journal of endourology.
2005 Oct; 19(8):1026-31. doi:
10.1089/end.2005.19.1026. [PMID: 16253075] - T Arafat, R Awad, M Hamad, R Azzam, A Al-Nasan, A Jehanli, K Matalka. Pharmacokinetics and pharmacodynamics profiles of enalapril maleate in healthy volunteers following determination of enalapril and enalaprilat by two specific enzyme immunoassays.
Journal of clinical pharmacy and therapeutics.
2005 Aug; 30(4):319-28. doi:
10.1111/j.1365-2710.2005.00646.x. [PMID: 15985045] - Phensri Thongnopnua, Chotima Poeaknapo. High-performance liquid chromatographic determination of enalapril in human plasma by enzyme kinetic analytical method.
Journal of pharmaceutical and biomedical analysis.
2005 Apr; 37(4):763-9. doi:
10.1016/j.jpba.2004.10.053. [PMID: 15797799] - Thomas Elung-Jensen, Jens Heisterberg, Jesper Sonne, Svend Strandgaard, Anne-Lise Kamper. Enalapril dosage in progressive chronic nephropathy: a randomised, controlled trial.
European journal of clinical pharmacology.
2005 Apr; 61(2):87-96. doi:
10.1007/s00228-005-0893-x. [PMID: 15761754] - Dewan S A Majid, Akira Nishiyama, Keith E Jackson, Alexander Castillo. Superoxide scavenging attenuates renal responses to ANG II during nitric oxide synthase inhibition in anesthetized dogs.
American journal of physiology. Renal physiology.
2005 Feb; 288(2):F412-9. doi:
10.1152/ajprenal.00294.2004. [PMID: 15467005] - Ningjun Li, Joseph Zimpelmann, Keding Cheng, John A Wilkins, Kevin D Burns. The role of angiotensin converting enzyme 2 in the generation of angiotensin 1-7 by rat proximal tubules.
American journal of physiology. Renal physiology.
2005 Feb; 288(2):F353-62. doi:
10.1152/ajprenal.00144.2004. [PMID: 15467007] - Fernando Boix, Cecilie Røe, Laila Rosenborg, Stein Knardahl. Kinin peptides in human trapezius muscle during sustained isometric contraction and their relation to pain.
Journal of applied physiology (Bethesda, Md. : 1985).
2005 Feb; 98(2):534-40. doi:
10.1152/japplphysiol.01340.2003. [PMID: 15475593] - Jill M Wecht, Miroslav Radulovic, Joseph P Weir, Joanah Lessey, Ann M Spungen, William A Bauman. Partial angiotensin-converting enzyme inhibition during acute orthostatic stress in persons with tetraplegia.
The journal of spinal cord medicine.
2005; 28(2):103-8. doi:
10.1080/10790268.2005.11753806. [PMID: 15889697] - Qi Gu, Xiaoyan Chen, Dafang Zhong, Yingwu Wang. Simultaneous determination of enalapril and enalaprilat in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Dec; 813(1-2):337-42. doi:
10.1016/j.jchromb.2004.09.031. [PMID: 15556550] - P L Toutain, H P Lefèbvre. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationships for angiotensin-converting enzyme inhibitors.
Journal of veterinary pharmacology and therapeutics.
2004 Dec; 27(6):515-25. doi:
10.1111/j.1365-2885.2004.00601.x. [PMID: 15601445] - Handan Türker, Asli Dönmez, Pinar Zeyneloğlu, Atilla Sezgin, Melek Uluçam. Effects of enalaprilat infusion on hemodynamics and renal function in patients undergoing cardiac surgery.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.
2004 Dec; 4(4):296-300. doi:
. [PMID: 15590356] - Joseph Francis, Shun-Guang Wei, Robert M Weiss, Robert B Felder. Brain angiotensin-converting enzyme activity and autonomic regulation in heart failure.
American journal of physiology. Heart and circulatory physiology.
2004 Nov; 287(5):H2138-46. doi:
10.1152/ajpheart.00112.2004. [PMID: 15475532] - S Adler, H Huang. Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase.
American journal of physiology. Renal physiology.
2004 Nov; 287(5):F907-13. doi:
10.1152/ajprenal.00060.2004. [PMID: 15475543] - Ana A F Padua, Rafael E Barrientos-Astigarraga, Vinicius M Rezende, Gustavo D Mendes, Gilberto De Nucci. Lisinopril quantification in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Oct; 809(2):211-6. doi:
10.1016/j.jchromb.2004.06.021. [PMID: 15315767] - Kate M Denton, Amany Shweta, Rebecca L Flower, Warwick P Anderson. Predominant postglomerular vascular resistance response to reflex renal sympathetic nerve activation during ANG II clamp in rabbits.
American journal of physiology. Regulatory, integrative and comparative physiology.
2004 Oct; 287(4):R780-6. doi:
10.1152/ajpregu.00202.2004. [PMID: 15191904] - Albert Quan, Sumana Chakravarty, Jian-Kang Chen, Jian-Chun Chen, Samer Loleh, Neel Saini, Ray C Harris, Jorge Capdevila, Raymond Quigley. Androgens augment proximal tubule transport.
American journal of physiology. Renal physiology.
2004 Sep; 287(3):F452-9. doi:
10.1152/ajprenal.00188.2003. [PMID: 15100096] - Ives Hubloue, Benoît Rondelet, François Kerbaul, Dominique Biarent, Guiti Malekzadeh Milani, Michel Staroukine, Pierre Bergmann, Robert Naeije, Marc Leeman. Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs.
Critical care (London, England).
2004 Aug; 8(4):R163-71. doi:
10.1186/cc2860. [PMID: 15312214] - Pedro Zapater, Jesús Novalbos, Sonia Gallego-Sandín, Flavia T Hernández, Francisco Abad-Santos. Gender differences in angiotensin-converting enzyme (ACE) activity and inhibition by enalaprilat in healthy volunteers.
Journal of cardiovascular pharmacology.
2004 May; 43(5):737-44. doi:
10.1097/00005344-200405000-00018. [PMID: 15071363] - Mehul P Dixit, John D Hughes, Andreas Theodorou, Naznin M Dixit. Hyponatremic hypertensive syndrome (HHS) in an 18-month old-child presenting as malignant hypertension: a case report.
BMC nephrology.
2004 Apr; 5(?):5. doi:
10.1186/1471-2369-5-5. [PMID: 15113447] - Sarah Y Gardner, Clarke E Atkins, Richard A Sams, A Brooke Schwabenton, Mark G Papich. Characterization of the pharmacokinetic and pharmacodynamic properties of the angiotensin-converting enzyme inhibitor, enalapril, in horses.
Journal of veterinary internal medicine.
2004 Mar; 18(2):231-7. doi:
10.1892/0891-6640(2004)18<231:cotpap>2.0.co;2. [PMID: 15058776] - Hartmut Schächinger, Thomas Dieterle, Benedict Martina, Christoph Haberthür, Peter R Huber, Andreas Bock, Jürgen Drewe, Klaus Gyr. Increased renovascular response to angiotensin II in persons genetically predisposed to arterial hypertension disappears after chronic angiotensin-converting enzyme inhibition.
Journal of hypertension.
2004 Jan; 22(1):175-80. doi:
10.1097/00004872-200401000-00027. [PMID: 15106809] - Stephen Adler, Harer Huang, Michael S Wolin, Pawel M Kaminski. Oxidant stress leads to impaired regulation of renal cortical oxygen consumption by nitric oxide in the aging kidney.
Journal of the American Society of Nephrology : JASN.
2004 Jan; 15(1):52-60. doi:
10.1097/01.asn.0000101032.21097.c5. [PMID: 14694157] - Ioannis Niopas, Athanasios C Daftsios, Nicolaos Nikolaidis. Evaluation of the bioequivalence of two tablet formulations of enalapril/hydrochlorothiazide after single oral administration to healthy volunteers.
Arzneimittel-Forschung.
2004; 54(3):160-5. doi:
10.1055/s-0031-1296953. [PMID: 15112862] - Kenichi Yasunari, Kensaku Maeda, Munehiro Nakamura, Takanori Watanabe, Junichi Yoshikawa, Akira Asada. Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile.
Cardiovascular drug reviews.
2004; 22(3):189-98. doi:
10.1111/j.1527-3466.2004.tb00140.x. [PMID: 15492767]
