clofibric acid (BioDeep_00000397717)

   

Chemicals and Drugs


代谢物信息卡片


clofibric acid

化学式: C10H11ClO3 (214.0397)
中文名称: 2-(4-氯苯氧基)异丁酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C(=O)O)OC1=CC=C(C=C1)Cl
InChI: InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)

描述信息

A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D009676 - Noxae > D000963 - Antimetabolites
CONFIDENCE standard compound; EAWAG_UCHEM_ID 204

同义名列表

2 个代谢物同义名

clofibric acid; Clofibric acid



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, CAT, CYP1A1, CYP2B6, CYP2E1, HPGDS, RXRA
Peripheral membrane protein 5 CRAT, CYP1A1, CYP1B1, CYP2B6, CYP2E1
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 8 CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2E1, HMGCR, HSP90B1, SCD
Nucleus 5 ALB, HSP90B1, JUND, PPARA, RXRA
cytosol 8 ACOX1, ALB, CAT, CLCN5, CRAT, HPGDS, HSP90B1, RXRA
centrosome 1 ALB
nucleoplasm 4 HPGDS, JUND, PPARA, RXRA
RNA polymerase II transcription regulator complex 2 JUND, RXRA
Cell membrane 1 CLCN5
Multi-pass membrane protein 3 CLCN5, HMGCR, SCD
Golgi apparatus membrane 1 CLCN5
Golgi apparatus 2 ALB, CLCN5
Golgi membrane 2 CLCN5, INS
lysosomal membrane 2 CLCN5, EGF
mitochondrial inner membrane 3 CRAT, CYP1A1, CYP2E1
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 1 CLCN5
plasma membrane 2 CLCN5, EGF
Membrane 8 ACOX1, CAT, CLCN5, CYP1B1, EGF, HMGCR, HSP90B1, SCD
extracellular exosome 4 ALB, CAT, EGF, HSP90B1
endoplasmic reticulum 5 ALB, CRAT, HMGCR, HSP90B1, SCD
extracellular space 4 ALB, EGF, IL6, INS
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 5 CAT, CRAT, CYP1A1, CYP1B1, RXRA
protein-containing complex 3 ALB, CAT, HSP90B1
intracellular membrane-bounded organelle 7 CAT, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2E1, HPGDS
Microsome membrane 5 CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2E1
Secreted 3 ALB, IL6, INS
extracellular region 6 ALB, CAT, EGF, HSP90B1, IL6, INS
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 2 JUND, RXRA
nucleolus 1 SCD
midbody 1 HSP90B1
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
Mitochondrion inner membrane 3 CRAT, CYP1A1, CYP2E1
Matrix side 1 CRAT
focal adhesion 2 CAT, HSP90B1
Peroxisome 3 ACOX1, CAT, CRAT
Peroxisome matrix 1 CAT
peroxisomal matrix 3 ACOX1, CAT, CRAT
peroxisomal membrane 3 ACOX1, CAT, HMGCR
collagen-containing extracellular matrix 1 HSP90B1
receptor complex 1 RXRA
ciliary basal body 1 ALB
chromatin 3 JUND, PPARA, RXRA
centriole 1 ALB
[Isoform 1]: Mitochondrion 1 CRAT
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
Peroxisome membrane 1 HMGCR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, HSP90B1, IL6, INS
transcription repressor complex 1 JUND
platelet alpha granule lumen 2 ALB, EGF
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 EGF
Sarcoplasmic reticulum lumen 1 HSP90B1
endocytic vesicle lumen 1 HSP90B1
transcription factor AP-1 complex 1 JUND
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
[Isoform 2]: Peroxisome 1 CRAT
ciliary transition fiber 1 ALB


文献列表

  • Hugo Alarie, Nadia Côté, Luc Gaudreau, Magali Houde, Pedro A Segura. Are 20-hydroxyecdysone and related genes potential biomarkers of sublethal exposure to lipid-altering contaminants?. Environmental science and pollution research international. 2023 Dec; 30(60):126104-126115. doi: 10.1007/s11356-023-31087-2. [PMID: 38010540]
  • Mariana N Miranda, Ana R Lado Ribeiro, Adrián M T Silva, M Fernando R Pereira. Can aged microplastics be transport vectors for organic micropollutants? - Sorption and phytotoxicity tests. The Science of the total environment. 2022 Dec; 850(?):158073. doi: 10.1016/j.scitotenv.2022.158073. [PMID: 35981591]
  • Yundong Xie, Jiping Liu, Yongheng Shi, Bin Wang, Xiaoping Wang, Wei Wang, Meng Sun, Xinya Xu, Haihui Jiang, Min Guo, Yiyi He, Cuicui Ren, Lifei Cheng. The combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity. Bioorganic & medicinal chemistry letters. 2021 07; 44(?):128121. doi: 10.1016/j.bmcl.2021.128121. [PMID: 34015506]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • D Rebelo, A T Correia, B Nunes. Acute and chronic effects of environmental realistic concentrations of clofibric acid in Danio rerio: Behaviour, oxidative stress, biotransformation and lipid peroxidation endpoints. Environmental toxicology and pharmacology. 2020 Nov; 80(?):103468. doi: 10.1016/j.etap.2020.103468. [PMID: 32805388]
  • Mengmeng Han, Baoyuan Wang, Guilong Song, Shengqing Shi. Comparative study of alleviation effects of DMTU and PCIB on root growth inhibition in two tall fescue varieties under cadmium stress. Ecotoxicology and environmental safety. 2020 Jun; 196(?):110528. doi: 10.1016/j.ecoenv.2020.110528. [PMID: 32240865]
  • I B Gomes, M M Querido, J P Teixeira, C C Pereira, L C Simões, M Simões. Prolonged exposure of Stenotrophomonas maltophilia biofilms to trace levels of clofibric acid alters antimicrobial tolerance and virulence. Chemosphere. 2019 Nov; 235(?):327-335. doi: 10.1016/j.chemosphere.2019.06.184. [PMID: 31265978]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Letizia Giampietro, Antonio Laghezza, Carmen Cerchia, Rosalba Florio, Lucia Recinella, Fabio Capone, Alessandra Ammazzalorso, Isabella Bruno, Barbara De Filippis, Marialuigia Fantacuzzi, Claudio Ferrante, Cristina Maccallini, Paolo Tortorella, Fabio Verginelli, Luigi Brunetti, Alessandro Cama, Rosa Amoroso, Fulvio Loiodice, Antonio Lavecchia. Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. ACS medicinal chemistry letters. 2019 Apr; 10(4):545-551. doi: 10.1021/acsmedchemlett.8b00574. [PMID: 30996794]
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  • Iwona Żur, Ewa Dubas, Monika Krzewska, Piotr Waligórski, Michał Dziurka, Franciszek Janowiak. Hormonal requirements for effective induction of microspore embryogenesis in triticale (× Triticosecale Wittm.) anther cultures. Plant cell reports. 2015 Jan; 34(1):47-62. doi: 10.1007/s00299-014-1686-4. [PMID: 25261160]
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  • Manoharan Saravanan, Jang-Hyun Hur, Narayanasamy Arul, Mathan Ramesh. Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures. Environmental toxicology and pharmacology. 2014 Nov; 38(3):948-58. doi: 10.1016/j.etap.2014.10.013. [PMID: 25461555]
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