Chanoclavine (BioDeep_00000003921)

   

natural product


代谢物信息卡片


2-Propen-1-ol, 2-methyl-3-(1,3,4,5-tetrahydro-4-(methylamino)benz(cd)indol-5-yl)-, (4R-(4alpha,5beta(E)))-

化学式: C16H20N2O (256.1576)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 43.7%

分子结构信息

SMILES: C/C(=C\[C@H]1[C@@H](CC2=CNC3=CC=CC1=C23)NC)/CO
InChI: InChI=1S/C16H20N2O/c1-10(9-19)6-13-12-4-3-5-14-16(12)11(8-18-14)7-15(13)17-2/h3-6,8,13,15,17-19H,7,9H2,1-2H3/b10-6+/t13-,15-/m1/s1

描述信息

CONFIDENCE Claviceps purpurea sclerotia

同义名列表

12 个代谢物同义名

Chanoclavine; 2-Propen-1-ol, 2-methyl-3-(1,3,4,5-tetrahydro-4-(methylamino)benz(cd)indol-5-yl)-, (4R-(4alpha,5beta(E)))-; Chanoclavine-I; Isochanoclavin; Chanoclavin-I; 11012-16-1; 1349-51-5; 2390-99-0; 479-04-9; C09131; 2-Methyl-3-[4-(methylamino)-1,3,4,5-tetrahydrobenzo[cd]indol-5-yl]prop-2-en-1-ol; Chanoclavine-I



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

85 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 1 CAT
Peripheral membrane protein 2 HSD17B6, SELENBP1
Nucleus 1 SELENBP1
cytosol 2 CAT, SELENBP1
nucleoplasm 1 ATP2B1
Cell membrane 3 ATP2B1, GPR34, HTR3A
Cleavage furrow 1 HTR3A
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 3 ATP2B1, GPR34, HTR3A
Synapse 2 ATP2B1, HTR3A
glutamatergic synapse 1 ATP2B1
postsynapse 1 HTR3A
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 SELENBP1
plasma membrane 3 ATP2B1, GPR34, HTR3A
synaptic vesicle membrane 1 ATP2B1
Membrane 5 ATP2B1, CAT, GPR34, HTR3A, SELENBP1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 3 ATP2B1, CAT, SELENBP1
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 1 SELENBP1
mitochondrion 1 CAT
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 3 ATP2B1, CAT, HSD17B6
Microsome membrane 1 HSD17B6
extracellular region 1 CAT
mitochondrial matrix 1 CAT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nucleolus 1 SELENBP1
postsynaptic membrane 1 HTR3A
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
Postsynaptic cell membrane 1 HTR3A
neuron projection 1 HTR3A
cell projection 1 ATP2B1
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
Basolateral cell membrane 1 ATP2B1
fibrillar center 1 SELENBP1
Presynaptic cell membrane 1 ATP2B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
immunological synapse 1 ATP2B1
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1


文献列表

  • R Bharadwaj, H Jagadeesan, S R Kumar, S Ramalingam. Molecular mechanisms in grass-Epichloë interactions: towards endophyte driven farming to improve plant fitness and immunity. World journal of microbiology & biotechnology. 2020 Jun; 36(7):92. doi: 10.1007/s11274-020-02868-5. [PMID: 32562008]
  • Sarah C Finch, John S Munday, Jan M Sprosen, Sweta Bhattarai. Toxicity Studies of Chanoclavine in Mice. Toxins. 2019 05; 11(5):. doi: 10.3390/toxins11050249. [PMID: 31052510]
  • Samantha J Fabian, Matthew D Maust, Daniel G Panaccione. Ergot Alkaloid Synthesis Capacity of Penicillium camemberti. Applied and environmental microbiology. 2018 10; 84(19):. doi: 10.1128/aem.01583-18. [PMID: 30076193]
  • Sarah L Robinson, Daniel G Panaccione. Chemotypic and genotypic diversity in the ergot alkaloid pathway of Aspergillus fumigatus. Mycologia. 2012 Jul; 104(4):804-12. doi: 10.3852/11-310. [PMID: 22453123]
  • Kerry E Goetz, Christine M Coyle, Johnathan Z Cheng, Sarah E O'Connor, Daniel G Panaccione. Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus. Current genetics. 2011 Jun; 57(3):201-11. doi: 10.1007/s00294-011-0336-4. [PMID: 21409592]