Apramycin (BioDeep_00000003432)
代谢物信息卡片
Apramycin sulfate
化学式: C21H41N5O11 (539.2802)
中文名称: 阿布拉霉素
谱图信息:
最多检出来源 not specific(plant) 0.69%
分子结构信息
SMILES: CNC1C(C2C(CC(C(O2)OC3C(CC(C(C3O)O)N)N)N)OC1OC4C(C(C(C(O4)CO)N)O)O)O
InChI: InChI=1S/C21H41N5O11/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31/h5-21,26-32H,2-4,22-25H2,1H3/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-/m1/s1
描述信息
An aminoglycoside that is 2-deoxystreptamine that is substituted on the oxygen at position 4 by an (8R)-2-amino-8-O-(4-amino-4-deoxy-alpha-D-glucopyranosyl)-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octodialdo-1,5:8,4-dipyranos-1-yl) group.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
KEIO_ID A100
同义名列表
4 个代谢物同义名
数据库引用编号
31 个数据库交叉引用编号
- ChEBI: CHEBI:2790
- KEGG: C01555
- KEGGdrug: D02322
- PubChem: 3081545
- Metlin: METLIN44099
- DrugBank: DB04626
- ChEMBL: CHEMBL1230961
- CAS: 37321-09-8
- MoNA: CO000075
- MoNA: CO000074
- MoNA: CO000073
- MoNA: CO000072
- MoNA: CO000071
- MoNA: KO002242
- MoNA: KO002239
- MoNA: KO002241
- MoNA: KO002246
- MoNA: KO008806
- MoNA: KO002244
- MoNA: KO002243
- MoNA: KO002240
- MoNA: KO002245
- MoNA: KO002238
- MoNA: KO002247
- PMhub: MS000009672
- MetaboLights: MTBLC2790
- PubChem: 4713
- PDB-CCD: AM2
- NIKKAJI: J139.315D
- RefMet: Apramycin
- KNApSAcK: 2790
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Katja Becker, Sha Cao, Anna Nilsson, Maria Erlandsson, Sven-Kevin Hotop, Janis Kuka, Jon Hansen, Klara Haldimann, Solveiga Grinberga, Talia Berruga-Fernández, Douglas L Huseby, Reza Shariatgorji, Evelina Lindmark, Björn Platzack, Erik C Böttger, David Crich, Lena E Friberg, Carina Vingsbo Lundberg, Diarmaid Hughes, Mark Brönstrup, Per E Andrén, Edgars Liepinsh, Sven N Hobbie. Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
EBioMedicine.
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Journal of medical microbiology.
2021 Oct; 70(10):. doi:
10.1099/jmm.0.001412. [PMID: 34612810] - Katja Becker, Vincent Aranzana-Climent, Sha Cao, Anna Nilsson, Reza Shariatgorji, Klara Haldimann, Björn Platzack, Diarmaid Hughes, Per E Andrén, Erik C Böttger, Lena E Friberg, Sven N Hobbie. Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
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10.1016/j.cmi.2020.12.004. [PMID: 33316399] - Tomás Sou, Jon Hansen, Edgars Liepinsh, Maria Backlund, Onur Ercan, Solveiga Grinberga, Sha Cao, Paraskevi Giachou, Anna Petersson, Magdalena Tomczak, Malgorzata Urbas, Dorota Zabicka, Carina Vingsbo Lundberg, Diarmaid Hughes, Sven N Hobbie, Lena E Friberg. Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
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2021 04; 109(4):1063-1073. doi:
10.1002/cpt.2104. [PMID: 33150591] - Yuqi Yang, Tianshi Xiao, Jiarui Li, Ping Cheng, Fulei Li, Hongxiao Yu, Ruimeng Liu, Ishfaq Muhammad, Xiuying Zhang. Wild-type cutoff for Apramycin against Escherichia coli.
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