aminophylline (BioDeep_00000279227)
natural product
代谢物信息卡片
Aminophylline (Truphylline)
化学式: C16H24N10O4 (420.1981904)
中文名称: 氨茶碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: Cn1c(=O)c2nc[nH]c2n(C)c1=O.Cn1c(=O)c2nc[nH]c2n(C)c1=O.NCCN
InChI: 1-4H2
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03D - Other systemic drugs for obstructive airway diseases > R03DA - Xanthines
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D002317 - Cardiovascular Agents
Aminophylline is a competitive and non-selective phosphodiesterase (PDE) inhibitor. Aminophylline is a competitive adenosine receptor antagonist. Aminophylline has apulmonary vasodilator action as well as a bronchodilator action and has the potential for asthma research[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:2659
- KEGGdrug: D00227
- PubChem: 9433
- DrugBank: DB01223
- ChEMBL: CHEMBL1370561
- MeSH: Aminophylline
- CAS: 95646-60-9
- CAS: 317-34-0
- MoNA: CCMSLIB00000078235
- PMhub: MS000016199
- medchemexpress: HY-B0140
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nengfeng Zhang, Zhifang Ma, Naiquan Yang, Xu Wang. [Clinical effect of Shenfu injection combined with glucocorticoid on patients with acute left heart failure complicated with bronchospasm].
Zhonghua wei zhong bing ji jiu yi xue.
2023 Dec; 35(12):1298-1303. doi:
10.3760/cma.j.cn121430-20230726-00557. [PMID: 38149393] - Tingting Yang, Qianqian Shen, Siyu Wang, Tianfang Dong, Liang Liang, Fan Xu, Youfang He, Chunlei Li, Fang Luo, Jiahong Liang, Chunhui Tang, Jinghui Yang. Risk factors that affect the degree of bronchopulmonary dysplasia in very preterm infants: a 5-year retrospective study.
BMC pediatrics.
2022 04; 22(1):200. doi:
10.1186/s12887-022-03273-7. [PMID: 35413820] - Jennifer M Reinhart, Gabriela A R de Oliveira, Lauren Forsythe, Zhong Li. Pharmacokinetics of a 503B outsourcing facility-produced theophylline in dogs.
PloS one.
2022; 17(1):e0262336. doi:
10.1371/journal.pone.0262336. [PMID: 34990472] - Ozge Surmeli Onay, Damla Gunes, Ozge Aydemir, Neslihan Tekin. A single dose of aminophylline administration during therapeutic hypothermia; does it make a difference in glomerular filtration rate?.
European journal of pediatrics.
2021 Nov; 180(11):3367-3377. doi:
10.1007/s00431-021-04128-6. [PMID: 34046718] - Valerie Y Chock, Seo-Ho Cho, Adam Frymoyer. Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia.
Pediatric research.
2021 03; 89(4):974-980. doi:
10.1038/s41390-020-0999-y. [PMID: 32503030] - Can Peng, Dongjie Xiao, Haiyan Chen, Lijie Rao, Haiyan Xiao, Huahua Li. Effects of beclomethasone and aminophylline combined with enteral nutrition in chronic obstructive pulmonary disease on nutritional status and immune function in elders.
Asia Pacific journal of clinical nutrition.
2021; 30(1):60-66. doi:
10.6133/apjcn.202103_30(1).0008. [PMID: 33787041] - Adam Frymoyer, Krisa P Van Meurs, David R Drover, Jelena Klawitter, Uwe Christians, Valerie Y Chock. Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia.
Pediatric research.
2020 12; 88(6):871-877. doi:
10.1038/s41390-020-01140-8. [PMID: 32919393] - Orly Haskin, Weiwen Shih, Cynthia J Wong, David M Axelrod, Paul C Grimm. Peri-transplant aminophylline in pediatric kidney transplant recipients of donation after brain death: a double-blinded placebo-controlled randomized clinical trial.
Pediatric nephrology (Berlin, Germany).
2020 09; 35(9):1729-1736. doi:
10.1007/s00467-020-04561-z. [PMID: 32418145] - Saniyya Khan, Imrana Naseem. Unravelling the interaction of a phosphodiesterase inhibitor, aminophylline with human serum albumin: implication of photoilluminated riboflavin upon binding.
Journal of biomolecular structure & dynamics.
2020 08; 38(13):4056-4065. doi:
10.1080/07391102.2019.1671223. [PMID: 31542997] - Meijuan Wang, Bowen Tian, Yuanyuan Xue, Rui Li, Tingting Zhai, Liang Tan. Determination of aminophylline based on fluorescence quenching of amino-functionalized graphene quantum dots induced by photoilluminated riboflavin-aminophylline system.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Jul; 235(?):118306. doi:
10.1016/j.saa.2020.118306. [PMID: 32247256] - George A Brusch, Anthony M Mills, Rachel M Walman, Garrett Masuda, Andy Byeon, Dale F DeNardo, Zachary R Stahlschmidt. Dehydration enhances cellular and humoral immunity in a mesic snake community.
Journal of experimental zoology. Part A, Ecological and integrative physiology.
2020 06; 333(5):306-315. doi:
10.1002/jez.2358. [PMID: 32277742] - Maryam Saboute, Javad Balasi, Saleheh Tajalli, Mahmoud Hajipour, Shaghayegh Heshmat, Nasrin Khalesi, Leila Allahqoli. Effect of Aminophylline in Preventing Renal Dysfunction among Neonates with Prenatal Asphyxia: A Clinical Trial.
Archives of Iranian medicine.
2020 05; 23(5):312-318. doi:
10.34172/aim.2020.20. [PMID: 32383615] - Guillermo Escalante, Patrick Bryan, Juan Rodriguez. Effects of a topical lotion containing aminophylline, caffeine, yohimbe, l-carnitine, and gotu kola on thigh circumference, skinfold thickness, and fat mass in sedentary females.
Journal of cosmetic dermatology.
2019 Aug; 18(4):1037-1043. doi:
10.1111/jocd.12801. [PMID: 30456780] - Girish Chandra Bhatt, Priya Gogia, Martin Bitzan, Rashmi Ranjan Das. Theophylline and aminophylline for prevention of acute kidney injury in neonates and children: a systematic review.
Archives of disease in childhood.
2019 07; 104(7):670-679. doi:
10.1136/archdischild-2018-315805. [PMID: 30798259] - Zeina Harhous, Sally Badawi, Noelle Gallo Bona, Bruno Pillot, Lionel Augeul, Melanie Paillard, George W Booz, Emmanuelle Canet-Soulas, Michel Ovize, Mazen Kurdi, Gabriel Bidaux. Critical appraisal of STAT3 pattern in adult cardiomyocytes.
Journal of molecular and cellular cardiology.
2019 06; 131(?):91-100. doi:
10.1016/j.yjmcc.2019.04.021. [PMID: 31022374] - Seth Kwabena Amponsah, Kwabena Frimpong-Manso Opuni, Kwabena Aboagye Antwi, Victor Pouzuing Kunkpeh. Effect of aminophylline on the pharmacokinetics of amikacin in Sprague-Dawley rats.
Journal of infection in developing countries.
2019 03; 13(3):251-254. doi:
10.3855/jidc.10514. [PMID: 32040456] - Chaohui Ye, Caiyun Miao, Li Yu, Zhuoya Dong, Jie Zhang, Yingying Mao, Xiaodong Lu, Qin Lyu. Factors affecting the efficacy and safety of aminophylline in treatment of apnea of prematurity in neonatal intensive care unit.
Pediatrics and neonatology.
2019 02; 60(1):43-49. doi:
10.1016/j.pedneo.2018.03.008. [PMID: 29673564] - Chao-Jie Yang, Tao Chen, Xin Ni, Wan-You Yu, Wei Wang. Effect of pre-administration with aminophylline on the occurrence of post-dural puncture headache in women undergoing caesarean section by combined spinal-epidural anaesthesia.
The Journal of international medical research.
2019 Jan; 47(1):420-426. doi:
10.1177/0300060518803231. [PMID: 30270800] - Katie Park, Lindsay C Trout, Cong Xu, Ming Wang, Robert F Tamburro, E Scott Halstead. No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2018 08; 19(8):e425-e432. doi:
10.1097/pcc.0000000000001608. [PMID: 29927879] - Chuanjie Wu, Dongsheng Guan, Ming Ren, Zhengfei Ma, Changming Wan, Yinglin Cui, Ping Zhong, Wenbo Zhao, Chuanhui Li, Feng Yan, Jinqiu Xie, Fang Xue, Yajun Lian, Hongbo Liu, Cui Wang, Xunming Ji, Nanchang Xie. Aminophylline for treatment of postdural puncture headache: A randomized clinical trial.
Neurology.
2018 04; 90(17):e1523-e1529. doi:
10.1212/wnl.0000000000005351. [PMID: 29572284] - Aviral Vij, Yasmeen Golzar, Rami Doukky. Regadenoson use in chronic kidney disease and end-stage renal disease: A focused review.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
2018 02; 25(1):137-149. doi:
10.1007/s12350-017-0960-6. [PMID: 28653271] - Wanping Zhu, Xia Liu, Yuji Wang, Yeling Tong, Yongzhou Hu. Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation.
European journal of medicinal chemistry.
2018 Jan; 143(?):419-425. doi:
10.1016/j.ejmech.2017.07.068. [PMID: 29202404] - Saniyya Khan, Imrana Naseem. Photocatalytic interaction of aminophylline-riboflavin leads to ROS-mediated DNA damage and cell death: A novel phototherapeutic mechanism for cancer.
IUBMB life.
2017 08; 69(8):611-622. doi:
10.1002/iub.1643. [PMID: 28636149] - Jiansheng Li, Peng Zhao, Liping Yang, Ya Li, Yange Tian, Suyun Li, Yunping Bai. Integrating 3-omics data analyze rat lung tissue of COPD states and medical intervention by delineation of molecular and pathway alterations.
Bioscience reports.
2017 Jun; 37(3):. doi:
10.1042/bsr20170042. [PMID: 28450497] - Hina Rehman, Syed Adnan Ali, Safila Naveed, Khan Usmanghani. An interquartile relationship between polyherbal extract based lozenges linkus a phase IV comparative randomised control trial.
Pakistan journal of pharmaceutical sciences.
2017 May; 30(3(Suppl.)):961-966. doi:
". [PMID: 28655692] - Xinyu Wang, Cen Li, Chaohui Du, Jing-Lin Gao, Ke-Xin Zhao, Rui Shi, Ye Jiang. Plasma protein binding monitoring of therapeutic drugs in patients using single set of hollow fiber centrifugal ultrafiltration.
Bioanalysis.
2017 Apr; 9(7):579-592. doi:
10.4155/bio-2016-0257. [PMID: 28355126] - Lewis Cooney, Antonia McBride, Andrew Lilley, Ian Sinha, Trevor N Johnson, Daniel B Hawcutt. Using pharmacokinetic modelling to improve prescribing practices of intravenous aminophylline in childhood asthma exacerbations.
Pulmonary pharmacology & therapeutics.
2017 04; 43(?):6-11. doi:
10.1016/j.pupt.2017.01.007. [PMID: 28108402] - Juthamas Khamseekaew, Sirinart Kumfu, Suwakon Wongjaikam, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C Chattipakorn, Nipon Chattipakorn. Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice.
European journal of pharmacology.
2017 Mar; 799(?):118-127. doi:
10.1016/j.ejphar.2017.02.015. [PMID: 28192097] - K Seo, J W Choi, D-W Kim, D Han, S J Noh, H S Jung. Aminophylline Effect on Renal Ischemia-Reperfusion Injury in Mice.
Transplantation proceedings.
2017 Mar; 49(2):358-365. doi:
10.1016/j.transproceed.2016.11.043. [PMID: 28219599] - George Chalikias, Ioannis Drosos, Dimitrios N Tziakas. Prevention of Contrast-Induced Acute Kidney Injury: an Update.
Cardiovascular drugs and therapy.
2016 Oct; 30(5):515-524. doi:
10.1007/s10557-016-6683-0. [PMID: 27541275] - Adam Frymoyer, Felice Su, Paul C Grimm, Scott M Sutherland, David M Axelrod. Theophylline Population Pharmacokinetics and Dosing in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass.
Journal of clinical pharmacology.
2016 09; 56(9):1084-93. doi:
10.1002/jcph.697. [PMID: 26712558] - Ali Mirza Onder, David Rosen, Charles Mullett, Lesley Cottrell, Sherry Kanosky, Oulimata Kane Grossman, Hafiz Imran Iqbal, Eric Seachrist, Lennie Samsell, Kelly Gustafson, Larry Rhodes, Robert Gustafson. Comparison of Intraoperative Aminophylline Versus Furosemide in Treatment of Oliguria During Pediatric Cardiac Surgery.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2016 08; 17(8):753-63. doi:
10.1097/pcc.0000000000000834. [PMID: 27355823] - Gui-Zhen Yang, Fu-Shan Xue, Gao-Pu Liu, Chao Sun. Use of Aminophylline to Prevent Acute Kidney Injury After Pediatric Cardiac Surgery.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2016 08; 17(8):814. doi:
10.1097/pcc.0000000000000838. [PMID: 27500627] - Daniel J Gebhard, Ayse Akcan-Arikan. You Can Teach an Old Drug New Tricks-Aminophylline for Cardiac Surgery-Associated Acute Kidney Injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2016 08; 17(8):798-9. doi:
10.1097/pcc.0000000000000867. [PMID: 27500617] - Chuanjie Wu, Yajun Lian, Dongsheng Guan, Lijun Wang, Yanyong Miao, Nanchang Xie, Yuan Chen, Yake Zheng. A Multicenter Clinical Study on Treating Post-Dural Puncture Headache with an Intravenous Injection of Aminophylline.
Pain physician.
2016 07; 19(5):E761-5. doi:
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Scientific reports.
2016 05; 6(?):25492. doi:
10.1038/srep25492. [PMID: 27146975] - Yan Li, Abulimiti Yili, Jun Li, Aziz Muhamat, Haji Akber Aisa. New isosteroidal alkaloids with tracheal relaxant effect from the bulbs of Fritillaria pallidiflora Schrenk.
Bioorganic & medicinal chemistry letters.
2016 Apr; 26(8):1983-7. doi:
10.1016/j.bmcl.2016.03.001. [PMID: 26965859] - Kelly McMahon, Michael Zappitelli. Aminophylline for Acute Kidney Injury After Pediatric Cardiac Surgery: Finally Entering the Next Phase in Child Acute Kidney Injury Research.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2016 Feb; 17(2):170-1. doi:
10.1097/pcc.0000000000000631. [PMID: 26841029] - Snezana Djordjević, Jasmina Jović-Stosić, Vesna Kilibarda, Zoran Segrt, Natasa Perković-Vukcević. Determination of flumazenil in serum by liquid chromatography-mass spectrometry: Application to kinetics study in acute diazepam overdose.
Vojnosanitetski pregled.
2016 Feb; 73(2):146-51. doi:
10.2298/vsp141222019d. [PMID: 27071281] - David M Axelrod, Scott M Sutherland, Andrew Anglemyer, Paul C Grimm, Stephen J Roth. A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial of Aminophylline to Prevent Acute Kidney Injury in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2016 Feb; 17(2):135-43. doi:
10.1097/pcc.0000000000000612. [PMID: 26669642] - Bin Yin, Jing Li, Shu-li Wang, Shao-yue Yan, Chao Sui, Shi-jun Wan, Feng Liu, Ren-zhong Wan. Studies on pharmacokinetics and bioavailability of aminophylline in partridge chickens.
European journal of drug metabolism and pharmacokinetics.
2016 Feb; 41(1):19-25. doi:
10.1007/s13318-014-0225-6. [PMID: 25323694] - Sheng Wang, Lingling Xiong, Xue Deng, Qun Zhou, Chunying Li, Wei Ren, Chundong Zhu. [Effect of aminophylline and simvastatin on airway inflammation and mucus hypersecretion in rats with chronic obstructive pulmonary disease].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2016 Jan; 41(1):37-43. doi:
10.11817/j.issn.1672-7347.2016.01.006. [PMID: 26819423] - Xiao-Yan Yang, Jing Zhao, Jing Shi, Jin-Lin Wu, Da-Peng Chen, Jun Tang, Ying Xiong, De-Zhi Mu. [Investigation of pharmacokinetics and pharmacodynamics of different doses of aminophylline in very low birth weight infants].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2015 Nov; 17(11):1171-5. doi:
NULL. [PMID: 26575873] - Maria Octavia Rangel, Raysa Morales Demori, Sarah T Voll, Marwan Wassouf, Rizcallah Dick, Rami Doukky. Severe chronic kidney disease as a predictor of benefit from aminophylline administration in patients undergoing regadenoson stress myocardial perfusion imaging: A substudy of the ASSUAGE and ASSUAGE-CKD trials.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
2015 Oct; 22(5):1008-18. doi:
10.1007/s12350-014-0036-9. [PMID: 25500799] - Chang Wang, Rong Wang, Hua Xie, Qiang Yin, Zhengping Jia, Wenbin Li, Yanling Wang, Hui Lu, Rui Tao. [Effect of aminophylline on physiological and pathological changes in acute exposure to high altitude in rats].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2015 Jan; 40(1):39-45. doi:
10.11817/j.issn.1672-7347.2015.01.007. [PMID: 25652383] - Aline F Brito, Alexandre S Silva, Iara L L Souza, Joedna C Pereira, Italo R R Martins, Bagnólia A Silva. Intensity of swimming exercise influences tracheal reactivity in rats.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2015; 51(?):70-81. doi:
10.1540/jsmr.51.70. [PMID: 26497013] - Abdallah R Dalabih, Steven A Bondi, Zena L Harris, Benjamin R Saville, Wenli Wang, Donald H Arnold. Aminophylline infusion for status asthmaticus in the pediatric critical care unit setting is independently associated with increased length of stay and time for symptom improvement.
Pulmonary pharmacology & therapeutics.
2014 Feb; 27(1):57-61. doi:
10.1016/j.pupt.2013.03.001. [PMID: 23523660] - David M Axelrod, Andrew T Anglemyer, Sara F Sherman-Levine, Aihua Zhu, Paul C Grimm, Stephen J Roth, Scott M Sutherland. Initial experience using aminophylline to improve renal dysfunction in the pediatric cardiovascular ICU.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2014 Jan; 15(1):21-7. doi:
10.1097/01.pcc.0000436473.12082.2f. [PMID: 24212284] - D Mokra, I Tonhajzerova, H Pistekova, Z Visnovcova, J Mokry, A Drgova, M Repcakova, A Calkovska. Short-term cardiovascular effects of selective phosphodiesterase 3 inhibitor olprinone versus non-selective phosphodiesterase inhibitor aminophylline in a meconium-induced acute lung injury.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2013 Dec; 64(6):751-9. doi:
NULL. [PMID: 24388890] - Rami Doukky, Maria Octavia Rangel, Rizcallah Dick, Marwan Wassouf, Ammar Alqaid, Bosko Margeta. Attenuation of the side effect profile of regadenoson: a randomized double-blind placebo-controlled study with aminophylline in patients undergoing myocardial perfusion imaging and have severe chronic kidney disease--the ASSUAGE-CKD trial.
The international journal of cardiovascular imaging.
2013 Jun; 29(5):1029-37. doi:
10.1007/s10554-012-0166-6. [PMID: 23224354] - X P Li, C L Zhang, P Gao, J Gao, D Liu. Effects of andrographolide on the pharmacokinetics of aminophylline and doxofylline in rats.
Drug research.
2013 May; 63(5):258-62. doi:
10.1055/s-0033-1341432. [PMID: 23539425] - Jing Shi, Da-Peng Chen, Ying Xiong, Jun Tang, Jin-Lin Wu, De-Zhi Mu. [Investigation on pharmacokinetics of aminophylline in very low birth weight infants].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2013 Mar; 44(2):291-4. doi:
NULL. [PMID: 23745275] - Tomoko Somekawa-Kondo, Keitaro Yamaguchi, Yoichi Ishitsuka, Sachiko Ito, Kaori Tanaka, Mitsuru Irikura, Hiroshi Moriuchi, Kazuo Takahama, Yukio Ando, Toshio Yamazaki, Tetsumi Irie. Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.
The Journal of pharmacy and pharmacology.
2013 Jan; 65(1):102-14. doi:
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Advances in experimental medicine and biology.
2013; 756(?):189-96. doi:
10.1007/978-94-007-4549-0_24. [PMID: 22836635] - Martins Ekor, Adesina O Odewabi, Oluwafemi E Kale, Titilayo O Bamidele, Omolola A Adesanoye, Ebenezer O Farombi. Modulation of paracetamol-induced hepatotoxicity by phosphodiesterase isozyme inhibition in rats: a preliminary study.
Journal of basic and clinical physiology and pharmacology.
2013; 24(1):73-9. doi:
10.1515/jbcpp-2012-0043. [PMID: 23425627] - Anil Pandit, Samuel Unzek Freiman. Complete heart block associated with regadenoson: a real side effect.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
2012 Dec; 19(6):1236-9. doi:
10.1007/s12350-012-9610-1. [PMID: 22915132] - Su-Yun Li, Ya Li, Jian-Sheng Li. [Effects of Bufei Jianpi Recipe on the diaphragmatic neural discharge and the diaphragmatic muscle function in rats with chronic obstructive pulmonary disease].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2012 Jun; 32(6):812-6. doi:
". [PMID: 22978110] - Jun Zhang, Guangdan Zhao, Xiaoling Yu, Xiaoming Pan. Intravenous diuretic and vasodilator therapy reduce plasma brain natriuretic peptide levels in acute exacerbation of chronic obstructive pulmonary disease.
Respirology (Carlton, Vic.).
2012 May; 17(4):715-20. doi:
10.1111/j.1440-1843.2012.02162.x. [PMID: 22394412] - B Rezaei, Ali A Ensafi, L Zarei. Fast and sensitive chemiluminescence assay of aminophylline in human serum using luminol-diperiodatoargentate(III) system catalyzed by coated iron nanoparticles.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2012 May; 90(?):223-9. doi:
10.1016/j.saa.2012.01.040. [PMID: 22343083] - Toshiaki Ara, Yoshiaki Fujinami, Hiroko Urano, Kaname Hirai, Toshimi Hatori, Hiroo Miyazawa. Protein kinase A enhances lipopolysaccharide-induced IL-6, IL-8, and PGE₂ production by human gingival fibroblasts.
Journal of negative results in biomedicine.
2012 Mar; 11(?):10. doi:
10.1186/1477-5751-11-10. [PMID: 22452847] - A R Merrikhi, S Ghaemi, A Gheissari, M Shokrani, Y Madihi, F Mousavinasab. Effects of aminophyllinein preventing renal failure in premature neonates with asphyxia in Isfahan-Iran.
JPMA. The Journal of the Pakistan Medical Association.
2012 Mar; 62(3 Suppl 2):S48-51. doi:
. [PMID: 22768459] - Paulo Sérgio Lucas da Silva, Vânia Euzébio de Aguiar, Marcelo Cunio Machado Fonseca. Additive diuretic response of concurrent aminophylline and furosemide in children: a case series and a brief literature review.
Journal of anesthesia.
2012 Feb; 26(1):118-23. doi:
10.1007/s00540-011-1250-0. [PMID: 22005755] - Chunmei Gao, Mingzhu Liu, Jun Chen, Chen Chen. pH- and Temperature-Responsive P(DMAEMA-GMA)-Alginate Semi-IPN Hydrogels Formed by Radical and Ring-Opening Polymerization for Aminophylline Release.
Journal of biomaterials science. Polymer edition.
2012; 23(8):1039-54. doi:
10.1163/092050611x570653. [PMID: 21513583] - Wasiu A Olowu, Olufemi Adefehinti. Aminophylline improves urine flow rates but not survival in childhood oliguric/anuric acute kidney injury.
Arab journal of nephrology and transplantation.
2012 Jan; 5(1):35-9. doi:
NULL. [PMID: 22283864] - Stefania Casella, Elisabetta Giudice, Claudia Giannetto, Simona Marafioti, Giuseppe Piccione. Effects of hydrocortisone and aminophylline on the aggregation of equine platelets in vitro.
Journal of veterinary science.
2011 Sep; 12(3):215-9. doi:
10.4142/jvs.2011.12.3.215. [PMID: 21897093] - Megha Kapoor, Nidhi Jasani, Niyati Acharya, Sanjeev Acharya, Vimal Kumar. Phytopharmacological evaluation and anti-asthmatic activity of Ficus religiosa leaves.
Asian Pacific journal of tropical medicine.
2011 Aug; 4(8):642-4. doi:
10.1016/s1995-7645(11)60163-6. [PMID: 21914543] - Peng-ke Yan, Guang-qing Lin, Qi-fu Luo, Jin-kui Xie. [Effect of Limax lyophilized powder on bronchial asthma].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2011 Jul; 34(7):1086-9. doi:
. [PMID: 22066405] - Carolina Alves Dos Santos, Gabriel Borghesan Ribeiro, Marcos Camargo Knirsch, Adalberto Pessoa Junior, Thereza Christina Vessoni Penna. Influence of Pluronic® F68 on ceftazidime biological activity in parenteral solutions.
Journal of pharmaceutical sciences.
2011 Feb; 100(2):715-20. doi:
10.1002/jps.22287. [PMID: 20799363] - Peili Chen, Shaopu Liu, Zhongfang Liu, Xiaoli Hu. Study on the ternary mixed ligand complex of palladium(II)-aminophylline-fluorescein sodium by resonance Rayleigh scattering, second-order scattering and frequency doubling scattering spectrum and its analytical application.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2011 Jan; 78(1):518-22. doi:
10.1016/j.saa.2010.11.020. [PMID: 21163688] - Hee-Jeong Son, Young-Cheol Lim, Kwon-Soo Ha, Seong-Sik Kang, Il-Young Cheong, Sang-Jin Lee, Seung-Woo Park, Byeong-Moon Hwang. Propofol and aminophylline antagonize each other during the mobilization of intracellular calcium in human umbilical vein endothelial cells.
Journal of Korean medical science.
2010 Aug; 25(8):1222-7. doi:
10.3346/jkms.2010.25.8.1222. [PMID: 20676337] - Katrien Koppo, Dominique Larrouy, Marie A Marques, Michel Berlan, Magda Bajzova, Jan Polak, Johan Van de Voorde, Jens Bülow, Max Lafontan, François Crampes, Dominique Langin, Vladimir Stich, Isabelle de Glisezinski. Lipid mobilization in subcutaneous adipose tissue during exercise in lean and obese humans. Roles of insulin and natriuretic peptides.
American journal of physiology. Endocrinology and metabolism.
2010 Aug; 299(2):E258-65. doi:
10.1152/ajpendo.00767.2009. [PMID: 20484012] - Yanzong Yang, Yiqing Yang, Bo Liang, Jinqiu Liu, Jun Li, Morten Grunnet, Søren-Peter Olesen, Hanne B Rasmussen, Patrick T Ellinor, Lianjun Gao, Xiaoping Lin, Li Li, Lei Wang, Junjie Xiao, Yi Liu, Ying Liu, Shulong Zhang, Dandan Liang, Luying Peng, Thomas Jespersen, Yi-Han Chen. Identification of a Kir3.4 mutation in congenital long QT syndrome.
American journal of human genetics.
2010 Jun; 86(6):872-80. doi:
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Journal of cardiology.
2010 Mar; 55(2):174-9. doi:
10.1016/j.jjcc.2009.10.006. [PMID: 20206069] - Hong-ying Liu, Xi-tian Pi, Xiao-lin Zheng, Wen-sheng Hou, Jian-guo Cui. Pharmacokinetics of aminophylline delivered to the small intestine and colon using remote controlled capsules.
Chinese medical journal.
2010 Feb; 123(3):320-5. doi:
NULL. [PMID: 20193253] - Hideo Shiohira, Makiko Fujii, Naoya Koizumi, Masuo Kondoh, Yoshiteru Watanabe. Novel chronotherapeutic rectal aminophylline delivery system for therapy of asthma.
International journal of pharmaceutics.
2009 Sep; 379(1):119-24. doi:
10.1016/j.ijpharm.2009.06.017. [PMID: 19555748] - Fernando Rodríguez-Ramos, Andrés Navarrete. Solving the confusion of gnaphaliin structure: gnaphaliin A and gnaphaliin B identified as active principles of Gnaphalium liebmannii with tracheal smooth muscle relaxant properties.
Journal of natural products.
2009 Jun; 72(6):1061-4. doi:
10.1021/np800746j. [PMID: 19505084] - Quanmin Li, Tiantian Zhang, Wenying Lv. A novel spectrophotometric method for the determination of aminophylline with boric acid in pharmaceutical and mixed serum samples.
European journal of medicinal chemistry.
2009 Apr; 44(4):1452-6. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2008 Dec; 59 Suppl 6(?):449-59. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2008 Dec; 59 Suppl 6(?):461-71. doi:
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Journal of plastic, reconstructive & aesthetic surgery : JPRAS.
2008 Nov; 61(11):1321-4. doi:
10.1016/j.bjps.2007.03.039. [PMID: 17954040] - P Asheim, O Spigset, K Aasarød, R A Walstad, P E Uggen, K Zahlsen, P Aadahl. Pharmacokinetics of intraperitoneally instilled aminophylline, terbutaline and tobramycin in pigs.
Acta anaesthesiologica Scandinavica.
2008 Feb; 52(2):243-8. doi:
10.1111/j.1399-6576.2007.01535.x. [PMID: 18005375] - Craig B Whitman, Walter S Schroeder, Peter J Ploch, Krishnan Raghavendran. Efficacy of aminophylline for treatment of recurrent symptomatic bradycardia after spinal cord injury.
Pharmacotherapy.
2008 Jan; 28(1):131-5. doi:
10.1592/phco.28.1.131. [PMID: 18154483] - Hooman Djaladat, Parvin Tajik, Salman Abbasi Fard, Sara Alehashemi. The effect of aminophylline on renal colic: a randomized double blind controlled trial.
Southern medical journal.
2007 Nov; 100(11):1081-4. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2007 Nov; 58 Suppl 5(Pt 1):399-407. doi:
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Journal of perinatology : official journal of the California Perinatal Association.
2007 Nov; 27(11):709-12. doi:
10.1038/sj.jp.7211804. [PMID: 17717520] - Edward D Kim. Editorial Comment on Djaladat's 'The Effect on Aminophylline of Renal Colic'.
Southern medical journal.
2007 Nov; 100(11):1069. doi:
10.1097/smj.0b013e3181583495. [PMID: 17984732] - Shinji Sato, Masaharu Nakajima, Akira Honda, Tetsuya Konishi, Hiroshi Miyazaki. Pharmacokinetics of theophylline in Guinea pig tears.
Drug metabolism and pharmacokinetics.
2007 Jun; 22(3):169-77. doi:
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Acta neurologica Scandinavica.
2007 May; 115(5):301-5. doi:
10.1111/j.1600-0404.2007.00643.x. [PMID: 17489939] - Lai-Hao Wang, Chia-Chen Wang, Su-Ching Kuo. Vehicle and enhancer effects on human skin penetration of aminophylline from cream formulations: evaluation in vivo.
Journal of cosmetic science.
2007 May; 58(3):245-54. doi:
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Journal of ethnopharmacology.
2007 Apr; 111(1):142-7. doi:
10.1016/j.jep.2006.11.001. [PMID: 17141995] - Bo Yang, Guang-Yi Wang, Bin Chen, Rong-Bin Qin, Si Lang Zha Xi, Lian Chen. Anti-hypoxia and anti-oxidation effects of aminophylline on human with acute high-altitude exposure.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.
2007 Mar; 22(1):62-5. doi:
. [PMID: 17441321] - Ayaka Fujita, Masatou Kitayama, Kazuyoshi Hirota. Anaphylactoid shock in a patient following 5\% human serum albumin infusion during off-pump coronary artery bypass grafting.
Journal of anesthesia.
2007; 21(3):396-8. doi:
10.1007/s00540-007-0512-3. [PMID: 17680193] - Muhammad Nabeel Ghayur, Anwarul Hassan Gilani. Studies on cardio-suppressant, vasodilator and tracheal relaxant effects of Sarcococca saligna.
Archives of pharmacal research.
2006 Nov; 29(11):990-7. doi:
10.1007/bf02969283. [PMID: 17146968] - Jian-ping Liu, Jia-bi Zhu, Sheng-jun Chen, Xin Zhao. [Study on evaluation index of acupoint transdermal administration--drug delivery coefficient].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2006 Jul; 26(7):507-9. doi:
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International journal of cardiology.
2006 Jun; 110(1):122-4. doi:
10.1016/j.ijcard.2005.06.013. [PMID: 16005532] - John Kellum, Martine Leblanc, Ramesh Venkataraman. Renal failure (acute).
Clinical evidence.
2006 Jun; ?(15):1191-212. doi:
NULL. [PMID: 16973048] - Jeremy R Parr, Amanda Salama, Peter Sebire. A survey of consultant practice: intravenous salbutamol or aminophylline for acute severe childhood asthma and awareness of potential hypokalaemia.
European journal of pediatrics.
2006 May; 165(5):323-5. doi:
10.1007/s00431-005-0049-0. [PMID: 16421724] - Fiona L R Williams, Simon A Ogston, Hans van Toor, Theo J Visser, Robert Hume. Serum thyroid hormones in preterm infants: associations with postnatal illnesses and drug usage.
The Journal of clinical endocrinology and metabolism.
2005 Nov; 90(11):5954-63. doi:
10.1210/jc.2005-1049. [PMID: 16105964] - Min Cai, Hong Chen, Xue-Dong Wang, Hui-Yong Zhang. [Clinical observation of bushen naqi huoxue granules in treating patients with chronic obstructive lung disease].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2005 Nov; 3(6):483-5. doi:
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