Rifampin (BioDeep_00000002921)

 

Secondary id: BioDeep_00000408916

human metabolite blood metabolite Chemicals and Drugs Antibiotics


代谢物信息卡片


(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,21Z)-2,15,17,23,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{[(4-methylpiperazin-1-yl)imino]methyl}-6-oxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1(28),2,4,9,19,21,23,25(29),26-nonaen-13-yl acetate

化学式: C43H58N4O12 (822.4051028)
中文名称: 利福平
谱图信息: 最多检出来源 Homo sapiens(blood) 0.45%

分子结构信息

SMILES: CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C
InChI: InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

描述信息

A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis > J04AB - Antibiotics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007917 - Leprostatic Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D012294 - Rifamycins
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
D065693 - Cytochrome P-450 Enzyme Inducers > D065697 - Cytochrome P-450 CYP2C19 Inducers
D065693 - Cytochrome P-450 Enzyme Inducers > D065695 - Cytochrome P-450 CYP2B6 Inducers
D065693 - Cytochrome P-450 Enzyme Inducers > D065698 - Cytochrome P-450 CYP2C9 Inducers
D065693 - Cytochrome P-450 Enzyme Inducers > D065696 - Cytochrome P-450 CYP2C8 Inducers
D065693 - Cytochrome P-450 Enzyme Inducers > D065701 - Cytochrome P-450 CYP3A Inducers
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C471 - Enzyme Inhibitor > C25995 - RNA Polymerase Inhibitor

同义名列表

3 个代谢物同义名

(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,21Z)-2,15,17,23,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-{[(4-methylpiperazin-1-yl)imino]methyl}-6-oxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^{4,7}.0^{5,28}]triaconta-1(28),2,4,9,19,21,23,25(29),26-nonaen-13-yl acetate; Rifampicin; Rifampin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(10)

BioCyc(0)

PlantCyc(0)

代谢反应

42 个相关的代谢反应过程信息。

Reactome(42)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pengcheng Gu, Peng Lu, Hui Ding, Qiao Liu, Xiaoyan Ding, Yongfa Chen, Limei Zhu. Effectiveness, cost, and safety of four regimens recommended by WHO for RR/MDR-TB treatment: a cohort study in Eastern China. Annals of medicine. 2024 Dec; 56(1):2344821. doi: 10.1080/07853890.2024.2344821. [PMID: 38697138]
  • Zengxin Li, Wenhong Li, Qing Mu, Yicheng Zhu, Weiwei Qin, Xiaobin Shi, Yueping He. Rifampicin synergizes the toxicity of insecticides against the green peach aphid, Myzus persicae. Ecotoxicology and environmental safety. 2024 May; 276(?):116291. doi: 10.1016/j.ecoenv.2024.116291. [PMID: 38581910]
  • Jian-Jun Liu, Yin-Ping Feng, Zhong-Da Liu, Jing Guo. Impact of delayed diagnosis and treatment on tuberculosis infection within families: A case report. Medicine. 2024 Mar; 103(11):e37406. doi: 10.1097/md.0000000000037406. [PMID: 38489738]
  • Malihe Khorramdel, Fatemeh Peyravii Ghadikolaii, Seyed Isaac Hashemy, Hossein Javid, Masoud Homayouni Tabrizi. Nanoformulated meloxicam and rifampin: inhibiting quorum sensing and biofilm formation in Pseudomonas aeruginosa. Nanomedicine (London, England). 2024 03; 19(7):615-632. doi: 10.2217/nnm-2023-0268. [PMID: 38348578]
  • Prapaporn Srilohasin, Saradee Warit, Therdsak Prammananan, Saijai Smithtikarn, Reka Kanitpun, Mutchamon Kaewparuehaschai, Kirana Noradechanon, Suthirote Meesawat, Nattakan Thakaew, Nonthakorn Sakulwittayasuk, Taratorn Kemthong, Tanapat Palaga, Suchinda Malaivijitnond, Angkana Chaiprasert. Advancing tuberculosis diagnosis and management in cynomolgus macaques using Xpert MTB/RIF ultra assay. Scientific reports. 2024 01; 14(1):1518. doi: 10.1038/s41598-024-51824-y. [PMID: 38233591]
  • Yu Wang, Han Fu, Xiao-Jie Shi, Guo-Ping Zhao, Liang-Dong Lyu. Genome-wide screen reveals cellular functions that counteract rifampicin lethality in Escherichia coli. Microbiology spectrum. 2024 Jan; 12(1):e0289523. doi: 10.1128/spectrum.02895-23. [PMID: 38054714]
  • Anastasia A Zhukovets, Vladimir V Chernyshov, Aidar Z Al'mukhametov, Tatiana A Seregina, Svetlana V Revtovich, Mariia A Kasatkina, Yulia E Isakova, Vitalia V Kulikova, Elena A Morozova, Anastasia I Cherkasova, Timur A Mannanov, Anastasia A Anashkina, Pavel N Solyev, Vladimir A Mitkevich, Roman A Ivanov. Novel Hydroxamic Acids Containing Aryl-Substituted 1,2,4- or 1,3,4-Oxadiazole Backbones and an Investigation of Their Antibiotic Potentiation Activity. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010096. [PMID: 38203266]
  • Ishani V Gaidhane, Kyle J Biegas, Helen E Erickson, Prachi Agarwal, Yashpal S Chhonker, Donald R Ronning, Benjamin M Swarts. Chemical remodeling of the mycomembrane with chain-truncated lipids sensitizes mycobacteria to rifampicin. Chemical communications (Cambridge, England). 2023 Nov; 59(93):13859-13862. doi: 10.1039/d3cc02364h. [PMID: 37929833]
  • Zhaoxin Li, Jin Wang, Xin Xiu, Zhenpeng Shi, Qiang Zhang, Deqiang Chen. Evaluation of different diagnostic methods for spinal tuberculosis infection. BMC infectious diseases. 2023 Oct; 23(1):695. doi: 10.1186/s12879-023-08655-5. [PMID: 37853312]
  • Wei-Yu Chen, Yi-Fang Chen, Jer-Min Tsai, Hsin-Mei Huang, Yong-Chao Su. Epidemiology-based wastewater monitoring for ecological risks of anti-tuberculosis drugs mixture effects. The Science of the total environment. 2023 Sep; 892(?):164560. doi: 10.1016/j.scitotenv.2023.164560. [PMID: 37268140]
  • Dennis Mwanza Nzilu, Edwin Shigwenya Madivoli, David Sujee Makhanu, Sammy Indire Wanakai, Gideon Kirui Kiprono, Patrick Gachoki Kareru. Green synthesis of copper oxide nanoparticles and its efficiency in degradation of rifampicin antibiotic. Scientific reports. 2023 08; 13(1):14030. doi: 10.1038/s41598-023-41119-z. [PMID: 37640783]
  • Kiamu Kurosawa, Masataka Nakano, Itsuki Yokoseki, Mai Nagaoka, Seiya Takemoto, Yoshiyuki Sakai, Kaoru Kobayashi, Yasuhiro Kazuki, Tatsuki Fukami, Miki Nakajima. ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver. Biochemical pharmacology. 2023 Aug; 215(?):115733. doi: 10.1016/j.bcp.2023.115733. [PMID: 37543347]
  • Walja C Wanney, Loubna Youssar, Gergana Kostova, Jens Georg. Improved RNA stability estimation indicates that transcriptional interference is frequent in diverse bacteria. Communications biology. 2023 07; 6(1):732. doi: 10.1038/s42003-023-05097-2. [PMID: 37454177]
  • Galo A Goig, Fabrizio Menardo, Zubeida Salaam-Dreyer, Anzaan Dippenaar, Elizabeth M Streicher, Johnny Daniels, Anja Reuter, Sonia Borrell, Miriam Reinhard, Anna Doetsch, Christian Beisel, Robin M Warren, Helen Cox, Sebastien Gagneux. Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study. The Lancet. Microbe. 2023 07; 4(7):e506-e515. doi: 10.1016/s2666-5247(23)00110-6. [PMID: 37295446]
  • Sajedeh Maghrebi, Nicky Thomas, Clive A Prestidge, Paul Joyce. Inulin-lipid hybrid (ILH) microparticles promote pH-triggered release of rifampicin within infected macrophages. Drug delivery and translational research. 2023 06; 13(6):1716-1729. doi: 10.1007/s13346-022-01287-3. [PMID: 36630076]
  • Devaraj Ezhilarasan. Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms. Drug metabolism reviews. 2023 May; ?(?):1-15. doi: 10.1080/03602532.2023.2215478. [PMID: 37218081]
  • Sampa Sarkar, Brendan Dyett, Biserka Lakic, Andrew S Ball, Leslie Y Yeo, Jacinta F White, Sarvesh Soni, Calum J Drummond, Charlotte E Conn. Cubosome Lipid Nanocarriers As a Drug Delivery Vehicle for Intracellular Mycobacterium tuberculosis Infections. ACS applied materials & interfaces. 2023 May; 15(18):21819-21829. doi: 10.1021/acsami.3c00101. [PMID: 37018059]
  • Yining Liu, Wenyan Chen, Yanli Cen, Xiaodeng Zhao, Zaiping Chen, Yuedong Liang, Zhongfeng Huang, Xiu He, Guanghong Yang. Hepatocyte ferroptosis contributes to anti-tuberculosis drug-induced liver injury: Involvement of the HIF-1α/SLC7A11/GPx4 axis. Chemico-biological interactions. 2023 Mar; ?(?):110439. doi: 10.1016/j.cbi.2023.110439. [PMID: 36878459]
  • Chantal M Wallenwein, Mukul Ashtikar, Götz Hofhaus, Isabel Haferland, Manuela Thurn, Anke König, Andreas Pinter, Jennifer Dressman, Matthias G Wacker. How wound environments trigger the release from Rifampicin-loaded liposomes. International journal of pharmaceutics. 2023 Feb; 633(?):122606. doi: 10.1016/j.ijpharm.2023.122606. [PMID: 36632921]
  • Fei Yuan, Jing Li, Xuening Li, Hui Li, Weili Chen, Mengjie Yang, Hanjing Chen, Lei Sheng, Chao Liu, Yujia Wu, Hongrong Xu. Pharmacokinetic Interaction of Chiglitazar with CYP3A4 Inducer or Inhibitor: An Open-Label, Sequential Crossover, Self-Control, 3-Period Study in Healthy Chinese Volunteers. Clinical pharmacology in drug development. 2023 Feb; 12(2):168-174. doi: 10.1002/cpdd.1198. [PMID: 36583526]
  • Julia Langeder, Kristin Döring, Hannes Schmietendorf, Ulrike Grienke, Michaela Schmidtke, Judith M Rollinger. 1H NMR-Based Biochemometric Analysis of Morus alba Extracts toward a Multipotent Herbal Anti-Infective. Journal of natural products. 2023 01; 86(1):8-17. doi: 10.1021/acs.jnatprod.2c00481. [PMID: 36543521]
  • Mumuni Sumaila, Pradeep Kumar, Philemon Ubanako, Samson A Adeyemi, Yahya E Choonara. Dual Rifampicin and Isoniazid Mannose-Decorated Lipopolysaccharide Nanospheres for Macrophage- Targeted Lung Delivery. Current drug delivery. 2023; 20(10):1487-1503. doi: 10.2174/1567201819666220812092556. [PMID: 35959905]
  • Zhiqiang Yang, Meirong Song, Xiaoyu Li, Qi Zhang, Jianzhong Shen, Kui Zhu. Synergy of outer membrane disruptor SLAP-S25 with hydrophobic antibiotics against Gram-negative pathogens. The Journal of antimicrobial chemotherapy. 2022 12; 78(1):263-271. doi: 10.1093/jac/dkac387. [PMID: 36385317]
  • Nishita Mistry, Rajdip Bandyopadhyaya, Sarika Mehra. Enhancement of Antimycobacterial Activity of Rifampicin Using Mannose-Anchored Lipid Nanoparticles against Intramacrophage Mycobacteria. ACS applied bio materials. 2022 12; 5(12):5779-5789. doi: 10.1021/acsabm.2c00796. [PMID: 36441965]
  • Milan Milenovic, Antoine Gouttepifre, Michael Eickermann, Jürgen Junk, Carmelo Rapisarda. Plant-mediated rifampicin treatment of Bemisia tabaci disrupts but does not eliminate endosymbionts. Scientific reports. 2022 12; 12(1):20766. doi: 10.1038/s41598-022-24788-0. [PMID: 36456664]
  • Yanqing Song, Xiaoyu Qu, Lina Tao, Huan Gao, Yueming Zhang, Jinghui Zhai, Jiawei Gong, Tingting Hu. Exploration of the underlying mechanisms of isoniazid/rifampicin-induced liver injury in mice using an integrated proteomics and metabolomics approach. Journal of biochemical and molecular toxicology. 2022 Dec; 36(12):e23217. doi: 10.1002/jbt.23217. [PMID: 36111668]
  • Mohd Hafidz Mahamad Maifiah, Yan Zhu, Brian T Tsuji, Darren J Creek, Tony Velkov, Jian Li. Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin-rifampicin combination against Pseudomonas aeruginosa. Journal of biomedical science. 2022 Oct; 29(1):89. doi: 10.1186/s12929-022-00874-3. [PMID: 36310165]
  • Murugan Thulasi Meenu, Grace Kaul, Abdul Akhir, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance. Journal of natural products. 2022 10; 85(10):2413-2423. doi: 10.1021/acs.jnatprod.2c00621. [PMID: 36222797]
  • Kristina Klobucar, Emily Jardine, Maya A Farha, Marc R MacKinnon, Meghan Fragis, Brenda Nkonge, Timsy Bhando, Louis Borrillo, Caressa N Tsai, Jarrod W Johnson, Brian K Coombes, Jakob Magolan, Eric D Brown. Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria. ACS infectious diseases. 2022 10; 8(10):2187-2197. doi: 10.1021/acsinfecdis.2c00357. [PMID: 36098580]
  • Karine Soetaert, Pieter-Jan Ceyssens, Samira Boarbi, Bert Bogaerts, Thomas Delcourt, Kevin Vanneste, Sigrid C J De Keersmaecker, Nancy H C Roosens, Alexandra Vodolazkaia, Marina Mukovnikova, Vanessa Mathys. Retrospective evaluation of routine whole genome sequencing of Mycobacterium tuberculosis at the Belgian National Reference Center, 2019. Acta clinica Belgica. 2022 Oct; 77(5):853-860. doi: 10.1080/17843286.2021.1999588. [PMID: 34751641]
  • Susan M Britza, Ian F Musgrave, Roger W Byard. Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I. Toxicology mechanisms and methods. 2022 Oct; 32(8):606-615. doi: 10.1080/15376516.2022.2057267. [PMID: 35354423]
  • Cong Wang, Jun Yang, Enliang Li, Shuaiwu Luo, Chi Sun, Yuting Liao, Min Li, Jin Ge, Jun Lei, Fan Zhou, Linquan Wu, Wenjun Liao. Metabolic signatures of hepatolithiasis using ultra-high performance liquid chromatography-tandem mass spectrometry. Metabolomics : Official journal of the Metabolomic Society. 2022 08; 18(9):69. doi: 10.1007/s11306-022-01927-2. [PMID: 35976530]
  • Xiaocui Wu, Guangkun Tan, Jinghui Yang, Yinjuan Guo, Chengchen Huang, Wei Sha, Fangyou Yu. Prediction of Mycobacterium tuberculosis drug resistance by nucleotide MALDI-TOF-MS. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022 Aug; 121(?):47-54. doi: 10.1016/j.ijid.2022.04.061. [PMID: 35523300]
  • Christo Tsilifis, Ina Schim van der Loeff, Eleri Williams, Stephen Owens, Steven Powell, Andrew Gennery, Mary Slatter. BCG lymphadenitis: a potential complication of immune reconstitution following haematopoietic stem cell transplant. Archives of disease in childhood. Education and practice edition. 2022 08; 107(4):274-275. doi: 10.1136/archdischild-2020-320883. [PMID: 33355234]
  • Ming-Min Cai, Ting Dou, Lu Tang, Qiu-Yue Sun, Zi-Hong Zhai, Hui-Ping Wang, Wei Qian. Effects of rifampicin on antineoplastic drug pyrotinib maleate pharmacokinetics in healthy subjects. Investigational new drugs. 2022 08; 40(4):756-761. doi: 10.1007/s10637-022-01241-7. [PMID: 35435627]
  • Richard Court, Kamunkhwala Gausi, Buyisile Mkhize, Lubbe Wiesner, Catriona Waitt, Helen McIlleron, Gary Maartens, Paolo Denti, Marian Loveday. Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin-resistant tuberculosis. British journal of clinical pharmacology. 2022 Aug; 88(8):3548-3558. doi: 10.1111/bcp.15380. [PMID: 35526837]
  • Min Lin, Ying-Wen Chen, Yun-Ran Li, Li-Jun Long, Le-Yao Qi, Ting-Ting Cui, Shao-Yong Wu, Jia-Yuan Lin, Tong Wu, Yi-Chen Yang, Wei-Hua Yuan, Ge-Yuan Wu, Qi-Wen Lan, Jia-Qi Liu, Ya-Ping Li, Zi-Yuan Yu, Xu-Guang Guo. Systematic evaluation of line probe assays for the diagnosis of tuberculosis and drug-resistant tuberculosis. Clinica chimica acta; international journal of clinical chemistry. 2022 Aug; 533(?):183-218. doi: 10.1016/j.cca.2022.06.020. [PMID: 35792161]
  • Wan-Mei Song, Shi-Jin Li, Jin-Yue Liu, Qi Fu, Ting-Ting Xu, Ning Ning Tao, Qian-Yun Zhang, Si-Qi Liu, Qi-Qi An, Xue-Han Zhu, Yao Liu, Chun-Bao Yu, Yi-Fan Li, Jihua Dong, Huai-Chen Li. Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004-2020. BMJ open. 2022 07; 12(7):e059149. doi: 10.1136/bmjopen-2021-059149. [PMID: 35902191]
  • Alessandro Brancatella, Daniele Cappellani, Martin Kaufmann, Antonella Semeraro, Simona Borsari, Chiara Sardella, Fulvia Baldinotti, Maria Adelaide Caligo, Glenville Jones, Claudio Marcocci, Filomena Cetani. Long-term Efficacy and Safety of Rifampin in the Treatment of a Patient Carrying a CYP24A1 Loss-of-Function Variant. The Journal of clinical endocrinology and metabolism. 2022 07; 107(8):e3159-e3166. doi: 10.1210/clinem/dgac315. [PMID: 35569070]
  • Anna S Dean, Olga Tosas Auguet, Philippe Glaziou, Matteo Zignol, Nazir Ismail, Tereza Kasaeva, Katherine Floyd. 25 years of surveillance of drug-resistant tuberculosis: achievements, challenges, and way forward. The Lancet. Infectious diseases. 2022 07; 22(7):e191-e196. doi: 10.1016/s1473-3099(21)00808-2. [PMID: 35248168]
  • Tao Ji, Xuejun Chen, Swamy Yeleswaram. Evaluation of drug-drug interaction potential for pemigatinib using physiologically based pharmacokinetic modeling. CPT: pharmacometrics & systems pharmacology. 2022 07; 11(7):894-905. doi: 10.1002/psp4.12805. [PMID: 35506332]
  • Medha Bargaje, Sandeep Bharaswadkar, Sathiyanarayanan Lohidasan, Bijoy Kumar Panda. Plasma drug concentrations of 4-drug fixed-dose combination regimen and its efficacy for treatment of pulmonary tuberculosis under National Tuberculosis Elimination Programme: A prospective pilot study. The Indian journal of tuberculosis. 2022 Jul; 69(3):311-319. doi: 10.1016/j.ijtb.2021.04.002. [PMID: 35760480]
  • İlknur Yurtsever, Ünsal Veli Üstündağ, İsmail Ünal, Perihan Seda Ateş, Ebru Emekli-Alturfan. Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish. Drug and chemical toxicology. 2022 Jul; 45(4):1544-1551. doi: 10.1080/01480545.2020.1846549. [PMID: 33187454]
  • Ryuta Asaumi, Ken-Ichi Nunoya, Yoshiyuki Yamaura, Kunal S Taskar, Yuichi Sugiyama. Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney. CPT: pharmacometrics & systems pharmacology. 2022 07; 11(7):919-933. doi: 10.1002/psp4.12807. [PMID: 35570332]
  • Taizong Wu, Angela A Salim, Zeinab G Khalil, Paul V Bernhardt, Robert J Capon. Glenthmycins A-M: Macrocyclic Spirotetronate Polyketide Antibacterials from the Australian Pasture Plant-Derived Streptomyces sp. CMB-PB041. Journal of natural products. 2022 06; 85(6):1641-1657. doi: 10.1021/acs.jnatprod.2c00444. [PMID: 35640100]
  • Martina Gruppuso, Benedetta Guagnini, Luigi Musciacchio, Francesca Bellemo, Gianluca Turco, Davide Porrelli. Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core-Shell Electrospun Membranes: A Proof of Concept. ACS applied materials & interfaces. 2022 Jun; 14(24):27599-27612. doi: 10.1021/acsami.2c04849. [PMID: 35671365]
  • Aida N Kawuma, Roeland E Wasmann, Kelly E Dooley, Marta Boffito, Gary Maartens, Paolo Denti. Population Pharmacokinetic Model and Alternative Dosing Regimens for Dolutegravir Coadministered with Rifampicin. Antimicrobial agents and chemotherapy. 2022 06; 66(6):e0021522. doi: 10.1128/aac.00215-22. [PMID: 35604212]
  • Amedeo De Nicolò, Andrea Calcagno, Ilaria Motta, Elisa De Vivo, Antonio D'Avolio, Giovanni Di Perri, Lubbe Wiesner, Isma-Eel Ebrahim, Gary Maartens, Catherine Orrell, Helen McIlleron. The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study. Antimicrobial agents and chemotherapy. 2022 06; 66(6):e0013622. doi: 10.1128/aac.00136-22. [PMID: 35583344]
  • Catherine Berry, Philipp du Cros, Katherine Fielding, Suzanne Gajewski, Emil Kazounis, Timothy D McHugh, Corinne Merle, Ilaria Motta, David A J Moore, Bern-Thomas Nyang'wa. TB-PRACTECAL: study protocol for a randomised, controlled, open-label, phase II-III trial to evaluate the safety and efficacy of regimens containing bedaquiline and pretomanid for the treatment of adult patients with pulmonary multidrug-resistant tuberculosis. Trials. 2022 Jun; 23(1):484. doi: 10.1186/s13063-022-06331-8. [PMID: 35698158]
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