metoprolol (BioDeep_00000397476)

Main id: BioDeep_00000002568

Secondary id: BioDeep_00000229728


代谢物信息卡片


metoprolol

化学式: C15H25NO3 (267.18343400000003)
中文名称: 1-[4-(2-甲氧基乙基)苯氧基]-3-丙-2-基氨基丙-2-醇, 美托洛尔
谱图信息: 最多检出来源 Homo sapiens(feces) 1.61%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
InChI: InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3

描述信息

C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
Metoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor by Novartis, and Toprol (in the USA); Seleken or Selokeen (elsewhere); A selective adrenergic beta-1-blocking agent with no stimulatory action. Its binding to plasma albumin is weaker than alprenolol and it may be useful in the treatment of several diseases of the cardiovascular system; Metoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor by Novartis, and Toprol (in the USA); Seleken or Selokeen (elsewhere); as Minax by Alphapharm (in Australia), as Betaloc by AstraZeneca and as Corvitol by Berlin-Chemie AG; A selective adrenergic beta-1-blocking agent with no stimulatory action. Its binding to plasma albumin is weaker than alprenolol and it may be useful in angina pectoris, hypertension, or cardiac arrhythmias; as Minax by Alphapharm (in Australia), as Betaloc by AstraZeneca and as Corvitol by Berlin-Chemie AG. [HMDB]
CONFIDENCE standard compound; INTERNAL_ID 1107
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 81
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 1080
CONFIDENCE standard compound; INTERNAL_ID 4072
CONFIDENCE Reference Standard (Level 1)
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3].

同义名列表

1 个代谢物同义名

metoprolol



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Florence Nantaba, John Wasswa, Henrik Kylin, Hindrik Bouwman, Wolf-Ulrich Palm, Klaus Kümmerer. Spatial trends and ecotoxic risk assessment of selected pharmaceuticals in sediments from Lake Victoria, Uganda, East Africa. The Science of the total environment. 2023 Sep; 906(?):167348. doi: 10.1016/j.scitotenv.2023.167348. [PMID: 37769731]
  • Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis. The Cochrane database of systematic reviews. 2023 Aug; 8(?):CD013573. doi: 10.1002/14651858.cd013573.pub2. [PMID: 37565307]
  • Pradeep Kumkar, Chandani R Verma, Štěpán Hýsek, Manoj Pise, Sonia Źółtowska, Sachin M Gosavi, Filip Mercl, Matěj Božik, Lukáš Praus, Kateřina Hanková, Radek Rinn, Pavel Klouček, Miloslav Petrtýl, Lukáš Kalous. Contaminants and their ecological risk assessment in beach sediments and water along the Maharashtra coast of India: A comprehensive approach using microplastics, heavy metal(loid)s, pharmaceuticals, personal care products and plasticizers. The Science of the total environment. 2023 Jun; ?(?):164712. doi: 10.1016/j.scitotenv.2023.164712. [PMID: 37301381]
  • Hasan Karkoosh, Meththika Vithanage, Ajit K Sarmah. The role of anthocyanin and kaolinite in modifying cabbage leaves biochar for removal of potentially toxic elements and pharmaceutical from aqueous solution. Environmental pollution (Barking, Essex : 1987). 2023 May; 325(?):121435. doi: 10.1016/j.envpol.2023.121435. [PMID: 36924915]
  • Ming Yi, Jinxiu Lou, Wanlu Zhu, Dan Li, Pingfeng Yu, Huijie Lu. Mechanism of β-blocker biodegradation by wastewater microorganisms. Journal of hazardous materials. 2023 02; 444(Pt A):130338. doi: 10.1016/j.jhazmat.2022.130338. [PMID: 36417780]
  • Yang-Yang Shi, Bo Wei, Jing Zhou, Zhi-Li Yin, Fei Zhao, Ya-Jie Peng, Qing-Wen Yu, Xin-Lu Wang, Ya-Jing Chen. Discovery of 5-(3,4-dihydroxybenzylidene)-1,3-dimethylpyrimidine- 2,4,6(1H,3H,5H)-trione as a novel and effective cardioprotective agent via dual anti-inflammatory and anti-oxidative activities. European journal of medicinal chemistry. 2022 Dec; 244(?):114848. doi: 10.1016/j.ejmech.2022.114848. [PMID: 36274277]
  • Hui-Lin Yang, Ying Li, Yi Chen, Si-Ying Chen, Yue-Ting Li, Yong Huang, Lin Zheng, Jing Huang, Yong-Lin Wang, Zi-Peng Gong. [Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(23):6320-6332. doi: 10.19540/j.cnki.cjcmm.20220623.204. [PMID: 36604876]
  • Urs Duthaler, Fabio Bachmann, Claudia Suenderhauf, Tanja Grandinetti, Florian Pfefferkorn, Manuel Haschke, Petr Hruz, Jamal Bouitbir, Stephan Krähenbühl. Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently. Clinical pharmacokinetics. 2022 07; 61(7):1039-1055. doi: 10.1007/s40262-022-01119-0. [PMID: 35570253]
  • M Mukkanti Eswarudu, A Lakshmana Rao, K Vijay. Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma. Journal of pharmacological and toxicological methods. 2022 Jul; 116(?):107186. doi: 10.1016/j.vascn.2022.107186. [PMID: 35644433]
  • Elnaz Marzi Khosrowshahi, Behnaz Limuie Khosrowshahi, Mir Ali Farajzadeh, Abolghasem Jouyban, Mustafa Tuzen, Mohammad Reza Afshar Mogaddam, Mahboob Nemati. Application of microcrystalline cellulose as an efficient and cheap sorbent for the extraction of metoprolol from plasma and wastewater before HPLC-MS/MS determination. Biomedical chromatography : BMC. 2022 Jul; 36(7):e5371. doi: 10.1002/bmc.5371. [PMID: 35305038]
  • Abdolhamid Esmaeeli, Zahra Keshavarz, Firoozeh Dehdar, Majid Assadi, Mohammad Seyedabadi. The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury. Drug and chemical toxicology. 2022 Jul; 45(4):1558-1564. doi: 10.1080/01480545.2020.1846551. [PMID: 33198524]
  • Meihua Li, Can Zheng, Toru Kawada, Kazunori Uemura, Masashi Inagaki, Keita Saku, Masaru Sugimachi. Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction. The journal of physiological sciences : JPS. 2022 Jun; 72(1):12. doi: 10.1186/s12576-022-00836-2. [PMID: 35725377]
  • Xiaonan Li, Gang Xing, Xinxin Guo, Yang Wang, Zixia Hu, Maosheng Cheng, Ying Peng, Jiang Zheng. Identification of Metoprolol Tartrate-Derived Reactive Metabolites Possibly Correlated with Its Cytotoxicity. Chemical research in toxicology. 2022 Jun; 35(6):1059-1069. doi: 10.1021/acs.chemrestox.2c00052. [PMID: 35575346]
  • Yuefei Ruan, Hongwen Sun, Yichun Lu, Yanwei Zhang, Jiayao Xu, Hongkai Zhu, Yuhe He. Evaluating phospholipid- and protein-water partitioning of two groups of chemicals of emerging concern: Diastereo- and enantioselectivity. Journal of hazardous materials. 2022 05; 430(?):128499. doi: 10.1016/j.jhazmat.2022.128499. [PMID: 35739679]
  • Maxime Meloche, Grégoire Leclair, Martin Jutras, Essaïd Oussaïd, Marie-Josée Gaulin, Ian Mongrain, David Busseuil, Jean-Claude Tardif, Marie-Pierre Dubé, Simon de Denus. Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof-of-concept study. Clinical and translational science. 2022 04; 15(4):1063-1073. doi: 10.1111/cts.13230. [PMID: 35122397]
  • Rabiha Salam, Syeda Nayyab Batool Rizvi, Naqi Hussain, Shama Firdous, Muhammad Zaheer, Muhammad Naeem. Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model. Xenobiotica; the fate of foreign compounds in biological systems. 2022 Mar; 52(3):295-300. doi: 10.1080/00498254.2022.2067507. [PMID: 35443873]
  • Daniela Luethy, Mary A Robinson, Darko Stefanovski, Joanne Haughan, Catherine Torcivia, Alycia Kowalski, Matthew Ford, Youwen You, Jaclyn Missanelli, Joann Slack. Pharmacokinetics and pharmacodynamics of oral and intravenous metoprolol tartrate in clinically healthy horses. Journal of veterinary pharmacology and therapeutics. 2022 Mar; 45(2):177-187. doi: 10.1111/jvp.13037. [PMID: 34913168]
  • Jing Wang, Chong Li, Peng Li. A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization. Journal of the American Society for Mass Spectrometry. 2022 Feb; 33(2):304-314. doi: 10.1021/jasms.1c00305. [PMID: 35040644]
  • Xinping Chen, Shengmiao Fu, Weihua Xu. Association Between Metoprolol and Prognosis of COVID-19 Patients. Journal of the American College of Cardiology. 2022 01; 79(1):e7. doi: 10.1016/j.jacc.2021.09.1383. [PMID: 34991794]
  • Arnoldo Santos, Juan Martínez-Milla, César Pérez-Calvo, Borja Ibáñez. Reply: Biological Plausibility Behind the Benefits of Intravenous Metoprolol in Severe COVID-19. Journal of the American College of Cardiology. 2022 01; 79(1):e13-e14. doi: 10.1016/j.jacc.2021.10.030. [PMID: 34991793]
  • Zhongbo Shi, Junhao Jiang, Dezhang Zhao, Baogang Xie, Yan Li, Chao Yu. Effects of Astragaloside IV on the Pharmacokinetics of Metoprolol in Rats and its Mechanism. Current drug metabolism. 2022; 23(2):131-136. doi: 10.2174/1389200223666220128143133. [PMID: 35088663]
  • Yingyi Lu, Fenglian Wang, Haoxuan Ni, Ying Sun, Hailing Shi. Observation of Curative Effect of Trimetazidine Combined with Metoprolol in Elderly Patients with Coronary Heart Disease Complicated with Heart Failure and the Effect of Myocardial Remodeling by Integrated Traditional Chinese and Western Medicine. BioMed research international. 2022; 2022(?):6098799. doi: 10.1155/2022/6098799. [PMID: 36246960]
  • Li Ye, Guofen Hu, Huamin Yu, Jindong Sun, Hong Yuan. Metoprolol Improves Myocardial Remodeling and Cardiac Function in Patients with Permanent Pacemaker Implantation. Journal of healthcare engineering. 2022; 2022(?):7340992. doi: 10.1155/2022/7340992. [PMID: 35449861]
  • Chunyu Liu, Jing Xu, Ran Liu, Miye Wang, Yixuan Zhuo, Lan Su, Hongmei Yan, Qing Zhang. Identifying drug-related attributes to personalise antihypertensive agents: the outcome report of patients receiving metoprolol therapy. BMC medical informatics and decision making. 2021 12; 21(1):370. doi: 10.1186/s12911-021-01739-9. [PMID: 34969399]
  • Cheng Chen, Jiao Tian, Zhicheng He, Wenyong Xiong, Yingying He, Shubai Liu. Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy. International journal of molecular sciences. 2021 Dec; 22(23):. doi: 10.3390/ijms222313116. [PMID: 34884921]
  • Cristina Almengló, Marinela Couselo-Seijas, Rosa M Agra, Alfonso Varela-Román, José M García-Acuña, Mercedes González-Peteiro, José R González-Juanatey, Sonia Eiras, Ezequiel Álvarez. Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value. Journal of molecular medicine (Berlin, Germany). 2021 12; 99(12):1741-1753. doi: 10.1007/s00109-021-02129-4. [PMID: 34529122]
  • Fabio Bachmann, Urs Duthaler, Stephan Krähenbühl. Effect of deglucuronidation on the results of the Basel phenotyping cocktail. British journal of clinical pharmacology. 2021 12; 87(12):4608-4618. doi: 10.1111/bcp.14874. [PMID: 33890704]
  • Maxime Meloche, Martin Jutras, Isabelle St-Jean, Simon de Denus, Grégoire Leclair. Isocyanate derivatization coupled with phospholipid removal microelution-solid phase extraction for the simultaneous quantification of (S)-metoprolol and (S)-α-hydroxymetoprolol in human plasma with LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2021 Sep; 204(?):114263. doi: 10.1016/j.jpba.2021.114263. [PMID: 34274593]
  • Agustín Clemente-Moragón, Juan Martínez-Milla, Eduardo Oliver, Arnoldo Santos, Javier Flandes, Iker Fernández, Lorena Rodríguez-González, Cristina Serrano Del Castillo, Ana-María Ioan, María López-Álvarez, Sandra Gómez-Talavera, Carlos Galán-Arriola, Valentín Fuster, César Pérez-Calvo, Borja Ibáñez. Metoprolol in Critically Ill Patients With COVID-19. Journal of the American College of Cardiology. 2021 09; 78(10):1001-1011. doi: 10.1016/j.jacc.2021.07.003. [PMID: 34474731]
  • Liqun Zhang, Jimusi Wuri, Lulu An, Xiaoxuan Liu, Ye Wu, Haotian Hu, Ruixia Wu, Yue Su, Quan Yuan, Tao Yan. Metoprolol attenuates intracerebral hemorrhage-induced cardiac damage by suppression of sympathetic overactivity in mice. Autonomic neuroscience : basic & clinical. 2021 09; 234(?):102832. doi: 10.1016/j.autneu.2021.102832. [PMID: 34126326]
  • Yuan-Yuan Wang, Zhen-Hui Han, Yu-Li Wang, Ying Liao, Chun-Yu Zhang, Ping Liu, Chao-Shu Tang, Jun-Bao Du, Hong-Fang Jin, Ya-Qian Huang. Baseline left ventricular ejection fraction associated with symptom improvements in both children and adolescents with postural tachycardia syndrome under metoprolol therapy. Chinese medical journal. 2021 08; 134(16):1977-1982. doi: 10.1097/cm9.0000000000001698. [PMID: 34387611]
  • Ravindra Babu Pingili, Sridhar Vemulapalli, Vijaya R Dirisala, Surya Sandeep Mullapudi, Yamini Gullapalli, Naveen Babu Kilaru. Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Aug; 51(8):926-932. doi: 10.1080/00498254.2021.1942311. [PMID: 34138683]
  • Sheelan Ahmad, Daniel Baker, Darragh Murnane, Neil Spooner, Ute Gerhard. Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis. Bioanalysis. 2021 Jul; 13(14):1101-1111. doi: 10.4155/bio-2021-0109. [PMID: 34275331]
  • Shameen Salam, Brandon Nornhold, Jihad Mallat. Massive metoprolol overdose requiring ECMO: brief review of the evidence behind recommended treatments. BMJ case reports. 2021 May; 14(5):. doi: 10.1136/bcr-2019-232130. [PMID: 33952561]
  • Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 05; 77(5):704-712. doi: 10.1053/j.ajkd.2020.07.023. [PMID: 33010357]
  • Ning Li, Shujuan He, Chunlan Li, Fatang Yang, Yuming Dong. Sensitive Analysis of Metoprolol Tartrate and Diltiazem Hydrochloride in Human Serum by Capillary Zone Electrophoresis Combining on Column Field-Amplified Sample Injection. Journal of chromatographic science. 2021 Apr; 59(5):465-472. doi: 10.1093/chromsci/bmab025. [PMID: 33675354]
  • Martin Nicol, Malha Sadoune, Evelyne Polidano, Jean Marie Launay, Jane Lise Samuel, Feriel Azibani, Alain Cohen-Solal. Doxorubicin-induced and trastuzumab-induced cardiotoxicity in mice is not prevented by metoprolol. ESC heart failure. 2021 04; 8(2):928-937. doi: 10.1002/ehf2.13198. [PMID: 33529501]
  • Shanjun Tan, Feng Zhou, Zhige Zhang, Junjie Wang, Jiahao Xu, Qiulin Zhuang, Qingyang Meng, Qiulei Xi, Yi Jiang, Guohao Wu. Beta-1 blocker reduces inflammation and preserves intestinal barrier function after open abdominal surgery. Surgery. 2021 04; 169(4):885-893. doi: 10.1016/j.surg.2020.11.004. [PMID: 33303271]
  • John Mach, XiaoSuo Wang, Sarah N Hilmer. Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy. Fundamental & clinical pharmacology. 2021 Apr; 35(2):410-422. doi: 10.1111/fcp.12602. [PMID: 32813878]
  • Katarzyna Markiewicz, Anna Białk-Bielińska, Paulina Łukaszewicz, Piotr Stepnowski, Joanna Dołżonek. Insight into the Sorption of 5-Fluorouracil and Methotrexate onto Soil-pH, Ionic Strength, and Co-Contaminant Influence. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061674. [PMID: 33802784]
  • Lea Wagmann, Aline C Vollmer, Lucas Lauder, Felix Mahfoud, Markus R Meyer. Assessing Adherence to Antihypertensive Medication by Means of Dose-Dependent Reference Plasma Concentration Ranges and Ultra-High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Analysis. Molecules (Basel, Switzerland). 2021 Mar; 26(5):. doi: 10.3390/molecules26051495. [PMID: 33803489]
  • Samer Asmar, Letitia Bible, Mohamad Chehab, Andrew Tang, Muhammad Khurrum, Lourdes Castanon, Michael Ditillo, Molly Douglas, Bellal Joseph. Traumatic brain injury induced temperature dysregulation: What is the role of β blockers?. The journal of trauma and acute care surgery. 2021 01; 90(1):177-184. doi: 10.1097/ta.0000000000002975. [PMID: 33332783]
  • Justin N Corcoran, Katherine J Jacoby, Travis D Olives, Stacey A Bangh, Jon B Cole. Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2020 10; 16(4):465-469. doi: 10.1007/s13181-020-00796-2. [PMID: 32656624]
  • Jia Tang, Chao Wu, Jian Cao, Liang Wang. Fabry disease with early-onset ventricular dilation: A case report. Medicine. 2020 Sep; 99(39):e22326. doi: 10.1097/md.0000000000022326. [PMID: 32991443]
  • Yuzhou Gui, Youli Lu, Shuijun Li, Mengqi Zhang, Xiaokun Duan, Charles C Liu, Jingying Jia, Gangyi Liu. Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring. Scientific reports. 2020 09; 10(1):15550. doi: 10.1038/s41598-020-72490-w. [PMID: 32968164]
  • Wafa F S Badulla, Arın G Dal Poçan, Zeki Atkoşar, Göksel Arlı. Capillary Electrophoresis Method for Determination of Escitalopram Oxalate in Urine Samples and Different Dosage Forms. Journal of chromatographic science. 2020 Aug; 58(8):759-769. doi: 10.1093/chromsci/bmaa036. [PMID: 32685979]
  • Peter Uchenna Amadi, Emmanuel Nnabugwu Agomuo, Chiamaka Winifred Adumekwe. Modulatory properties of cardiac and quercetin glycosides from Dacryodes edulis seeds during L-NAME-induced vascular perturbation. Journal of basic and clinical physiology and pharmacology. 2020 Jul; 31(5):. doi: 10.1515/jbcpp-2019-0116. [PMID: 32653874]
  • Ken Ogasawara, Patricia M LoRusso, Anthony J Olszanski, Olivier Rixe, Christine Xu, Jian Yin, Maria Palmisano, Gopal Krishna. Assessment of effects of repeated oral doses of fedratinib on inhibition of cytochrome P450 activities in patients with solid tumors using a cocktail approach. Cancer chemotherapy and pharmacology. 2020 07; 86(1):87-95. doi: 10.1007/s00280-020-04102-3. [PMID: 32537715]
  • Aml A Emam, Ibrahim A Naguib, Eman S Hassan, Eglal A Abdelaleem. Development and Validation of RP-HPLC and an Ecofriendly HPTLC Method for Simultaneous Determination of Felodipine and Metoprolol Succinate, and their Major Metabolites in Human Spiked Plasma. Journal of AOAC International. 2020 Jul; 103(4):966-971. doi: 10.1093/jaoacint/qsz040. [PMID: 33241342]
  • Lei Xu, Weiqi Meng, Jing Lu, Fengjuan Cui, Lidi Gao, Lin Chen, Yang Xin. Hyphenation of field-amplified sample injection and transient isotachophoresis in CE for the determination of sotalol and metoprolol in human urine samples. Journal of separation science. 2020 Jun; 43(11):2193-2200. doi: 10.1002/jssc.201901165. [PMID: 32068343]
  • Anne Kristine Anstensrud, Espen Molden, Hans Jørgen Haug, Rehman Qazi, Hysen Muriq, Linn E Fosshaug, Olav Spigset, Erik Øie. Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction - a prospective observational study. European journal of clinical pharmacology. 2020 May; 76(5):673-683. doi: 10.1007/s00228-020-02832-0. [PMID: 31940084]
  • Alexander Juusela, Munir Nazir, Martin Gimovsky. Two cases of coronavirus 2019-related cardiomyopathy in pregnancy. American journal of obstetrics & gynecology MFM. 2020 05; 2(2):100113. doi: 10.1016/j.ajogmf.2020.100113. [PMID: 32363336]
  • Richard L Verrier, Luiz Belardinelli. Pulmonary Delivery of Antiarrhythmic Drugs for Rapid Conversion of New-Onset Atrial Fibrillation. Journal of cardiovascular pharmacology. 2020 04; 75(4):276-283. doi: 10.1097/fjc.0000000000000804. [PMID: 32032206]
  • Qiong Lai, Guangying Yuan, Hao Wang, Zeliang Liu, Junping Kou, Boyang Yu, Fang Li. Metabolomic profiling of metoprolol-induced cardioprotection in a murine model of acute myocardial ischemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Apr; 124(?):109820. doi: 10.1016/j.biopha.2020.109820. [PMID: 31972362]
  • Chad N Brocker, Thomas Velenosi, Hania K Flaten, Glenn McWilliams, Kyle McDaniel, Shelby K Shelton, Jessica Saben, Kristopher W Krausz, Frank J Gonzalez, Andrew A Monte. Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites. Human genomics. 2020 03; 14(1):10. doi: 10.1186/s40246-020-00260-w. [PMID: 32160915]
  • Marion Leclercq, Marion Soichot, Brigitte Delhotal-Landes, Emmanuel Bourgogne, Hervé Gourlain, Bruno Mégarbane, Laurence Labat. False positive amphetamines and 3,4-methylenedioxymethamphetamine immunoassays in the presence of metoprolol-two cases reported in clinical toxicology. Journal of analytical toxicology. 2020 Mar; 44(2):200-205. doi: 10.1093/jat/bkz051. [PMID: 31384953]
  • Jan Peter Yska, Jacquelien T M Wanders, Blessing Odigie, Jan A Apers, Marloes Emous, Erik R E Totté, E Christiaan Boerma, Froukje L Ubels, Herman J Woerdenbag, Henderik W Frijlink, Bob Wilffert, Eric N van Roon. Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: a single oral dose study before and after surgery. European journal of hospital pharmacy : science and practice. 2020 03; 27(e1):e19-e24. doi: 10.1136/ejhpharm-2018-001804. [PMID: 32296500]
  • Miao Ye, Wen Xu, Da-Qing He, Xian Wu, Wen-Fang Lai, Xiao-Qin Zhang, Yu Lin, Wei Xu, Xu-Wen Li. Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis. Journal of natural products. 2020 02; 83(2):362-373. doi: 10.1021/acs.jnatprod.9b00857. [PMID: 32031812]
  • Pascal Schlosser, Yong Li, Peggy Sekula, Johannes Raffler, Franziska Grundner-Culemann, Maik Pietzner, Yurong Cheng, Matthias Wuttke, Inga Steinbrenner, Ulla T Schultheiss, Fruzsina Kotsis, Tim Kacprowski, Lukas Forer, Birgit Hausknecht, Arif B Ekici, Matthias Nauck, Uwe Völker, Gerd Walz, Peter J Oefner, Florian Kronenberg, Robert P Mohney, Michael Köttgen, Karsten Suhre, Kai-Uwe Eckardt, Gabi Kastenmüller, Anna Köttgen. Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans. Nature genetics. 2020 02; 52(2):167-176. doi: 10.1038/s41588-019-0567-8. [PMID: 31959995]
  • Andrew E Shouksmith, Justyna M Gawel, Nabanita Nawar, Diana Sina, Yasir S Raouf, Shazreh Bukhari, Liying He, Alexandra E Johns, Pimyupa Manaswiyoungkul, Olasunkanmi O Olaoye, Aaron D Cabral, Abootaleb Sedighi, Elvin D de Araujo, Patrick T Gunning. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia. ACS medicinal chemistry letters. 2020 Jan; 11(1):56-64. doi: 10.1021/acsmedchemlett.9b00471. [PMID: 31938464]
  • Jason Barricklow, Joseph Tweed, Christopher L Holliman, Ragu Ramanathan. Evaluation of OptiFlow™-MS/MS for bioanalysis of pharmaceutical drugs and metabolites. Bioanalysis. 2020 Jan; 12(1):23-34. doi: 10.4155/bio-2019-0250. [PMID: 31849261]
  • Mei-Ling Wu, Yi-Ping Lin, Yan-Li Wei, Hong-Jian Du, Xiao-Qian Ying, Wen-Zhuang Tan, Bi-E Tang. Calycosin Influences the Metabolism of Five Probe Drugs in Rats. Drug design, development and therapy. 2020; 14(?):429-434. doi: 10.2147/dddt.s236221. [PMID: 32099327]
  • Bo Liang, Fei-Hu Zou, Ling Fu, Hui-Ling Liao. Chinese Herbal Medicine Dingji Fumai Decoction for Ventricular Premature Contraction: A Real-World Trial. BioMed research international. 2020; 2020(?):5358467. doi: 10.1155/2020/5358467. [PMID: 32351995]
  • Diego A C Cusinato, Edson Z Martinez, Mônica T C Cintra, Gabriela C O Filgueira, Andresa A Berretta, Vera L Lanchote, Eduardo B Coelho. Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach. Journal of ethnopharmacology. 2019 Dec; 245(?):112174. doi: 10.1016/j.jep.2019.112174. [PMID: 31442620]
  • Qingyu Kong, Xiaofei Yang, Zhifeng Cai, Yanyan Pan, Minmin Wang, Mengmeng Liu, Cuifen Zhao. Twenty-four-hour urine NE level as a predictor of the therapeutic response to metoprolol in children with recurrent vasovagal syncope. Irish journal of medical science. 2019 Nov; 188(4):1279-1287. doi: 10.1007/s11845-019-01979-9. [PMID: 30761458]
  • Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121793. doi: 10.1016/j.jchromb.2019.121793. [PMID: 31629310]
  • Sumit Basu, Haitao Yang, Lanyan Fang, Mario Gonzalez-Sales, Liang Zhao, Mirjam N Trame, Lawrence Lesko, Stephan Schmidt. Physiologically Based Pharmacokinetic Modeling to Evaluate Formulation Factors Influencing Bioequivalence of Metoprolol Extended-Release Products. Journal of clinical pharmacology. 2019 09; 59(9):1252-1263. doi: 10.1002/jcph.1017. [PMID: 31087553]
  • Perrine Courlet, Dany Spaggiari, Vincent Desfontaine, Matthias Cavassini, Susana Alves Saldanha, Thierry Buclin, Catia Marzolini, Chantal Csajka, Laurent-Arthur Decosterd. UHPLC-MS/MS assay for simultaneous determination of amlodipine, metoprolol, pravastatin, rosuvastatin, atorvastatin with its active metabolites in human plasma, for population-scale drug-drug interactions studies in people living with HIV. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 09; 1125(?):121733. doi: 10.1016/j.jchromb.2019.121733. [PMID: 31374423]
  • Maurizio Sessa, Annamaria Mascolo, Daniel Bech Rasmussen, Kristian Kragholm, Magnus Thorsten Jensen, Liberata Sportiello, Concetta Rafaniello, Giuseppe Michele Tari, Claudia Pagliaro, Morten Andersen, Francesco Rossi, Annalisa Capuano. Beta-blocker choice and exchangeability in patients with heart failure and chronic obstructive pulmonary disease: an Italian register-based cohort study. Scientific reports. 2019 08; 9(1):11465. doi: 10.1038/s41598-019-47967-y. [PMID: 31391573]
  • Frederik N Ågesen, Peter E Weeke, Peer Tfelt-Hansen, Jacob Tfelt-Hansen. Pharmacokinetic variability of beta-adrenergic blocking agents used in cardiology. Pharmacology research & perspectives. 2019 08; 7(4):e00496. doi: 10.1002/prp2.496. [PMID: 31338197]
  • Asma A Swadi, Bassim I Mohammad, Najah R Hadi, Hayder A Al-Aubaidy. Correlation of CYP2D6 allelic polymorphism to outcome of acute coronary syndrome in mid-Euphrates Iraqi patients on metoprolol therapy. Gene. 2019 Jun; 703(?):112-119. doi: 10.1016/j.gene.2019.04.012. [PMID: 30965129]
  • Mai Mehanna, Zhiying Wang, Yan Gong, Caitrin W McDonough, Amber L Beitelshees, John G Gums, Arlene B Chapman, Gary L Schwartz, Kent R Bailey, Julie A Johnson, Stephen T Turner, Rhonda M Cooper-DeHoff. Plasma Renin Activity Is a Predictive Biomarker of Blood Pressure Response in European but not in African Americans With Uncomplicated Hypertension. American journal of hypertension. 2019 06; 32(7):668-675. doi: 10.1093/ajh/hpz022. [PMID: 30753254]
  • Cláudia M B Neves, Olga M S Filipe, Nuno Mota, Sónia A O Santos, Armando J D Silvestre, Eduarda B H Santos, M Graça P M S Neves, Mário M Q Simões. Photodegradation of metoprolol using a porphyrin as photosensitizer under homogeneous and heterogeneous conditions. Journal of hazardous materials. 2019 05; 370(?):13-23. doi: 10.1016/j.jhazmat.2018.11.055. [PMID: 30503313]
  • Mohamed H Solayman, Taimour Y Langaee, Yan Gong, Mohamed H Shahin, Stephen T Turner, Arlene B Chapman, John G Gums, Eric Boerwinkle, Amber L Beitelshees, Manal El-Hamamsy, Lamia El-Wakeel, Rhonda M Cooper-DeHoff, Osama A Badary, Julie A Johnson. Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Apr; 131(?):93-98. doi: 10.1016/j.ejps.2019.02.013. [PMID: 30753892]
  • Kasper Meidahl Petersen, Søren Bøgevig, Tonny Studsgaard Petersen, Thomas Bo Jensen, Kim Peder Dalhoff, Trine Henriksen, Henrik Enghusen Poulsen, Mikkel Bring Christensen. Hemodynamic Effects of Intravenous, High-Dose Lipid Emulsion With and Without Metoprolol Infusion in Healthy Volunteers: A Randomized Clinical Trial. Clinical pharmacology and therapeutics. 2019 04; 105(4):1009-1017. doi: 10.1002/cpt.1281. [PMID: 30412277]
  • Jia Wu, Xue Xiao, Zhenqun Li, Li Jia. Enantioseparation of chiral β-blockers using polynorepinephrine-coated nanoparticles and chiral capillary electrophoresis. Analytical and bioanalytical chemistry. 2019 Apr; 411(10):2121-2129. doi: 10.1007/s00216-019-01641-4. [PMID: 30734853]
  • Qian Zhu, Weihua Lai, Liwen Li, Hanping Li, Shilong Zhong. [Effects of CYP2D6*10 on plasma trough concentration of metoprolol in patients with coronary artery disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2019 Mar; 39(3):328-336. doi: 10.12122/j.issn.1673-4254.2019.03.11. [PMID: 31068311]
  • Jan-Ole Johannsen, Hannes Reuter, Fabian Hoffmann, Cornelia Blaich, Martin H J Wiesen, Thomas Streichert, Carsten Müller. Reliable and easy-to-use LC-MS/MS-method for simultaneous determination of the antihypertensives metoprolol, amlodipine, canrenone and hydrochlorothiazide in patients with therapy-refractory arterial hypertension. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 164(?):373-381. doi: 10.1016/j.jpba.2018.11.002. [PMID: 30439665]
  • Diego Alberto Ciscato Cusinato, Gabriela Campos de Oliveira Filgueira, Adriana Rocha, Monica Akissue C T Cintra, Vera Lucia Lanchote, Eduardo Barbosa Coelho. LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 and P-glycoprotein probe substrates and their metabolites using subtherapeutic doses. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 164(?):430-441. doi: 10.1016/j.jpba.2018.10.029. [PMID: 30445356]
  • Zhe Wang, Wei Sun, Zheng-Feng Lin, Rui Sun, Cheng-Ke Huang, Wei-Jian Ye, Yao-Yao Dong, Xiao-Dan Zhang, Rui-Jie Chen. A UHPLC-MS/MS method coupled with liquid-liquid extraction for the quantitation of phenacetin, omeprazole, metoprolol, midazolam and their metabolites in rat plasma and its application to the study of four CYP450 activities. Journal of pharmaceutical and biomedical analysis. 2019 Jan; 163(?):204-210. doi: 10.1016/j.jpba.2018.10.012. [PMID: 30317077]
  • Dinah S Khatir, Michael Pedersen, Per Ivarsen, Kent L Christensen, Bente Jespersen, Niels H Buus. Effects of additional vasodilatory or nonvasodilatory treatment on renal function, vascular resistance and oxygenation in chronic kidney disease: a randomized clinical trial. Journal of hypertension. 2019 01; 37(1):116-124. doi: 10.1097/hjh.0000000000001835. [PMID: 29995697]
  • Juan Wei, Wenjuan Ma, Guangzhe Yao, Qi Jia, Xuejing Cheng, Huizi Ouyang, Yanxu Chang, Xiaopeng Chen, Jun He. A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats. BioMed research international. 2019; 2019(?):7537618. doi: 10.1155/2019/7537618. [PMID: 31467909]
  • Ewa Klara Stuermer, Manuela Besser, Nils Terberger, Hagen Sjard Bachmann, Anna-Lena Severing. Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro. Skin pharmacology and physiology. 2019; 32(3):162-172. doi: 10.1159/000499433. [PMID: 31018213]
  • Ahmad Abdulrahman Almeman, Yasir Ahmed Beshir, Ahmad Hamad Aldosary. Comparison of the Effects of Metoprolol and Bisoprolol on Lipid and Glucose Profiles in Cardiovascular Patients. Current drug safety. 2019; 14(1):27-30. doi: 10.2174/1574886313666181029101247. [PMID: 30370856]
  • Won Seok Bang, Ye Ran Hwang, Zhengri Li, Inchul Lee, Hee Eun Kang. Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2019; 22(1):98-111. doi: 10.18433/jpps30268. [PMID: 30786957]
  • Saylav Bora, Mümin Alper Erdoğan, Gürkan Yiğittürk, Oytun Erbaş, İsmet Parlak. The Effects of Lipid Emulsion, Magnesium Sulphate and Metoprolol in Amitriptyline-Induced Cardiovascular Toxicity in Rats. Cardiovascular toxicology. 2018 12; 18(6):547-556. doi: 10.1007/s12012-018-9466-y. [PMID: 29873021]
  • Stephen P Juraschek, Lawrence J Appel, Edgar R Miller, Kenneth J Mukamal, Lewis A Lipsitz. Hypertension Treatment Effects on Orthostatic Hypotension and Its Relationship With Cardiovascular Disease. Hypertension (Dallas, Tex. : 1979). 2018 10; 72(4):986-993. doi: 10.1161/hypertensionaha.118.11337. [PMID: 30354704]
  • Alexander Vladimirovich Ivanov, Valery Vasil'evich Alexandrin, Alexander Alexandrovich Paltsyn, Edward Danielevich Virus, Ksenya Alexandrovna Nikiforova, Polina Olegovna Bulgakova, Nadezhda Borisovna Sviridkina, Svetlana Alexandrovna Apollonova, Aslan Amirkhanovich Kubatiev. Metoprolol and Nebivolol Prevent the Decline of the Redox Status of Low-Molecular-Weight Aminothiols in Blood Plasma of Rats During Acute Cerebral Ischemia. Journal of cardiovascular pharmacology. 2018 10; 72(4):195-203. doi: 10.1097/fjc.0000000000000616. [PMID: 30188870]
  • Jiaxi Pan, Weiwei Wang, Xiaoxue Wu, Fanqi Kong, Jialin Pan, Jiafeng Lin, Minxue Zhang. Inflammatory cytokines in cardiac pacing patients with atrial fibrillation and asymptomatic atrial fibrillation. Panminerva medica. 2018 Sep; 60(3):86-91. doi: 10.23736/s0031-0808.18.03452-3. [PMID: 29696963]
  • Magdalene M Assimon, M Alan Brookhart, Jason P Fine, Gerardo Heiss, J Bradley Layton, Jennifer E Flythe. A Comparative Study of Carvedilol Versus Metoprolol Initiation and 1-Year Mortality Among Individuals Receiving Maintenance Hemodialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2018 09; 72(3):337-348. doi: 10.1053/j.ajkd.2018.02.350. [PMID: 29653770]
  • Chandan Vangala, Wolfgang C Winkelmayer. Heterogeneity in Outcomes Among β-Blockers Elucidated by Intradialytic Data. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2018 09; 72(3):318-321. doi: 10.1053/j.ajkd.2018.03.032. [PMID: 30144835]
  • Bruna Eibel, Melissa Kristochek, Thiago R Peres, Lucinara D Dias, Daniela R Dartora, Karina R Casali, Renato A K Kalil, Alexandre M Lehnen, Maria Claudia Irigoyen, Melissa M Markoski. β-blockers interfere with cell homing receptors and regulatory proteins in a model of spontaneously hypertensive rats. Cardiovascular therapeutics. 2018 Aug; 36(4):e12434. doi: 10.1111/1755-5922.12434. [PMID: 29752864]
  • Odilson M Silvestre, Alberto Q Farias, Danusa S Ramos, Meive S Furtado, Ana C Rodrigues, Rafael O Ximenes, Daniel F de Campos Mazo, Patricia M Yoshimura Zitelli, Marcio A Diniz, José L Andrade, Celia Strunz, Antônio A Friedmann, Samuel S Lee, Flair J Carrilho, Luiz A C D'Albuquerque, Fernando Bacal. β-Blocker therapy for cirrhotic cardiomyopathy: a randomized-controlled trial. European journal of gastroenterology & hepatology. 2018 08; 30(8):930-937. doi: 10.1097/meg.0000000000001128. [PMID: 29979644]
  • Wanying Jiang, Chu Chen, Junyu Huo, Dasheng Lu, Zhixin Jiang, Jie Geng, Hai Xu, Qijun Shan. Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction. Scientific reports. 2018 07; 8(1):10206. doi: 10.1038/s41598-018-28562-z. [PMID: 29976952]
  • Akiko Toda, Shotaro Uehara, Takashi Inoue, Masahiro Utoh, Takashi Kusama, Makiko Shimizu, Yasuhiro Uno, Masayuki Mogi, Erika Sasaki, Hiroshi Yamazaki. Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Jul; 48(7):720-726. doi: 10.1080/00498254.2017.1353716. [PMID: 28686070]
  • André Dallmann, Ibrahim Ince, Katrin Coboeken, Thomas Eissing, Georg Hempel. A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways. Clinical pharmacokinetics. 2018 06; 57(6):749-768. doi: 10.1007/s40262-017-0594-5. [PMID: 28924743]
  • Hannu Kokki, Martin Maaroos, Sten Ellam, Jari Halonen, Ilkka Ojanperä, Merja Ranta, Veli-Pekka Ranta, Aleksandra Tolonen, Oscar Lindberg, Matias Viitala, Juha Hartikainen. How do different extracorporeal circulation systems affect metoprolol bioavailability in coronary artery bypass surgery patients. European journal of clinical pharmacology. 2018 Jun; 74(6):785-792. doi: 10.1007/s00228-018-2437-1. [PMID: 29523917]
  • Hong Cao, Xin Wang, Shaozheng Ying, Congxin Huang. AMPKα2 deficiency enhanced susceptibility to ventricular arrhythmias in mice by the role of β-adrenoceptor signaling. Experimental biology and medicine (Maywood, N.J.). 2018 05; 243(8):708-714. doi: 10.1177/1535370218767389. [PMID: 29597876]
  • Jeroen Van Renterghem, Heleen Dhondt, Glenn Verstraete, Michiel De Bruyne, Chris Vervaet, Thomas De Beer. The impact of the injection mold temperature upon polymer crystallization and resulting drug release from immediate and sustained release tablets. International journal of pharmaceutics. 2018 Apr; 541(1-2):108-116. doi: 10.1016/j.ijpharm.2018.01.053. [PMID: 29409747]