temazepam (BioDeep_00000397500)

Main id: BioDeep_00000002000

 


代谢物信息卡片


temazepam

化学式: C16H13ClN2O2 (300.0665508)
中文名称: 替马西泮
谱图信息: 最多检出来源 Homo sapiens(urine) 2.56%

分子结构信息

SMILES: Clc(c3)cc(c(c3)2)C(=NC(O)C(=O)N(C)2)c(c1)cccc1
InChI: InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
CONFIDENCE standard compound; INTERNAL_ID 1557
CONFIDENCE standard compound; INTERNAL_ID 8605

同义名列表

1 个代谢物同义名

temazepam



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Daniel Cerveny, Jerker Fick, Jonatan Klaminder, Michael G Bertram, Tomas Brodin. Exposure via biotransformation: Oxazepam reaches predicted pharmacological effect levels in European perch after exposure to temazepam. Ecotoxicology and environmental safety. 2021 Jul; 217(?):112246. doi: 10.1016/j.ecoenv.2021.112246. [PMID: 33901781]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Paula Melo, Pedro Costa, Maria José Quintas, André Castro, Sónia Tarelho, João Miguel Franco, Helena M Teixeira. Pentobarbital in the context of possible suicides: Analysis of a Case. Forensic science international. 2017 May; 274(?):109-112. doi: 10.1016/j.forsciint.2016.11.042. [PMID: 28007369]
  • Sabine Klein, Marion Bankstahl, Martina Gramer, Maria Hausknecht, Wolfgang Löscher. Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. Epilepsy research. 2014 Dec; 108(10):1719-27. doi: 10.1016/j.eplepsyres.2014.10.002. [PMID: 25458535]
  • Janne Nurminen, Juha Puustinen, Ritva Lähteenmäki, Tero Vahlberg, Alan Lyles, Markku Partinen, Ismo Räihä, Pertti J Neuvonen, Sirkka-Liisa Kivelä. Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics. BMC geriatrics. 2014 Nov; 14(?):121. doi: 10.1186/1471-2318-14-121. [PMID: 25416480]
  • Elisabetta Bertol, Francesco Mari, Rafael Boscolo Berto, Guido Mannaioni, Fabio Vaiano, Donata Favretto. A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case. Forensic science international. 2014 Oct; 243(?):149-55. doi: 10.1016/j.forsciint.2014.08.002. [PMID: 25199615]
  • Ayodele A Morris, Scot A Chester, Erin C Strickland, Gregory L McIntire. Rapid enzymatic hydrolysis using a novel recombinant β-glucuronidase in benzodiazepine urinalysis. Journal of analytical toxicology. 2014 Oct; 38(8):610-4. doi: 10.1093/jat/bku083. [PMID: 25217555]
  • Samantha Luk, Rabia S Atayee, Joseph D Ma, Brookie M Best. Urinary diazepam metabolite distribution in a chronic pain population. Journal of analytical toxicology. 2014 Apr; 38(3):135-42. doi: 10.1093/jat/bku001. [PMID: 24500275]
  • Juha Puustinen, Ritva Lähteenmäki, Päivi Polo-Kantola, Paula Salo, Tero Vahlberg, Alan Lyles, Pertti J Neuvonen, Markku Partinen, Ismo Räihä, Sirkka-Liisa Kivelä. Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults. European journal of clinical pharmacology. 2014 Mar; 70(3):319-29. doi: 10.1007/s00228-013-1613-6. [PMID: 24337417]
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  • Stephanie J Marin, Mark Roberts, Michelle Wood, Gwendolyn A McMillin. Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma. Journal of analytical toxicology. 2012 Sep; 36(7):472-6. doi: 10.1093/jat/bks059. [PMID: 22833647]
  • Ruth Verplaetse, Eva Cuypers, Jan Tytgat. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. Journal of chromatography. A. 2012 Aug; 1249(?):147-54. doi: 10.1016/j.chroma.2012.06.023. [PMID: 22749457]
  • Sevasti Karampela, Ioanna Vardakou, Ioannis Papoutsis, Artemis Dona, Chara Spiliopoulou, Sotirios Athanaselis, Constantinos Pistos. Direct urine analysis for the identification and quantification of selected benzodiazepines for toxicology screening. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Aug; 902(?):42-6. doi: 10.1016/j.jchromb.2012.06.012. [PMID: 22790390]
  • B KuKanich, J L Nauss. Pharmacokinetics of the cytochrome P-450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs. Journal of veterinary pharmacology and therapeutics. 2012 Jun; 35(3):275-81. doi: 10.1111/j.1365-2885.2011.01316.x. [PMID: 21692812]
  • Werner J Heinz, Anna Grau, Anne Ulrich, Annegret Helle-Beyersdorf, Janina Zirkel, Diana Schirmer, Ulrike Lenker, Hermann Einsele, Hartwig Klinker. Impact of benzodiazepines on posaconazole serum concentrations. A population-based pharmacokinetic study on drug interaction. Current medical research and opinion. 2012 Apr; 28(4):551-7. doi: 10.1185/03007995.2012.664123. [PMID: 22303909]
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  • Paul K L Chin, Berit P Jensen, Helle S Larsen, Evan J Begg. Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects. British journal of clinical pharmacology. 2011 Dec; 72(6):985-9. doi: 10.1111/j.1365-2125.2011.04036.x. [PMID: 21671987]
  • Elise Bekele, Simon Toze, Bradley Patterson, Simon Higginson. Managed aquifer recharge of treated wastewater: water quality changes resulting from infiltration through the vadose zone. Water research. 2011 Nov; 45(17):5764-72. doi: 10.1016/j.watres.2011.08.058. [PMID: 21914556]
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  • Massimo Caputo, Kirkpatrick C Santo, Gianni D Angelini, Carlo Fino, Marco Agostini, Claudio Grossi, M-Saadeh Suleiman, Barnaby C Reeves. Warm-blood cardioplegia with low or high magnesium for coronary bypass surgery: a randomised controlled trial. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2011 Sep; 40(3):722-9. doi: 10.1016/j.ejcts.2010.09.049. [PMID: 21353585]
  • Michael Maringka, Shibashish Giri, Karen Nieber, Ali Acikgöz, Augustinus Bader. Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes. Fundamental & clinical pharmacology. 2011 Jun; 25(3):343-53. doi: 10.1111/j.1472-8206.2010.00857.x. [PMID: 20618872]
  • Helle S Larsen, Paul Kl Chin, Evan J Begg, Berit P Jensen. Quantification of total and unbound concentrations of lorazepam, oxazepam and temazepam in human plasma by ultrafiltration and LC-MS/MS. Bioanalysis. 2011 Apr; 3(8):843-52. doi: 10.4155/bio.11.46. [PMID: 21510758]
  • Jurjen S Lagas, Abraham J Wilhelm, René M Vos, Erik-Jan van den Dool, Yvonne van der Heide, Sandra Huissoon, Jos H Beijnen, Desiderius P M Brandjes. Toxicokinetics of a dipyridamole (Persantin) intoxication: case report. Human & experimental toxicology. 2011 Jan; 30(1):74-8. doi: 10.1177/0960327110368696. [PMID: 20375123]
  • Shawn P Vorce, Barry Levine, Pamela C McDonough, Marilyn R Past. An overdose death involving the insufflation of extended-release oxymorphone tablets. Journal of analytical toxicology. 2010 Oct; 34(8):521-6. doi: 10.1093/jat/34.8.521. [PMID: 21819798]
  • Monique A J Mets, Edmund R Volkerts, Berend Olivier, Joris C Verster. Effect of hypnotic drugs on body balance and standing steadiness. Sleep medicine reviews. 2010 Aug; 14(4):259-67. doi: 10.1016/j.smrv.2009.10.008. [PMID: 20171127]
  • Amadeo Pesce, Murray Rosenthal, Robert West, Cameron West, Bridgit Crews, Charles Mikel, Perla Almazan, Sergey Latyshev. An evaluation of the diagnostic accuracy of liquid chromatography-tandem mass spectrometry versus immunoassay drug testing in pain patients. Pain physician. 2010 May; 13(3):273-81. doi: 10.36076/ppj.2010/13/273. [PMID: 20495592]
  • Christiaan H Vinkers, Gerdien A H Korte-Bouws, Javier Sastre Toraño, Naheed R Mirza, Elsebet Ø Nielsen, Philip K Ahring, Gerhardus J de Jong, Berend Olivier. The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies. Psychopharmacology. 2010 Mar; 208(4):555-62. doi: 10.1007/s00213-009-1752-8. [PMID: 20066402]
  • Sarah J Glover, Keith R Allen. Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay. Annals of clinical biochemistry. 2010 Mar; 47(Pt 2):111-7. doi: 10.1258/acb.2009.009172. [PMID: 19969595]
  • Stephanie J Marin, Gwendolyn A McMillin. LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium. Methods in molecular biology (Clifton, N.J.). 2010; 603(?):89-105. doi: 10.1007/978-1-60761-459-3_9. [PMID: 20077062]
  • Josh Gunn, Scott Kriger, Andrea R Terrell. Simultaneous determination and quantification of 12 benzodiazepines in serum or whole blood using UPLC/MS/MS. Methods in molecular biology (Clifton, N.J.). 2010; 603(?):107-19. doi: 10.1007/978-1-60761-459-3_10. [PMID: 20077063]
  • Bruce A Goldberger, Chris W Chronister, Michele L Merves. Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):75-87. doi: 10.1007/978-1-60761-459-3_8. [PMID: 20077061]
  • Laura Mercolini, Roberto Mandrioli, Carmelina Iannello, Francesco Matrisciano, Ferdinando Nicoletti, Maria Augusta Raggi. Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE. Talanta. 2009 Nov; 80(1):279-85. doi: 10.1016/j.talanta.2009.06.074. [PMID: 19782227]
  • Sarah M R Wille, Elke Raes, Pirjo Lillsunde, Teemu Gunnar, Marleen Laloup, Nele Samyn, Asbjørg S Christophersen, Manfred R Moeller, Karin P Hammer, Alain G Verstraete. Relationship between oral fluid and blood concentrations of drugs of abuse in drivers suspected of driving under the influence of drugs. Therapeutic drug monitoring. 2009 Aug; 31(4):511-9. doi: 10.1097/ftd.0b013e3181ae46ea. [PMID: 19571773]
  • Stephanie J Marin, Rebecka Coles, Miles Merrell, Gwendolyn A McMillin. Quantitation of benzodiazepines in urine, serum, plasma, and meconium by LC-MS-MS. Journal of analytical toxicology. 2008 Sep; 32(7):491-8. doi: 10.1093/jat/32.7.491. [PMID: 18713517]
  • Hironobu Umezawa, Xiao-Pen Lee, Yoshiko Arima, Chika Hasegawa, Akemi Marumo, Takeshi Kumazawa, Keizo Sato. Determination of diazepam and its metabolites in human urine by liquid chromatography/tandem mass spectrometry using a hydrophilic polymer column. Rapid communications in mass spectrometry : RCM. 2008 Aug; 22(15):2333-41. doi: 10.1002/rcm.3613. [PMID: 18618924]
  • Marci L Chew, Benoit H Mulsant, Bruce G Pollock, Mark E Lehman, Andrew Greenspan, Ramy A Mahmoud, Margaret A Kirshner, Denise A Sorisio, Robert R Bies, Georges Gharabawi. Anticholinergic activity of 107 medications commonly used by older adults. Journal of the American Geriatrics Society. 2008 Jul; 56(7):1333-41. doi: 10.1111/j.1532-5415.2008.01737.x. [PMID: 18510583]
  • Thomas Roth, David Mayleben, Bruce C Corser, Nikhilesh N Singh. Daytime pharmacodynamic and pharmacokinetic evaluation of low-dose sublingual transmucosal zolpidem hemitartrate. Human psychopharmacology. 2008 Jan; 23(1):13-20. doi: 10.1002/hup.884. [PMID: 17907263]
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  • Snezana Dordević, Vesna Kilibarda. [Determination of diazepam and its metabolites in serum by the use of liquid chromatography-mass spectrometry method]. Vojnosanitetski pregled. 2007 Oct; 64(10):659-62. doi: 10.2298/vsp0710659d. [PMID: 18041566]
  • Tiina J Kauppila, Nari Talaty, Tiia Kuuranne, Tapio Kotiaho, Risto Kostiainen, R Graham Cooks. Rapid analysis of metabolites and drugs of abuse from urine samples by desorption electrospray ionization-mass spectrometry. The Analyst. 2007 Sep; 132(9):868-75. doi: 10.1039/b703524a. [PMID: 17710261]
  • Jing Li, Ming Zhao, Antonio Jimeno, Ping He, M V Ramana Reddy, Manuel Hidalgo, Ross C Donehower, Michelle A Rudek. Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate ON 01910.Na, a mitotic progression modulator, in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 856(1-2):198-204. doi: 10.1016/j.jchromb.2007.05.047. [PMID: 17588831]
  • Jaime M Monti, S R Pandi-Perumal. Eszopiclone: its use in the treatment of insomnia. Neuropsychiatric disease and treatment. 2007 Aug; 3(4):441-53. doi: NULL. [PMID: 19300573]
  • Marleen Laloup, Maria Del Mar Ramirez Fernandez, Michelle Wood, Viviane Maes, Gert De Boeck, Yvan Vanbeckevoort, Nele Samyn. Detection of diazepam in urine, hair and preserved oral fluid samples with LC-MS-MS after single and repeated administration of Myolastan and Valium. Analytical and bioanalytical chemistry. 2007 Aug; 388(7):1545-56. doi: 10.1007/s00216-007-1297-9. [PMID: 17468852]
  • Juha Puustinen, Janne Nurminen, Matti Kukola, Tero Vahlberg, Kari Laine, Sirkka-Liisa Kivelä. Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive function: a non-randomised clinical study in the elderly. Drugs & aging. 2007; 24(12):1045-59. doi: 10.2165/00002512-200724120-00007. [PMID: 18020536]
  • Tobias Welt, Mario Engelmann, Ulrich Renner, Angelika Erhardt, Marianne B Müller, Rainer Landgraf, Florian Holsboer, Martin E Keck. Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006 Dec; 31(12):2573-9. doi: 10.1038/sj.npp.1301006. [PMID: 16395302]
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