Mesylate (BioDeep_00000002916)
Secondary id: BioDeep_00001871748
natural product human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
Methanesulfonic acid solution
化学式: CH4SO3 (95.9881)
中文名称: 甲烷磺酸溶液, 甲磺酸
谱图信息:
最多检出来源 Homo sapiens(otcml) 43.31%
分子结构信息
SMILES: CS(=O)(=O)O
InChI: InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)
描述信息
Mesylate, also known as methanesulfonate or mesylic acid, belongs to the class of organic compounds known as organosulfonic acids. Organosulfonic acids are compounds containing the sulfonic acid group, which has the general structure RS(=O)2OH (R is not a hydrogen atom). Mesylate exists as a solid, soluble (in water), and an extremely strong acidic compound (based on its pKa). Mesylate is also a parent compound for other transformation products, including but not limited to, methanesulfonates, S-methyl methanethiosulfonate, and (Z)-11-methyl-N-(methylsulfonyl)dodec-2-enamide.
KEIO_ID M135
KEIO_ID M021
同义名列表
16 个代谢物同义名
Methanesulfonic acid solution; Methanesulphonic acid; Methylsulphonic acid; METHANESULFONIC ACID; Methylsulfonic acid; Methansulphonsaeure; Methanesulfonate(2); Methansulfonsaeure; Methanesulphonate; Methanesulfonate; Methylsulphonate; Methylsulfonate; Mesylic acid; Mesylate; Methanesulfonic acid; Methanesulfonic acid
数据库引用编号
29 个数据库交叉引用编号
- ChEBI: CHEBI:27376
- KEGG: C11145
- PubChem: 6395
- HMDB: HMDB0240280
- Metlin: METLIN68873
- ChEMBL: CHEMBL3039600
- Wikipedia: Methanesulfonic_acid
- MetaCyc: CPD-3746
- foodb: FDB098394
- chemspider: 6155
- CAS: 75-75-2
- MoNA: KO001491
- MoNA: KO001357
- MoNA: KO001487
- MoNA: KO001360
- MoNA: KO001356
- MoNA: KO001488
- MoNA: KO001358
- MoNA: KO001489
- MoNA: KO001359
- MoNA: KO001490
- MoNA: PS029808
- MoNA: PS029807
- PMhub: MS000006927
- PubChem: 13327
- PDB-CCD: 03S
- NIKKAJI: J1.465F
- RefMet: Methanesulfonic acid
- KNApSAcK: 27376
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Clinical and experimental gastroenterology.
2011; 4(?):75-119. doi:
10.2147/ceg.s17114. [PMID: 21753893] - Jessica M van der Bol, Theo J Visser, Walter J Loos, Floris A de Jong, Erik A C Wiemer, Maarten O van Aken, Andre S Planting, Jan H Schellens, Jaap Verweij, Ron H J Mathijssen. Effects of methimazole on the elimination of irinotecan.
Cancer chemotherapy and pharmacology.
2011 Jan; 67(1):231-6. doi:
10.1007/s00280-010-1414-x. [PMID: 20680278] - Josef Madl, Julian Weghuber, Reinhard Fritsch, Isabella Derler, Marc Fahrner, Irene Frischauf, Barbara Lackner, Christoph Romanin, Gerhard J Schütz. Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells.
The Journal of biological chemistry.
2010 Dec; 285(52):41135-42. doi:
10.1074/jbc.m110.177881. [PMID: 20961852] - M Ann Mongan, Robert T Dunn, Steven Vonderfecht, Nancy Everds, Guang Chen, Cheng Su, Marnie Higgins-Garn, Yuan Chen, Cynthia A Afshari, Toni L Williamson, Linda Carlock, Christopher Dipalma, Suzanne Moss, Jeanine Bussiere, Charles Qualls, Yudong D He, Hisham K Hamadeh. A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity.
PloS one.
2010 Dec; 5(12):e15595. doi:
10.1371/journal.pone.0015595. [PMID: 21203578] - F McCoy, J Hurwitz, N McTavish, I Paul, C Barnes, B O'Hagan, K Odrzywol, J Murray, D Longley, G McKerr, D A Fennell. Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.
Cell death & disease.
2010 Dec; 1(?):e108. doi:
10.1038/cddis.2010.86. [PMID: 21368880] - Roberto Imberti, Maria Cusato, Paola Villani, Livio Carnevale, Giorgio A Iotti, Martin Langer, Mario Regazzi. Steady-state pharmacokinetics and BAL concentration of colistin in critically Ill patients after IV colistin methanesulfonate administration.
Chest.
2010 Dec; 138(6):1333-9. doi:
10.1378/chest.10-0463. [PMID: 20558557] - Mathew B Sonier, Harold G Weger. Plasma membrane ferric reductase activity of iron-limited algal cells is inhibited by ferric chelators.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2010 Dec; 23(6):1029-42. doi:
10.1007/s10534-010-9348-7. [PMID: 20508972] - Naoto Takahashi, Masatomo Miura, Stuart A Scott, Hideaki Kagaya, Yoshihiro Kameoka, Hiroyuki Tagawa, Hirobumi Saitoh, Naohito Fujishima, Tomoko Yoshioka, Makoto Hirokawa, Kenichi Sawada. Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia.
Journal of human genetics.
2010 Nov; 55(11):731-7. doi:
10.1038/jhg.2010.98. [PMID: 20720558] - Paraskevi Krashia, Mirko Moroni, Steven Broadbent, Giovanna Hofmann, Sebastian Kracun, Marco Beato, Paul J Groot-Kormelink, Lucia G Sivilotti. Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells.
PloS one.
2010 Oct; 5(10):e13611. doi:
10.1371/journal.pone.0013611. [PMID: 21049012] - Jacek Makarewicz, Andrzej Lewiński, Małgorzata Karbownik-Lewińska. Radioiodine remnant ablation of differentiated thyroid cancer does not further increase oxidative damage to membrane lipids - early effect.
Thyroid research.
2010 Oct; 3(1):7. doi:
10.1186/1756-6614-3-7. [PMID: 20925955] - Adam W Hantman, Thomas M Jessell. Clarke's column neurons as the focus of a corticospinal corollary circuit.
Nature neuroscience.
2010 Oct; 13(10):1233-9. doi:
10.1038/nn.2637. [PMID: 20835249] - Xiaozhen Huang, Jianyong Li, Fei Bao, Xiaoyan Zhang, Shuhua Yang. A gain-of-function mutation in the Arabidopsis disease resistance gene RPP4 confers sensitivity to low temperature.
Plant physiology.
2010 Oct; 154(2):796-809. doi:
10.1104/pp.110.157610. [PMID: 20699401] - Qingxin Lei, Christopher M Liebold, William L Boatright, M Shah Jahan. Distribution of stable free radicals among amino acids of isolated soy proteins.
Journal of food science.
2010 Sep; 75(7):C633-40. doi:
10.1111/j.1750-3841.2010.01746.x. [PMID: 21535530] - Kye Won Park, Hironori Waki, Sung-Pil Choi, Ki-Moon Park, Peter Tontonoz. The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression.
Journal of lipid research.
2010 Sep; 51(9):2775-84. doi:
10.1194/jlr.m008490. [PMID: 20519739] - Cinzia Scambi, Valentina La Verde, Lucia De Franceschi, Giovanni Barausse, Fabio Poli, Fabio Benedetti, Marco Sorio, Francesca Deriu, Paola Roncada, Oscar Bortolami, Francesco Turrini, Paola Caramaschi, Chiara Stranieri, Lisa M Bambara, Domenico Biasi. Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H.
PloS one.
2010 Aug; 5(8):e12162. doi:
10.1371/journal.pone.0012162. [PMID: 20730046] - Sandrine Marchand, Isabelle Lamarche, Patrice Gobin, William Couet. Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses.
The Journal of antimicrobial chemotherapy.
2010 Aug; 65(8):1753-8. doi:
10.1093/jac/dkq183. [PMID: 20507861] - Shreya Kanodia, Eric Wieder, Sijie Lu, Moshe Talpaz, Gheath Alatrash, Karen Clise-Dwyer, Jeffrey J Molldrem. PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal.
PloS one.
2010 Jul; 5(7):e11770. doi:
10.1371/journal.pone.0011770. [PMID: 20668669] - Qian Liu, Junguo Wang, Daisuke Miki, Ran Xia, Wenxiang Yu, Junna He, Zhimin Zheng, Jian-Kang Zhu, Zhizhong Gong. DNA replication factor C1 mediates genomic stability and transcriptional gene silencing in Arabidopsis.
The Plant cell.
2010 Jul; 22(7):2336-52. doi:
10.1105/tpc.110.076349. [PMID: 20639449] - Rajesh V Dudhani, Roger L Nation, Jian Li. Evaluating the stability of colistin and colistin methanesulphonate in human plasma under different conditions of storage.
The Journal of antimicrobial chemotherapy.
2010 Jul; 65(7):1412-5. doi:
10.1093/jac/dkq134. [PMID: 20413406] - Silke Haubeiss, Jens O Schmid, Thomas E Mürdter, Maike Sonnenberg, Godehard Friedel, Heiko van der Kuip, Walter E Aulitzky. Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts.
Molecular cancer.
2010 Jun; 9(?):168. doi:
10.1186/1476-4598-9-168. [PMID: 20579391] - John W Simmons, Kevin K Chung, Evan M Renz, Christopher E White, Casey L Cotant, Molly A Tilley, Mark O Hardin, John A Jones, Lorne H Blackbourne, Steven E Wolf. Fenoldopam use in a burn intensive care unit: a retrospective study.
BMC anesthesiology.
2010 Jun; 10(?):9. doi:
10.1186/1471-2253-10-9. [PMID: 20576149] - M Angela Montesano, Ralph D Whitehead, Nayana K Jayatilaka, Peter Kuklenyik, Mark D Davis, Larry L Needham, Dana Boyd Barr. Measurement of ethyl methanesulfonate in human plasma and breast milk samples using high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2010 Jun; 52(2):260-4. doi:
10.1016/j.jpba.2009.12.030. [PMID: 20102787] - G L Daikos, A Skiada, J Pavleas, C Vafiadi, K Salatas, P Tofas, K Tzanetou, A Markogiannakis, G Thomopoulos, I Vafiadi, G Petrikkos. Serum bactericidal activity of three different dosing regimens of colistin with implications for optimum clinical use.
Journal of chemotherapy (Florence, Italy).
2010 Jun; 22(3):175-8. doi:
10.1179/joc.2010.22.3.175. [PMID: 20566422] - Rainer Strotmann, Marcus Semtner, Frauke Kepura, Tim D Plant, Torsten Schöneberg. Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4.
PloS one.
2010 May; 5(5):e10580. doi:
10.1371/journal.pone.0010580. [PMID: 20485495] - Chang-Suk Kong, Jung-Ae Kim, Tae Kil Eom, Se-Kwon Kim. Phosphorylated glucosamine inhibits adipogenesis in 3T3-L1 adipocytes.
The Journal of nutritional biochemistry.
2010 May; 21(5):438-43. doi:
10.1016/j.jnutbio.2009.01.018. [PMID: 19427183] - Irena Cojbasić, Lana Macukanović-Golubović. Prognostic factors associated with complete cytogenetic response in patients with chronic myelogenous leukemia on imatinib mesylate therapy.
Srpski arhiv za celokupno lekarstvo.
2010 May; 138(5-6):305-8. doi:
10.2298/sarh1006305c. [PMID: 20607973] - M Ranucci, D De Benedetti, C Bianchini, S Castelvecchio, A Ballotta, A Frigiola, L Menicanti. Effects of fenoldopam infusion in complex cardiac surgical operations: a prospective, randomized, double-blind, placebo-controlled study.
Minerva anestesiologica.
2010 Apr; 76(4):249-59. doi:
. [PMID: 20332738] - Yogendra Keche. Bromocriptine mesylate: Food and Drug Administration approved new approach in therapy of non-insulin dependant diabetes mellitus with poor glycemic control.
Journal of pharmacy & bioallied sciences.
2010 Apr; 2(2):148-50. doi:
10.4103/0975-7406.67000. [PMID: 21814451] - Chien-Yu Cheng, Wang-Huei Sheng, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang. Safety and efficacy of intravenous colistin (colistin methanesulphonate) for severe multidrug-resistant Gram-negative bacterial infections.
International journal of antimicrobial agents.
2010 Mar; 35(3):297-300. doi:
10.1016/j.ijantimicag.2009.11.016. [PMID: 20045293] - Alice Melotti, Antonio Daga, Daniela Marubbi, Annalisa Zunino, Luciano Mutti, Giorgio Corte. In vitro and in vivo characterization of highly purified human mesothelioma derived cells.
BMC cancer.
2010 Feb; 10(?):54. doi:
10.1186/1471-2407-10-54. [PMID: 20175889] - Andrea Godino, Lisandra Oliveira Margatho, Ximena E Caeiro, José Antunes-Rodrigues, Laura Vivas. Activation of lateral parabrachial afferent pathways and endocrine responses during sodium appetite regulation.
Experimental neurology.
2010 Feb; 221(2):275-84. doi:
10.1016/j.expneurol.2009.11.001. [PMID: 19913016] - Massimo Meco, Silvia Cirri. Effects of fenoldopam mesylate on central hemodynamics and renal flow in patients undergoing cardiac surgery: color Doppler echocardiographic evaluation.
Journal of cardiothoracic and vascular anesthesia.
2010 Feb; 24(1):58-62. doi:
10.1053/j.jvca.2009.04.012. [PMID: 19553140] - Lars R Perk, Maria J W D Vosjan, Gerard W M Visser, Marianne Budde, Paul Jurek, Garry E Kiefer, Guus A M S van Dongen. p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging.
European journal of nuclear medicine and molecular imaging.
2010 Feb; 37(2):250-9. doi:
10.1007/s00259-009-1263-1. [PMID: 19763566] - Jacky M K Kwong, Joseph Caprioli, Natik Piri. RNA binding protein with multiple splicing: a new marker for retinal ganglion cells.
Investigative ophthalmology & visual science.
2010 Feb; 51(2):1052-8. doi:
10.1167/iovs.09-4098. [PMID: 19737887] - Flavia V Castelino, John Varga. Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management.
Arthritis research & therapy.
2010; 12(4):213. doi:
10.1186/ar3097. [PMID: 20735863] - Damian J Williams, Henry L Puhl, Stephen R Ikeda. A Simple, Highly Efficient Method for Heterologous Expression in Mammalian Primary Neurons Using Cationic Lipid-mediated mRNA Transfection.
Frontiers in neuroscience.
2010; 4(?):181. doi:
10.3389/fnins.2010.00181. [PMID: 21267423] - Tülay Aşkin Celik, Ozlem Sultan Aslantürk. Evaluation of cytotoxicity and genotoxicity of Inula viscosa leaf extracts with Allium test.
Journal of biomedicine & biotechnology.
2010; 2010(?):189252. doi:
10.1155/2010/189252. [PMID: 20617136] - Anat Gafter-Gvili, Ron Ram, Uzi Gafter, Ofer Shpilberg, Pia Raanani. Renal failure associated with tyrosine kinase inhibitors--case report and review of the literature.
Leukemia research.
2010 Jan; 34(1):123-7. doi:
10.1016/j.leukres.2009.07.009. [PMID: 19640584] - Colin W Taylor, David L Prole, Taufiq Rahman. Ca(2+) channels on the move.
Biochemistry.
2009 Dec; 48(51):12062-80. doi:
10.1021/bi901739t. [PMID: 19928968]
