cetirizine (BioDeep_00000397560)

 

Secondary id: BioDeep_00000002909

Volatile Flavor Compounds


代谢物信息卡片


Levocetirizine

化学式: C21H25ClN2O3 (388.15536099999997)
中文名称: 西替利嗪, 左西替利嗪
谱图信息: 最多检出来源 Homo sapiens(blood) 7.04%

分子结构信息

SMILES: c1ccc(cc1)C(c1ccc(cc1)Cl)N1CCN(CC1)CCOCC(=O)O
InChI: InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)

描述信息

R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AE - Piperazine derivatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
S - Sensory organs > S01 - Ophthalmologicals > S01G - Decongestants and antiallergics
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
Cetirizine is a medication used for the treatment of allergies, hay fever, angioedema, and hives. It is a second-generation H1-receptor antagonist antihistamine and works by blocking H1 histamine receptors. It is a major metabolite of hydroxyzine, and has the same basic side effects, including dry mouth.; A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.; Cetirizine hydrochloride is a medication used for the treatment of allergies, hay fever, angioedema, and hives. It is a second-generation H1-receptor antagonist antihistamine and works by blocking H1 histamine receptors. It is a major metabolite of hydroxyzine, and has the same basic side effects, including dry mouth. [HMDB]
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4258; ORIGINAL_PRECURSOR_SCAN_NO 4255
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4282; ORIGINAL_PRECURSOR_SCAN_NO 4280
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4227; ORIGINAL_PRECURSOR_SCAN_NO 4225
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4253; ORIGINAL_PRECURSOR_SCAN_NO 4251
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4259; ORIGINAL_PRECURSOR_SCAN_NO 4258
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4253; ORIGINAL_PRECURSOR_SCAN_NO 4250
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8478; ORIGINAL_PRECURSOR_SCAN_NO 8477
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8516; ORIGINAL_PRECURSOR_SCAN_NO 8514
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8525; ORIGINAL_PRECURSOR_SCAN_NO 8524
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8560; ORIGINAL_PRECURSOR_SCAN_NO 8559
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8566; ORIGINAL_PRECURSOR_SCAN_NO 8564
CONFIDENCE standard compound; INTERNAL_ID 535; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8574; ORIGINAL_PRECURSOR_SCAN_NO 8573
CONFIDENCE standard compound; INTERNAL_ID 2124
CONFIDENCE standard compound; INTERNAL_ID 8582
CONFIDENCE standard compound; INTERNAL_ID 4110
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2772
Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1].

同义名列表

4 个代谢物同义名

cetirizine; Levocetirizine; (R)-Cetirizine; Cetirizine



数据库引用编号

83 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

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PlantCyc(0)

COVID-19 Disease Map(0)

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Warangkana Arpornchayanon, Soraya Klinprung, Sunee Chansakaow, Nutthiya Hanprasertpong, Saisawat Chaiyasate, Masaaki Tokuda, Hirotoshi Tamura. Antiallergic activities of shallot (Allium ascalonicum L.) and its therapeutic effects in allergic rhinitis. Asian Pacific journal of allergy and immunology. 2022 Dec; 40(4):393-400. doi: 10.12932/ap-300319-0529. [PMID: 31421664]
  • Hongjun Chen, Yujie Cheng, Hongmei Du, Cui Zhang, Yuan Zhou, Zhentao Zhao, Yong Li, Thomas Friedemann, Jinyu Mei, Sven Schröder, Ming Chen. Shufeng Jiedu capsule ameliorates olfactory dysfunction via the AMPK/mTOR autophagy pathway in a mouse model of allergic rhinitis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154426. doi: 10.1016/j.phymed.2022.154426. [PMID: 36116201]
  • Christine Wegler, Aljona Saleh, Annika Lindqvist, Hedvig Nordeng, John Smeraglia, Pawel Baranczewski. Simple and rapid quantification of cetirizine, venlafaxine, and O-desmethylvenlafaxine in human breast milk, and metformin in human milk and plasma with UHPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Aug; 1205(?):123340. doi: 10.1016/j.jchromb.2022.123340. [PMID: 35732105]
  • Tingnian Qu, Bo Huang, Li Lei, Shirong Luo. [Cetirizine inhibits activation of JAK2-STAT3 pathway and mast cell activation in lung tissue of asthmatic mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2022 Mar; 38(3):193-198. doi: . [PMID: 35365983]
  • Reza Tabaraki, Fereshteh Nazari. Comparison of Carbon Dots Prepared in Deep Eutectic Solvent and Water/Deep Eutectic Solvent: Study of Fluorescent Detection of Fe3+ and Cetirizine and their Photocatalytic Antibacterial Activity. Journal of fluorescence. 2022 Mar; 32(2):549-558. doi: 10.1007/s10895-021-02875-1. [PMID: 34989925]
  • Bruce Chandler May, Kathleen Holly Gallivan. Levocetirizine and montelukast in the COVID-19 treatment paradigm. International immunopharmacology. 2022 Feb; 103(?):108412. doi: 10.1016/j.intimp.2021.108412. [PMID: 34942461]
  • Yixuan Cui, Aoxuan Su, Jingying Feng, Weichong Dong, Junmei Li, Huan Wang, Xiaoyu Ni, Ye Jiang. Development of silica molecularly imprinted polymer on carbon dots as a fluorescence probe for selective and sensitive determination of cetirizine in saliva and urine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Jan; 264(?):120293. doi: 10.1016/j.saa.2021.120293. [PMID: 34455374]
  • A Yu Ovchinnikov, N A Miroshnichenko, Yu O Nikolaeva. [Modern H1 antihistamines in the treatment of patients with allergic rhinitis and comorbid acute respiratory infections]. Vestnik otorinolaringologii. 2022; 87(3):30-39. doi: 10.17116/otorino20228703130. [PMID: 35818943]
  • Stuart W Paine, Mohammed Aldurdunji, Alix Garth-Greeves, Tessa Muir, Pamela R Hincks. Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. Journal of veterinary pharmacology and therapeutics. 2022 Jan; 45(1):46-53. doi: 10.1111/jvp.13010. [PMID: 34469007]
  • Hina Shamshad, Ali Sayqal, Jahan Zeb, Agha Zeeshan Mirza. Simultaneous Determination of Chloroquine and Pyrimethamine with Cetirizine in an Active Form and Human Serum by RP-HPLC. Journal of chromatographic science. 2021 Oct; 59(10):923-927. doi: 10.1093/chromsci/bmab018. [PMID: 33621328]
  • Nida Naz, Saeeda Nadir Ali, Amtul Qayoom, Sajid Iqbal, Shumaila Akram. Rapid and sensitive method for simultaneous determination of citalopram with antihistamines by liquid chromatography. Pakistan journal of pharmaceutical sciences. 2021 May; 34(3):835-841. doi: . [PMID: 34602404]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Franklin R Aguilar-Gamboa, Dennis Cubas-Alarcon, Miguel Villegas-Chiroque, Virgilio E Failoc-Rojas. Pityriasis rubra pilaris post-infection due COVID-19: case report. Colombia medica (Cali, Colombia). 2021 Mar; 52(1):e7014577. doi: 10.25100/cm.v52i1.4577. [PMID: 33911322]
  • Stefano Veraldi, Maurizio Romagnuolo, Valentina Benzecry. Urticaria as a first clinical manifestation of COVID-19. European journal of dermatology : EJD. 2020 Dec; 30(6):737-738. doi: 10.1684/ejd.2020.3907. [PMID: 33459263]
  • Dipankar Bhattacharyya. Reposition of montelukast either alone or in combination with levocetirizine against SARS-CoV-2. Medical hypotheses. 2020 Nov; 144(?):110046. doi: 10.1016/j.mehy.2020.110046. [PMID: 33254480]
  • Almudena Perona, M Piedad Ros, Alberto Mills, Antonio Morreale, Federico Gago. Distinct binding of cetirizine enantiomers to human serum albumin and the human histamine receptor H1. Journal of computer-aided molecular design. 2020 10; 34(10):1045-1062. doi: 10.1007/s10822-020-00328-8. [PMID: 32572668]
  • Frane Banovic, Tara Denley, Amanda Blubaugh, Ileia Scheibe, Niksa Lemo, Mark G Papich. Effect of diphenhydramine and cetirizine on immediate and late-phase cutaneous allergic reactions in healthy dogs: a randomized, double-blinded crossover study. Veterinary dermatology. 2020 Aug; 31(4):256-e58. doi: 10.1111/vde.12840. [PMID: 31899570]
  • Reed B Hogan Ii, Reed B Hogan Iii, Tim Cannon, Maria Rappai, John Studdard, Doug Paul, Thomas P Dooley. Dual-histamine receptor blockade with cetirizine - famotidine reduces pulmonary symptoms in COVID-19 patients. Pulmonary pharmacology & therapeutics. 2020 08; 63(?):101942. doi: 10.1016/j.pupt.2020.101942. [PMID: 32871242]
  • Ana Carolina Conchon Costa, Priscila Akemi Yamamoto, Gabriela Rocha Lauretti, Jhohann Richard de Lima Benzi, Cleslei Fernando Zanelli, Vivien Barz, Giuliano Ciarimboli, Natália Valadares de Moraes. Cetirizine Reduces Gabapentin Plasma Concentrations and Effect: Role of Renal Drug Transporters for Organic Cations. Journal of clinical pharmacology. 2020 08; 60(8):1076-1086. doi: 10.1002/jcph.1603. [PMID: 32149389]
  • Seol Ju Moon, Kyung-Sang Yu, Jina Jung, Yong-Il Kim, Min-Gul Kim. Comparative pharmacokinetics of a montelukast/levocetirizine fixed-dose combination chewable tablet versus individual administration of montelukast and levocetirizine after a single oral administration in healthy Korean male subjects
. International journal of clinical pharmacology and therapeutics. 2020 Jun; 58(6):354-362. doi: 10.5414/cp203709. [PMID: 32271144]
  • Uriel Villela-Segura, Alessandra Irais Miranda-Aguirre, Lorena Estrada-Aguilar. Crateriform plaques in a patient with end-stage renal disease. The case of an acquired reactive perforating collagenosis. Nefrologia. 2020 May; 40(3):358-360. doi: 10.1016/j.nefro.2019.04.005. [PMID: 31351699]
  • Priyanka Lohar, Manish Kumar Sharma, Amit Kumar Sahu, Rajeswari Rathod, Pinaki Sengupta. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomedical chromatography : BMC. 2019 Dec; 33(12):e4672. doi: 10.1002/bmc.4672. [PMID: 31386207]
  • Heather K Knych, Daniel Weiner, Stacy Steinmetz, Katherine Flynn, Daniel S McKemie. Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics. 2019 Nov; 42(6):617-623. doi: 10.1111/jvp.12808. [PMID: 31490561]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Mehdi Bakhshaee, Mohammadreza Sharifian, Freshteh Esmatinia, Bashir Rasoulian, Masoud Mohebbi. Therapeutic effect of vitamin D supplementation on allergic rhinitis. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2019 Oct; 276(10):2797-2801. doi: 10.1007/s00405-019-05546-x. [PMID: 31332549]
  • Xianqiong Huang, Zhaoyang Li, Renshan Sun. High-dose levocetirizine for the treatment of refractory chronic spontaneous urticaria and the effect on the serum inositol triphosphate level. The Journal of international medical research. 2019 Sep; 47(9):4374-4379. doi: 10.1177/0300060519857768. [PMID: 31342821]
  • Ravi Raj Pal, Poonam Parashar, Indu Singh, Shubhini A Saraf. Tamanu oil potentiated novel sericin emulgel of levocetirizine: repurposing for topical delivery against DNCB-induced atopic dermatitis, QbD based development and in vivo evaluation. Journal of microencapsulation. 2019 Aug; 36(5):432-446. doi: 10.1080/02652048.2019.1637474. [PMID: 31238752]
  • Yu Cheng, Bi-Juan Lin, Jin-Hua Guo, Bing-Lin Huang, Lin-Ping Fang, Wan-Cai Que, Mao-Bai Liu, Xin-Feng Chen, Hong-Qiang Qiu. The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers. Drug design, development and therapy. 2019; 13(?):3625-3634. doi: 10.2147/dddt.s215316. [PMID: 31695330]
  • Carl Ekstrand, Carina Ingvast-Larsson, Ulf Bondesson, Mikael Hedeland, Lena Olsén. Cetirizine per os: exposure and antihistamine effect in the dog. Acta veterinaria Scandinavica. 2018 Nov; 60(1):77. doi: 10.1186/s13028-018-0431-3. [PMID: 30477556]
  • Seokuee Kim, Jae-Wook Ko, Jung-Ryul Kim. Comparison of the pharmacokinetics and tolerability of montelukast/levocetirizine administered as a fixed-dose combination and as separate tablets. International journal of clinical pharmacology and therapeutics. 2018 Sep; 56(9):443-450. doi: 10.5414/cp203265. [PMID: 30021691]
  • Ronan Gealageas, Alice Devineau, Pauline P L So, Catrina M J Kim, Jayakumar Surendradoss, Christian Buchwalder, Markus Heller, Verena Goebeler, Edith M Dullaghan, David S Grierson, Edward E Putnins. Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases. Journal of medicinal chemistry. 2018 08; 61(16):7043-7064. doi: 10.1021/acs.jmedchem.7b01588. [PMID: 30016860]
  • Young-Eun Kim, Mi Ju Son, So Young Jung, Ojin Kwon, Jun-Hwan Lee, Dong-Hyo Lee. Socheongryong-tang for improving nasal symptoms associated with allergic rhinitis: A study protocol for a randomized, open-label, cetirizine controlled, clinical trial. Medicine. 2018 Aug; 97(34):e11812. doi: 10.1097/md.0000000000011812. [PMID: 30142767]
  • Ângela Almeida, Vânia Calisto, Valdemar I Esteves, Rudolf J Schneider, Amadeu M V M Soares, Etelvina Figueira, Rosa Freitas. Effects of single and combined exposure of pharmaceutical drugs (carbamazepine and cetirizine) and a metal (cadmium) on the biochemical responses of R. philippinarum. Aquatic toxicology (Amsterdam, Netherlands). 2018 May; 198(?):10-19. doi: 10.1016/j.aquatox.2018.02.011. [PMID: 29494826]
  • Cecilie Hurup Munkboel, Stine Bjerregaard Hasselstrøm, David Møbjerg Kristensen, Bjarne Styrishave. Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3β-HSD inhibition. Toxicology in vitro : an international journal published in association with BIBRA. 2018 Apr; 48(?):302-309. doi: 10.1016/j.tiv.2018.01.026. [PMID: 29409762]
  • Ahmad Salimi, Mosleh Razian, Jalal Pourahmad. Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model. Current clinical pharmacology. 2018; 13(2):120-127. doi: 10.2174/1574884713666180516112920. [PMID: 29766823]
  • Ângela Almeida, Vânia Calisto, Valdemar I Esteves, Rudolf J Schneider, Amadeu M V M Soares, Etelvina Figueira, Rosa Freitas. Ecotoxicity of the antihistaminic drug cetirizine to Ruditapes philippinarum clams. The Science of the total environment. 2017 Dec; 601-602(?):793-801. doi: 10.1016/j.scitotenv.2017.05.149. [PMID: 28578237]
  • G X Fang, Z Li, C Su, G H Hu. [Clinical observation of saccharomyces boulardii combined with cetirizine hydrochloride in children allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2017 Nov; 31(21):1649-1652. doi: 10.13201/j.issn.1001-1781.2017.21.007. [PMID: 29798120]
  • R X Ma, L Hou, J R Hu. [To observe the effect of "Fangfenggubenkeli" on IL-4, IL-5, IL-10 and IFN-γ cytokines in PBMC supernatant of allergic rhinitis patients with lung depression and spleen efficiency]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2017 Nov; 31(21):1662-1665. doi: 10.13201/j.issn.1001-1781.2017.21.010. [PMID: 29798123]
  • Lufen Huang, Yan Dong, Jianlin Wu, Peixun Wang, Hua Zhou, Ting Li, Liang Liu. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacological research. 2017 Nov; 125(Pt B):150-160. doi: 10.1016/j.phrs.2017.08.014. [PMID: 28867637]
  • Hua Chen, Qiuqin Wang, Hongli An. [Clinical therapeutic effects of scraping therapy on allergic rhinitis of different syndromes]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2017 Sep; 37(9):985-9. doi: 10.13703/j.0255-2930.2017.09.020. [PMID: 29354921]
  • Saki Noguchi, Tomohiro Nishimura, Saya Mukaida, Leslie Z Benet, Emi Nakashima, Masatoshi Tomi. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. Journal of pharmaceutical sciences. 2017 09; 106(9):2895-2898. doi: 10.1016/j.xphs.2017.03.026. [PMID: 28385546]
  • Miguel Teixeira, Ângela Almeida, Vânia Calisto, Valdemar I Esteves, Rudolf J Schneider, Frederick J Wrona, Amadeu M V M Soares, Etelvina Figueira, Rosa Freitas. Toxic effects of the antihistamine cetirizine in mussel Mytilus galloprovincialis. Water research. 2017 05; 114(?):316-326. doi: 10.1016/j.watres.2017.02.032. [PMID: 28273617]
  • R Munoz-Cano, E Ainsua-Enrich, I Torres-Atencio, M Martin, J Sánchez-Lopez, J Bartra, C Picado, J Mullol, A Valero. Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study). Journal of investigational allergology & clinical immunology. 2017 ; 27(3):161-168. doi: 10.18176/jiaci.0117. [PMID: 27758758]
  • Aleksandra Chmielewska, Lucyna Konieczna, Tomasz Bączek. A Novel Two-Step Liquid-Liquid Extraction Procedure Combined with Stationary Phase Immobilized Human Serum Albumin for the Chiral Separation of Cetirizine Enantiomers along with M and P Parabens. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121654. [PMID: 27941625]
  • H K Knych, S D Stanley, R M Arthur, D S McKemie. Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses. Journal of veterinary pharmacology and therapeutics. 2016 Oct; 39(5):522-4. doi: 10.1111/jvp.12318. [PMID: 27121892]
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