O-Phosphotyrosine (BioDeep_00000003169)
Secondary id: BioDeep_00001868577
human metabolite Endogenous blood metabolite
代谢物信息卡片
(2S)-2-amino-3-[4-(phosphonooxy)phenyl]propanoic acid
化学式: C9H12NO6P (261.0402222)
中文名称: O-磷酸基-L-酪氨酸, O-磷酸-DL-酪氨酸
谱图信息:
最多检出来源 Danio rerio(blood) 1.09%
分子结构信息
SMILES: C1=CC(=CC=C1CC(C(=O)O)N)OP(=O)(O)O
InChI: InChI=1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)
描述信息
O-Phosphotyrosine is a phosphorylated amino acid that occurs in a number of proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis. Small amounts of free phosphotyrosine can be found in urine (PMID: 7693088). Levels of this amino acid appear to be elevated in mammalian urine during liver regeneration (PMID: 7516161). Phosphotyrosine is also able to induce platelet aggregation in vitro and it has been suggested that free phosphotyrosine in blood could be meaningful for in vivo platelet activation (PMID: 1282059). [HMDB]
O-Phosphotyrosine is a phosphorylated amino acid that occurs in a number of proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis. Small amounts of free phosphotyrosine can be found in urine (PMID: 7693088). Levels of this amino acid appear to be elevated in mammalian urine during liver regeneration (PMID: 7516161). Phosphotyrosine is also able to induce platelet aggregation in vitro and it has been suggested that free phosphotyrosine in blood could be meaningful for in vivo platelet activation (PMID: 1282059).
同义名列表
19 个代谢物同义名
(2S)-2-amino-3-[4-(phosphonooxy)phenyl]propanoic acid; L-3-(4-Hydroxyphenyl)alanine 4-phosphate; Tyrosine phosphoric acid; L-Tyrosine-O-phosphate; O-Phosphono-L-tyrosine; O-Phospho-DL-Tyrosine; O(4)-phosphotyrosine; Tyrosine O phosphate; Tyrosine O-phosphate; Tyrosine-O-phosphate; Phosphotyrosine (py); o-phospho-l-tyrosine; phospho-L-Tyrosine; O4-phosphotyrosine; Tyrosine phosphate; O-Phosphotyrosine; Phosphonotyrosine; L-Phosphotyrosine; Phosphotyrosine
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:74956
- ChEBI: CHEBI:37788
- KEGG: C06501
- PubChem: 4589477
- PubChem: 30819
- HMDB: HMDB0006049
- Metlin: METLIN44797
- DrugBank: DB01962
- ChEMBL: CHEMBL310565
- ChEMBL: CHEMBL286939
- Wikipedia: Tyrosine
- MeSH: Phosphotyrosine
- foodb: FDB023821
- chemspider: 28593
- CAS: 21820-51-9
- CAS: 41863-47-2
- PMhub: MS000008347
- PubChem: 8732
- PDB-CCD: PTR
- NIKKAJI: J208.898C
- RefMet: O-Phosphotyrosine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Tyrosine Biosynthesis:
4-Hydroxyphenylpyruvic acid + L-Glutamic acid ⟶ L-Tyrosine + Oxoglutaric acid
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wonhwa Cho, Kyli Berkley, Ashutosh Sharma. Lipid Binding of SH2 Domains.
Methods in molecular biology (Clifton, N.J.).
2023; 2705(?):239-253. doi:
10.1007/978-1-0716-3393-9_13. [PMID: 37668978] - Megan V Farrell, Andrea C Nunez, Zhengmin Yang, Pablo Pérez-Ferreros, Katharina Gaus, Jesse Goyette. Protein-PAINT: Superresolution microscopy with signaling proteins.
Science signaling.
2022 02; 15(719):eabg9782. doi:
10.1126/scisignal.abg9782. [PMID: 35104163] - Farhana Yesmin, Robiul H Bhuiyan, Yuhsuke Ohmi, Satoko Yamamoto, Kei Kaneko, Yuki Ohkawa, Pu Zhang, Kazunori Hamamura, Nai-Kong V Cheung, Norihiro Kotani, Koichi Honke, Tetsuya Okajima, Mariko Kambe, Orie Tajima, Keiko Furukawa, Koichi Furukawa. Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010423. [PMID: 35008849] - Seula Keum, Soo Jung Yang, Esther Park, TaeIn Kang, Jee-Hye Choi, Jangho Jeong, Ye Eun Hwang, Jung-Woong Kim, Dongeun Park, Sangmyung Rhee. Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics.
Cellular oncology (Dordrecht).
2021 Dec; 44(6):1287-1305. doi:
10.1007/s13402-021-00637-6. [PMID: 34582006] - Akiko Katano-Toki, Satoshi Yoshino, Yasuyo Nakajima, Takuya Tomaru, Ayaka Nishikido, Emi Ishida, Kazuhiko Horiguchi, Tsugumichi Saito, Atsushi Ozawa, Tetsurou Satoh, Masanobu Yamada. SFPQ associated with a co-activator for PPARγ, HELZ2, regulates key nuclear factors for adipocyte differentiation.
Biochemical and biophysical research communications.
2021 07; 562(?):139-145. doi:
10.1016/j.bbrc.2021.05.014. [PMID: 34052659] - Shifaa O Alshammari, Sivanesan Dakshanamurthy, Hemayet Ullah. Small compounds targeting tyrosine phosphorylation of Scaffold Protein Receptor for Activated C Kinase1A (RACK1A) regulate auxin mediated lateral root development in Arabidopsis.
Plant signaling & behavior.
2021 05; 16(5):1899488. doi:
10.1080/15592324.2021.1899488. [PMID: 33784940] - Rueyhung R Weng, Hsuan-Hsuan Lu, Chien-Ting Lin, Chia-Chi Fan, Rong-Shan Lin, Tai-Chung Huang, Shu-Yung Lin, Yi-Jhen Huang, Yi-Hsiu Juan, Yi-Chieh Wu, Zheng-Ci Hung, Chi Liu, Xuan-Hui Lin, Wan-Chen Hsieh, Tzu-Yuan Chiu, Jung-Chi Liao, Yen-Ling Chiu, Shih-Yu Chen, Chong-Jen Yu, Hsing-Chen Tsai. Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer.
Nature communications.
2021 04; 12(1):2163. doi:
10.1038/s41467-021-22433-4. [PMID: 33846331] - Jean K Chung, William Y C Huang, Catherine B Carbone, Laura M Nocka, Atul N Parikh, Ronald D Vale, Jay T Groves. Coupled membrane lipid miscibility and phosphotyrosine-driven protein condensation phase transitions.
Biophysical journal.
2021 04; 120(7):1257-1265. doi:
10.1016/j.bpj.2020.09.017. [PMID: 33080222] - Cláudia Almeida Loureiro, Francisco R Pinto, Patrícia Barros, Paulo Matos, Peter Jordan. A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane.
Cellular and molecular life sciences : CMLS.
2020 Dec; 77(23):4997-5015. doi:
10.1007/s00018-020-03448-4. [PMID: 31974654] - Panae Noomuna, Mary Risinger, Sitong Zhou, Katie Seu, Yuncheng Man, Ran An, Daniel A Sheik, Jiandi Wan, Jane A Little, Umut A Gurkan, Francesco M Turrini, Theodosia Kalfa, Philip S Low. Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease.
British journal of haematology.
2020 08; 190(4):599-609. doi:
10.1111/bjh.16671. [PMID: 32346864] - Richard T Cattley, Mijoon Lee, William C Boggess, William F Hawse. Transforming growth factor β (TGF-β) receptor signaling regulates kinase networks and phosphatidylinositol metabolism during T-cell activation.
The Journal of biological chemistry.
2020 06; 295(24):8236-8251. doi:
10.1074/jbc.ra120.012572. [PMID: 32358062] - Hala Guedouari, Marie-Claude Savoie, Stéphanie Jean, Marie-Ange Djeungoue-Petga, Nicolas Pichaud, Etienne Hebert-Chatelain. Multi-omics Reveal that c-Src Modulates the Mitochondrial Phosphotyrosine Proteome and Metabolism According to Nutrient Availability.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2020 May; 54(4):517-537. doi:
10.33594/000000237. [PMID: 32428391] - Huanhuan Ma, Jia Zhang, Lin Zhou, Shixiong Wen, Hsiang-Yu Tang, Bin Jiang, Fengqiong Zhang, Muhammad Suleman, Dachao Sun, Ai Chen, Wentao Zhao, Furong Lin, Ming-Tong Tsau, Lu-Min Shih, Changchuan Xie, Xiaotong Li, Donghai Lin, Li-Man Hung, Mei-Ling Cheng, Qinxi Li. c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3.
Cell reports.
2020 03; 30(12):4235-4249.e6. doi:
10.1016/j.celrep.2020.03.005. [PMID: 32209481] - Marcos Francisco Núñez, Kathleen Wisser, Sarah L Veatch. Synergistic factors control kinase-phosphatase organization in B-cells engaged with supported bilayers.
Molecular biology of the cell.
2020 03; 31(7):667-682. doi:
10.1091/mbc.e19-09-0507. [PMID: 31877064] - Zachary Hartman, Werner J Geldenhuys, Yehenew M Agazie. A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2).
The Journal of biological chemistry.
2020 03; 295(11):3563-3575. doi:
10.1074/jbc.ra119.011422. [PMID: 32024694] - Nagib Ahsan, Rashaun S Wilson, R Shyama Prasad Rao, Fernanda Salvato, Mercy Sabila, Hemayet Ullah, Ján A Miernyk. Mass Spectrometry-Based Identification of Phospho-Tyr in Plant Proteomics.
Journal of proteome research.
2020 02; 19(2):561-571. doi:
10.1021/acs.jproteome.9b00550. [PMID: 31967836] - Regina Gratz, Tzvetina Brumbarova, Rumen Ivanov, Ksenia Trofimov, Laura Tünnermann, Rocio Ochoa-Fernandez, Tim Blomeier, Johannes Meiser, Stefanie Weidtkamp-Peters, Matias D Zurbriggen, Petra Bauer. Phospho-mutant activity assays provide evidence for alternative phospho-regulation pathways of the transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR.
The New phytologist.
2020 01; 225(1):250-267. doi:
10.1111/nph.16168. [PMID: 31487399] - Mark J Daniels, Mark Yeager. Phosphorylation of TIP3 Aquaporins during Phaseolus vulgaris Embryo Development.
Cells.
2019 10; 8(11):. doi:
10.3390/cells8111362. [PMID: 31683651] - Markus Dietrich, Muhammad Salman Malik, Marianne Skeie, Vibeke Bertelsen, Espen Stang. Protein kinase C regulates ErbB3 turnover.
Experimental cell research.
2019 09; 382(2):111473. doi:
10.1016/j.yexcr.2019.06.018. [PMID: 31233741] - Heedoo Lee, Chunhua Li, Yang Zhang, Duo Zhang, Leo E Otterbein, Yang Jin. Caveolin-1 selectively regulates microRNA sorting into microvesicles after noxious stimuli.
The Journal of experimental medicine.
2019 09; 216(9):2202-2220. doi:
10.1084/jem.20182313. [PMID: 31235510] - Antje Dittmann, Norman J Kennedy, Nina L Soltero, Nader Morshed, Miyeko D Mana, Ömer H Yilmaz, Roger J Davis, Forest M White. High-fat diet in a mouse insulin-resistant model induces widespread rewiring of the phosphotyrosine signaling network.
Molecular systems biology.
2019 08; 15(8):e8849. doi:
10.15252/msb.20198849. [PMID: 31464373] - Marvin Rausch, Julia P Deisinger, Hannah Ulm, Anna Müller, Wenjin Li, Patrick Hardt, Xiaogang Wang, Xue Li, Marc Sylvester, Marianne Engeser, Waldemar Vollmer, Christa E Müller, Hans Georg Sahl, Jean Claire Lee, Tanja Schneider. Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus.
Nature communications.
2019 03; 10(1):1404. doi:
10.1038/s41467-019-09356-x. [PMID: 30926919] - Yajin Zhao, Xiang Wang, Ruofeng Wang, Dong Chen, Milody Noviana, Hongliang Zhu. Nitric oxide inhibits hypoxia-induced impairment of human RBC deformability through reducing the cross-linking of membrane protein band 3.
Journal of cellular biochemistry.
2019 01; 120(1):305-320. doi:
10.1002/jcb.27359. [PMID: 30218451] - Gisele Luiza Pavan, Igor Tadeu Lazzarotto Bresolin, Aline Ferreira Velho Muzio, Daniele Celestino Cunha, Sonia Maria Alves Bueno. Phospho-l-tyrosine-agarose chromatography: Adsorption of human IgG and its proteolytic fragments.
Biomedical chromatography : BMC.
2019 Jan; 33(1):e4397. doi:
10.1002/bmc.4397. [PMID: 30246450] - Li Zheng, Hanjun Li, Andrew Cannon, Andrew J Trease, Gaelle Spagnol, Hong Zheng, Stanley Radio, Kaushik Patel, Surinder Batra, Paul L Sorgen. Phosphorylation of Cx43 residue Y313 by Src contributes to blocking the interaction with Drebrin and disassembling gap junctions.
Journal of molecular and cellular cardiology.
2019 01; 126(?):36-49. doi:
10.1016/j.yjmcc.2018.11.008. [PMID: 30448479] - Christian Parr, Ahmed Y Ali. Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling.
Journal of translational medicine.
2018 10; 16(1):281. doi:
10.1186/s12967-018-1660-y. [PMID: 30314527] - Artemis Perraki, Thomas A DeFalco, Paul Derbyshire, Julian Avila, David Séré, Jan Sklenar, Xingyun Qi, Lena Stransfeld, Benjamin Schwessinger, Yasuhiro Kadota, Alberto P Macho, Shushu Jiang, Daniel Couto, Keiko U Torii, Frank L H Menke, Cyril Zipfel. Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling.
Nature.
2018 09; 561(7722):248-252. doi:
10.1038/s41586-018-0471-x. [PMID: 30177827] - Ugo Dionne, François J M Chartier, Yossef López de Los Santos, Noémie Lavoie, David N Bernard, Sara L Banerjee, François Otis, Kévin Jacquet, Michel G Tremblay, Mani Jain, Sylvie Bourassa, Gerald D Gish, Jean-Philippe Gagné, Guy G Poirier, Patrick Laprise, Normand Voyer, Christian R Landry, Nicolas Doucet, Nicolas Bisson. Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks.
Molecular cell.
2018 06; 70(6):995-1007.e11. doi:
10.1016/j.molcel.2018.05.013. [PMID: 29910111] - Dov Kesten, Miriam Horovitz-Fried, Tamar Brutman-Barazani, Sanford R Sampson. Insulin-induced translocation of IR to the nucleus in insulin responsive cells requires a nuclear translocation sequence.
Biochimica et biophysica acta. Molecular cell research.
2018 Apr; 1865(4):551-559. doi:
10.1016/j.bbamcr.2018.01.004. [PMID: 29317261] - Yangyang Li, Tengteng Zhu, Huan Yang, Sulayman D Dib-Hajj, Stephen G Waxman, Ye Yu, Tian-Le Xu, Xiaoyang Cheng. Nav1.7 is phosphorylated by Fyn tyrosine kinase which modulates channel expression and gating in a cell type-dependent manner.
Molecular pain.
2018 Jan; 14(?):1744806918782229. doi:
10.1177/1744806918782229. [PMID: 29790812] - Andrew J Trease, Juan M V Capuccino, Jorge Contreras, Andrew L Harris, Paul L Sorgen. Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization.
Journal of molecular and cellular cardiology.
2017 10; 111(?):69-80. doi:
10.1016/j.yjmcc.2017.07.010. [PMID: 28754342] - Sa Zhou, Qiuhong Chen, Yuhui Sun, Yingzhang Li. Histone H2B monoubiquitination regulates salt stress-induced microtubule depolymerization in Arabidopsis.
Plant, cell & environment.
2017 Aug; 40(8):1512-1530. doi:
10.1111/pce.12950. [PMID: 28337773] - Gisele Luiza Pavan, Igor Tadeu Lazzarotto Bresolin, Angélica Grespan, Sonia Maria Alves Bueno. Phosphorylated-tyrosine based pseudobioaffinity adsorbent for the purification of immunoglobulin G.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 May; 1052(?):10-18. doi:
10.1016/j.jchromb.2017.03.018. [PMID: 28343107] - Changqian Zhou, Kaili Ma, Ruize Gao, Chenglong Mu, Linbo Chen, Qiangqiang Liu, Qian Luo, Du Feng, Yushan Zhu, Quan Chen. Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy.
Cell research.
2017 Feb; 27(2):184-201. doi:
10.1038/cr.2016.146. [PMID: 27934868] - Ming You, Guanjun Dong, Fanlin Li, Feiya Ma, Jing Ren, Yujun Xu, Huimin Yue, Ruijing Tang, Deshan Ren, Yayi Hou. Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.
Cellular & molecular immunology.
2017 Feb; 14(2):192-202. doi:
10.1038/cmi.2015.61. [PMID: 26277892] - Scott M Haake, Jiannong Li, Yun Bai, Fumi Kinose, Bin Fang, Eric A Welsh, Roy Zent, Jasreman Dhillon, Julio M Pow-Sang, Y Ann Chen, John M Koomen, W Kimryn Rathmell, Mayer Fishman, Eric B Haura. Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2016 Nov; 22(22):5605-5616. doi:
10.1158/1078-0432.ccr-15-1673. [PMID: 27220961] - Linyu Zhu, Xiahui Xiong, Yongsoon Kim, Naomi Okada, Fei Lu, Hui Zhang, Hong Sun. Acid sphingomyelinase is required for cell surface presentation of Met receptor tyrosine kinase in cancer cells.
Journal of cell science.
2016 11; 129(22):4238-4251. doi:
10.1242/jcs.191684. [PMID: 27802163] - Michael Xiang, Haesook Kim, Vincent T Ho, Sarah R Walker, Michal Bar-Natan, Melodi Anahtar, Suhu Liu, Patricia A Toniolo, Yasmin Kroll, Nichole Jones, Zachary T Giaccone, Lisa N Heppler, Darwin Q Ye, Jason J Marineau, Daniel Shaw, James E Bradner, Traci Blonquist, Donna Neuberg, Claudio Hetz, Richard M Stone, Robert J Soiffer, David A Frank. Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent.
Blood.
2016 10; 128(14):1845-1853. doi:
10.1182/blood-2015-07-660506. [PMID: 27531676] - Ching-Hui Huang, Chih-Chin Hsu, Carl Pai-Chu Chen, Shu-Er Chow, Jong-Shyan Wang, Yu-Chiau Shyu, Mu-Jie Lu. Negative pressure induces p120-catenin-dependent adherens junction disassembly in keratinocytes during wound healing.
Biochimica et biophysica acta.
2016 09; 1863(9):2212-20. doi:
10.1016/j.bbamcr.2016.05.017. [PMID: 27220534] - Huaimin Wang, Zhaoqianqi Feng, Dongdong Wu, Keith J Fritzsching, Mike Rigney, Jie Zhou, Yujie Jiang, Klaus Schmidt-Rohr, Bing Xu. Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells.
Journal of the American Chemical Society.
2016 08; 138(34):10758-61. doi:
10.1021/jacs.6b06075. [PMID: 27529637] - Barbara Torsello, Cristina Bianchi, Chiara Meregalli, Vitalba Di Stefano, Lara Invernizzi, Sofia De Marco, Giorgio Bovo, Rinaldo Brivio, Guido Strada, Silvia Bombelli, Roberto A Perego. Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions.
Journal of cell science.
2016 08; 129(15):2925-36. doi:
10.1242/jcs.183640. [PMID: 27298228] - Jing Li, Jun Zhang, Minghui Tang, Junping Xin, Yan Xu, Andrew Volk, Caiqin Hao, Chenglong Hu, Jiewen Sun, Wei Wei, Quichan Cao, Peter Breslin, Jiwang Zhang. Hematopoietic Stem Cell Activity Is Regulated by Pten Phosphorylation Through a Niche-Dependent Mechanism.
Stem cells (Dayton, Ohio).
2016 08; 34(8):2130-44. doi:
10.1002/stem.2382. [PMID: 27096933] - Amanda Buyan, Antreas C Kalli, Mark S P Sansom. Multiscale Simulations Suggest a Mechanism for the Association of the Dok7 PH Domain with PIP-Containing Membranes.
PLoS computational biology.
2016 07; 12(7):e1005028. doi:
10.1371/journal.pcbi.1005028. [PMID: 27459095] - Lilian Sepúlveda, Eva Bussalleu, Marc Yeste, Sergi Bonet. Effect of Pseudomonas aeruginosa on sperm capacitation and protein phosphorylation of boar spermatozoa.
Theriogenology.
2016 May; 85(8):1421-31. doi:
10.1016/j.theriogenology.2015.12.025. [PMID: 26810830] - S R Tie, D J McCarthy, T S Kendrick, A Louw, C Le, J Satiaputra, N Kucera, M Phillips, E Ingley. Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway.
Oncogene.
2016 Apr; 35(16):2098-111. doi:
10.1038/onc.2015.272. [PMID: 26212012] - Mi-Jeong Park, Ren Sheng, Antonina Silkov, Da-Jung Jung, Zhi-Gang Wang, Yao Xin, Hyunjin Kim, Pallavi Thiagarajan-Rosenkranz, Seohyeon Song, Youngdae Yoon, Wonhee Nam, Ilshin Kim, Eui Kim, Dong-Gyu Lee, Yong Chen, Indira Singaram, Li Wang, Myoung Ho Jang, Cheol-Sang Hwang, Barry Honig, Sungho Ryu, Justin Lorieau, You-Me Kim, Wonhwa Cho. SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins.
Molecular cell.
2016 Apr; 62(1):7-20. doi:
10.1016/j.molcel.2016.01.027. [PMID: 27052731] - Kyung Lock Kim, Daehyung Kim, Seongsil Lee, Su-Jeong Kim, Jung Eun Noh, Joung-Hun Kim, Young Chan Chae, Jong-Bong Lee, Sung Ho Ryu. Pairwise detection of site-specific receptor phosphorylations using single-molecule blotting.
Nature communications.
2016 Mar; 7(?):11107. doi:
10.1038/ncomms11107. [PMID: 27009355] - Pieter Giesbertz, Inken Padberg, Dietrich Rein, Josef Ecker, Anja S Höfle, Britta Spanier, Hannelore Daniel. Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes.
Diabetologia.
2015 Sep; 58(9):2133-43. doi:
10.1007/s00125-015-3656-y. [PMID: 26058503] - Hayeong Kwon, Jaewoong Lee, Kyuho Jeong, Donghwan Jang, Yunbae Pak. Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Biochimica et biophysica acta.
2015 May; 1853(5):1022-34. doi:
10.1016/j.bbamcr.2015.02.002. [PMID: 25667086] - Mark A Baker, Anita Weinberg, Louise Hetherington, Ana-Izabel Villaverde, Tony Velkov, Jonathan Baell, Christopher P Gordon. Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function.
Biology of reproduction.
2015 Apr; 92(4):108. doi:
10.1095/biolreprod.114.126680. [PMID: 25673561] - Alexandr Prokhorov, Bernhard F Gibbs, Marco Bardelli, Laura Rüegg, Elizaveta Fasler-Kan, Luca Varani, Vadim V Sumbayev. The immune receptor Tim-3 mediates activation of PI3 kinase/mTOR and HIF-1 pathways in human myeloid leukaemia cells.
The international journal of biochemistry & cell biology.
2015 Feb; 59(?):11-20. doi:
10.1016/j.biocel.2014.11.017. [PMID: 25483439] - Benoit Denhez, Farah Lizotte, Marie-Odile Guimond, Nina Jones, Tomoko Takano, Pedro Geraldes. Increased SHP-1 protein expression by high glucose levels reduces nephrin phosphorylation in podocytes.
The Journal of biological chemistry.
2015 Jan; 290(1):350-8. doi:
10.1074/jbc.m114.612721. [PMID: 25404734] - Jianghong Wu, Paul P Masci, Chenfeng Chen, Jiezhong Chen, Martin F Lavin, Kong-Nan Zhao. β-Adducin siRNA disruption of the spectrin-based cytoskeleton in differentiating keratinocytes prevented by calcium acting through calmodulin/epidermal growth factor receptor/cadherin pathway.
Cellular signalling.
2015 Jan; 27(1):15-25. doi:
10.1016/j.cellsig.2014.10.001. [PMID: 25305142] - Byung-Ju Kim, Dae-Ryoung Park, Tae-Sik Nam, Seo Ho Lee, Uh-Hyun Kim. Seminal CD38 Enhances Human Sperm Capacitation through Its Interaction with CD31.
PloS one.
2015; 10(9):e0139110. doi:
10.1371/journal.pone.0139110. [PMID: 26407101] - Amit Singhai, Devin L Wakefield, Kirsten L Bryant, Stephen R Hammes, David Holowka, Barbara Baird. Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex.
Biophysical journal.
2014 Dec; 107(11):2639-51. doi:
10.1016/j.bpj.2014.09.048. [PMID: 25468343] - Xuemei Fan, Panlai Shi, Jing Dai, Yeling Lu, Xue Chen, Xiaoye Liu, Kandi Zhang, Xiaolin Wu, Yueping Sun, Kemin Wang, Li Zhu, Cheng Cheng Zhang, Junfeng Zhang, Guo-Qiang Chen, Junke Zheng, Junling Liu. Paired immunoglobulin-like receptor B regulates platelet activation.
Blood.
2014 Oct; 124(15):2421-30. doi:
10.1182/blood-2014-03-557645. [PMID: 25075127] - Yan-Bo Tang, Jun-Zheng Liu, Shu-En Zhang, Xin Du, Feilin Nie, Jin-Ying Tian, Fei Ye, Kai Huang, Jin-Ping Hu, Yan Li, Zhiyan Xiao. 3-Phenylpropanoic acid-based phosphotyrosine (pTyr) mimetics: hit evolution to a novel orally active protein tyrosine phosphatase 1B (PTP1B) inhibitor.
ChemMedChem.
2014 May; 9(5):918-21. doi:
10.1002/cmdc.201400007. [PMID: 24644278] - A K M Mahbub Hasan, Aki Hashimoto, Yuka Maekawa, Takashi Matsumoto, Shota Kushima, Takashi W Ijiri, Yasuo Fukami, Ken-ichi Sato. The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis.
Development (Cambridge, England).
2014 Apr; 141(8):1705-14. doi:
10.1242/dev.105510. [PMID: 24715460] - Min Hu, Bao-Lei Pei, Li-Fan Zhang, Ying-Zhang Li. Histone H2B monoubiquitination is involved in regulating the dynamics of microtubules during the defense response to Verticillium dahliae toxins in Arabidopsis.
Plant physiology.
2014 Apr; 164(4):1857-65. doi:
10.1104/pp.113.234567. [PMID: 24567190] - Ulrike Engel, Yougen Zhan, Jennifer B Long, Scott N Boyle, Bryan A Ballif, Karel Dorey, Steven P Gygi, Anthony J Koleske, David Vanvactor. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin.
Cytoskeleton (Hoboken, N.J.).
2014 Mar; 71(3):195-209. doi:
10.1002/cm.21164. [PMID: 24520051] - Zhao Zhang, Yun Zhang, Zheng Mou, Shifeng Chu, Xiaoyu Chen, Wenbin He, Xiaofeng Guo, Yuhe Yuan, Masami Takahashi, Naihong Chen. Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release.
PloS one.
2014; 9(4):e94574. doi:
10.1371/journal.pone.0094574. [PMID: 24718602] - Hui Dong, Jian-hong Wang, Fu-er Lu, Li-jun Xu, Yan-lin Gong, Xin Zou. Jiaotai Pill enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats.
Chinese journal of integrative medicine.
2013 Sep; 19(9):668-74. doi:
10.1007/s11655-013-1560-1. [PMID: 23975131] - A Khadjavi, A Notarpietro, F Mannu, A Pantaleo, E Ferru, P Destefanis, D Fontana, F Turrini. A high-throughput assay for the detection of Tyr-phosphorylated proteins in urine of bladder cancer patients.
Biochimica et biophysica acta.
2013 Jun; 1830(6):3664-9. doi:
10.1016/j.bbagen.2013.03.016. [PMID: 23528894] - Valentina Kovaleva, Rainer Cramer, Hryhoriy Krynytskyy, Ivan Gout, Roman Gout. Analysis of tyrosine phosphorylation and phosphotyrosine-binding proteins in germinating seeds from Scots pine.
Plant physiology and biochemistry : PPB.
2013 Jun; 67(?):33-40. doi:
10.1016/j.plaphy.2013.02.008. [PMID: 23542181] - Takahiro Fuchigami, Yutaka Sato, Yuya Tomita, Tetsuya Takano, Shin-ya Miyauchi, Yukinori Tsuchiya, Taro Saito, Ken-ichiro Kubo, Kazunori Nakajima, Mitsunori Fukuda, Mitsuharu Hattori, Shin-ichi Hisanaga. Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons.
Genes to cells : devoted to molecular & cellular mechanisms.
2013 May; 18(5):410-24. doi:
10.1111/gtc.12045. [PMID: 23506116] - Ching Yin Lee, Isabelle Ruel, Maxime Denis, Jacques Genest, Robert S Kiss. Cholesterol trapping in Niemann-Pick disease type B fibroblasts can be relieved by expressing the phosphotyrosine binding domain of GULP.
Journal of clinical lipidology.
2013 Mar; 7(2):153-64. doi:
10.1016/j.jacl.2012.02.006. [PMID: 23415435] - R A Bradshaw, R J Chalkley, J Biarc, A L Burlingame. Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics.
Advances in biological regulation.
2013 Jan; 53(1):87-96. doi:
10.1016/j.jbior.2012.10.006. [PMID: 23266087] - Man-Ho Oh, Xia Wu, Steven C Huber. Impact of Ca(2+) on structure of soybean CDPKβ and accessibility of the Tyr-24 autophosphorylation site.
Plant signaling & behavior.
2013; 8(12):e27671. doi:
10.4161/psb.27671. [PMID: 24394563] - Hiroshi Suzuki, Yasuyuki Ito, Yuji Yamazaki, Katsuhiko Mineta, Masami Uji, Kazuhiro Abe, Kazutoshi Tani, Yoshinori Fujiyoshi, Sachiko Tsukita. The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat.
Nature communications.
2013; 4(?):1766. doi:
10.1038/ncomms2731. [PMID: 23612307] - Tania E Saez Lancellotti, Paola V Boarelli, Aida A Romero, Abi K Funes, Macarena Cid-Barria, María E Cabrillana, María A Monclus, Layla Simón, Amanda E Vicenti, Miguel W Fornés. Semen quality and sperm function loss by hypercholesterolemic diet was recovered by addition of olive oil to diet in rabbit.
PloS one.
2013; 8(1):e52386. doi:
10.1371/journal.pone.0052386. [PMID: 23326331] - Shi-Xiong Tan, Yvonne Ng, James G Burchfield, Georg Ramm, David G Lambright, Jacqueline Stöckli, David E James. The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.
Molecular and cellular biology.
2012 Dec; 32(24):4946-59. doi:
10.1128/mcb.00761-12. [PMID: 23045393] - Jürgen van Baal, John de Widt, Nullin Divecha, Wim J van Blitterswijk. Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.
The international journal of biochemistry & cell biology.
2012 Nov; 44(11):1791-9. doi:
10.1016/j.biocel.2012.06.021. [PMID: 22732145] - Ilse Timmerman, Mark Hoogenboezem, Anton M Bennett, Dirk Geerts, Peter L Hordijk, Jaap D van Buul. The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation.
Molecular biology of the cell.
2012 Nov; 23(21):4212-25. doi:
10.1091/mbc.e12-01-0038. [PMID: 22956765] - S A Patel, K L Hoehn, R T Lawrence, L Sawbridge, N A Talbot, J L Tomsig, N Turner, G J Cooney, J P Whitehead, E W Kraegen, M E Cleasby. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity.
Endocrinology.
2012 Nov; 153(11):5231-46. doi:
10.1210/en.2012-1368. [PMID: 22989629] - Erika Hooker, Cindy Baldwin, Serge Lemay. New insights into Dok-4 PTB domain structure and function.
Biochemical and biophysical research communications.
2012 Oct; 427(1):67-72. doi:
10.1016/j.bbrc.2012.08.148. [PMID: 22982678] - Syouichi Katayama, Yasunori Sugiyama, Naoya Hatano, Toru Terachi, Noriyuki Sueyoshi, Isamu Kameshita. PKL01, an Ndr kinase homologue in plant, shows tyrosine kinase activity.
Journal of biochemistry.
2012 Oct; 152(4):347-53. doi:
10.1093/jb/mvs075. [PMID: 22753892] - C Johnson, C Chun-Jen Lin, M Stern. Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons.
Genes, brain, and behavior.
2012 Oct; 11(7):848-58. doi:
10.1111/j.1601-183x.2012.00822.x. [PMID: 22783951] - Clare M Gladding, Marja D Sepers, Jian Xu, Lily Y J Zhang, Austen J Milnerwood, Paul J Lombroso, Lynn A Raymond. Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.
Human molecular genetics.
2012 Sep; 21(17):3739-52. doi:
10.1093/hmg/dds154. [PMID: 22523092] - Robert J Huber, Danton H O'Day. EGF-like peptide-enhanced cell movement in Dictyostelium is mediated by protein kinases and the activity of several cytoskeletal proteins.
Cellular signalling.
2012 Sep; 24(9):1770-80. doi:
10.1016/j.cellsig.2012.05.004. [PMID: 22588127] - Dongmyung Oh, Mari Ogiue-Ikeda, Joshua A Jadwin, Kazuya Machida, Bruce J Mayer, Ji Yu. Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Aug; 109(35):14024-9. doi:
10.1073/pnas.1203397109. [PMID: 22886086] - Wei Jiang, Ellen G Duysen, Oksana Lockridge. Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry.
Toxicology.
2012 May; 295(1-3):15-22. doi:
10.1016/j.tox.2012.03.001. [PMID: 22406659] - Radhika Susarla, Ana-Maria Gonzalez, John C Watkinson, Margaret C Eggo. Expression of receptors for VEGFs on normal human thyroid follicular cells and their role in follicle formation.
Journal of cellular physiology.
2012 May; 227(5):1992-2002. doi:
10.1002/jcp.22930. [PMID: 21751212] - Man-Ho Oh, Hyoung Seok Kim, Xia Wu, Steven D Clouse, Raymond E Zielinski, Steven C Huber. Calcium/calmodulin inhibition of the Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase provides a possible link between calcium and brassinosteroid signalling.
The Biochemical journal.
2012 Apr; 443(2):515-23. doi:
10.1042/bj20111871. [PMID: 22309147] - Juan M Teijeiro, Patricia E Marini. Apical membranes prepared by peeling from whole porcine oviducts interact with homologous sperm.
Cell and tissue research.
2012 Apr; 348(1):213-23. doi:
10.1007/s00441-012-1338-3. [PMID: 22370593] - Y-J Yi, S W Zimmerman, G Manandhar, J F Odhiambo, C Kennedy, V Jonáková, P Maňásková-Postlerová, M Sutovsky, C-S Park, P Sutovsky. Ubiquitin-activating enzyme (UBA1) is required for sperm capacitation, acrosomal exocytosis and sperm-egg coat penetration during porcine fertilization.
International journal of andrology.
2012 Apr; 35(2):196-210. doi:
10.1111/j.1365-2605.2011.01217.x. [PMID: 21950462] - Kristin Katsch, Sarah Jill de Jong, Jens-Christian Albrecht, Julia Steger, Harald Genth, Guido Posern, Brigitte Biesinger. Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip.
Cell communication and signaling : CCS.
2012 Mar; 10(1):5. doi:
10.1186/1478-811x-10-5. [PMID: 22385615] - Serene Keilani, DeLacy Healey, Kiminobu Sugaya. Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation.
Canadian journal of physiology and pharmacology.
2012 Mar; 90(3):361-9. doi:
10.1139/y2012-001. [PMID: 22394407] - Ling Tian, Nanlan Luo, Xiaolin Zhu, Byung-Hong Chung, W Timothy Garvey, Yuchang Fu. Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses.
Atherosclerosis.
2012 Mar; 221(1):66-75. doi:
10.1016/j.atherosclerosis.2011.12.014. [PMID: 22227293] - Rachana Sainger, Juan B Grau, Paolo Poggio, Emanuela Branchetti, Joseph E Bavaria, Joseph H Gorman, Robert C Gorman, Giovanni Ferrari. Dephosphorylation of circulating human osteopontin correlates with severe valvular calcification in patients with calcific aortic valve disease.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2012 Mar; 17(2):111-8. doi:
10.3109/1354750x.2011.642407. [PMID: 22191734] - K M Habegger, B A Penque, W Sealls, L Tackett, L N Bell, E K Blue, P J Gallagher, M Sturek, M A Alloosh, H O Steinberg, R V Considine, J S Elmendorf. Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.
Diabetologia.
2012 Feb; 55(2):457-67. doi:
10.1007/s00125-011-2334-y. [PMID: 22002007] - Firas Younis, Yoram Oron, Rona Limor, Naftali Stern, Talma Rosenthal. Prophylactic treatment with telmisartan induces tissue-specific gene modulation favoring normal glucose homeostasis in Cohen-Rosenthal diabetic hypertensive rats.
Metabolism: clinical and experimental.
2012 Feb; 61(2):164-74. doi:
10.1016/j.metabol.2011.06.007. [PMID: 21820685] - Jiping Wang, Hongxia Liu, Bo Chen, Qiang Li, Xuliang Huang, Liqun Wang, Xiaohua Guo, Qiaobing Huang. RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response.
Cardiovascular diabetology.
2012 Jan; 11(?):7. doi:
10.1186/1475-2840-11-7. [PMID: 22251897] - Boyang Zhao, Mark A Knepper, Chung-Lin Chou, Trairak Pisitkun. Large-scale phosphotyrosine proteomic profiling of rat renal collecting duct epithelium reveals predominance of proteins involved in cell polarity determination.
American journal of physiology. Cell physiology.
2012 Jan; 302(1):C27-45. doi:
10.1152/ajpcell.00300.2011. [PMID: 21940666] - J P Lopes de Almeida, T Freitas-Santos, C Saldanha. Erythrocyte deformability dependence on band 3 protein in an in-vitro model of hyperfibrinogenemia.
Clinical hemorheology and microcirculation.
2012; 50(3):213-9. doi:
10.3233/ch-2010-1433. [PMID: 22240357] - Pierre Mazot, Alex Cazes, Florent Dingli, Joffrey Degoutin, Théano Irinopoulou, Marie-Claude Boutterin, Bérangère Lombard, Damarys Loew, Bengt Hallberg, Ruth Helen Palmer, Olivier Delattre, Isabelle Janoueix-Lerosey, Marc Vigny. Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.
PloS one.
2012; 7(3):e33581. doi:
10.1371/journal.pone.0033581. [PMID: 22479414] - Diana L Esposito, Federica Aru, Rossano Lattanzio, Annalisa Morgano, Michela Abbondanza, Reza Malekzadeh, Faraz Bishehsari, Rosa Valanzano, Antonio Russo, Mauro Piantelli, Antonio Moschetta, Lavinia Vittoria Lotti, Renato Mariani-Costantini. The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.
PloS one.
2012; 7(4):e36190. doi:
10.1371/journal.pone.0036190. [PMID: 22558377] - Simon P Hart, Adriano G Rossi, Christopher Haslett, Ian Dransfield. Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN.
PloS one.
2012; 7(3):e33142. doi:
10.1371/journal.pone.0033142. [PMID: 22427969] - Sharon C Mithoe, Paul J Boersema, Lidija Berke, Berend Snel, Albert J R Heck, Frank L H Menke. Targeted quantitative phosphoproteomics approach for the detection of phospho-tyrosine signaling in plants.
Journal of proteome research.
2012 Jan; 11(1):438-48. doi:
10.1021/pr200893k. [PMID: 22074104] - Kenji Nakashima, Kenji Takeuchi, Kazuyasu Chihara, Tomoko Horiguchi, Xuedong Sun, Lin Deng, Ikuo Shoji, Hak Hotta, Kiyonao Sada. HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells.
PloS one.
2012; 7(10):e46634. doi:
10.1371/journal.pone.0046634. [PMID: 23077515]