fluvastatin (BioDeep_00000397825)

Main id: BioDeep_00000002436

 


代谢物信息卡片


(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid

化学式: C24H26FNO4 (411.1846)
中文名称: 氟伐他汀
谱图信息: 最多检出来源 Danio rerio(blood) 16.67%

分子结构信息

SMILES: CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)O)O)O)C3=CC=C(C=C3)F
InChI: InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
C471 - Enzyme Inhibitor > C1655 - HMG-CoA Reductase Inhibitor
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3136
Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1][2][3].

同义名列表

5 个代谢物同义名

(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; fluvastatin; Fluvastatine; XU 62-320 (free acid); Fluvastatin



数据库引用编号

46 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Stephen P Adams, Nima Alaeiilkhchi, Sara Tasnim, James M Wright. Pravastatin for lowering lipids. The Cochrane database of systematic reviews. 2023 09; 9(?):CD013673. doi: 10.1002/14651858.cd013673.pub2. [PMID: 37721222]
  • Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis. The Cochrane database of systematic reviews. 2023 Aug; 8(?):CD013573. doi: 10.1002/14651858.cd013573.pub2. [PMID: 37565307]
  • Zi Hao Zhang, Li Chao Yue Sun, Hong Yan Gu, De Chun Jiang, Zhan Miao Yi. Associations between SLCO1B1, APOE and CYP2C9 and lipid-lowering efficacy and pharmacokinetics of fluvastatin: a meta-analysis. Pharmacogenomics. 2023 06; 24(8):475-484. doi: 10.2217/pgs-2023-0004. [PMID: 37318060]
  • Gökçe Ceren Kuşçu, Çevik Gürel, Aylin Buhur, Nefise Ülkü Karabay Yavaşoğlu, Timur Köse, Altuğ Yavaşoğlu, Fatih Oltulu. Fluvastatin alleviates doxorubicin-induced cardiac and renal toxicity in rats via regulation of oxidative stress, inflammation, and apoptosis associated genes expressions. Drug and chemical toxicology. 2023 Mar; 46(2):400-411. doi: 10.1080/01480545.2022.2043351. [PMID: 35209778]
  • Michalina Zaborowska, Dorota Matyszewska, Renata Bilewicz. Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins. Langmuir : the ACS journal of surfaces and colloids. 2022 11; 38(45):13888-13897. doi: 10.1021/acs.langmuir.2c02115. [PMID: 36335466]
  • Mohamed H Al-Sabri, Neha Behare, Ahmed M Alsehli, Samuel Berkins, Aadeya Arora, Eirini Antoniou, Eleni I Moysiadou, Sowmya Anantha-Krishnan, Patricia D Cosmen, Johanna Vikner, Thiago C Moulin, Nourhene Ammar, Hadi Boukhatmi, Laura E Clemensson, Mathias Rask-Andersen, Jessica Mwinyi, Michael J Williams, Robert Fredriksson, Helgi B Schiöth. Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes. Cells. 2022 11; 11(22):. doi: 10.3390/cells11223528. [PMID: 36428957]
  • Wenhao Wang, Fangqin Fu, Zhengwei Huang, Wenhua Wang, Minglong Chen, Xiao Yue, Jintao Fu, Xiaoqian Feng, Ying Huang, Chuanbin Wu, Xin Pan. Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy. ACS nano. 2022 05; 16(5):8370-8387. doi: 10.1021/acsnano.2c02634. [PMID: 35575209]
  • Hanan Elimam, Jihan Hussein, Yasmin Abdel-Latif, Amal Kamal Abdel-Aziz, Khalid M El-Say. Preclinical activity of fluvastatin-loaded self-nanoemulsifying delivery system against breast cancer models: Emphasis on apoptosis. Journal of cellular biochemistry. 2022 05; 123(5):947-963. doi: 10.1002/jcb.30238. [PMID: 35342983]
  • Dipanjan Ghosh, Debabrata Ghosh Dastidar, Kamalesh Roy, Arnab Ghosh, Debanjan Mukhopadhyay, Nilabja Sikdar, Nidhan K Biswas, Gopal Chakrabarti, Amlan Das. Computational prediction of the molecular mechanism of statin group of drugs against SARS-CoV-2 pathogenesis. Scientific reports. 2022 04; 12(1):6241. doi: 10.1038/s41598-022-09845-y. [PMID: 35422113]
  • Neeti Vashi, Cameron Ackerley, Martin Post, Monica J Justice. Aberrant lung lipids cause respiratory impairment in a Mecp2-deficient mouse model of Rett syndrome. Human molecular genetics. 2021 11; 30(22):2161-2176. doi: 10.1093/hmg/ddab182. [PMID: 34230964]
  • Najah S Alanazi, Tahani S Alenazi, Khalidah A Alenzi. Hepatotoxicity Induced by Fluvastatin: A Reversible Acute Cholestatic Liver Injury. The American journal of case reports. 2021 Aug; 22(?):e931418. doi: 10.12659/ajcr.931418. [PMID: 34383728]
  • Yue Xiang, Hideaki Okochi, Ivan Kozachenko, Jasleen K Sodhi, Lynda A Frassetto, Leslie Z Benet. Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers. Clinical pharmacology and therapeutics. 2021 08; 110(2):480-485. doi: 10.1002/cpt.2268. [PMID: 33880760]
  • Fauziah Mohd Jaafar, Baptiste Monsion, Mourad Belhouchet, Peter P C Mertens, Houssam Attoui. Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved. Viruses. 2021 07; 13(8):. doi: 10.3390/v13081437. [PMID: 34452303]
  • Hatice Nurdan Aksoy, Cagatay Ceylan. Comparison of the Effects of Statins on A549 Nonsmall-Cell Lung Cancer Cell Line Lipids Using Fourier Transform Infrared Spectroscopy: Rosuvastatin Stands Out. Lipids. 2021 05; 56(3):289-299. doi: 10.1002/lipd.12296. [PMID: 33611813]
  • Joseph Longo, Petr Smirnov, Zhihua Li, Emily Branchard, Jenna E van Leeuwen, Jonathan D Licht, Benjamin Haibe-Kains, David W Andrews, Jonathan J Keats, Trevor J Pugh, Suzanne Trudel, Linda Z Penn. The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma. Leukemia. 2021 03; 35(3):796-808. doi: 10.1038/s41375-020-0962-2. [PMID: 32665698]
  • Martina Felder, Claudia Irene Maushart, Gani Gashi, Jaël Rut Senn, Anton S Becker, Julian Müller, Miroslav Balaz, Christian Wolfrum, Irene A Burger, Matthias Johannes Betz. Fluvastatin Reduces Glucose Tolerance in Healthy Young Individuals Independently of Cold Induced BAT Activity. Frontiers in endocrinology. 2021; 12(?):765807. doi: 10.3389/fendo.2021.765807. [PMID: 34858338]
  • Zhiqiang Zhao, Yu Yang, Jianwei Wang, Zhaojie Dong, Xiaowei Niu, Enzhao Liu, Tong Liu, Lifeng Li, Yingzi Liang, Guangping Li. Combined treatment with valsartan and fluvastatin to delay disease progression in nonpermanent atrial fibrillation with hypertension: A clinical trial. Clinical cardiology. 2020 Dec; 43(12):1592-1600. doi: 10.1002/clc.23487. [PMID: 33103770]
  • Joseph Longo, Robert J Hamilton, Mehdi Masoomian, Najia Khurram, Emily Branchard, Peter J Mullen, Mohamad Elbaz, Karen Hersey, Dianne Chadwick, Sangeet Ghai, David W Andrews, Eric X Chen, Theodorus H van der Kwast, Neil E Fleshner, Linda Z Penn. A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer. Prostate cancer and prostatic diseases. 2020 12; 23(4):630-637. doi: 10.1038/s41391-020-0221-7. [PMID: 32203069]
  • Furqan Muqri, Alex Helkin, Kristopher G Maier, Vivian Gahtan. Thrombospondin-5 and fluvastatin promote angiogenesis and are protective against endothelial cell apoptosis. Journal of cellular biochemistry. 2020 10; 121(10):4154-4165. doi: 10.1002/jcb.29686. [PMID: 32348623]
  • Shun Tanimura, Mutsumi Nishida, Tatsunori Horie, Tamotsu Kamishima, Hitomi Matsumoto, Yutaka Morimura, Yuka Nishibata, Sakiko Masuda, Daigo Nakazawa, Utano Tomaru, Tatsuya Atsumi, Akihiro Ishizu. Fluvastatin prevents the development of arthritis in env-pX rats via up-regulation of Rho GTPase-activating protein 12. Experimental and molecular pathology. 2020 08; 115(?):104454. doi: 10.1016/j.yexmp.2020.104454. [PMID: 32422132]
  • Patrick A Paez, Motunrayo Kolawole, Marcela T Taruselli, Siddarth Ajith, Jordan M Dailey, Sydney A Kee, Tamara T Haque, Brian O Barnstein, Jamie Josephine Avila McLeod, Heather L Caslin, Kasalina N Kiwanuka, Yoshihiro Fukuoka, Quang T Le, Lawrence B Schwartz, David B Straus, David A Gewirtz, Rebecca K Martin, John J Ryan. Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells. The Journal of pharmacology and experimental therapeutics. 2020 07; 374(1):104-112. doi: 10.1124/jpet.119.264234. [PMID: 32434944]
  • Xiaoqing Fan, Jie Bai, Minwan Hu, Yanxia Xu, Shengyu Zhao, Yanhong Sun, Baolian Wang, Jinping Hu, Yan Li. Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects. Toxicology. 2020 05; 437(?):152445. doi: 10.1016/j.tox.2020.152445. [PMID: 32259555]
  • Akihiro Maenaka, Iwasaki Kenta, Akinobu Ota, Yuko Miwa, Wataru Ohashi, Kosei Horimi, Yutaka Matsuoka, Masafumi Ohnishi, Kazuharu Uchida, Takaaki Kobayashi. Interferon-γ-induced HLA Class II expression on endothelial cells is decreased by inhibition of mTOR and HMG-CoA reductase. FEBS open bio. 2020 05; 10(5):927-936. doi: 10.1002/2211-5463.12854. [PMID: 32237049]
  • Roberta Natália Cestari, Juciene Aparecida Caris, Adriana Rocha, Glauco Henrique Balthazar Nardotto, Renê Donizeti Ribeiro de Oliveira, Vera Lucia Lanchote. Plasma mevalonic acid exposure as a pharmacodynamic biomarker of fluvastatin/atorvastatin in healthy volunteers. Journal of pharmaceutical and biomedical analysis. 2020 Apr; 182(?):113128. doi: 10.1016/j.jpba.2020.113128. [PMID: 32004772]
  • Juciene Aparecida Caris, Jhohann Richard de Lima Benzi, Flávio Falcão Lima de Souza, Renê Donizeti Ribeiro de Oliveira, Eduardo Antônio Donadi, Vera Lucia Lanchote. Rheumatoid arthritis downregulates the drug transporter OATP1B1: Fluvastatin as a probe. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Apr; 146(?):105264. doi: 10.1016/j.ejps.2020.105264. [PMID: 32058056]
  • Kazuki Okubo, Makoto Isono, Kosuke Miyai, Takako Asano, Akinori Sato. Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells. Cancer science. 2020 Jan; 111(1):112-126. doi: 10.1111/cas.14225. [PMID: 31675763]
  • Cevik Gurel, Gokce Ceren Kuscu, Aylin Buhur, Melih Dagdeviren, Fatih Oltulu, Nefise Ulku Karabay Yavasoglu, Altug Yavasoglu. Fluvastatin attenuates doxorubicin-induced testicular toxicity in rats by reducing oxidative stress and regulating the blood-testis barrier via mTOR signaling pathway. Human & experimental toxicology. 2019 Dec; 38(12):1329-1343. doi: 10.1177/0960327119862006. [PMID: 31272229]
  • K Esmeijer, Olaf M Dekkers, Johan W de Fijter, Friedo W Dekker, Ellen K Hoogeveen. Effect of different types of statins on kidney function decline and proteinuria: a network meta-analysis. Scientific reports. 2019 11; 9(1):16632. doi: 10.1038/s41598-019-53064-x. [PMID: 31719617]
  • Ji Woong Roh, Kyeong-Hyeon Chun, Moonjong Kang, Chan Joo Lee, Jaewon Oh, Chi-Young Shim, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Sungha Park, Hyuk-Jae Chang, Geu-Ru Hong, Young-Guk Ko, Seok-Min Kang, Donghoon Choi, Jong-Won Ha, Myeong-Ki Hong, Yangsoo Jang, Sang-Hak Lee. PRavastatin Versus FlUVastatin After Statin Intolerance: The PRUV-Intolerance Study With Propensity Score Matching. The American journal of medicine. 2019 11; 132(11):1320-1326.e1. doi: 10.1016/j.amjmed.2019.06.003. [PMID: 31278931]
  • Amin Farzanegan Gharabolagh, Taravat Bamdad, Mehdi Hedayati, Seyed Ali Dehghan Manshadi. The Synergistic Effect of Fluvastatin and IFN-λ on Peripheral Blood Mononuclear Cells of Chronic Hepatitis C Virus (HCV) Patients with IL-28B rs12979860 CC Genotype. Iranian journal of allergy, asthma, and immunology. 2019 Oct; 18(5):533-542. doi: 10.18502/ijaai.v18i5.1923. [PMID: 32245297]
  • Seun Deuk Hwang, Jin Ho Lee, Jong Hyun Jhee, Yoon Ji Kim, Keun-Myoung Park, Joong Kyung Kim, Seoung Woo Lee, Joon Ho Song. Effect of Fluvastatin on Cardiovascular Complications in Kidney Transplant Patients: A Systemic Review and Meta-analysis. Transplantation proceedings. 2019 Oct; 51(8):2710-2713. doi: 10.1016/j.transproceed.2019.04.087. [PMID: 31447193]
  • Päivi Hirvensalo, Aleksi Tornio, Mikko Neuvonen, Wilma Kiander, Heidi Kidron, Maria Paile-Hyvärinen, Tuija Tapaninen, Janne T Backman, Mikko Niemi. Enantiospecific Pharmacogenomics of Fluvastatin. Clinical pharmacology and therapeutics. 2019 09; 106(3):668-680. doi: 10.1002/cpt.1463. [PMID: 30989645]
  • Masanobu Tsubaki, Tomoya Takeda, Naoya Obata, Keishi Kawashima, Mitsuki Tabata, Motohiro Imano, Takao Satou, Shozo Nishida. Combination therapy with dacarbazine and statins improved the survival rate in mice with metastatic melanoma. Journal of cellular physiology. 2019 08; 234(10):17975-17989. doi: 10.1002/jcp.28430. [PMID: 30834527]
  • Piotr Ruszkowski, Anna Masajtis-Zagajewska, Michał Nowicki. Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2019 Jul; 20(3):1470320319868890. doi: 10.1177/1470320319868890. [PMID: 31486700]
  • Joseph Longo, Peter J Mullen, Rosemary Yu, Jenna E van Leeuwen, Mehdi Masoomian, Dixon T S Woon, Yuzhuo Wang, Eric X Chen, Robert J Hamilton, Joan M Sweet, Theodorus H van der Kwast, Neil E Fleshner, Linda Z Penn. An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer. Molecular metabolism. 2019 07; 25(?):119-130. doi: 10.1016/j.molmet.2019.04.003. [PMID: 31023626]
  • Jae H Chang, Xiaolin Zhang, Kirsten Messick, Yi-Chen Chen, Eugene Chen, Jonathan Cheong, Justin Ly. Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse. Xenobiotica; the fate of foreign compounds in biological systems. 2019 May; 49(5):602-610. doi: 10.1080/00498254.2018.1478167. [PMID: 29768081]
  • Xiaorong Xu Parks, Elsa Ronzier, Jin O-Uchi, Coeli M Lopes. Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic Ca2+-dependent PKC activation. Journal of molecular and cellular cardiology. 2019 04; 129(?):314-325. doi: 10.1016/j.yjmcc.2019.03.016. [PMID: 30898664]
  • Henock G Yebyo, Hélène E Aschmann, Marco Kaufmann, Milo A Puhan. Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis, and network meta-analysis of randomized trials with 94,283 participants. American heart journal. 2019 04; 210(?):18-28. doi: 10.1016/j.ahj.2018.12.007. [PMID: 30716508]
  • Rei Miyamoto, Takashi Nozawa, Koichi Shiozuka, Kenji Tabata. The Impact of Endogenous Breast Cancer Resistance Protein on Human P-Glycoprotein-Mediated Transport Assays Using LLC-PK1 Cells Transfected With Human P-Glycoprotein. Journal of pharmaceutical sciences. 2019 Mar; 108(3):1085-1089. doi: 10.1016/j.xphs.2018.10.012. [PMID: 30339864]
  • Leisan F Galiullina, Holger A Scheidt, Daniel Huster, Albert Aganov, Vladimir Klochkov. Interaction of statins with phospholipid bilayers studied by solid-state NMR spectroscopy. Biochimica et biophysica acta. Biomembranes. 2019 03; 1861(3):584-593. doi: 10.1016/j.bbamem.2018.12.013. [PMID: 30578770]
  • Lilian H J Richter, Andreas Beck, Veit Flockerzi, Hans H Maurer, Markus R Meyer. Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay. Toxicology letters. 2019 Feb; 301(?):79-89. doi: 10.1016/j.toxlet.2018.11.007. [PMID: 30465810]
  • James C Y Chan, Shawn P F Tan, Zee Upton, Eric C Y Chan. Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing. ALTEX. 2019; 36(4):597-612. doi: 10.14573/altex.1812051. [PMID: 31079160]
  • Qian Xiang, Xiaodan Zhang, Lingyue Ma, Kun Hu, Zhuo Zhang, Guangyan Mu, Qiufen Xie, Shuqing Chen, Yimin Cui. The association between the SLCO1B1, apolipoprotein E, and CYP2C9 genes and lipid response to fluvastatin: a meta-analysis. Pharmacogenetics and genomics. 2018 12; 28(12):261-267. doi: 10.1097/fpc.0000000000000356. [PMID: 30363031]
  • Yinzi Yue, Shuai Yan, Huan Li, Yang Zong, Jin Yue, Li Zeng. The role of oral fluvastatin on postoperative peritoneal adhesion formation in an experimental rat model. Acta chirurgica Belgica. 2018 Dec; 118(6):372-379. doi: 10.1080/00015458.2018.1444549. [PMID: 29482467]
  • Usama A Fahmy. Augmentation of Fluvastatin Cytotoxicity Against Prostate Carcinoma PC3 Cell Line Utilizing Alpha Lipoic-Ellagic Acid Nanostructured Lipid Carrier Formula. AAPS PharmSciTech. 2018 Nov; 19(8):3454-3461. doi: 10.1208/s12249-018-1199-5. [PMID: 30350252]
  • Prasanthi Polamreddy, Vinita Vishwakarma, Puneet Saxena. Identification of potential anti-hepatitis C virus agents targeting non structural protein 5B using computational techniques. Journal of cellular biochemistry. 2018 11; 119(10):8574-8587. doi: 10.1002/jcb.27071. [PMID: 30058078]
  • Shingen Misaka, Osamu Abe, Hideyuki Sato, Tomoyuki Ono, Yayoi Shikama, Satomi Onoue, Hirooki Yabe, Junko Kimura. Lack of pharmacokinetic interaction between fluvastatin and green tea in healthy volunteers. European journal of clinical pharmacology. 2018 May; 74(5):601-609. doi: 10.1007/s00228-018-2420-x. [PMID: 29368187]
  • Katla Venu Madhav, Veerabrahma Kishan. Improvement of Anti-Hyperlipidemic Activity and Oral Bioavailability of Fluvastatin Via Solid Self-Microemulsifying Systems and Comparative with Liquisolid Formulation. Current drug delivery. 2018; 15(9):1245-1260. doi: 10.2174/1567201815666180723115141. [PMID: 30033871]
  • Katja Vogt, Shailaja Mahajan-Thakur, Robert Wolf, Susanne Bröderdorf, Conny Vogel, Andreas Böhm, Christoph A Ritter, Markus Gräler, Stefan Oswald, Andreas Greinacher, Heyo K Kroemer, Gabriele Jedlitschky, Bernhard H Rauch. Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins. Thrombosis and haemostasis. 2018 01; 118(1):132-142. doi: 10.1160/th17-04-0291. [PMID: 29304533]
  • Miodrag Janić, Mojca Lunder, Alenka France Štiglic, Aleš Jerin, Milan Skitek, Darko Černe, Janja Marc, Gorazd Drevenšek, Mišo Šabovič. Sub-therapeutic doses of fluvastatin and valsartan are more effective than therapeutic doses in providing beneficial cardiovascular pleiotropic effects in rats: A proof of concept study. Vascular pharmacology. 2017 12; 99(?):45-52. doi: 10.1016/j.vph.2017.09.005. [PMID: 28951255]
  • Jung Eun Jang, Han-Sol Park, Hyun Ju Yoo, In-Jeoung Baek, Ji Eun Yoon, Myoung Seok Ko, Ah-Ram Kim, Hyoun Sik Kim, Hye-Sun Park, Seung Eun Lee, Seung-Whan Kim, Su Jung Kim, Jaechan Leem, Yu Mi Kang, Min Kyo Jung, Chan-Gi Pack, Chong Jai Kim, Chang Ohk Sung, In-Kyu Lee, Joong-Yeol Park, José C Fernández-Checa, Eun Hee Koh, Ki-Up Lee. Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice. Hepatology (Baltimore, Md.). 2017 08; 66(2):416-431. doi: 10.1002/hep.29039. [PMID: 28073164]
  • Balasaheb B Chavan, Pradipbhai D Kalariya, Rakesh D Nimbalkar, Prabha Garg, R Srinivas, M V N Kumar Talluri. Identification and characterization of fluvastatin metabolites in rats by UHPLC/Q-TOF/MS/MS and in silico toxicological screening of the metabolites. Journal of mass spectrometry : JMS. 2017 05; 52(5):296-314. doi: 10.1002/jms.3929. [PMID: 28295913]
  • Young Hee Shin, Jeong Jin Min, Jong-Hwan Lee, Eun-Hee Kim, Go Eun Kim, Myung Hee Kim, Jeong Jin Lee, Hyun Joo Ahn. The effect of fluvastatin on cardiac fibrosis and angiotensin-converting enzyme-2 expression in glucose-controlled diabetic rat hearts. Heart and vessels. 2017 May; 32(5):618-627. doi: 10.1007/s00380-016-0936-5. [PMID: 28013371]
  • Jie-Hua Shi, Qi Wang, Dong-Qi Pan, Ting-Ting Liu, Min Jiang. Characterization of interactions of simvastatin, pravastatin, fluvastatin, and pitavastatin with bovine serum albumin: multiple spectroscopic and molecular docking. Journal of biomolecular structure & dynamics. 2017 May; 35(7):1529-1546. doi: 10.1080/07391102.2016.1188416. [PMID: 27484332]
  • Yang Cheng, RongCheng Luo, Hang Zheng, Biao Wang, YaHui Liu, DingLi Liu, JinZhang Chen, WanFu Xu, AiMin Li, Yun Zhu. Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma. Oncotarget. 2017 Apr; 8(14):23265-23276. doi: 10.18632/oncotarget.15575. [PMID: 28423574]
  • Pratik Desai, Alex Helkin, Adeola Odugbesi, Jeff Stein, David Bruch, Jack Lawler, Kristopher G Maier, Vivian Gahtan. Fluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice. The Journal of surgical research. 2017 04; 210(?):1-7. doi: 10.1016/j.jss.2016.10.007. [PMID: 28457315]
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