temazepam (BioDeep_00000397500)
Main id: BioDeep_00000002000
代谢物信息卡片
temazepam
化学式: C16H13ClN2O2 (300.0666)
中文名称: 替马西泮
谱图信息:
最多检出来源 Homo sapiens(urine) 33.33%
分子结构信息
SMILES: Clc(c3)cc(c(c3)2)C(=NC(O)C(=O)N(C)2)c(c1)cccc1
InChI: InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
CONFIDENCE standard compound; INTERNAL_ID 1557
CONFIDENCE standard compound; INTERNAL_ID 8605
同义名列表
数据库引用编号
26 个数据库交叉引用编号
- ChEBI: CHEBI:9435
- KEGG: C07125
- KEGGdrug: D00370
- PubChem: 5391
- DrugBank: DB00231
- ChEMBL: CHEMBL967
- MeSH: Temazepam
- CAS: 846-50-4
- MoNA: AU155706
- MoNA: WA000300
- MoNA: WA000299
- MoNA: WA000298
- MoNA: WA000297
- MoNA: WA000296
- MoNA: WA000295
- MoNA: FiehnHILIC002350
- MoNA: FiehnHILIC000783
- MoNA: SM860501
- MoNA: AU155705
- MoNA: AU155704
- MoNA: AU155703
- MoNA: AU155702
- MoNA: AU155701
- PubChem: 9335
- RefMet: Temazepam
- KNApSAcK: 9435
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daniel Cerveny, Jerker Fick, Jonatan Klaminder, Michael G Bertram, Tomas Brodin. Exposure via biotransformation: Oxazepam reaches predicted pharmacological effect levels in European perch after exposure to temazepam.
Ecotoxicology and environmental safety.
2021 Jul; 217(?):112246. doi:
10.1016/j.ecoenv.2021.112246. [PMID: 33901781] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
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10.1016/j.forsciint.2016.11.042. [PMID: 28007369] - Sabine Klein, Marion Bankstahl, Martina Gramer, Maria Hausknecht, Wolfgang Löscher. Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Epilepsy research.
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BMC geriatrics.
2014 Nov; 14(?):121. doi:
10.1186/1471-2318-14-121. [PMID: 25416480] - Elisabetta Bertol, Francesco Mari, Rafael Boscolo Berto, Guido Mannaioni, Fabio Vaiano, Donata Favretto. A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case.
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Journal of analytical toxicology.
2014 Oct; 38(8):610-4. doi:
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Journal of analytical toxicology.
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European journal of clinical pharmacology.
2014 Mar; 70(3):319-29. doi:
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2011 Jun; 25(3):343-53. doi:
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PloS one.
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