amitriptyline (BioDeep_00000397488)

Main id: BioDeep_00000001424

 


代谢物信息卡片


amitriptyline

化学式: C20H23N (277.183)
中文名称: 阿米替林
谱图信息: 最多检出来源 Homo sapiens(not specific) 22.41%

分子结构信息

SMILES: C1(\c2c(CCc3c1cccc3)cccc2)=C\CCN(C)C
InChI: InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

描述信息

N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D049990 - Membrane Transport Modulators
CONFIDENCE standard compound; INTERNAL_ID 943; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8144; ORIGINAL_PRECURSOR_SCAN_NO 8142
CONFIDENCE standard compound; INTERNAL_ID 943; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8187; ORIGINAL_PRECURSOR_SCAN_NO 8185
CONFIDENCE standard compound; INTERNAL_ID 943; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8212; ORIGINAL_PRECURSOR_SCAN_NO 8209
CONFIDENCE standard compound; INTERNAL_ID 943; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8233; ORIGINAL_PRECURSOR_SCAN_NO 8231
CONFIDENCE standard compound; INTERNAL_ID 943; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8247; ORIGINAL_PRECURSOR_SCAN_NO 8245
CONFIDENCE standard compound; INTERNAL_ID 943; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8225; ORIGINAL_PRECURSOR_SCAN_NO 8223
CONFIDENCE standard compound; INTERNAL_ID 1504
CONFIDENCE standard compound; INTERNAL_ID 8592
[Raw Data] CB205_Amitriptyline_pos_50eV_CB000074.txt
[Raw Data] CB205_Amitriptyline_pos_40eV_CB000074.txt
[Raw Data] CB205_Amitriptyline_pos_30eV_CB000074.txt
[Raw Data] CB205_Amitriptyline_pos_20eV_CB000074.txt
[Raw Data] CB205_Amitriptyline_pos_10eV_CB000074.txt
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2821

同义名列表

4 个代谢物同义名

amitriptyline; Amitryptiline; Amitriptyline; Amitriptyline



数据库引用编号

55 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ALB, AXIN2, BDNF, CYP2C19, CYP2D6, CYP3A4, NTRK2
Peripheral membrane protein 1 CYP1B1
Endosome membrane 2 NTRK1, NTRK2
Endoplasmic reticulum membrane 4 CYP1B1, CYP2C19, CYP2D6, CYP3A4
Nucleus 2 ALB, AXIN2
cytosol 4 ALB, AXIN2, NTRK2, PRKCQ
dendrite 4 BDNF, HTR1A, NTRK1, NTRK2
centrosome 2 ALB, AXIN2
nucleoplasm 1 SCNN1G
Cell membrane 5 ABCB1, HTR1A, NTRK1, NTRK2, SLC1A2
Cell projection, axon 1 NTRK2
Early endosome membrane 2 NTRK1, NTRK2
Multi-pass membrane protein 5 ABCB1, CACNA1I, HTR1A, SCNN1G, SLC1A2
Synapse 2 CRH, HTR1A
cell surface 3 ABCB1, NTRK1, SLC1A2
glutamatergic synapse 1 SLC1A2
Golgi apparatus 2 ALB, GDNF
Golgi membrane 1 INS
neuronal cell body 1 NTRK1
presynaptic membrane 1 SLC1A2
synaptic vesicle 1 BDNF
Lysosome 1 SMPD1
endosome 1 SMPD1
plasma membrane 11 ABCB1, AXIN2, CACNA1I, CYP2C19, HTR1A, NTRK1, NTRK2, PRKCQ, SCNN1G, SLC1A2, SMPD1
terminal bouton 1 NTRK2
Membrane 10 ABCB1, BDNF, CACNA1I, CYP1B1, CYP2D6, CYP3A4, NTRK1, NTRK2, SLC1A2, SMPD1
apical plasma membrane 2 ABCB1, SCNN1G
axon 3 BDNF, NTRK1, NTRK2
extracellular exosome 4 ABCB1, ALB, SCNN1G, SMPD1
endoplasmic reticulum 2 ALB, CYP2D6
extracellular space 7 ALB, BDNF, CRH, GDNF, IL10, INS, SMPD1
lysosomal lumen 1 SMPD1
perinuclear region of cytoplasm 2 BDNF, NTRK2
mitochondrion 3 CYP1B1, CYP2D6, NTRK1
protein-containing complex 2 ALB, NTRK1
intracellular membrane-bounded organelle 4 CYP1B1, CYP2C19, CYP2D6, CYP3A4
Microsome membrane 3 CYP1B1, CYP2D6, CYP3A4
postsynaptic density 1 NTRK2
Single-pass type I membrane protein 2 NTRK1, NTRK2
Secreted 7 ALB, BDNF, CRH, GDNF, IL10, INS, SMPD1
extracellular region 7 ALB, BDNF, CRH, GDNF, IL10, INS, SMPD1
Single-pass membrane protein 1 CYP2D6
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 SCNN1G
varicosity 1 CRH
dendritic spine 1 NTRK2
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
beta-catenin destruction complex 1 AXIN2
Early endosome 2 NTRK1, NTRK2
vesicle 1 SLC1A2
Apical cell membrane 2 ABCB1, SCNN1G
Cytoplasm, perinuclear region 1 NTRK2
Membrane raft 1 SLC1A2
axolemma 1 SLC1A2
Late endosome 1 NTRK1
receptor complex 2 NTRK1, NTRK2
ciliary basal body 1 ALB
Late endosome membrane 1 NTRK1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Recycling endosome membrane 1 NTRK1
endosome lumen 1 INS
Lipid droplet 1 SMPD1
sodium channel complex 1 SCNN1G
Cell projection, dendrite 2 HTR1A, NTRK2
cell body 1 SLC1A2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, BDNF, INS
platelet alpha granule lumen 1 ALB
axon terminus 1 NTRK2
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
external side of apical plasma membrane 1 ABCB1
astrocyte projection 1 SLC1A2
lamellar body 1 SMPD1
neuron projection terminus 1 SLC1A2
[Sphingomyelin phosphodiesterase, processed form]: Secreted, extracellular space 1 SMPD1
endolysosome 1 SMPD1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
membrane protein complex 1 SLC1A2
ciliary transition fiber 1 ALB


文献列表

  • Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review. Medicine. 2024 Mar; 103(11):e37612. doi: 10.1097/md.0000000000037612. [PMID: 38489675]
  • Anna Detzlhofer, Christian Grechhamer, Lawrence Madikizela, Markus Himmelsbach, Franz Mlynek, Wolfgang Buchberger, Christian W Klampfl. Uptake, translocation, and metabolization of amitriptyline, lidocaine, orphenadrine, and tramadol by cress and pea. Environmental science and pollution research international. 2024 Mar; 31(13):19649-19657. doi: 10.1007/s11356-024-32379-x. [PMID: 38363510]
  • Daria A Belinskaia, Natalia N Shestakova. Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data. Biochemistry. Biokhimiia. 2024 Mar; 89(3):507-522. doi: 10.1134/s0006297924030106. [PMID: 38648769]
  • Chi-Jung Tsai, Chuang-Hsin Chiu, Yu-Yeh Kuo, Wen-Sheng Huang, Tsung-Hsun Yu, Leo Garcia Flores, Skye Hsin-Hsien Yeh, Kuo-Hsing Ma. Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[18F]-ADAM PET Imaging. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23137035. [PMID: 35806049]
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  • Elena Isaeva, Ruslan Bohovyk, Mykhailo Fedoriuk, Alexey Shalygin, Christine A Klemens, Adrian Zietara, Vladislav Levchenko, Jerod S Denton, Alexander Staruschenko, Oleg Palygin. Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir 4.1/Kir 5.1) in the cortical collecting duct. British journal of pharmacology. 2022 06; 179(12):2953-2968. doi: 10.1111/bph.15779. [PMID: 34904226]
  • I Prins-Can, I R F van Berlo-van de Laar, M Zeeman, C G Vermeij, E van 't Riet, K Taxis, F G A Jansman. Assessing the binding interaction of polystyrene sulfonate with amitriptyline in healthy volunteers: a cross-over design - The BIND study. European journal of clinical pharmacology. 2022 May; 78(5):839-845. doi: 10.1007/s00228-022-03283-5. [PMID: 35171315]
  • Mitchelle Katemauswa, Ekram Hossain, Zongyuan Liu, Mahbobeh Lesani, Adwaita R Parab, Danya A Dean, Laura-Isobel McCall. Enabling Quantitative Analysis of Surface Small Molecules for Exposomics and Behavioral Studies. Journal of the American Society for Mass Spectrometry. 2022 Mar; 33(3):412-419. doi: 10.1021/jasms.1c00263. [PMID: 35084848]
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  • Wen-Cong Zhou, Lin Jia, Qi Deng, Yu-Guan Wen, De-Wei Shang, Xiao-Jia Ni, Yao-Xing Huang, Yao Liu, Han-Bing Zhao, Meng Yang, Guo-Yuan Dou. Role of serum amitriptyline concentration and CYP2C19 polymorphism in predicting the response to low-dose amitriptyline in irritable bowel syndrome. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2021 Nov; 53(11):1422-1427. doi: 10.1016/j.dld.2021.02.020. [PMID: 33753003]
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  • Kathleen E Singer, Taylor E Wallen, Mackenzie C Morris, Emily McGlone, Sabre Stevens-Topie, Ryan Earnest, Michael D Goodman. Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI. The journal of trauma and acute care surgery. 2021 08; 91(2S Suppl 2):S89-S98. doi: 10.1097/ta.0000000000003259. [PMID: 33938511]
  • Rafaela F Rodrigues, Taila Kawano, Rodrigo V Placido, Lellis H Costa, Marcia H M C Podesta, Rafaela S Santos, Giovane Galdino, Carlos M Barros, Vanessa B Boralli. Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats. Pain physician. 2021 07; 24(4):E511-E520. doi: NULL. [PMID: 34213877]
  • Ibrahim A Naguib, Nesma A Ali, Fadwa A Elroby, Mohamed R Elghobashy. Green HPLC-DAD and HPTLC Methods for Quantitative Determination of Binary Mixture of Pregabalin and Amitriptyline Used for Neuropathic Pain Management. Journal of chromatographic science. 2021 May; 59(6):536-547. doi: 10.1093/chromsci/bmab031. [PMID: 33778855]
  • Haidara Majid, Andreas Puzik, Tanja Maier, Daniel Eberhard, Anke Bartel, Hans-Christian Mueller, Bjoern B Burckhardt. Exploring the transmucosal permeability of cyclobenzaprine: A comparative preformulation by standardized and controlled ex vivo and in vitro permeation studies. International journal of pharmaceutics. 2021 May; 601(?):120574. doi: 10.1016/j.ijpharm.2021.120574. [PMID: 33831487]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepeköylü, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Tölle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan. Acid sphingomyelinase promotes SGK1-dependent vascular calcification. Clinical science (London, England : 1979). 2021 02; 135(3):515-534. doi: 10.1042/cs20201122. [PMID: 33479769]
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  • Ehab Tousson, Ezar Hafez, Somia Zaki, Amani Gad, Rehab M Elgharabawy. Evaluation of the testicular protection conferred by damiana (Turnera diffusa Willd.) against amitriptyline-induced testicular toxicity, DNA damage and apoptosis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Dec; 132(?):110819. doi: 10.1016/j.biopha.2020.110819. [PMID: 33035829]
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  • Mahin Hashemi Hedeshi, Omid Rezvani, Habib Bagheri. Silane-based modified papers and their extractive phase roles in a microfluidic platform. Analytica chimica acta. 2020 Sep; 1128(?):31-41. doi: 10.1016/j.aca.2020.05.069. [PMID: 32825910]
  • Judy Caron, Randall Kaye, Thomas Wessel, Amy Halseth, Gary Kay. An assessment of the centrally acting muscle relaxant tolperisone on driving ability and cognitive effects compared to placebo and cyclobenzaprine. Journal of clinical pharmacy and therapeutics. 2020 Aug; 45(4):774-782. doi: 10.1111/jcpt.13165. [PMID: 32390248]
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  • Maike Scherf-Clavel, Jasper Zebner, Leif Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Nortriptyline serum concentration as a predictor for cardiac risk in amitriptyline-treated patients. European journal of clinical pharmacology. 2020 Jan; 76(1):73-80. doi: 10.1007/s00228-019-02766-2. [PMID: 31641787]
  • You Zhai, Lihua Wu, Yunliang Zheng, Minglan Wu, Yujie Huang, Qian Huang, Jianzhong Shentu, Qingwei Zhao, Jian Liu. Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions. Drug design, development and therapy. 2020; 14(?):3131-3142. doi: 10.2147/dddt.s258173. [PMID: 32801649]
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