Uridine diphosphate glucuronic acid (BioDeep_00000002809)

 

Secondary id: BioDeep_00000014634, BioDeep_00000400422, BioDeep_00000406184, BioDeep_00001106334

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2S,3S,4S,5R,6R)-6-({[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid

化学式: C15H22N2O18P2 (580.0342852)
中文名称: UDP葡萄糖醛酸, 尿苷二磷酸葡糖醛酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.15%

分子结构信息

SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OC3C(C(C(C(O3)C(=O)O)O)O)O)O)O
InChI: InChI=1S/C15H22N2O18P2/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26)/t4-,6-,7+,8+,9-,10-,11+,12-,14-/m1/s1

描述信息

Uridine diphosphate glucuronic acid, also known as udpglucuronate or udp-D-glucuronic acid, is a member of the class of compounds known as pyrimidine nucleotide sugars. Pyrimidine nucleotide sugars are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group. Uridine diphosphate glucuronic acid is soluble (in water) and a moderately acidic compound (based on its pKa). Uridine diphosphate glucuronic acid can be synthesized from alpha-D-glucuronic acid. Uridine diphosphate glucuronic acid can also be synthesized into UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid. Uridine diphosphate glucuronic acid can be found in a number of food items such as parsley, chervil, black mulberry, and malabar plum, which makes uridine diphosphate glucuronic acid a potential biomarker for the consumption of these food products. Uridine diphosphate glucuronic acid can be found primarily in human liver tissue. Uridine diphosphate glucuronic acid exists in all living species, ranging from bacteria to humans. In humans, uridine diphosphate glucuronic acid is involved in several metabolic pathways, some of which include etoposide metabolism pathway, estrone metabolism, tamoxifen action pathway, and androgen and estrogen metabolism. Uridine diphosphate glucuronic acid is also involved in several metabolic disorders, some of which include porphyria variegata (PV), glycogenosis, type III. cori disease, debrancher glycogenosis, 17-beta hydroxysteroid dehydrogenase III deficiency, and hereditary coproporphyria (HCP). Uridine diphosphate glucuronic acid is made from UDP-glucose by UDP-glucose 6-dehydrogenase (EC 1.1.1.22) using NAD+ as a cofactor. It is the source of the glucuronosyl group in glucuronosyltransferase reactions .
Uridine diphosphate glucuronic acid is a nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP Iduronic acid, which donates Iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones. The transfer of glucuronic acid from UDP-alpha-D-glucuronic acid onto a terminal galactose residue is done by beta1,3-glucuronosyltransferases, responsible for the completion of the protein-glycosaminoglycan linkage region of proteoglycans and of the HNK1 epitope of glycoproteins and glycolipids. In humans the enzyme galactose-beta-1,3-glucuronosyltransferase I completes the synthesis of the common linker region of glycosaminoglycans (GAGs) by transferring glucuronic acid (GlcA) onto the terminal galactose of the glycopeptide primer of proteoglycans. The GAG chains of proteoglycans regulate major biological processes such as cell proliferation and recognition, extracellular matrix deposition, and morphogenesis. (PMID:16815917).
Acquisition and generation of the data is financially supported in part by CREST/JST.

同义名列表

68 个代谢物同义名

(2S,3S,4S,5R,6R)-6-({[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid; 6-[[[5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid; alpha-delta-Glucopyranuronic acid 1->5-ester with uridine 5-(trihydrogen pyrophosphate); alpha-delta-Glucopyranuronic acid 1-p-ester with uridine 5-(trihydrogen diphosphate); alpha-D-Glucopyranuronic acid 1-p-ester with uridine 5-(trihydrogen diphosphate); a-D-Glucopyranuronic acid 1->5-ester with uridine 5-(trihydrogen pyrophosphate); Uridine 5-[3-(D-glucopyranosyloxyuronic acid) dihydrogen diphosphate]; alpha-delta-Glucopyranuronic acid ester with uridine 5-pyrophosphate; a-D-Glucopyranuronic acid ester with uridine 5-pyrophosphate; Glucopyranuronic acid 1-ester with uridine 5-pyrophosphate; Uridine[5]diphospho[1]-α-D-glucopyranosuronic acid; Uridine-5′-diphosphoglucuronic acid trisodium salt; Uridine 5-diphospho-alpha-delta-glucuronic acid; URIDINE-5-diphosphoric acid-glucuronic acid; Uridine 5-diphospho-alpha-D-glucuronic acid; Uridine 5-diphospho-alpha-delta-glucuronate; Uridine diphosphoric acid glucuronic acid; Uridine 5’-diphospho-α-D-glucuronic acid; Uridine 5-diphospho-a-D-glucuronic acid; Uridine diphospho-delta-glucuronic acid; Uridine 5-diphospho-α-D-glucuronic acid; URIDINE-5-diphosphATE-glucuronIC ACID; Uridine-diphosphate-glucuronic acid; Uridine diphosphate glucuronic acid; Uridine diphospho-D-glucuronic acid; Uridine 5’-diphosphoglucuronic acid; Uridine 5-diphospho-a-D-glucuronate; Uridine 5-diphospho-glucuronic acid; Uridine diphospho-delta-glucuronate; Uridine pyrophosphoglucuronic acid; Uridine 5-diphosphoglucuronic acid; Diphosphoglucuronic acid, uridine; Acid, uridine diphosphoglucuronic; URIDINE-5-diphosphate-glucuronate; Uridine diphosphoglucuronic acid; Uridinediphosphoglucuronic acid; Uridine diphosphate-glucuronate; Uridine diphosphate glucuronate; Uridine diphospho-D-glucuronate; Uridine pyrophosphoglucuronate; Uridine 5-diphosphoglucuronate; Uridine diphosphoglucuronate; UDP-alpha-delta-Glucuronate; UDP-alpha-D-Glucuronic acid; UDP-a-D-Galacturonic acid; UDP-delta-Glucuronic acid; UDP-α-D-glucuronate; UDP-Α-D-glucuronic acid; UDP-alpha-D-Glucuronate; UDP-a-D-Glucuronic acid; UDP-delta-Glucuronate; UDP-D-Glucuronic acid; Acid, UDP glucuronic; Glucuronic acid, UDP; UDP-a-D-Glucuronate; UDP-Α-D-glucuronate; UDP Glucuronic acid; UDP-Glucuronic acid; UDPglucuronic acid; UDP-D-Glucuronate; UDP-Glucuronate; UDP Glucuronate; UDPglucuronate; UDP-GlcUA; UDP-GlcA; UDPGA; UGA; Uridine diphosphate glucuronic acid



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

602 个相关的代谢反应过程信息。

Reactome(28)

BioCyc(2)

WikiPathways(4)

Plant Reactome(462)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(106)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ze Li, Shaoguo Ru, Jiali Li, Yunjia Yang, Weiwei Wang. Continuous exposure to bisphenol S increases the accumulation of endogenous metabolic toxicants by obstructing the glucuronic acid pathway. Environmental pollution (Barking, Essex : 1987). 2023 Sep; 336(?):122433. doi: 10.1016/j.envpol.2023.122433. [PMID: 37659633]
  • Megan E Mitchell, Petia Z Gatzeva-Topalova, Austin D Bargmann, Tarek Sammakia, Marcelo C Sousa. Targeting the Conformational Change in ArnA Dehydrogenase for Selective Inhibition of Polymyxin Resistance. Biochemistry. 2023 Jul; ?(?):. doi: 10.1021/acs.biochem.3c00227. [PMID: 37410993]
  • Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Apr; 80(?):105324. doi: 10.1016/j.tiv.2022.105324. [PMID: 35101544]
  • Ilaria Caon, Arianna Parnigoni, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti. Cell Energy Metabolism and Hyaluronan Synthesis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2021 01; 69(1):35-47. doi: 10.1369/0022155420929772. [PMID: 32623953]
  • Pramod C Nair, Nuy Chau, Ross A McKinnon, John O Miners. Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity. Molecular pharmacology. 2020 12; 98(6):710-718. doi: 10.1124/molpharm.120.000104. [PMID: 33008919]
  • Soo Yeon Chung, Hikaru Seki, Yukiko Fujisawa, Yoshikazu Shimoda, Susumu Hiraga, Yuhta Nomura, Kazuki Saito, Masao Ishimoto, Toshiya Muranaka. A cellulose synthase-derived enzyme catalyses 3-O-glucuronosylation in saponin biosynthesis. Nature communications. 2020 11; 11(1):5664. doi: 10.1038/s41467-020-19399-0. [PMID: 33199711]
  • Eva Hansmann, Elvira Mennillo, Emiko Yoda, Mélanie Verreault, Olivier Barbier, Shujuan Chen, Robert H Tukey. Differential Role of Liver X Receptor (LXR) α and LXRβ in the Regulation of UDP-Glucuronosyltransferase 1A1 in Humanized UGT1 Mice. Drug metabolism and disposition: the biological fate of chemicals. 2020 04; 48(4):255-263. doi: 10.1124/dmd.119.090068. [PMID: 31980500]
  • Meng Zhang, Fu-Dong Li, Kai Li, Zi-Long Wang, Yu-Xi Wang, Jun-Bin He, Hui-Fei Su, Zhong-Yi Zhang, Chang-Biao Chi, Xiao-Meng Shi, Cai-Hong Yun, Zhi-Yong Zhang, Zhen-Ming Liu, Liang-Ren Zhang, Dong-Hui Yang, Ming Ma, Xue Qiao, Min Ye. Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase from Glycyrrhiza glabra. Journal of the American Chemical Society. 2020 02; 142(7):3506-3512. doi: 10.1021/jacs.9b12211. [PMID: 31986016]
  • Yuhta Nomura, Hikaru Seki, Tomonori Suzuki, Kiyoshi Ohyama, Masaharu Mizutani, Tomomi Kaku, Keita Tamura, Eiichiro Ono, Manabu Horikawa, Hiroshi Sudo, Hiroaki Hayashi, Kazuki Saito, Toshiya Muranaka. Functional specialization of UDP-glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin. The Plant journal : for cell and molecular biology. 2019 09; 99(6):1127-1143. doi: 10.1111/tpj.14409. [PMID: 31095780]
  • Nuy Chau, Leyla Kaya, Benjamin C Lewis, Peter I Mackenzie, John O Miners. Drug and Chemical Glucosidation by Control Supersomes and Membranes from Spodoptera frugiperda (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5. Drug metabolism and disposition: the biological fate of chemicals. 2019 03; 47(3):271-278. doi: 10.1124/dmd.118.084947. [PMID: 30541877]
  • Justine Badée, Nahong Qiu, Neil Parrott, Abby C Collier, Stephan Schmidt, Stephen Fowler. Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry. Drug metabolism and disposition: the biological fate of chemicals. 2019 02; 47(2):124-134. doi: 10.1124/dmd.118.084301. [PMID: 30478159]
  • Yin Yao Dong, Hua Wang, Ashley C W Pike, Stephen A Cochrane, Sadra Hamedzadeh, Filip J Wyszyński, Simon R Bushell, Sylvain F Royer, David A Widdick, Andaleeb Sajid, Helena I Boshoff, Yumi Park, Ricardo Lucas, Wei-Min Liu, Seung Seo Lee, Takuya Machida, Leanne Minall, Shahid Mehmood, Katsiaryna Belaya, Wei-Wei Liu, Amy Chu, Leela Shrestha, Shubhashish M M Mukhopadhyay, Claire Strain-Damerell, Rod Chalk, Nicola A Burgess-Brown, Mervyn J Bibb, Clifton E Barry Iii, Carol V Robinson, David Beeson, Benjamin G Davis, Elisabeth P Carpenter. Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design. Cell. 2018 11; 175(4):1045-1058.e16. doi: 10.1016/j.cell.2018.10.037. [PMID: 30388443]
  • Hyesoo Jeong, Jimin Lee, Soolin Kim, Yoo Yeon Yeo, Hyunyoung So, Honghua Wu, Yun Seon Song, Chang-Young Jang, Hee-Doo Kim, Min Jung Kim, Minsun Chang. Hepatic Metabolism of Sakuranetin and Its Modulating Effects on Cytochrome P450s and UDP-Glucuronosyltransferases. Molecules (Basel, Switzerland). 2018 Jun; 23(7):. doi: 10.3390/molecules23071542. [PMID: 29949932]
  • S R Salinas, A A Petruk, N G Brukman, M I Bianco, M Jacobs, M A Marti, L Ielpi. Binding of the substrate UDP-glucuronic acid induces conformational changes in the xanthan gum glucuronosyltransferase. Protein engineering, design & selection : PEDS. 2016 06; 29(6):197-207. doi: 10.1093/protein/gzw007. [PMID: 27099353]
  • Benedikt Warth, Gerald Siegwart, Marc Lemmens, Rudolf Krska, Gerhard Adam, Rainer Schuhmacher. Hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for the quantification of uridine diphosphate-glucose, uridine diphosphate-glucuronic acid, deoxynivalenol and its glucoside: In-house validation and application to wheat. Journal of chromatography. A. 2015 Dec; 1423(?):183-9. doi: 10.1016/j.chroma.2015.10.070. [PMID: 26554298]
  • Xu C Duan, Ai M Lu, Bin Gu, Zhi P Cai, Hong Y Ma, Shuang Wei, Pedro Laborda, Li Liu, Josef Voglmeir. Functional characterization of the UDP-xylose biosynthesis pathway in Rhodothermus marinus. Applied microbiology and biotechnology. 2015 Nov; 99(22):9463-72. doi: 10.1007/s00253-015-6683-1. [PMID: 26033773]
  • Chitra Bhatia, Stephanie Oerum, James Bray, Kathryn L Kavanagh, Naeem Shafqat, Wyatt Yue, Udo Oppermann. Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chemico-biological interactions. 2015 Jun; 234(?):114-25. doi: 10.1016/j.cbi.2014.12.013. [PMID: 25526675]
  • Zhufeng Wu, Hongming Liu, Baojian Wu. Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7. The Journal of pharmacy and pharmacology. 2015 Apr; 67(4):583-96. doi: 10.1111/jphp.12351. [PMID: 25496264]
  • Utz Fischer, Simon Hertlein, Clemens Grimm. The structure of apo ArnA features an unexpected central binding pocket and provides an explanation for enzymatic cooperativity. Acta crystallographica. Section D, Biological crystallography. 2015 Mar; 71(Pt 3):687-96. doi: 10.1107/s1399004714026686. [PMID: 25760615]
  • Adrian Semeniuk, Christian Sohlenkamp, Katarzyna Duda, Georg Hölzl. A bifunctional glycosyltransferase from Agrobacterium tumefaciens synthesizes monoglucosyl and glucuronosyl diacylglycerol under phosphate deprivation. The Journal of biological chemistry. 2014 Apr; 289(14):10104-14. doi: 10.1074/jbc.m113.519298. [PMID: 24558041]
  • Davide Vigetti, Manuela Viola, Evgenia Karousou, Giancarlo De Luca, Alberto Passi. Metabolic control of hyaluronan synthases. Matrix biology : journal of the International Society for Matrix Biology. 2014 Apr; 35(?):8-13. doi: 10.1016/j.matbio.2013.10.002. [PMID: 24134926]
  • Roman Gangl, Robert Behmüller, Raimund Tenhaken. Molecular cloning of a novel glucuronokinase/putative pyrophosphorylase from zebrafish acting in an UDP-glucuronic acid salvage pathway. PloS one. 2014; 9(2):e89690. doi: 10.1371/journal.pone.0089690. [PMID: 24586965]
  • Nenad Manevski, Jari Yli-Kauhaluoma, Moshe Finel. UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin. Drug metabolism and disposition: the biological fate of chemicals. 2012 Nov; 40(11):2192-203. doi: 10.1124/dmd.112.047746. [PMID: 22912433]
  • Yuelin Song, Xiaojuan Yang, Yong Jiang, Pengfei Tu. Characterization of the metabolism of sibiricaxanthone F and its aglycone in vitro by high performance liquid chromatography coupled with Q-trap mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2012 Nov; 70(?):700-7. doi: 10.1016/j.jpba.2012.06.038. [PMID: 22819207]
  • Mitsuhiro Nishihara, Miyako Sudo, Naohiro Kawaguchi, Junzo Takahashi, Yutaka Kiyota, Takahiro Kondo, Satoru Asahi. An unusual metabolic pathway of sipoglitazar, a novel antidiabetic agent: cytochrome P450-catalyzed oxidation of sipoglitazar acyl glucuronide. Drug metabolism and disposition: the biological fate of chemicals. 2012 Feb; 40(2):249-58. doi: 10.1124/dmd.111.040105. [PMID: 22028317]
  • Bryan Broach, Xiaogang Gu, Maor Bar-Peled. Biosynthesis of UDP-glucuronic acid and UDP-galacturonic acid in Bacillus cereus subsp. cytotoxis NVH 391-98. The FEBS journal. 2012 Jan; 279(1):100-12. doi: 10.1111/j.1742-4658.2011.08402.x. [PMID: 22023070]
  • Rebecca Reboul, Claudia Geserick, Martin Pabst, Beat Frey, Doris Wittmann, Ursula Lütz-Meindl, Renaud Léonard, Raimund Tenhaken. Down-regulation of UDP-glucuronic acid biosynthesis leads to swollen plant cell walls and severe developmental defects associated with changes in pectic polysaccharides. The Journal of biological chemistry. 2011 Nov; 286(46):39982-92. doi: 10.1074/jbc.m111.255695. [PMID: 21949134]
  • Nenad Manevski, Paolo Svaluto Moreolo, Jari Yli-Kauhaluoma, Moshe Finel. Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9. Drug metabolism and disposition: the biological fate of chemicals. 2011 Nov; 39(11):2117-29. doi: 10.1124/dmd.111.041418. [PMID: 21856742]
  • Ana I Loureiro, Carlos Fernandes-Lopes, Maria J Bonifácio, Lyndon C Wright, Patricio Soares-da-Silva. Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation. Drug metabolism and disposition: the biological fate of chemicals. 2011 Sep; 39(9):1486-94. doi: 10.1124/dmd.111.038620. [PMID: 21673130]
  • Haizheng Hong, Hong Su, Li Ma, Ming Yao, Ramaswamy A Iyer, W Griffith Humphreys, Lisa J Christopher. In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor. Drug metabolism and disposition: the biological fate of chemicals. 2011 Sep; 39(9):1658-67. doi: 10.1124/dmd.111.039776. [PMID: 21673131]
  • Mukesh K Mahajan, Vinita Uttamsingh, Liang-Shang Gan, Barbara Leduc, David A Williams. Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9. Journal of pharmaceutical sciences. 2011 Feb; 100(2):784-93. doi: 10.1002/jps.22303. [PMID: 20669329]
  • Hee E Kang, Se I Sohn, Seung R Baek, Jee W Lee, Myung G Lee. Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of liquiritigenin and its two glucuronides, M1 and M2, in rats. The Journal of pharmacy and pharmacology. 2011 Jan; 63(1):49-57. doi: 10.1111/j.2042-7158.2010.01175.x. [PMID: 21155815]
  • Donglu Zhang, Nirmala Raghavan, Lifei Wang, Yongjun Xue, Mary Obermeier, Stephanie Chen, Shiwei Tao, Hao Zhang, Peter T Cheng, Wenying Li, Ragu Ramanathan, Zheng Yang, W Griffith Humphreys. Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment. Drug metabolism and disposition: the biological fate of chemicals. 2011 Jan; 39(1):123-31. doi: 10.1124/dmd.110.035048. [PMID: 20876787]
  • Jin Zhou, Timothy S Tracy, Rory P Remmel. Bilirubin glucuronidation revisited: proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1. Drug metabolism and disposition: the biological fate of chemicals. 2010 Nov; 38(11):1907-11. doi: 10.1124/dmd.110.033829. [PMID: 20668247]
  • Yu-Qi He, Li Yang, Hui-Xin Liu, Jiang-Wei Zhang, Yong Liu, Alan Fong, Ai-Zhen Xiong, Yan-Liu Lu, Ling Yang, Chang-Hong Wang, Zheng-Tao Wang. Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids. Chemical research in toxicology. 2010 Mar; 23(3):591-9. doi: 10.1021/tx900328f. [PMID: 20092275]
  • Isao Horiuchi, Yuya Kato, Arisa Nakamura, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto. Inhibitory and stimulative effects of amiodarone on metabolism of carvedilol in human liver microsomes. Biological & pharmaceutical bulletin. 2010; 33(4):717-20. doi: 10.1248/bpb.33.717. [PMID: 20410613]
  • Arijit Das, Yixing Zhou, Andrei A Ivanov, Rhonda L Carter, T Kendall Harden, Kenneth A Jacobson. Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition. Bioconjugate chemistry. 2009 Aug; 20(8):1650-9. doi: 10.1021/bc900206g. [PMID: 19572637]
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  • Anja Maria Pieslinger, Marion Christine Hoepflinger, Raimund Tenhaken. Nonradioactive enzyme measurement by high-performance liquid chromatography of partially purified sugar-1-kinase (glucuronokinase) from pollen of Lilium longiflorum. Analytical biochemistry. 2009 May; 388(2):254-9. doi: 10.1016/j.ab.2009.03.002. [PMID: 19272347]
  • Mitch A Phelps, Thomas S Lin, Amy J Johnson, Eunju Hurh, Darlene M Rozewski, Katherine L Farley, Di Wu, Kristie A Blum, Beth Fischer, Sarah M Mitchell, Mollie E Moran, Michelle Brooker-McEldowney, Nyla A Heerema, David Jarjoura, Larry J Schaaf, John C Byrd, Michael R Grever, James T Dalton. Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. Blood. 2009 Mar; 113(12):2637-45. doi: 10.1182/blood-2008-07-168583. [PMID: 18981292]
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