2-Oxovaleric acid (BioDeep_00000003577)
Secondary id: BioDeep_00000400466
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
化学式: C5H8O3 (116.0473)
中文名称: 2-氧代戊酸, 2-戊酮酸
谱图信息:
最多检出来源 Homo sapiens(plant) 13.44%
分子结构信息
SMILES: CCCC(=O)C(=O)O
InChI: InChI=1S/C5H8O3/c1-2-3-4(6)5(7)8/h2-3H2,1H3,(H,7,8)
描述信息
2-Oxovaleric acid is an alpha-ketoacid is a metabolite usually found in human biofluids. Ketoacids have been known to play an important part in the metabolism of valine, leucine, isoleucine. 2-Oxovaleric acid presence has been determined in human blood serum and urine in numerous scientific documents, although its origin remains unclear. (PMID: 11482739, 9869358, 3235498).
Acquisition and generation of the data is financially supported in part by CREST/JST.
Isolated from Trigonella caerulea (sweet trefoil)
2-Oxovaleric acid is a keto acid that is found in human blood.
同义名列表
38 个代谢物同义名
2-Ketopentanoic acid, sodium salt; .alpha.-keto-N-valeric acid; alpha-oxo-N-Valeric acid; α-Ketovaleric acid; alpha-Oxopentanoic acid; alpha-keto-Valeric acid; alpha-Ketovaleric acid; alpha-Oxovaleric acid; 2-keto-N-Valeric acid; 2-oxo-pentanoic acid; 2-oxo-N-Valeric acid; 2-Ketopentanoic acid; a-oxo-N-Valeric acid; a-Oxopentanoic acid; alpha-Oxopentanoate; 2-keto valeric acid; a-keto-Valeric acid; 2-Oxopentanoic acid; α-oxopentanoic acid; Α-ketovaleric acid; 2-Ketovaleric acid; a-Ketovaleric acid; 2-oxo-Valeric acid; alpha-Ketovalerate; a-Oxovaleric acid; 2-Oxovaleric acid; 2-Ketopentanoate; 2-oxo-Pentanoate; a-Oxopentanoate; 2-Keto valerate; 2-Oxopentanoate; Α-ketovalerate; a-Ketovalerate; 2-Ketovalerate; 2-Oxovalerate; FA 5:1;O; 2-Oxopentanoic acid; 2-Oxopentanoic acid
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:33033
- KEGG: C06255
- PubChem: 74563
- HMDB: HMDB0001865
- Metlin: METLIN3243
- ChEMBL: CHEMBL1162544
- LipidMAPS: LMFA01060004
- KNApSAcK: C00055637
- foodb: FDB003366
- chemspider: 67142
- CAS: 1821-02-9
- MoNA: PR100865
- MoNA: PS102101
- MoNA: PS102107
- PMhub: MS000010060
- PubChem: 8494
- PDB-CCD: 69O
- 3DMET: B00929
- NIKKAJI: J150.812A
- RefMet: 2-Oxovaleric acid
- medchemexpress: HY-113098
- KNApSAcK: 33033
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jacques Viljoen, Jakobus J Bergh, Lodewyk J Mienie, Hercullas F Kotze, Gisella Terre'Blanche. Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate.
Metabolic brain disease.
2012 Sep; 27(3):327-35. doi:
10.1007/s11011-012-9285-y. [PMID: 22350964] - Kristine E Mulier, Daniel R Lexcen, Elizabeth Luzcek, Joseph J Greenberg, Gregory J Beilman. Treatment with beta-hydroxybutyrate and melatonin is associated with improved survival in a porcine model of hemorrhagic shock.
Resuscitation.
2012 Feb; 83(2):253-8. doi:
10.1016/j.resuscitation.2011.08.003. [PMID: 21864484] - Yong Nie, Yue-Qin Tang, Yan Li, Chang-Qiao Chi, Man Cai, Xiao-Lei Wu. The genome sequence of Polymorphum gilvum SL003B-26A1(T) reveals its genetic basis for crude oil degradation and adaptation to the saline soil.
PloS one.
2012; 7(2):e31261. doi:
10.1371/journal.pone.0031261. [PMID: 22359583] - Stephanie M Quanbeck, Libuse Brachova, Alexis A Campbell, Xin Guan, Ann Perera, Kun He, Seung Y Rhee, Preeti Bais, Julie A Dickerson, Philip Dixon, Gert Wohlgemuth, Oliver Fiehn, Lenore Barkan, Iris Lange, B Markus Lange, Insuk Lee, Diego Cortes, Carolina Salazar, Joel Shuman, Vladimir Shulaev, David V Huhman, Lloyd W Sumner, Mary R Roth, Ruth Welti, Hilal Ilarslan, Eve S Wurtele, Basil J Nikolau. Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of 'Unknown Function'.
Frontiers in plant science.
2012; 3(?):15. doi:
10.3389/fpls.2012.00015. [PMID: 22645570] - Rubén Rellán-Álvarez, Hamdi El-Jendoubi, Gert Wohlgemuth, Anunciación Abadía, Oliver Fiehn, Javier Abadía, Ana Alvarez-Fernández. Metabolite profile changes in xylem sap and leaf extracts of strategy I plants in response to iron deficiency and resupply.
Frontiers in plant science.
2011; 2(?):66. doi:
10.3389/fpls.2011.00066. [PMID: 22645546] - Jan-Willem de Kraker, Jonathan Gershenzon. From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis.
The Plant cell.
2011 Jan; 23(1):38-53. doi:
10.1105/tpc.110.079269. [PMID: 21205930] - Phuc Thi Do, Marion Prudent, Ronan Sulpice, Mathilde Causse, Alisdair R Fernie. The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population.
Plant physiology.
2010 Nov; 154(3):1128-42. doi:
10.1104/pp.110.163030. [PMID: 20841452] - Federico Martinelli, Sandra L Uratsu, Russell L Reagan, Ying Chen, David Tricoli, Oliver Fiehn, David M Rocke, Charles S Gasser, Abhaya M Dandekar. Gene regulation in parthenocarpic tomato fruit.
Journal of experimental botany.
2009; 60(13):3873-90. doi:
10.1093/jxb/erp227. [PMID: 19700496] - Kay A Lawton, Alvin Berger, Matthew Mitchell, K Eric Milgram, Anne M Evans, Lining Guo, Richard W Hanson, Satish C Kalhan, John A Ryals, Michael V Milburn. Analysis of the adult human plasma metabolome.
Pharmacogenomics.
2008 Apr; 9(4):383-97. doi:
10.2217/14622416.9.4.383. [PMID: 18384253] - Isabelle M Frey, Isabel Rubio-Aliaga, Anne Siewert, Daniela Sailer, Aleksey Drobyshev, Johannes Beckers, Martin Hrabé de Angelis, Julie Aubert, Avner Bar Hen, Oliver Fiehn, Hans M Eichinger, Hannelore Daniel. Profiling at mRNA, protein, and metabolite levels reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2-/- mice.
Physiological genomics.
2007 Feb; 28(3):301-10. doi:
10.1152/physiolgenomics.00193.2006. [PMID: 17077276] - Margret Sauter, René Lorbiecke, Bo Ouyang, Thomas C Pochapsky, Guillaume Rzewuski. The immediate-early ethylene response gene OsARD1 encodes an acireductone dioxygenase involved in recycling of the ethylene precursor S-adenosylmethionine.
The Plant journal : for cell and molecular biology.
2005 Dec; 44(5):718-29. doi:
10.1111/j.1365-313x.2005.02564.x. [PMID: 16297065] - Tara Kearney, Carmen Navas de Gallegos, Anthony Proudler, Kim Parker, Victor Anayaoku, Peter Bannister, Soundararajan Venkatesan, Desmond G Johnston. Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects.
Metabolism: clinical and experimental.
2003 Jan; 52(1):50-9. doi:
10.1053/meta.2003.50061. [PMID: 12524662] - Richard A Hawkins, Darryl R Peterson, Juan R Viña. The complementary membranes forming the blood-brain barrier.
IUBMB life.
2002 Sep; 54(3):101-7. doi:
10.1080/15216540214541. [PMID: 12489636] - Yong-Ming Yu, Colleen M Ryan, Zhe-Wei Fei, Xiao-Ming Lu, Leticia Castillo, John T Schultz, Ronald G Tompkins, Vernon R Young. Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans.
American journal of physiology. Endocrinology and metabolism.
2002 Feb; 282(2):E247-58. doi:
10.1152/ajpendo.00206.2001. [PMID: 11788355]
