amlodipine (BioDeep_00000397496)
Main id: BioDeep_00000001425
natural product
代谢物信息卡片
Amlodipine (Norvasc)
化学式: C20H25ClN2O5 (408.1452)
中文名称: 氨氯地平
谱图信息:
最多检出来源 Homo sapiens(natural_products) 20.24%
分子结构信息
SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
InChI: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 1544
同义名列表
3 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:2668
- KEGG: C06825
- KEGGdrug: D07450
- PubChem: 2162
- DrugBank: DB00381
- ChEMBL: CHEMBL3304444
- ChEMBL: CHEMBL3211346
- ChEMBL: CHEMBL1491
- MeSH: Amlodipine
- CAS: 88150-42-9
- MoNA: WA001850
- MoNA: WA001849
- MoNA: WA001848
- MoNA: WA001847
- MoNA: WA001846
- MoNA: WA001845
- MoNA: FiehnHILIC002592
- MoNA: FiehnHILIC001762
- MoNA: FiehnHILIC000187
- MoNA: CCMSLIB00000078338
- MoNA: AU154406
- PubChem: 9043
- NIKKAJI: J33.383B
- KNApSAcK: 2668
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shiqi Wang, Jiahui Wu, Qingcheng Wang, Yunfeng Zhang, Hong Yuan, Jianding Wang, Yonghui Wu, Yaxi Xu, Na Ji, Bin Quan, Haixing Wang, Qing Shen. Evaluation of a miniature mass spectrometer based point-of-care-test method for direct analysis of amlodipine and benazepril in whole blood.
Journal of pharmaceutical and biomedical analysis.
2024 Aug; 245(?):116194. doi:
10.1016/j.jpba.2024.116194. [PMID: 38704878] - Qi-Fang Huang, Di Zhang, Yihong Luo, Kun Hu, Qiong Wu, Hailong Qiu, Fei Xu, Mei-Ling Wang, Xin Chen, Yan Li, Ji-Guang Wang. Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial.
BMC medicine.
2024 01; 22(1):28. doi:
10.1186/s12916-023-03244-4. [PMID: 38263021] - Aozi Feng, Weizhao Lin, Li Li, Mengnan Zeng, Jun Lyu. Pharmacoeconomic evaluation of stroke and myocardial infarction prevention in hypertensive patients: Markov model based on the ACCOMPLISH trial.
The Journal of international medical research.
2023 Dec; 51(12):3000605231214921. doi:
10.1177/03000605231214921. [PMID: 38114070] - Wen Yuan, Hongjun Fan, Haibing Yang, Liang Tang, Zhiming Liu, Fan Ouyang, Wei Luo, Yong Yan. Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathway.
Diagnostic pathology.
2023 Sep; 18(1):108. doi:
10.1186/s13000-023-01393-x. [PMID: 37759223] - O A Ahmed-Farid, Areeg M Abdelrazek, Hend Elwakel, Maha M Mohamed. Hordeum vulgare ethanolic extract mitigates high salt-induced cerebellum damage via attenuation of oxidative stress, neuroinflammation, and neurochemical alterations in hypertensive rats.
Metabolic brain disease.
2023 Aug; ?(?):. doi:
10.1007/s11011-023-01277-5. [PMID: 37646962] - Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Seung Hyun Ahn, Gyujin Sim, Soonghee Chung, Ju-Tae Sohn. Lipid Emulsion Inhibits Amlodipine-Induced Nitric Oxide-Mediated Vasodilation in Isolated Rat Aorta.
International journal of molecular sciences.
2023 May; 24(10):. doi:
10.3390/ijms24108741. [PMID: 37240087] - Giovanna Gallo, Riccardo Sarzani, Arrigo Francesco Giuseppe Cicero, Stefano Genovese, Matteo Pirro, Luca Gallelli, Andrea Faggiano, Massimo Volpe. An Expert Opinion on the Role of the Rosuvastatin/Amlodipine Single Pill Fixed Dose Combination in Cardiovascular Prevention.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension.
2023 Apr; ?(?):. doi:
10.1007/s40292-023-00570-9. [PMID: 37020154] - Tian Xia, Lu-Lu Xu, Peng-Yue Guo, Wan-Ting Shi, Yan-Qiong Cheng, Ai-Jun Liu. Synergism of amlodipine and telmisartan or candesartan on blood pressure reduction by using SynergyFinder 3.0 and probability sum test in vivo.
Pharmacology research & perspectives.
2023 04; 11(2):e01064. doi:
10.1002/prp2.1064. [PMID: 36810974] - Ju-Tae Sohn. Lipid Emulsion-Mediated Improvement of Hemodynamic Depression Caused by Amlodipine Toxicity.
Pediatric emergency care.
2023 03; 39(3):205-206. doi:
10.1097/pec.0000000000002842. [PMID: 36083186] - Stephen Y Wang, Jonathan M Hanna, Prajesh Gongal, Oyere K Onuma, Michael G Nanna. Choice of antihypertensive agent in isolated systolic hypertension and isolated diastolic hypertension: A secondary analysis of the ALLHAT trial.
American heart journal.
2022 Dec; 254(?):30-34. doi:
10.1016/j.ahj.2022.07.006. [PMID: 35932912] - G Christina Gutierrez, Christopher Dayton, Rebecca L Attridge, Lucas Smedley, Haritha Saikumar, Christopher Everett, Abraham Rodriguez, Shawn Varney. Angiotensin II Use in Treatment of Refractory Shock Due to Benazepril and Amlodipine Toxic Ingestion.
Journal of pharmacy practice.
2022 Oct; ?(?):8971900221137389. doi:
10.1177/08971900221137389. [PMID: 36314764] - Pandeng Miao, Jie Gan, Jian Zhang, Mingxuan Ma, Xiaoqi Li, Yingxiang Du, Zijie Feng, Liu Zhang. Carboxymethyl-β-cyclodextrin and histidine-zeolitic imidazolate framework-8 used for enantioseparation of three basic drugs in open-tubular capillary electrochromatography.
Chirality.
2022 09; 34(9):1209-1218. doi:
10.1002/chir.23480. [PMID: 35678370] - Xiying Zhao, Jiahao Mo, Beiping Zhang, Jian Tang. Hypertension as a rare adverse effect caused by infliximab in the treatment of Crohn's disease: a case report.
Annals of palliative medicine.
2022 Sep; 11(9):3001-3004. doi:
10.21037/apm-22-807. [PMID: 36217627] - Peng Liu, Xiaowei Wu, Suyi Pan, Jiamin Dai, Zixuan Zhang, Xuetao Guo. Photochlorination-induced degradation of microplastics and interaction with Cr(VI) and amlodipine.
The Science of the total environment.
2022 Aug; 835(?):155499. doi:
10.1016/j.scitotenv.2022.155499. [PMID: 35472361] - Ting Li, Yan-Ping Liu, Shu-Qin Liu, Ping Shi, Xin Jiang, Ye Tao, Xiao-Meng Gao, Ya-Ping Ma, Yu Cao. Bioequivalence evaluation and food effect assessment of Lisinopril/amlodipine tablets in healthy Chinese subjects under fasting and fed conditions.
BMC pharmacology & toxicology.
2022 07; 23(1):45. doi:
10.1186/s40360-022-00590-6. [PMID: 35794660] - Sonali R Gnanenthiran, Nelson Wang, Gian Luca Di Tanna, Abdul Salam, Ruth Webster, H Asita de Silva, Rama Guggilla, Stephen Jan, Pallab K Maulik, Nitish Naik, Vanessa Selak, Simon Thom, Dorairaj Prabhakaran, Aletta E Schutte, Anushka Patel, Anthony Rodgers. Association of Low-Dose Triple Combination Therapy vs Usual Care With Time at Target Blood Pressure: A Secondary Analysis of the TRIUMPH Randomized Clinical Trial.
JAMA cardiology.
2022 06; 7(6):645-650. doi:
10.1001/jamacardio.2022.0471. [PMID: 35416909] - Vineeta Gupta, Ishan Kumar, Vibhesh Raj, Priyanka Aggarwal, Vikas Agrawal. Comparison of the effects of calcium channel blockers plus iron chelation therapy versus chelation therapy only on iron overload in children and young adults with transfusion-dependent thalassemia: A randomized double-blind placebo-controlled trial.
Pediatric blood & cancer.
2022 06; 69(6):e29564. doi:
10.1002/pbc.29564. [PMID: 35092347] - Bin Chen, ZhiMin Chen, DongQing Lv, Yuan Sun, HuaFang Chen. Pharmacokinetics, Bioequivalence, and Safety Studies of Amlodipine Besylate in Healthy Subjects.
Clinical pharmacology in drug development.
2022 06; 11(6):717-723. doi:
10.1002/cpdd.1064. [PMID: 34981666] - Xinjing Li, Enpan Mo, Lin Chen. Pharmacokinetics and Bioequivalence Evaluation of 2 Olmesartan Medoxomil and Amlodipine Besylate Fixed-Dose Combination Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions.
Clinical pharmacology in drug development.
2022 06; 11(6):761-769. doi:
10.1002/cpdd.1086. [PMID: 35289500] - Yang Li, Danyang Zhao, Minyi Qian, Jun Liu, Chuyue Pan, Xinxin Zhang, Xubin Duan, Yufei Zhang, Wenxin Jia, Lirui Wang. Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota.
British journal of pharmacology.
2022 05; 179(9):2054-2077. doi:
10.1111/bph.15768. [PMID: 34862599] - Jessica L Ward, Emilie Guillot, Oliver Domenig, Wendy A Ware, Lingnan Yuan, Jonathan P Mochel. Circulating renin-angiotensin-aldosterone system activity in cats with systemic hypertension or cardiomyopathy.
Journal of veterinary internal medicine.
2022 May; 36(3):897-909. doi:
10.1111/jvim.16401. [PMID: 35285549] - Hee-Won Jang, Su-Min Park, Seo-Young Hwang, Kyuyong Kang, Mincheol Choi, Ju-Hyun An, Hyung-Kyu Chae, Ye-In Oh, Hwa-Young Youn. Unusual case of pleural effusion caused by amlodipine in a dog with systemic hypertension.
Veterinary medicine and science.
2022 03; 8(2):445-449. doi:
10.1002/vms3.727. [PMID: 35132803] - Yu Wang, Zhen Hua, Wenjing Chen, Yushuo Zhu, Yunlun Li. Efficacy and safety of Tengfu Jiangya tablet combined with valsartan/amlodipine in the treatment of stage 2 hypertension: study protocol for a randomized controlled trial.
Trials.
2022 Feb; 23(1):171. doi:
10.1186/s13063-022-06089-z. [PMID: 35193665] - Mohd Aftab Alam, Yousef A Bin Jardan, Mohammad Raish, Abdullah M Al-Mohizea, Abdul Ahad, Fahad I Al-Jenoobi. Herb-drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa.
Xenobiotica; the fate of foreign compounds in biological systems.
2022 Feb; 52(2):177-185. doi:
10.1080/00498254.2021.2023787. [PMID: 34958609] - Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration.
Hypertension (Dallas, Tex. : 1979).
2022 02; 79(2):413-423. doi:
10.1161/hypertensionaha.121.18026. [PMID: 34879704] - Abdul-Fatawu Osman, Rohan Madhu Prasad, Shawn Marein, Corey O'Brien. Multi-organ dysfunction as a presentation of calcium channel blocker intoxication.
BMJ case reports.
2022 Jan; 15(1):. doi:
10.1136/bcr-2021-245711. [PMID: 35039350] - L Koliastasis, I Lampadakis, A Milkas, P Strempelas, V Sourides, K Kakava, P Tsioufis, S Papaioannou. Refractory Shock from Amlodipine Overdose Overcomed with Hyperinsulinemia.
Cardiovascular toxicology.
2022 01; 22(1):63-66. doi:
10.1007/s12012-021-09699-2. [PMID: 34643856] - Jenna Essink, Sydney Berg, Jaka Montange, Andrew Sankey, Veronica Taylor, Jeffrey Salomon. Single-Pass Albumin Dialysis as Rescue Therapy for Pediatric Calcium Channel Blocker Overdose.
Journal of investigative medicine high impact case reports.
2022 Jan; 10(?):23247096221105251. doi:
10.1177/23247096221105251. [PMID: 35856321] - Inseung Jeon, Seol Ju Moon, Sang-In Park, Yewon Choi, Jina Jung, Kyung-Sang Yu, Jae-Yong Chung. Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan and Chlorthalidone Compared to Concurrent Administration of the Separate Components.
Clinical pharmacology in drug development.
2022 01; 11(1):91-99. doi:
10.1002/cpdd.963. [PMID: 34159751] - Jianli Fu, Ting Wang, Botao Li, Na Zhao. The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation.
Disease markers.
2022; 2022(?):1111438. doi:
10.1155/2022/1111438. [PMID: 36284992] - Maryana I Prokosa. INDICATORS OF ENDOTHELIAL DYSFUNCTION, MARKERS OF INFLAMMATION AND LIPID METABOLISM IN PATIENTS WITH HYPERTENSION WITH THE ADMINISTRATION OF QUERCETIN.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2022; 75(7):1653-1657. doi:
10.36740/wlek202207107. [PMID: 35962675] - Jung-Chi Li, Po-Chung Cheng, Chien-Nin Huang, Li-Fen Jian, Ying-Syuan Wu, Chih-Li Lin. Antihypertensive treatment improves glycemic control in patients with newly diagnosed type 2 diabetes mellitus: A prospective cohort study.
Frontiers in endocrinology.
2022; 13(?):935561. doi:
10.3389/fendo.2022.935561. [PMID: 36157468] - Ahmed Mohamed Youssef, Hesham Abdallah Elghoneimy, Maged Wasfy Helmy, Ahmed Mokhtar Abdelazeem, Noha Mahmoud El-Khodary. Effect of amlodipine versus bisoprolol in hypertensive patients on maintenance hemodialysis: A randomized controlled trial.
Medicine.
2021 Dec; 100(51):e28322. doi:
10.1097/md.0000000000028322. [PMID: 34941131] - Di Zhang, Qi-Fang Huang, Chang-Sheng Sheng, Yan Li, Ji-Guang Wang. Serum uric acid change in relation to antihypertensive therapy with the dihydropyridine calcium channel blockers.
Blood pressure.
2021 12; 30(6):395-402. doi:
10.1080/08037051.2021.1996220. [PMID: 34714194] - Gwenolé Loas, Pascal Le Corre. Comment on 'Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial'.
International journal of clinical practice.
2021 12; 75(12):e14957. doi:
10.1111/ijcp.14957. [PMID: 34965651] - Nisita Chaihongsa, Putcharawipa Maneesai, Weerapon Sangartit, Prapassorn Potue, Sarawoot Bunbupha, Poungrat Pakdeechote. Galangin alleviates vascular dysfunction and remodelling through modulation of the TNF-R1, p-NF-κB and VCAM-1 pathways in hypertensive rats.
Life sciences.
2021 Nov; 285(?):119965. doi:
10.1016/j.lfs.2021.119965. [PMID: 34543638] - Robert Hermann, Kristina Gundlach, Dan Seiler. Mechanistic Considerations About an Unexpected Ramipril Drug-Drug Interaction in the Development of a Triple Fixed-Dose Combination Product Containing Ramipril, Amlodipine, and Atorvastatin.
Clinical pharmacology in drug development.
2021 11; 10(11):1307-1315. doi:
10.1002/cpdd.930. [PMID: 33773093] - Nathan K Itoga, Daniel S Tawfik, Maria E Montez-Rath, Tara I Chang. Contributions of Systolic and Diastolic Blood Pressures to Cardiovascular Outcomes in the ALLHAT Study.
Journal of the American College of Cardiology.
2021 10; 78(17):1671-1678. doi:
10.1016/j.jacc.2021.08.035. [PMID: 34674811] - Brian Pearlman, Bereket T Lodebo. Renin secreting tumour: a rare cause of secondary hypertension.
Lancet (London, England).
2021 09; 398(10305):1074. doi:
10.1016/s0140-6736(21)01696-2. [PMID: 34537092] - Masayo Koide, Osama F Harraz, Fabrice Dabertrand, Thomas A Longden, Hannah R Ferris, George C Wellman, David C Hill-Eubanks, Adam S Greenstein, Mark T Nelson. Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease.
The Journal of clinical investigation.
2021 09; 131(18):. doi:
10.1172/jci149029. [PMID: 34351870] - Jack S Lawson, Rosanne E Jepson. Feline comorbidities: The intermingled relationship between chronic kidney disease and hypertension.
Journal of feline medicine and surgery.
2021 09; 23(9):812-822. doi:
10.1177/1098612x211037872. [PMID: 34428941] - Muhammed Khaled Elfaituri, Sherief Ghozy, Amr Ebied, Mostafa Ebraheem Morra, Osama Gamal Hassan, Ahmed Alhusseiny, Alzhraa Salah Abbas, Nourin Ali Sherif, Juliano Lara Fernandes, Nguyen Tien Huy. Amlodipine as adjuvant therapy to current chelating agents for reducing iron overload in thalassaemia major: a systematic review, meta-analysis and simulation of future studies.
Vox sanguinis.
2021 Sep; 116(8):887-897. doi:
10.1111/vox.13083. [PMID: 33634883] - Qian Wei, Zhang Jing, Hao Zhi-Ye. Evaluation of Danzhi Xiaoyao powder and amlodipine sustained-release tablets in follow-up treatment of the hypertensive crisis and the interleukin-6 gene expression.
Cellular and molecular biology (Noisy-le-Grand, France).
2021 Aug; 67(2):166-170. doi:
10.14715/cmb/2021.67.2.26. [PMID: 34817321] - N N Pribylova, M V Yakovleva, C A Pribylov, T A Barbashina, E V Gavriljuk, G S Mal, V S Pribylov. [Vasoprotective effects hypotensive therapy in patients with coronary heart disease combined with chronic kidney disease stage 2-3 after coronary stenting].
Kardiologiia.
2021 Aug; 61(8):14-22. doi:
10.18087/cardio.2021.8.n1525. [PMID: 34549689] - Mohd Aftab Alam, Yousef A Bin Jardan, Bader Alzenaidy, Mohammad Raish, Abdullah M Al-Mohizea, Abdul Ahad, Fahad Ibrahim Al-Jenoobi. Effect of Hibiscus sabdariffa and Zingiber officinale on pharmacokinetics and pharmacodynamics of amlodipine.
The Journal of pharmacy and pharmacology.
2021 Aug; 73(9):1151-1160. doi:
10.1093/jpp/rgaa062. [PMID: 34383955] - Hossein Karami, Hadiseh Khalilzadeh Arjmandi, Ebrahim Salehifar, Hadi Darvishi-Khezri, Mojdeh Dabirian, Mehrnoush Kosaryan, Aily Aliasgharian, Rosetta Akbarzadeh, Raheleh Naeimayi Aali, Amirreza Nasirzadeh. A double-blind, controlled, crossover trial of amlodipine on iron overload status in transfusion dependent β-thalassemia patients.
International journal of clinical practice.
2021 Aug; 75(8):e14337. doi:
10.1111/ijcp.14337. [PMID: 33969592] - O D Ostroumova, A I Kochetkov, N A Arablincky, N A Shatalova, R R Romanovsky, A A Kirichenko. [What do we Mean by "Ideal" Blood Pressure Control?].
Kardiologiia.
2021 Jul; 61(7):68-78. doi:
10.18087/cardio.2021.7.n1662. [PMID: 34397344] - Kawin Khachornsakkul, Wijitar Dungchai. A Portable Reflective Absorbance Spectrophotometric Smartphone Device for the Rapid and Highly Accurate Determination of Amlodipine in Pharmaceutical Formulation and Human Urine Samples.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2021 Jul; 37(7):963-969. doi:
10.2116/analsci.20p349. [PMID: 33229823] - M U Maneesh, Syed Sagheer Ahmed, T Yunus Pasha, B Ramesh, Manish Majumder. A Simple Bioanalytical Method for Simultaneous Estimation of Amlodipine and Celecoxib in Rat Plasma by High Performance Liquid Chromatography.
Journal of chromatographic science.
2021 Jun; 59(7):627-633. doi:
10.1093/chromsci/bmab046. [PMID: 33912904] - Masoud Nouri-Vaskeh, Niusha Kalami, Ramin Zand, Zahra Soroureddin, Mojtaba Varshochi, Khalil Ansarin, Haleh Rezaee, Ali Taghizadieh, Armin Sadeghi, Masoud Ahangari Maleki, Azam Esmailnajad, Parviz Saleh, Mehdi Haghdoost, Mehdi Maleki, Akbar Sharifi. Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial.
International journal of clinical practice.
2021 Jun; 75(6):e14124. doi:
10.1111/ijcp.14124. [PMID: 33650197] - Christine Quentin, Rūta Gerasimaitė, Alexandra Freidzon, Levon S Atabekyan, Gražvydas Lukinavičius, Vladimir N Belov, Gyuzel Y Mitronova. Direct Visualization of Amlodipine Intervention into Living Cells by Means of Fluorescence Microscopy.
Molecules (Basel, Switzerland).
2021 May; 26(10):. doi:
10.3390/molecules26102997. [PMID: 34070063] - Eri Harada, Kazumi Sugino, Megumi Aimoto, Akira Takahara. Effects of the L/N-Type Ca2+ Channel Blocker Cilnidipine on the Cardiac Histological Remodelling and Inducibility of Atrial Fibrillation in High-Salt-Fed Rats.
Biological & pharmaceutical bulletin.
2021 May; 44(5):707-713. doi:
10.1248/bpb.b21-00024. [PMID: 33642455] - Mamdouh R Rezk, Kamal A Badr. Determination of amlodipine, indapamide and perindopril in human plasma by a novel LC-MS/MS method: Application to a bioequivalence study.
Biomedical chromatography : BMC.
2021 May; 35(5):e5048. doi:
10.1002/bmc.5048. [PMID: 33314205] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Soo Hee Lee, Sung Il Bae, Kyeong-Eon Park, Yeran Hwang, Il-Woo Shin, Sangcheol Yoon, Ju-Tae Sohn. Lipid emulsion attenuates extrinsic apoptosis induced by amlodipine toxicity in rat cardiomyoblasts.
Human & experimental toxicology.
2021 Apr; 40(4):695-706. doi:
10.1177/0960327120964551. [PMID: 33030052] - Lea Wagmann, Aline C Vollmer, Lucas Lauder, Felix Mahfoud, Markus R Meyer. Assessing Adherence to Antihypertensive Medication by Means of Dose-Dependent Reference Plasma Concentration Ranges and Ultra-High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Analysis.
Molecules (Basel, Switzerland).
2021 Mar; 26(5):. doi:
10.3390/molecules26051495. [PMID: 33803489] - Y Ivashchuk. [REMODELING OF THE LEFT VENTRICLE, SUBCLINICAL MANIFESTATIONS OF ATHEROSCLEROSIS IN PATIENTS WITH HYPERTONIC DISEASE WITH RHEUMATOID ARTHRITIS BY THE INFLUENCE OF DIFFERENT TREATMENT SCHEMES].
Georgian medical news.
2021 Mar; ?(312):46-52. doi:
". [PMID: 33964825] - Alokkumar S Pathak, Mauricio Rojas, George A Stouffer. Expression of Cyr61 in ApoE-/- mice with chronic unilateral renal artery ligation.
Scientific reports.
2021 02; 11(1):3606. doi:
10.1038/s41598-021-81646-1. [PMID: 33574403] - Kristina Gundlach, Katharina Wolf, Isam Salem, Olaf Randerath, Dan Seiler. Safety of Candesartan, Amlodipine, and Atorvastatin in Combination: Interaction Study in Healthy Subjects.
Clinical pharmacology in drug development.
2021 02; 10(2):190-197. doi:
10.1002/cpdd.787. [PMID: 32388918] - Maedeh Khayyat-Kholghi, Suzanne Oparil, Barry R Davis, Larisa G Tereshchenko. Worsening Kidney Function Is the Major Mechanism of Heart Failure in Hypertension: The ALLHAT Study.
JACC. Heart failure.
2021 02; 9(2):100-111. doi:
10.1016/j.jchf.2020.09.006. [PMID: 33189627] - Wei Ma, Ningling Sun, Chongyang Duan, Lianyou Zhao, Qi Hua, Yingxian Sun, Aimin Dang, Pingjin Gao, Peng Qu, Wei Cui, Luosha Zhao, Yugang Dong, Lianqun Cui, Xiaoyong Qi, Yinong Jiang, Jianhong Xie, Jun Li, Gang Wu, Xinping Du, Yong Huo, Pingyan Chen. Effectiveness of Levoamlodipine Maleate for Hypertension Compared with Amlodipine Besylate: a Pragmatic Comparative Effectiveness Study.
Cardiovascular drugs and therapy.
2021 02; 35(1):41-50. doi:
10.1007/s10557-020-07054-1. [PMID: 32915349] - Xianglin L Du, Lara M Simpson, Brian C Tandy, Judith L Bettencourt, Barry R Davis. Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker.
PloS one.
2021; 16(11):e0260107. doi:
10.1371/journal.pone.0260107. [PMID: 34793552] - K S Kokilambigai, J Kavitha, R Seetharaman, K S Lakshmi, A Sai Susmitha. Analytical and Bioanalytical Techniques for the Quantification of the Calcium Channel Blocker - Amlodipine: A Critical Review.
Critical reviews in analytical chemistry.
2021; 51(8):754-786. doi:
10.1080/10408347.2020.1772036. [PMID: 32506944] - Eline H Groenland, Monique E A M van Kleef, Michiel L Bots, Frank L J Visseren, Kim C M van der Elst, Wilko Spiering. Plasma Trough Concentrations of Antihypertensive Drugs for the Assessment of Treatment Adherence: A Meta-Analysis.
Hypertension (Dallas, Tex. : 1979).
2021 01; 77(1):85-93. doi:
10.1161/hypertensionaha.120.16061. [PMID: 33249865] - Sema Nur Arasan, Ezgi Coskun Yenigun, Simal Koksal Cevher, Fatih Dede. Amlodipine Induced Massive Ascites, a Rare Clinical Case.
Iranian journal of kidney diseases.
2020 Dec; 14(6):517-519. doi:
NULL. [PMID: 33277458] - Ahmed Adel Sofy, Ahmed Taha Abdelsattar, Omar Magdy Mohammed, Mohammad Abrar Shareef, Abdulhadi A Alamodi, Nso Nso, Marinelle Payton, Ahmed Taher Masoud. Amlodipine Compared with Benidipine in the Management of Hypertension: A Systematic Review and Meta-Analysis.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension.
2020 Dec; 27(6):527-537. doi:
10.1007/s40292-020-00412-y. [PMID: 33001356] - Xin Li, Chenjing Wang, Ting Li, Yanping Liu, Shuqin Liu, Ye Tao, Yaping Ma, Xiaomeng Gao, Yu Cao. Bioequivalence of levamlodipine besylate tablets in healthy Chinese subjects: a single-dose and two-period crossover randomized study.
BMC pharmacology & toxicology.
2020 11; 21(1):80. doi:
10.1186/s40360-020-00459-6. [PMID: 33213527] - J C Alvarez, C Mayer-Duverneuil, J Cappy, G Lorin de la Grandamison, A Knapp-Gisclon. Postmortem fatal and non-fatal concentrations of amlodipine.
Forensic science international.
2020 Nov; 316(?):110555. doi:
10.1016/j.forsciint.2020.110555. [PMID: 33152659] - Javed Shaikh Afzal Shaikh, Santosh Raut, Ahad Abdul, Mohd Arif Ali Khan Pathan. High performance liquid chromatographic assay of amlodipine, valsartan and hydrochlorothiazide simultaneously and its application to pharmaceuticals, urine and plasma analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Oct; 1155(?):122295. doi:
10.1016/j.jchromb.2020.122295. [PMID: 32771968] - Khaled Attala, Maya S Eissa, Mohamed A Hasan, Magda M El-Henawee, Soad S Abd El-Hay. An enhanced first derivative synchronous spectrofluorimetric method for determination of the newly co-formulated drugs, amlodipine and celecoxib in pharmaceutical preparation and human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Oct; 240(?):118533. doi:
10.1016/j.saa.2020.118533. [PMID: 32526403] - Ibtsam Khairat, Lamiaa Khedr, Rehab Werida. Valsartan Versus Amlodipine Effect on Left Ventricular Multidirectional Deformation and Adipocytokines Levels in Hypertensive Patients: Speckle Tracking Echocardiography.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension.
2020 Oct; 27(5):379-388. doi:
10.1007/s40292-020-00398-7. [PMID: 32705504] - Xuan Jin, Moo Hyun Kim, Ki Hoon Han, Soon Jun Hong, Jeong-Cheon Ahn, Jung-Hoon Sung, Jin-Man Cho, Han Cheol Lee, So-Yeon Choi, Kyounghoon Lee, Woo-Shik Kim, Moo-Yong Rhee, Ju Han Kim, Seung Pyo Hong, Byung Su Yoo, Eun Joo Cho, Jae-Hwan Lee, Pum-Joon Kim, Chang-Gyu Park, Min Su Hyon, Jin Ho Shin, Sang Hyun Lee, Ki Chul Sung, Jinyong Hwang, Kihwan Kwon, In-Ho Chae, Jeong-Sook Seo, Hyungseop Kim, Hana Lee, Yoonhwa Cho, Hyo-Soo Kim. Efficacy and safety of co-administered telmisartan/amlodipine and rosuvastatin in subjects with hypertension and dyslipidemia.
Journal of clinical hypertension (Greenwich, Conn.).
2020 10; 22(10):1835-1845. doi:
10.1111/jch.13893. [PMID: 32937023] - Ratih Ratih, Hermann Wätzig, Matthias Stein, Sami El Deeb. Investigation of the enantioselective interaction between selected drug enantiomers and human serum albumin by mobility shift-affinity capillary electrophoresis.
Journal of separation science.
2020 Oct; 43(20):3960-3968. doi:
10.1002/jssc.202000372. [PMID: 32823373] - Justin N Corcoran, Katherine J Jacoby, Travis D Olives, Stacey A Bangh, Jon B Cole. Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2020 10; 16(4):465-469. doi:
10.1007/s13181-020-00796-2. [PMID: 32656624] - Siddika Selva Sume, Ezel Berker, Yagmur Ilarslan, Ozlem Ozer Yucel, Cagman Tan, Samir Goyushov, Sibel E Gultekin, Ilhan Tezcan. Elevated Interleukin-17A expression in amlodipine-induced gingival overgrowth.
Journal of periodontal research.
2020 Oct; 55(5):613-621. doi:
10.1111/jre.12747. [PMID: 32173874] - Dmitry Sychev, Karin Mirzaev, Marina Cherniaeva, Maria Kulikova, Pavel Bochkov, Roman Shevchenko, Svetlana Gorbatenkova, Olga Golovina, Olga Ostroumova, Damirya Bahteeva, Eric Rytkin. Drug-drug interaction of rivaroxaban and calcium channel blockers in patients aged 80 years and older with nonvalvular atrial fibrillation.
Drug metabolism and personalized therapy.
2020 09; 35(3):. doi:
10.1515/dmpt-2020-0127. [PMID: 32975202] - Naoki Nakagawa, Nobuyuki Sato, Yasuaki Saijo, Hideo Morimoto, Satoshi Koyama, Yuji Ogawa, Kazumi Uekita, Junichi Maruyama, Takafumi Ohta, Yasuhiro Nakamura, Toshiharu Takeuchi, Naoyuki Hasebe. Assessment of suitable antihypertensive therapies: Combination with high-dose amlodipine/irbesartan vs triple combination with amlodipine/irbesartan/indapamide (ASAHI-AI study).
Journal of clinical hypertension (Greenwich, Conn.).
2020 09; 22(9):1577-1584. doi:
10.1111/jch.13977. [PMID: 32762115] - Ikenna Kingsley Uchendu, Chidozie Elochukwu Agu, Ebuka Bitrus Nnedu, Ikechukwu JohnPaul Chukwu. Combination of aqueous extracts of Curcuma longa (turmeric) and some calcium channel blockers synergistically improves CCl4-induced nephrotoxicity in albino rats.
Pakistan journal of pharmaceutical sciences.
2020 Sep; 33(5):2059-2065. doi:
. [PMID: 33824114] - Sung-Ji Park, Si Jae Rhee. Real-World Effectiveness and Safety of a Single-Pill Combination of Olmesartan/Amlodipine/Hydrochlorothiazide in Korean Patients with Essential Hypertension (RESOLVE): A Large, Observational, Retrospective, Cohort Study.
Advances in therapy.
2020 08; 37(8):3500-3514. doi:
10.1007/s12325-020-01404-z. [PMID: 32557349] - Sumera Qasim, Alamgeer, Saima Kalsoom, Muhammad Shahzad, Hafiz Muhammad Irfan, Muhammad Shoaib Zafar, Ishfaq Ali Bukhari, Fahim Vohra, Sibtain Afzal. Appraisal of disease-modifying potential of amlodipine as an anti-arthritic agent: new indication for an old drug.
Inflammopharmacology.
2020 Aug; 28(4):1121-1136. doi:
10.1007/s10787-020-00692-9. [PMID: 32141013] - Yoshiaki Kirigaya, Masanari Shiramoto, Tomoko Ishizuka, Hinako Uchimaru, Shin Irie, Manabu Kato, Takako Shimizu, Takafumi Nakatsu, Yasuhiro Nishikawa, Hitoshi Ishizuka. Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects.
BMC pharmacology & toxicology.
2020 07; 21(1):55. doi:
10.1186/s40360-020-00423-4. [PMID: 32727577] - Ko Jin Quek, Omar Z Ameer, Jacqueline K Phillips. Amlodipine Improves Vessel Function and Remodeling in the Lewis Polycystic Kidney Rat Mesenteric Artery.
American journal of hypertension.
2020 07; 33(7):634-643. doi:
10.1093/ajh/hpaa054. [PMID: 32215654] - Evgenia Shikh, Vladlena Zozina, Svetlana Kondratenko, Evgeny Melnikov, Vladimir Kukes. The particulars of certain drugs' effect on the endogenous coenzyme Q10 plasma level in patients with cardiovascular diseases.
Drug metabolism and personalized therapy.
2020 06; 35(2):. doi:
10.1515/dmpt-2020-0106. [PMID: 32609647] - Peng Liu, Xiaowei Wu, Haiyong Liu, Hanyu Wang, Kun Lu, Shixiang Gao. Desorption of pharmaceuticals from pristine and aged polystyrene microplastics under simulated gastrointestinal conditions.
Journal of hazardous materials.
2020 06; 392(?):122346. doi:
10.1016/j.jhazmat.2020.122346. [PMID: 32097859] - V Yu Mareev, Yu V Minina, Yu L Begrambekova, A M Levin. [Therapeutic approaches to the Rational Use of trip-le combination therapy with a fixed combination of amlodipine, indapamide and perindopril arginine (TRIPLE COMBINATION) in patients with hypertension who do not control blood pressure on conventional treatment. (Description and main results of the TRIO program)].
Kardiologiia.
2020 Jun; 60(5):1149. doi:
10.18087/cardio.2020.5.n1149. [PMID: 32515706] - Jianling Yang, Yuanyuan Li, Yang Li, Xueqi Rui, Meiqing Du, Zengfu Wang. Effects of atorvastatin on pharmacokinetics of amlodipine in rats and its potential mechanism.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Jun; 50(6):685-688. doi:
10.1080/00498254.2019.1673918. [PMID: 31556335] - Tongtong Wang, Yannan Wang, Sisi Lin, Lu Fang, Sai Lou, Di Zhao, Jingjing Zhu, Qigang Yang, Ying Wang. Evaluation of pharmacokinetics and safety with bioequivalence of Amlodipine in healthy Chinese volunteers: Bioequivalence Study Findings.
Journal of clinical laboratory analysis.
2020 Jun; 34(6):e23228. doi:
10.1002/jcla.23228. [PMID: 32034814] - Kollengode Ramanathan, Bishwabikash Mohanty, Simeon Tang, Graeme MacLaren. Extracorporeal therapy for amlodipine poisoning.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs.
2020 Jun; 23(2):183-186. doi:
10.1007/s10047-019-01132-4. [PMID: 31552515] - Bih-Show Lou, Umamaheswari Rajaji, Shen-Ming Chen, Tse-Wei Chen. A simple sonochemical assisted synthesis of NiMoO4/chitosan nanocomposite for electrochemical sensing of amlodipine in pharmaceutical and serum samples.
Ultrasonics sonochemistry.
2020 Jun; 64(?):104827. doi:
10.1016/j.ultsonch.2019.104827. [PMID: 31953007] - Stephen P Juraschek, Lara M Simpson, Barry R Davis, Robert H Shmerling, Jennifer L Beach, Anthony Ishak, Kenneth J Mukamal. The effects of antihypertensive class on gout in older adults: secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Journal of hypertension.
2020 05; 38(5):954-960. doi:
10.1097/hjh.0000000000002359. [PMID: 31977576] - Seokuee Kim, Jae-Wook Ko, Jung-Ryul Kim. Pharmacokinetic and Safety Profiles of a Fixed-Dose Combination of Amlodipine, Valsartan, and Atorvastatin: A 3-Period Replicate Crossover Study.
Clinical pharmacology in drug development.
2020 04; 9(3):386-394. doi:
10.1002/cpdd.727. [PMID: 31373174] - Jingwei Li, Min Zhao, Xue Jiang, Tingting Liu, Miao Wang, Chunjie Zhao. Synergistic therapeutic effects of Duzhong Jiangya Tablets and amlodipine besylate combination in spontaneously hypertensive rats using 1 H-NMR- and MS-based metabolomics.
Biomedical chromatography : BMC.
2020 Apr; 34(4):e4741. doi:
10.1002/bmc.4741. [PMID: 31743479] - Seong-Ho Ok, Ju-Tae Sohn. Lipid emulsion treatment of amlodipine toxicity.
Journal of clinical pharmacy and therapeutics.
2020 Apr; 45(2):397-398. doi:
10.1111/jcpt.13119. [PMID: 31984542] - Hanaa S Sallam, Demidmaa R Tuvdendorj, Ishwarlal Jialal, Manisha Chandalia, Nicola Abate. Therapeutic lifestyle change intervention improved metabolic syndrome criteria and is complementary to amlodipine/atorvastatin.
Journal of diabetes and its complications.
2020 03; 34(3):107480. doi:
10.1016/j.jdiacomp.2019.107480. [PMID: 31902653] - Yuko Ohta, Kei Kamide, Hironori Hanada, Shigeto Morimoto, Takeshi Nakahashi, Shin Takiuchi, Toshihiko Ishimitsu, Takuya Tsuchihashi, Masayoshi Soma, T Tomohiro Katsuya, Ken Sugimoto, Hiromi Rakugi, Takafumi Oukura, Jitsuo Higaki, Hideo Matsuura, Tatsuo Shinagawa, Yosikazu Miwa, Toshiyuki Sasaguri, Michiya Igase, Tetsuro Miki, Kazuo Takeda, Katsuhiro Higashiura, Kazuaki Shimamoto, Ritsuko Katabuchi, Michio Ueno, Naonaga Hosomi, Johji Kato, Norio Komai, Shunichi Kojima, Kazuhiro Sase, Yoshio Iwashima, Fumiki Yoshihara, Takeshi Horio, Satoko Nakamura, Hajime Nakahama, Toshiyuki Miyata, Yuhei Kawano. Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension.
2020 03; 43(3):220-226. doi:
10.1038/s41440-019-0356-x. [PMID: 31748705] - Jesús Mario Arancón-Monge, Alicia de Castro-Cuenca, Ángel Serrano-Vázquez, Luz Campos-Díaz, Ricardo Rodríguez Barrientos, Isabel Del Cura-González. [Effects of changing the appearance of medications in safety and adherence in chronic patients over 65 years of age in primary care. CAMBIMED Study].
Atencion primaria.
2020 02; 52(2):77-85. doi:
10.1016/j.aprim.2019.06.001. [PMID: 31481266] - Areti Sofogianni, Konstantinos Tziomalos. Fixed-dose combinations of lipid-lowering and antihypertensive agents: The way forward?.
Journal of clinical hypertension (Greenwich, Conn.).
2020 02; 22(2):270-272. doi:
10.1111/jch.13765. [PMID: 32003930] - Yoomin Ahn, Myung Hee Nam, Eungbin Kim. Relationship Between the Gastrointestinal Side Effects of an Anti-Hypertensive Medication and Changes in the Serum Lipid Metabolome.
Nutrients.
2020 Jan; 12(1):. doi:
10.3390/nu12010205. [PMID: 31941114] - Mohd Aftab Alam, Yousef Abdullah Bin Jardan, Mohammad Raish, Abdullah Mohammad Al-Mohizea, Abdul Ahad, Fahad Ibrahim Al-Jenoobi. Effect of Nigella sativa and Fenugreek on the Pharmacokinetics and Pharmacodynamics of Amlodipine in Hypertensive Rats.
Current drug metabolism.
2020; 21(4):318-325. doi:
10.2174/1389200221666200514121501. [PMID: 32407268]
