Fenoldopam (BioDeep_00000003124)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol

化学式: C16H16ClNO3 (305.0819)
中文名称: 盐酸非诺多泮
谱图信息: 最多检出来源 Homo sapiens(urine) 18%

分子结构信息

SMILES: c1cc(ccc1C1CNCCc2c1cc(c(c2Cl)O)O)O
InChI: InChI=1S/C16H16ClNO3/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21/h1-4,7,13,18-21H,5-6,8H2

描述信息

Fenoldopam is only found in individuals that have used or taken this drug. It is a dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. [PubChem]Fenoldopam is a rapid-acting vasodilator. It is an agonist for D₁-like dopamine receptors and binds with moderate affinity to α₂-adrenoceptors. It has no significant affinity for D₂-like receptors, α₁ and β-adrenoceptors, 5_HT1 and 5_HT2 receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D₁-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D₂-like dopamine receptors, or α or β -adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Fenoldopam may increase norepinephrine plasma concentration.
C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

15 个代谢物同义名

6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol; Hydrobromide, fenoldopam; Fenoldopam hydrobromide; Fenoldopam mesylate; SK And F 82526J; SK And F-82526J; SK And F 82526; SK And F-82526; SK And F82526J; SK And F82526; Fenoldopamum; fenoldopam; Carlacor; Corlopam; Fenoldopam

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:5002
KEGG: C07693
KEGGdrug: D07946
PubChem: 3341
HMDB: HMDB0014938
Metlin: METLIN4024
DrugBank: DB00800
ChEMBL: CHEMBL588
Wikipedia: Fenoldopam
MeSH: Fenoldopam
chemspider: 3224
CAS: 1092382-99-4
CAS: 67227-56-9
PMhub: MS000008147
PubChem: 9895
NIKKAJI: J23.754J
RefMet: Fenoldopam
KNApSAcK: 5002

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	6	ACE, ADRA1A, CST3, DDC, GRK4, PRL
Endoplasmic reticulum membrane	1	DRD1
Nucleus	4	ADRA1A, DRD1, PLCZ1, PRL
cytosol	5	ADRA1A, DDC, GRK4, PLCZ1, PRKCQ
dendrite	1	DRD2
nucleoplasm	4	ADRA1A, ATP2B1, PLCZ1, PRL
RNA polymerase II transcription regulator complex	1	PRL
Cell membrane	9	ACE, ADRA1A, ADRB3, ATP2B1, DRD1, DRD2, GPRC5A, ITPRIP, TNF
Multi-pass membrane protein	7	ADRA1A, ADRB3, ATP2B1, CACNA1I, DRD1, DRD2, GPRC5A
Golgi apparatus membrane	1	DRD2
Synapse	2	ATP2B1, DRD2
cell cortex	1	GRK4
cell surface	1	TNF
glutamatergic synapse	3	ATP2B1, DRD1, DRD2
Golgi apparatus	1	CST3
Golgi membrane	2	DRD2, INS
neuronal cell body	1	TNF
presynaptic membrane	3	ATP2B1, DRD1, DRD2
Lysosome	1	ACE
acrosomal vesicle	1	DRD2
endosome	1	ACE
plasma membrane	14	ACE, ADRA1A, ADRB3, ATP2B1, CACNA1I, CST3, DRD1, DRD2, GPRC5A, GRK4, ITPRIP, PRKCQ, REN, TNF
synaptic vesicle membrane	2	ATP2B1, DRD2
Membrane	5	ACE, ATP2B1, CACNA1I, ITPRIP, REN
axon	1	DRD2
basolateral plasma membrane	1	ATP2B1
caveola	1	ADRA1A
extracellular exosome	5	ACE, ATP2B1, CST3, DDC, GPRC5A
endoplasmic reticulum	1	CST3
extracellular space	8	ACE, CST3, CXCL8, IL6, INS, PRL, REN, TNF
perinuclear region of cytoplasm	1	PLCZ1
intracellular membrane-bounded organelle	3	ADRA1A, ATP2B1, GPRC5A
pronucleus	1	PLCZ1
Single-pass type I membrane protein	2	ACE, ITPRIP
Secreted	7	ACE, CST3, CXCL8, IL6, INS, PRL, REN
extracellular region	8	ACE, CST3, CXCL8, IL6, INS, PRL, REN, TNF
centriolar satellite	1	PRKCQ
ciliary membrane	2	DRD1, DRD2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane	1	ATP2B1
Nucleus membrane	1	ADRA1A
nuclear membrane	1	ADRA1A
external side of plasma membrane	2	ACE, TNF
dendritic spine	2	DRD1, DRD2
perikaryon	1	DRD2
nucleolus	2	GPRC5A, PLCZ1
apical part of cell	1	REN
recycling endosome	1	TNF
Single-pass type II membrane protein	1	TNF
vesicle	2	CST3, GPRC5A
postsynaptic membrane	2	DRD1, DRD2
Cytoplasm, perinuclear region	1	PLCZ1
Membrane raft	1	TNF
GABA-ergic synapse	2	DRD1, DRD2
Cell projection, dendritic spine	1	DRD1
lateral plasma membrane	2	ATP2B1, DRD2
Nucleus outer membrane	1	ITPRIP
nuclear outer membrane	1	ITPRIP
receptor complex	2	ADRB3, GPRC5A
cilium	2	DRD1, DRD2
chromatin	1	PRL
cell projection	1	ATP2B1
phagocytic cup	1	TNF
brush border membrane	1	ACE
non-motile cilium	2	DRD1, DRD2
sperm midpiece	1	ACE
Basolateral cell membrane	1	ATP2B1
sperm flagellum	1	DRD2
endosome lumen	2	INS, PRL
Membrane, caveola	1	ADRA1A
Cytoplasmic vesicle membrane	1	GPRC5A
Cell projection, dendrite	1	DRD1
Presynaptic cell membrane	1	ATP2B1
basal plasma membrane	1	ACE
ficolin-1-rich granule lumen	1	CST3
secretory granule lumen	1	INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	3	CST3, IL6, INS
axon terminus	1	DRD2
voltage-gated calcium channel complex	1	CACNA1I
tertiary granule lumen	1	CST3
endocytic vesicle	1	DRD2
transport vesicle	1	INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
immunological synapse	2	ATP2B1, PRKCQ
aggresome	1	PRKCQ
dopaminergic synapse	1	DRD2
Cell projection, cilium membrane	1	DRD1
photoreceptor disc membrane	1	GRK4
[Tumor necrosis factor, soluble form]: Secreted	1	TNF
sperm head	1	PLCZ1
interleukin-6 receptor complex	1	IL6
photoreceptor ribbon synapse	1	ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted	1	ACE
[Isoform Testis-specific]: Cell membrane	1	ACE
G protein-coupled receptor complex	2	DRD1, DRD2
[C-domain 2]: Secreted	1	TNF
[Tumor necrosis factor, membrane form]: Membrane	1	TNF
[C-domain 1]: Secreted	1	TNF

文献列表

Bibhas Amatya, Sufei Yang, Peiying Yu, Pedro A S Vaz de Castro, Ines Armando, Chunyu Zeng, Robin A Felder, Laureano D Asico, Pedro A Jose, Hewang Lee. Peroxiredoxin-4 and dopamine D5 receptor interact to reduce oxidative stress and inflammation in the kidney. Antioxidants & redox signaling. 2022 Nov; ?(?):. doi: 10.1089/ars.2022.0034. [PMID: 36401517]
Xiao Teng, Sijia Chen, Yingying Nie, Peng Xiao, Xiao Yu, Zhenhua Shao, Sanduo Zheng. Ligand recognition and biased agonism of the D1 dopamine receptor. Nature communications. 2022 06; 13(1):3186. doi: 10.1038/s41467-022-30929-w. [PMID: 35676276]
Cindy Zeng, Tianyang Xia, Shuo Zheng, Lijia Liang, Yue Chen. Synergistic Effect of Uroguanylin and D1 Dopamine Receptors on Sodium Excretion in Hypertension. Journal of the American Heart Association. 2022 03; 11(6):e022827. doi: 10.1161/jaha.121.022827. [PMID: 35229618]
Fuqiang Zhao, Xiaoyan Zhou, Eric Messina, Lufei Hu, Marie A Holahan, Gayathri Swaminath, Catherine D G Hines. Robust arterial spin labeling MRI measurement of pharmacologically induced perfusion change in rat kidneys. NMR in biomedicine. 2021 09; 34(9):e4566. doi: 10.1002/nbm.4566. [PMID: 34096123]
Gianluigi Ardissino, Antenore Giussani, Valentina Capone, Sara Testa, Cristiano Gandini, Giovanni Montini. Fenoldopam and renal hemodynamics in shiga toxin-related hemolytic uremic syndrome. Pediatric nephrology (Berlin, Germany). 2021 09; 36(9):2891-2894. doi: 10.1007/s00467-021-05127-3. [PMID: 34002291]
Ting Du, Rongjin Sun, Nyma Siddiqui, Linda Moatamed, Yun Zhang, Dong Liang, Ming Hu, Song Gao. A positive-negative switching LC-MS/MS method for quantification of fenoldopam and its phase II metabolites: Applications to a pharmacokinetic study in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Aug; 1179(?):122854. doi: 10.1016/j.jchromb.2021.122854. [PMID: 34242859]
Hewang Lee, Xiaoliang Jiang, Imran Perwaiz, Peiying Yu, Jin Wang, Ying Wang, Maik Hüttemann, Robin A Felder, David R Sibley, Brian M Polster, Selim Rozyyev, Ines Armando, Zhiwei Yang, Peng Qu, Pedro A Jose. Dopamine D5 receptor-mediated decreases in mitochondrial reactive oxygen species production are cAMP and autophagy dependent. Hypertension research : official journal of the Japanese Society of Hypertension. 2021 Jun; 44(6):628-641. doi: 10.1038/s41440-021-00646-w. [PMID: 33820956]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Peng Xiao, Wei Yan, Lu Gou, Ya-Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan-Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong-Hao He, Dao-Lai Zhang, Chao Zhang, Gui-Hua Hou, Huanxiang Liu, Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M Rosenbaum, Jin-Peng Sun, Yang Du, Lei Zhang, Xiao Yu, Zhenhua Shao. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. 2021 02; 184(4):943-956.e18. doi: 10.1016/j.cell.2021.01.028. [PMID: 33571432]
Stacey L Crockett, Micah Harris, Naoko Boatwright, Rachel L Su, Michael T Yarboro, Courtney D Berger, Elaine L Shelton, Jeff Reese, Jeffrey L Segar. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatric research. 2020 05; 87(6):991-997. doi: 10.1038/s41390-019-0716-x. [PMID: 31816622]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Haibing Sun, Qin Xie, Zhiyong Peng. Does Fenoldopam Protect Kidney in Cardiac Surgery? A Systemic Review and Meta-Analysis With Trial Sequential Analysis. Shock (Augusta, Ga.). 2019 09; 52(3):326-333. doi: 10.1097/shk.0000000000001313. [PMID: 30601331]
Shaoxiong Wang, Xiaorong Tan, Peng Chen, Shuo Zheng, Hongmei Ren, Jin Cai, Lin Zhou, Pedro A Jose, Jian Yang, Chunyu Zeng. Role of Thioredoxin 1 in Impaired Renal Sodium Excretion of hD 5 R F173L Transgenic Mice. Journal of the American Heart Association. 2019 04; 8(8):e012192. doi: 10.1161/jaha.119.012192. [PMID: 30957627]
Rajasekharreddy Pala, Ashraf M Mohieldin, Rinzhin T Sherpa, Sarmed H Kathem, Kiumars Shamloo, Zhongyue Luan, Jing Zhou, Jian-Guo Zheng, Amir Ahsan, Surya M Nauli. Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles. ACS nano. 2019 03; 13(3):3555-3572. doi: 10.1021/acsnano.9b00033. [PMID: 30860808]
Rajasekharreddy Pala, Ashraf M Mohieldin, Kiumars Shamloo, Rinzhin T Sherpa, Sarmed H Kathem, Jing Zhou, Zhongyue Luan, Jian-Guo Zheng, Amir Ahsan, Surya M Nauli. Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular Hypertension. Nano letters. 2019 02; 19(2):904-914. doi: 10.1021/acs.nanolett.8b04138. [PMID: 30582331]
Valentina Rovella, Michele Ferrannini, Manfredi Tesauro, Giulia Marrone, Andrea Busca, Roberto Sorge, Simone Manca di Villahermosa, Maurizio Casasco, Nicola Di Daniele, Annalisa Noce. Effects of fenoldopam on renal blood flow in hypertensive chronic kidney disease. Journal of nephrology. 2019 Feb; 32(1):75-81. doi: 10.1007/s40620-018-0496-0. [PMID: 29766465]
Annalisa Noce, Giulia Marrone, Valentina Rovella, Andrea Busca, Caterina Gola, Michele Ferrannini, Nicola Di Daniele. Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury. Current pharmaceutical biotechnology. 2019; 20(5):366-375. doi: 10.2174/1389201020666190417124711. [PMID: 31038062]
Gilad Segev, Yaron Bruchim, Noga Berl, Adar Cohen, Itamar Aroch. Effects of fenoldopam on kidney function parameters and its therapeutic efficacy in the management of acute kidney injury in dogs with heatstroke. Journal of veterinary internal medicine. 2018 May; 32(3):1109-1115. doi: 10.1111/jvim.15081. [PMID: 29575360]
Zhengmeng Ye, Xi Lu, Yi Deng, Xinquan Wang, Shuo Zheng, Hongmei Ren, Miao Zhang, Tingting Chen, Pedro A Jose, Jian Yang, Chunyu Zeng. In Utero Exposure to Fine Particulate Matter Causes Hypertension Due to Impaired Renal Dopamine D1 Receptor in Offspring. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 46(1):148-159. doi: 10.1159/000488418. [PMID: 29614490]
S Mas-Font, J Ros-Martinez, C Pérez-Calvo, P Villa-Díaz, S Aldunate-Calvo, E Moreno-Clari. Prevention of acute kidney injury in Intensive Care Units. Medicina intensiva. 2017 Mar; 41(2):116-126. doi: 10.1016/j.medin.2016.12.004. [PMID: 28190602]
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Emiel Hendrik Post, Fuhong Su, Fabio Silvio Taccone, Koji Hosokawa, Antoine Herpain, Jacques Creteur, Jean-Louis Vincent, Daniel De Backer. THE EFFECTS OF FENOLDOPAM ON RENAL FUNCTION AND METABOLISM IN AN OVINE MODEL OF SEPTIC SHOCK. Shock (Augusta, Ga.). 2016 Apr; 45(4):385-92. doi: 10.1097/shk.0000000000000516. [PMID: 26506071]
Xiaoliang Jiang, Wei Chen, Xing Liu, Zihao Wang, Yunpeng Liu, Robin A Felder, John J Gildea, Pedro A Jose, Chuan Qin, Zhiwei Yang. The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion. PloS one. 2016; 11(1):e0146641. doi: 10.1371/journal.pone.0146641. [PMID: 26751218]
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John J Gildea, Ishan T Shah, Robert E Van Sciver, Jonathan A Israel, Christoph Enzensperger, Helen E McGrath, Pedro A Jose, Robin A Felder. The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. Kidney international. 2014 Jul; 86(1):118-26. doi: 10.1038/ki.2014.5. [PMID: 24552847]
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Shaoxiong Wang, Xi Lu, Jian Yang, Hongyong Wang, CaiYu Chen, Yu Han, Hongmei Ren, Shuo Zheng, Duofen He, Lin Zhou, Laureano D Asico, Wei Eric Wang, Pedro A Jose, Chunyu Zeng. Regulation of renalase expression by D5 dopamine receptors in rat renal proximal tubule cells. American journal of physiology. Renal physiology. 2014 Mar; 306(6):F588-96. doi: 10.1152/ajprenal.00196.2013. [PMID: 24500688]
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