Acetylcholine (BioDeep_00000002989)

 

Secondary id: BioDeep_00000415879, BioDeep_00000871731

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


Bournonville brand OF acetylcholine chloride

化学式: [C7H16NO2]+ (146.1181)
中文名称: 乙酰胆碱, 氯化乙酰胆碱
谱图信息: 最多检出来源 Homo sapiens(otcml) 27.95%

分子结构信息

SMILES: CC(=O)OCC[N+1](C)(C)C
InChI: InChI=1/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1

描述信息

Acetylcholine (ACh) is a neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. Its physiological and pharmacological effects, metabolism, release, and receptors have been well documented in several species. ACh has been considered an important excitatory neurotransmitter in the carotid body (CB). Various nicotinic and muscarinic ACh receptors are present in both afferent nerve endings and glomus cells. Therefore, ACh can depolarize or hyperpolarize the cell membrane depending on the available receptor type in the vicinity. Binding of ACh to its receptor can create a wide variety of cellular responses including opening cation channels (nicotinic ACh receptor activation), releasing Ca2+ from intracellular storage sites (via muscarinic ACh receptors), and modulating activities of K+ and Ca2+ channels. Interactions between ACh and other neurotransmitters (dopamine, adenosine, nitric oxide) have been known, and they may induce complicated responses. Cholinergic biology in the CB differs among species and even within the same species due to different genetic composition. Development and environment influence cholinergic biology. Pharmacological data clearly indicate that both muscarinic and nicotinic acetylcholine receptors have a role in the encoding of new memories. Localized lesions and antagonist infusions demonstrate the anatomical locus of these cholinergic effects, and computational modeling links the function of cholinergic modulation to specific cellular effects within these regions. Acetylcholine has been shown to increase the strength of afferent input relative to feedback, to contribute to theta rhythm oscillations, activate intrinsic mechanisms for persistent spiking, and increase the modification of synapses. These effects might enhance different types of encoding in different cortical structures. In particular, the effects in entorhinal and perirhinal cortex and hippocampus might be important for encoding new episodic memories. The role of ACh in attention has been repeatedly demonstrated in several tasks. Acetylcholine is linked to response accuracy in voluntary and reflexive attention and also to response speed in reflexive attention. It is well known that those with Attention-deficit/hyperactivity disorders tend to be inaccurate and slow to respond. (PMID:17284361, 17011181, 15556286). Acetylcholine has been found to be a microbial product, urinary acetylcholine is produced by Lactobacillus (PMID:24621061).
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EB - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
Acquisition and generation of the data is financially supported in part by CREST/JST.
C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
IPB_RECORD: 232; CONFIDENCE confident structure
COVID info from COVID-19 Disease Map
Corona-virus
KEIO_ID A060
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

42 个代谢物同义名

Bournonville brand OF acetylcholine chloride; Ciba vision brand OF acetylcholine chloride; 2-(Acetyloxy)-N,N,N-trimethylethanaminium; 2-Acetyloxy-N,N,N-trimethylethanaminium; Alcon brand OF acetylcholine chloride; Iolab brand OF acetylcholine chloride; [2-(acetyloxy)ethyl]trimethylazanium; (2-acetoxyethyl)trimethylammonium; Acetylcholinium: acetyl-choline; Acetylcholine picrate (1:1); Acetylcholine sulfate (1:1); Perchlorate, acetylcholine; Acetylcholine perchlorate; L-Tartrate, acetylcholine; Acetylcholine L tartrate; Acetylcholine L-tartrate; Hydroxide, acetylcholine; Fluoride, acetylcholine; Acetylcholine hydroxide; Choline acetate (ester); Bromide, acetylcholine; Acetylcholine chloride; Acetylcholine fluoride; Acetylcholine picrate; Acetylcholine Bromide; Iodide, acetylcholine; Acetylcholine cation; Acetylcholine iodide; Chloroacetylcholine; Choline acetic acid; Acetyl choline ion; Bromoacetylcholine; Cusi, acetilcolina; Acetilcolina cusi; Choline acetate; O-Acetylcholine; Acetylcholine; Azetylcholin; Miochol; ACh; Acetylcholine; Acetylcholine



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(17)

BioCyc(0)

PlantCyc(0)

代谢反应

340 个相关的代谢反应过程信息。

Reactome(329)

BioCyc(0)

WikiPathways(4)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(6)

PharmGKB(0)

100 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CALCA, EDN1, GAL, GUCY1A1, NOS1, POMC, PTGS1
Peripheral membrane protein 3 CYP1B1, NOS1, PTGS1
Endoplasmic reticulum membrane 2 CYP1B1, PTGS1
Nucleus 2 FOS, NOS1
cytosol 5 FOS, GUCY1A1, NGF, NOS1, SST
dendrite 1 NGF
nucleoplasm 2 FOS, NOS1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 2 GAL, GRID1
Multi-pass membrane protein 3 GRID1, KCNA3, SLC18A3
Synapse 2 NOS1, TAC1
glutamatergic synapse 3 GRID1, GUCY1A1, KCNA3
Golgi apparatus 2 NPY, PTGS1
neuronal cell body 4 CALCA, GAL, SST, TAC1
presynaptic membrane 1 KCNA3
sarcolemma 1 NOS1
synaptic vesicle 1 NGF
plasma membrane 7 BCHE, GAL, GRID1, KCNA3, NOS1, REN, SLC18A3
synaptic vesicle membrane 1 SLC18A3
terminal bouton 2 CALCA, SLC18A3
Membrane 3 CYP1B1, KCNA3, REN
axon 3 KCNA3, NGF, TAC1
extracellular exosome 2 GRID1, PTGS1
endoplasmic reticulum 1 FOS
extracellular space 12 BCHE, CALCA, CRP, EDN1, GAL, GAST, NGF, NPY, POMC, REN, SST, TAC1
perinuclear region of cytoplasm 2 KCNA3, NOS1
mitochondrion 2 CYP1B1, NOS1
protein-containing complex 1 NOS1
intracellular membrane-bounded organelle 2 CYP1B1, PTGS1
Microsome membrane 2 CYP1B1, PTGS1
postsynaptic density 1 NOS1
Secreted 11 BCHE, CALCA, CRP, EDN1, GAL, GAST, NGF, NPY, POMC, REN, SST
extracellular region 12 BCHE, CALCA, CRP, EDN1, GAL, GAST, NGF, NPY, POMC, REN, SST, TAC1
basal part of cell 1 EDN1
hippocampal mossy fiber to CA3 synapse 1 CALCA
photoreceptor inner segment 1 NOS1
photoreceptor outer segment 1 PTGS1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SLC18A3
dendritic spine 1 NOS1
apical part of cell 1 REN
postsynaptic membrane 2 GRID1, KCNA3
Cell membrane, sarcolemma 1 NOS1
Cytoplasm, perinuclear region 1 NOS1
Membrane raft 2 KCNA3, NOS1
GABA-ergic synapse 4 GRID1, GUCY1A1, NPY, SST
sarcoplasmic reticulum 1 NOS1
Cell projection, dendritic spine 1 NOS1
secretory granule 2 GAL, POMC
Postsynaptic cell membrane 1 GRID1
neuron projection 1 PTGS1
chromatin 1 FOS
cell periphery 1 NOS1
cytoskeleton 1 NOS1
blood microparticle 1 BCHE
[Isoform 2]: Cell membrane 1 KCNA3
Endomembrane system 1 PTGS1
endosome lumen 1 NGF
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 1 POMC
Golgi lumen 1 NGF
endoplasmic reticulum lumen 1 BCHE
nuclear matrix 1 FOS
transport vesicle 1 EDN1
postsynaptic density membrane 1 GRID1
neuronal dense core vesicle 3 CALCA, NPY, SST
nuclear envelope lumen 1 BCHE
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 SLC18A3
protein-DNA complex 1 FOS
[Isoform 1]: Cell membrane 1 KCNA3
AP-1 adaptor complex 1 SLC18A3
guanylate cyclase complex, soluble 1 GUCY1A1
AP-2 adaptor complex 1 SLC18A3
transcription factor AP-1 complex 1 FOS
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
clathrin-sculpted acetylcholine transport vesicle membrane 1 SLC18A3
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3


文献列表

  • Mohsen Akbari, Salar Moardi, Homeyra Piri, Roonak Amiri, Farzaneh Aliaqabozorg, Elham Sadat Afraz. The identification of active compounds and therapeutic properties of fermented and non-fermented red sorghum for the treatment of Alzheimer's dementia. Experimental gerontology. 2024 Jul; 192(?):112459. doi: 10.1016/j.exger.2024.112459. [PMID: 38740315]
  • Maria-Christina Zerva, Christos Triantafylloudis, Vassilis Paspaliaris, Efthimios M C Skoulakis, Katerina Papanikolopoulou. Choline Metabolites Reverse Differentially the Habituation Deficit and Elevated Memory of Tau Null Drosophila. Cells. 2024 Apr; 13(9):. doi: 10.3390/cells13090746. [PMID: 38727282]
  • S K Johnsy Sugitha, Raja Venkatesan, R Gladis Latha, Alexandre A Vetcher, Bandar Ali Al-Asbahi, Seong-Cheol Kim. A Study on the Antibacterial, Antispasmodic, Antipyretic, and Anti-Inflammatory Activity of ZnO Nanoparticles Using Leaf Extract from Jasminum sambac (L. Aiton). Molecules (Basel, Switzerland). 2024 Mar; 29(7):. doi: 10.3390/molecules29071464. [PMID: 38611744]
  • Ying Yu, Li Yun Wang, Yan Chi Liu, Hao Cui, Cheng Yuan, Cheng Xiao Wang. Acetylcholine Analog-Modified Albumin Nanoparticles for the Enhanced and Synchronous Brain Delivery of Saponin Components of Panax Notoginseng. Pharmaceutical research. 2024 Mar; 41(3):513-529. doi: 10.1007/s11095-024-03670-w. [PMID: 38383935]
  • Fan Zhang, Lingnan Guo, Jingjing Shi, Hao Jiang, Feini Zhou, Yanlin Zhou, Bin Lv, Maosheng Xu. Choline metabolism in regulating inflammatory bowel disease-linked anxiety disorders: A multi-omics exploration of the gut-brain axis. Neurobiology of disease. 2024 Feb; 191(?):106390. doi: 10.1016/j.nbd.2023.106390. [PMID: 38145852]
  • Musa Dirak, Jefferson Chan, Safacan Kolemen. Optical imaging probes for selective detection of butyrylcholinesterase. Journal of materials chemistry. B. 2024 Jan; 12(5):1149-1167. doi: 10.1039/d3tb02468g. [PMID: 38196348]
  • Guadalupe E Ángeles-López, Angélica Hernández-Ruíz, Ma Eva González-Trujano, Sol Cristians, Berenice Ovalle-Magallanes, Rosa Ventura-Martínez. Pharmacological disadvantages in the spasmolytic effects by using the mixture known as 'three toronjiles' in folk medicine. Journal of ethnopharmacology. 2024 Jan; 318(Pt B):116978. doi: 10.1016/j.jep.2023.116978. [PMID: 37524233]
  • Baolei Zhan, Ting Zhou, Di Tong, Zile Xu, Xiaoyu Liang, Anqi Ma, Shumin Lü. Expression of the non-neuronal cholinergic system components in Malpighian tubules of Mythimna separata and evidence for non-neuronal acetylcholine synthesis. Insect biochemistry and molecular biology. 2024 Jan; 164(?):104047. doi: 10.1016/j.ibmb.2023.104047. [PMID: 38072082]
  • Dominika Szadkowska, Magdalena Chłopecka, Jakub W Strawa, Katarzyna Jakimiuk, Daniel Augustynowicz, Michał Tomczyk, Marta Mendel. Effects of Cirsium palustre Extracts and Their Main Flavonoids on Colon Motility-An Ex Vivo Study. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417283. [PMID: 38139112]
  • Hu Chen, Na Wang, Shunli Wei, Xinjian Xu, Chunxiao Wu, Shugang Liu. Inhibition of Acetylcholine Expression in the Tumor Microenvironment by Mustard Oil: A Potential Strategy to Retard Colon Cancer Progression. Alternative therapies in health and medicine. 2023 Nov; 29(8):246-251. doi: ". [PMID: 37573596]
  • Guzalia F Zakirjanova, Arthur R Giniatullin, Chulpan R Gafurova, Artem I Malomouzh, Nikita S Fedorov, Arthur N Khaziev, Andrei N Tsentsevitsky, Alexey M Petrov. Effects of cholesterol oxidase on neurotransmission and acetylcholine levels at the mice neuromuscular junctions. Archives of biochemistry and biophysics. 2023 Nov; 749(?):109803. doi: 10.1016/j.abb.2023.109803. [PMID: 37955112]
  • Tokaa Mansour, Wafaa H Radwan, Menna Mansour, Mohamed Gomaa, Farouk Farouk, Mohamed Shepl, Ahmed G Soliman, Basma T Abd-Elhalim, Mohamed M K El-Senosy, Ashraf Bakry, Naglaa M Ebeed, Neima K Alsenosy, Hesham Elhariry, Ahmed Galal, Salwa M El-Sayed, Eslam Adly, Samah H Abu-Hussien. Larvicidal potential, toxicological assessment, and molecular docking studies of four Egyptian bacterial strains against Culex pipiens L. (Diptera: Culicidae). Scientific reports. 2023 10; 13(1):17230. doi: 10.1038/s41598-023-44279-0. [PMID: 37821509]
  • S B Caine, S Plant, K Furbish, M Yerton, E Smaragdi, B Niclou, J M Lorusso, J Y Chang, C Bitter, A Basu, S Miller, C-Y Huang, R Komson, D Liu, S Behar, M Thomsen. Sprague Dawley rats from different vendors vary in the modulation of prepulse inhibition of startle (PPI) by dopamine, acetylcholine, and glutamate drugs. Psychopharmacology. 2023 Aug; ?(?):. doi: 10.1007/s00213-023-06444-1. [PMID: 37580441]
  • Lin Yang, Xu Ma, Yuhan Guo, Yuman He, Yunwen Yang, Wenqiao Wang, Ziyi Xu, Zhaojiang Zuo, Ying Xue, Rui Yang, Bing Han, Jinsheng Sun. Acetylcholine (ACh) enhances Cd tolerance through transporting ACh in vesicles and modifying Cd absorption in duckweed (Lemna turionifera 5511). Environmental pollution (Barking, Essex : 1987). 2023 Aug; 335(?):122305. doi: 10.1016/j.envpol.2023.122305. [PMID: 37580008]
  • Sheba R David, Penny Pei Ni Lai, Jestin Chellian, Srikumar Chakravarthi, Rajan Rajabalaya. Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes. Scientific reports. 2023 08; 13(1):12423. doi: 10.1038/s41598-023-39442-6. [PMID: 37528147]
  • Jonnelle M Edwards-Glenn, Milene T Fontes, Emily W Waigi, Tiago J Costa, Andrei Maiseyeu, Clinton Webb, Cameron G McCarthy, Camilla F Wenceslau. Specialized pro-resolving mediator therapy improves vascular relaxation via formyl peptide-receptor-2. American journal of hypertension. 2023 Jul; ?(?):. doi: 10.1093/ajh/hpad062. [PMID: 37439351]
  • Karelle Kouam Yacine Madjo, Marius Mbiantcha, Linda Zenab Njoya Fagni, Vanessa Mba Matah Marthe, Elvira Azanze Ngoufack, Gonzal Eric Tsafack, Stephanie Flore Djuichou Nguemnang, Carine Flore Adjouzem, Gilbert Ateufack. Gastroprotective and ulcer healing effects of Nauclea pobeguinii (Rubiaceae) on experimentally induced gastric ulcers in male Wistar rats. Journal of complementary & integrative medicine. 2023 Jun; ?(?):. doi: 10.1515/jcim-2023-0024. [PMID: 37382892]
  • Kripa Shankar Nainawat, Sarita Singh, Karishma Agarwal, Hina Iqbal, Poonam Rani, Divya Bhatt, Sana Khan, Debabrata Chanda, Dnyaneshwar Umrao Bawankule, Sudeep Tandon, Feroz Khan, Anil Kumar Gupta, Atul Gupta. Synthesis of 6-alkoxy and 6-hydroxy-alkyl amine derivatives of braylin as vasorelaxing agents. Bioorganic & medicinal chemistry letters. 2023 06; 89(?):129311. doi: 10.1016/j.bmcl.2023.129311. [PMID: 37149230]
  • Qin Zeng, Shuyi Wang, Mengyuan Li, Shuang Wang, Chaohuan Guo, Xinyuan Ruan, Ryu Watanabe, Yimei Lai, Yuefang Huang, Xiaoyu Yin, Chuanzhao Zhang, Binfeng Chen, Niansheng Yang, Hui Zhang. Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses. Cell metabolism. 2023 05; 35(5):837-854.e8. doi: 10.1016/j.cmet.2023.03.010. [PMID: 37019104]
  • Qing Wu, Ming Zhao, Dongling Li, Xi He, Weijin Zang. Cholinergic drugs reduce metabolic inflammation and diabetic myocardial injury by regulating the gut bacterial component lipopolysaccharide-induced ERK/Egr-1 pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 05; 37(5):e22917. doi: 10.1096/fj.202202108r. [PMID: 37039813]
  • Yixi Zhang, Xiaoyong Xu, Jingting Wang, Xusheng Shao, Zewen Liu, Zhong Li. Molecular Mechanism of Action of Cycloxaprid, An Oxabridged cis-Nitromethylene Neonicotinoid. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087511. [PMID: 37108674]
  • Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu. Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087356. [PMID: 37108518]
  • Ayad A Alawadi, Vagner A Benedito, R Chris Skinner, Derek C Warren, Casey Showman, Janet C Tou. RNA-sequencing revealed apple pomace ameliorates expression of genes in the hypothalamus associated with neurodegeneration in female rats fed a Western diet during adolescence to adulthood. Nutritional neuroscience. 2023 Apr; 26(4):332-344. doi: 10.1080/1028415x.2022.2050008. [PMID: 35296223]
  • Petar Šušnjara, Zrinka Mihaljević, Ana Stupin, Nikolina Kolobarić, Anita Matić, Ivana Jukić, Zlata Kralik, Gordana Kralik, Anđelina Miloloža, Tihana Pavošević, Vatroslav Šerić, Zdenko Lončarić, Darko Kerovec, Olivera Galović, Ines Drenjančević. Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People-A Randomized Study. Nutrients. 2023 Mar; 15(7):. doi: 10.3390/nu15071599. [PMID: 37049437]
  • Pilar Rodríguez-Rodríguez, Anuson Poasakate, Santiago Ruvira-Hernando, Perla Y Gutierrez-Arzapalo, Rainer Böger, Juliane Hannemann, Nicole Lüneburg, Silvia M Arribas. Vascular nitrosative stress in hypertension induced by fetal undernutrition in rats. Journal of physiology and biochemistry. 2023 Feb; ?(?):. doi: 10.1007/s13105-023-00949-1. [PMID: 36821073]
  • Yuqiu Yang, Yufeng Gao, Chelimoge Wang. [Mongolian medicine Heisuga-25 promotes the expression of neuroskeletal protein, increases the content of neurotransmitter and improves the symptoms of Alzheimer's disease in mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Feb; 39(2):153-158. doi: . [PMID: 36872434]
  • Mohammad Asif, Kaneez Fatima, Sadaf Jamal Gilani, Mohamad Taleuzzaman, Syed Salman Ali, Samera Ali Siddiqui. Evaluation of Nootropic Potential of Aerva persica Roots against D-galactose-induced Memory Impairment. Central nervous system agents in medicinal chemistry. 2023; 23(2):126-136. doi: 10.2174/1871524923666230822100016. [PMID: 37608652]
  • Wei Sun, Xuanyin Zhao, Yiwen Wan, Yang Yang, Xiaoliang Li, Xiao Chen, Yazi Mei, Lei An. Prenatal cyanuric acid exposure induced spatial learning impairments associated with alteration of acetylcholine-mediated neural information flow at the hippocampal CA3-CA1 synapses of male rats. Human & experimental toxicology. 2023 Jan; 42(?):9603271231163477. doi: 10.1177/09603271231163477. [PMID: 36890733]
  • Xing Tian, Jiamin Guo, Xinxin Su, Baolei Zhan, Xiaoyu Liang, Anqi Ma, Yalin Zhang, Shumin Lü. Comparative transcriptome analysis reveals the non-neuronal cholinergic system in the ovary of the oriental armyworm, Mythimna separata Walker (Lepidoptera: Noctuidae). Pest management science. 2022 Dec; 78(12):5220-5233. doi: 10.1002/ps.7141. [PMID: 36053883]
  • Cao Thi Hue, Vu Thanh Trung, Nguyen Thanh Hoa, Nguyen Thi Lan Huong, Pham Thanh Binh, Nguyen The Cuong, Nguyen Van Thanh, Nguyen Phuong Thao. Glycoside constituents from Miliusa sinensis leaves and their anti-inflammatory and acetylcholine protective effects. Natural product research. 2022 Dec; 36(23):5967-5976. doi: 10.1080/14786419.2022.2050226. [PMID: 35275510]
  • M I Yousef, S Roychoudhury, K S Jafaar, P Slama, K K Kesari, M Ae-N Kamel. Aluminum oxide and zinc oxide induced nanotoxicity in rat brain, heart, and lung. Physiological research. 2022 11; 71(5):677-694. doi: 10.33549/physiolres.934831. [PMID: 36121020]
  • Muhammad Junaid Rao, Mingzheng Duan, Xiaoshuang Wei, Hou Zuo, Li Ma, Muhammad Tahir Ul Qamar, Min Li, Shijian Han, Lihua Hu, Lingqiang Wang. LC-MS/MS-based metabolomics approach revealed novel phytocompounds from sugarcane rind with promising pharmacological value. Journal of the science of food and agriculture. 2022 Nov; 102(14):6632-6642. doi: 10.1002/jsfa.12030. [PMID: 35603546]
  • Guo-Rui Yuan, Meng-Ling Chen, Meng-Lan Peng, Wei Lei, Li-Wei Meng, Wei Dou, Jin-Jun Wang. Knockdown of a Nicotinic Acetylcholine Receptor Subunit Gene Bdorβ1 Decreases Susceptibility to Oxa-Bridged trans- instead of cis-Nitromethylene Neonicotinoid Insecticides in Bactrocera dorsalis. Journal of agricultural and food chemistry. 2022 Oct; 70(42):13554-13562. doi: 10.1021/acs.jafc.2c04709. [PMID: 36224100]
  • Marwa M Saeed, Álvaro Fernández-Ochoa, Fatema R Saber, Rabab H Sayed, María de la Luz Cádiz-Gurrea, Amira K Elmotayam, Francisco Javier Leyva-Jiménez, Antonio Segura-Carretero, Rania I Nadeem. The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27207118. [PMID: 36296710]
  • Yan Zhou, Yuehan Wang, Chi Teng Vong, Yanyan Zhu, Baojun Xu, Cheng-Chao Ruan, Yitao Wang, Wai San Cheang. Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012064. [PMID: 36292919]
  • Yunting Xie, Linlin Cai, Zhiji Huang, Kai Shan, Xinglian Xu, Guanghong Zhou, Chunbao Li. Plant-Based Meat Analogues Weaken Gastrointestinal Digestive Function and Show Less Digestibility Than Real Meat in Mice. Journal of agricultural and food chemistry. 2022 Oct; 70(39):12442-12455. doi: 10.1021/acs.jafc.2c04246. [PMID: 36070521]
  • Suman Manandhar, Runali Sankhe, Keerthi Priya, Gangadhar Hari, Harish Kumar B, Chetan H Mehta, Usha Y Nayak, K Sreedhara Ranganath Pai. Molecular dynamics and structure-based virtual screening and identification of natural compounds as Wnt signaling modulators: possible therapeutics for Alzheimer's disease. Molecular diversity. 2022 Oct; 26(5):2793-2811. doi: 10.1007/s11030-022-10395-8. [PMID: 35146638]
  • Eman A Mohamed, Hebatalla I Ahmed, Heba S Zaky, Amira M Badr. Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway. Environmental science and pollution research international. 2022 Oct; 29(50):76135-76143. doi: 10.1007/s11356-022-20611-5. [PMID: 35668264]
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