Rifampicin (BioDeep_00000276194)
natural product Chemicals and Drugs
代谢物信息卡片
[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
化学式: C43H58N4O12 (822.4051028)
中文名称: 利福平
谱图信息:
最多检出来源 Anoectochilus roxburghii(viridiplantae) 92.86%
分子结构信息
SMILES: CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C
InChI: InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
描述信息
A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis > J04AB - Antibiotics
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.201
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.200
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.202
Acquisition and generation of the data is financially supported by the Max-Planck-Society
IPB_RECORD: 2361; CONFIDENCE confident structure
同义名列表
4 个代谢物同义名
Rifampicin; [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate; [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(Z)-(4-methylpiperazin-1-yl)iminomethyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate; "Rifampin (Rifadin, Rimactane)"
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:28077
- PubChem: 137270779
- PubChem: 137225336
- PubChem: 5381226
- PubChem: 135512673
- CAS: 13292-46-1
- MoNA: CCMSLIB00000078280
- MoNA: BML82088
- MoNA: BML82086
- MoNA: BML82085
- MoNA: CE000185
- MoNA: CE000184
- MoNA: CE000183
- MoNA: CE000182
- MoNA: CE000181
- MoNA: PB005807
- MoNA: PB005806
- MoNA: PB005805
- PMhub: MS000009508
- MetaboLights: MTBLC28077
- RefMet: Rifampicin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pengcheng Gu, Peng Lu, Hui Ding, Qiao Liu, Xiaoyan Ding, Yongfa Chen, Limei Zhu. Effectiveness, cost, and safety of four regimens recommended by WHO for RR/MDR-TB treatment: a cohort study in Eastern China.
Annals of medicine.
2024 Dec; 56(1):2344821. doi:
10.1080/07853890.2024.2344821. [PMID: 38697138] - Zengxin Li, Wenhong Li, Qing Mu, Yicheng Zhu, Weiwei Qin, Xiaobin Shi, Yueping He. Rifampicin synergizes the toxicity of insecticides against the green peach aphid, Myzus persicae.
Ecotoxicology and environmental safety.
2024 May; 276(?):116291. doi:
10.1016/j.ecoenv.2024.116291. [PMID: 38581910] - Jian-Jun Liu, Yin-Ping Feng, Zhong-Da Liu, Jing Guo. Impact of delayed diagnosis and treatment on tuberculosis infection within families: A case report.
Medicine.
2024 Mar; 103(11):e37406. doi:
10.1097/md.0000000000037406. [PMID: 38489738] - Malihe Khorramdel, Fatemeh Peyravii Ghadikolaii, Seyed Isaac Hashemy, Hossein Javid, Masoud Homayouni Tabrizi. Nanoformulated meloxicam and rifampin: inhibiting quorum sensing and biofilm formation in Pseudomonas aeruginosa.
Nanomedicine (London, England).
2024 03; 19(7):615-632. doi:
10.2217/nnm-2023-0268. [PMID: 38348578] - Prapaporn Srilohasin, Saradee Warit, Therdsak Prammananan, Saijai Smithtikarn, Reka Kanitpun, Mutchamon Kaewparuehaschai, Kirana Noradechanon, Suthirote Meesawat, Nattakan Thakaew, Nonthakorn Sakulwittayasuk, Taratorn Kemthong, Tanapat Palaga, Suchinda Malaivijitnond, Angkana Chaiprasert. Advancing tuberculosis diagnosis and management in cynomolgus macaques using Xpert MTB/RIF ultra assay.
Scientific reports.
2024 01; 14(1):1518. doi:
10.1038/s41598-024-51824-y. [PMID: 38233591] - Yu Wang, Han Fu, Xiao-Jie Shi, Guo-Ping Zhao, Liang-Dong Lyu. Genome-wide screen reveals cellular functions that counteract rifampicin lethality in Escherichia coli.
Microbiology spectrum.
2024 Jan; 12(1):e0289523. doi:
10.1128/spectrum.02895-23. [PMID: 38054714] - Anastasia A Zhukovets, Vladimir V Chernyshov, Aidar Z Al'mukhametov, Tatiana A Seregina, Svetlana V Revtovich, Mariia A Kasatkina, Yulia E Isakova, Vitalia V Kulikova, Elena A Morozova, Anastasia I Cherkasova, Timur A Mannanov, Anastasia A Anashkina, Pavel N Solyev, Vladimir A Mitkevich, Roman A Ivanov. Novel Hydroxamic Acids Containing Aryl-Substituted 1,2,4- or 1,3,4-Oxadiazole Backbones and an Investigation of Their Antibiotic Potentiation Activity.
International journal of molecular sciences.
2023 Dec; 25(1):. doi:
10.3390/ijms25010096. [PMID: 38203266] - Ishani V Gaidhane, Kyle J Biegas, Helen E Erickson, Prachi Agarwal, Yashpal S Chhonker, Donald R Ronning, Benjamin M Swarts. Chemical remodeling of the mycomembrane with chain-truncated lipids sensitizes mycobacteria to rifampicin.
Chemical communications (Cambridge, England).
2023 Nov; 59(93):13859-13862. doi:
10.1039/d3cc02364h. [PMID: 37929833] - Zhaoxin Li, Jin Wang, Xin Xiu, Zhenpeng Shi, Qiang Zhang, Deqiang Chen. Evaluation of different diagnostic methods for spinal tuberculosis infection.
BMC infectious diseases.
2023 Oct; 23(1):695. doi:
10.1186/s12879-023-08655-5. [PMID: 37853312] - Wei-Yu Chen, Yi-Fang Chen, Jer-Min Tsai, Hsin-Mei Huang, Yong-Chao Su. Epidemiology-based wastewater monitoring for ecological risks of anti-tuberculosis drugs mixture effects.
The Science of the total environment.
2023 Sep; 892(?):164560. doi:
10.1016/j.scitotenv.2023.164560. [PMID: 37268140] - Dennis Mwanza Nzilu, Edwin Shigwenya Madivoli, David Sujee Makhanu, Sammy Indire Wanakai, Gideon Kirui Kiprono, Patrick Gachoki Kareru. Green synthesis of copper oxide nanoparticles and its efficiency in degradation of rifampicin antibiotic.
Scientific reports.
2023 08; 13(1):14030. doi:
10.1038/s41598-023-41119-z. [PMID: 37640783] - Kiamu Kurosawa, Masataka Nakano, Itsuki Yokoseki, Mai Nagaoka, Seiya Takemoto, Yoshiyuki Sakai, Kaoru Kobayashi, Yasuhiro Kazuki, Tatsuki Fukami, Miki Nakajima. ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver.
Biochemical pharmacology.
2023 Aug; 215(?):115733. doi:
10.1016/j.bcp.2023.115733. [PMID: 37543347] - Walja C Wanney, Loubna Youssar, Gergana Kostova, Jens Georg. Improved RNA stability estimation indicates that transcriptional interference is frequent in diverse bacteria.
Communications biology.
2023 07; 6(1):732. doi:
10.1038/s42003-023-05097-2. [PMID: 37454177] - Galo A Goig, Fabrizio Menardo, Zubeida Salaam-Dreyer, Anzaan Dippenaar, Elizabeth M Streicher, Johnny Daniels, Anja Reuter, Sonia Borrell, Miriam Reinhard, Anna Doetsch, Christian Beisel, Robin M Warren, Helen Cox, Sebastien Gagneux. Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study.
The Lancet. Microbe.
2023 07; 4(7):e506-e515. doi:
10.1016/s2666-5247(23)00110-6. [PMID: 37295446] - Sajedeh Maghrebi, Nicky Thomas, Clive A Prestidge, Paul Joyce. Inulin-lipid hybrid (ILH) microparticles promote pH-triggered release of rifampicin within infected macrophages.
Drug delivery and translational research.
2023 06; 13(6):1716-1729. doi:
10.1007/s13346-022-01287-3. [PMID: 36630076] - Devaraj Ezhilarasan. Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms.
Drug metabolism reviews.
2023 May; ?(?):1-15. doi:
10.1080/03602532.2023.2215478. [PMID: 37218081] - Sampa Sarkar, Brendan Dyett, Biserka Lakic, Andrew S Ball, Leslie Y Yeo, Jacinta F White, Sarvesh Soni, Calum J Drummond, Charlotte E Conn. Cubosome Lipid Nanocarriers As a Drug Delivery Vehicle for Intracellular Mycobacterium tuberculosis Infections.
ACS applied materials & interfaces.
2023 May; 15(18):21819-21829. doi:
10.1021/acsami.3c00101. [PMID: 37018059] - Chantal M Wallenwein, Mukul Ashtikar, Götz Hofhaus, Isabel Haferland, Manuela Thurn, Anke König, Andreas Pinter, Jennifer Dressman, Matthias G Wacker. How wound environments trigger the release from Rifampicin-loaded liposomes.
International journal of pharmaceutics.
2023 Feb; 633(?):122606. doi:
10.1016/j.ijpharm.2023.122606. [PMID: 36632921] - Fei Yuan, Jing Li, Xuening Li, Hui Li, Weili Chen, Mengjie Yang, Hanjing Chen, Lei Sheng, Chao Liu, Yujia Wu, Hongrong Xu. Pharmacokinetic Interaction of Chiglitazar with CYP3A4 Inducer or Inhibitor: An Open-Label, Sequential Crossover, Self-Control, 3-Period Study in Healthy Chinese Volunteers.
Clinical pharmacology in drug development.
2023 Feb; 12(2):168-174. doi:
10.1002/cpdd.1198. [PMID: 36583526] - Mumuni Sumaila, Pradeep Kumar, Philemon Ubanako, Samson A Adeyemi, Yahya E Choonara. Dual Rifampicin and Isoniazid Mannose-Decorated Lipopolysaccharide Nanospheres for Macrophage- Targeted Lung Delivery.
Current drug delivery.
2023; 20(10):1487-1503. doi:
10.2174/1567201819666220812092556. [PMID: 35959905] - Zhiqiang Yang, Meirong Song, Xiaoyu Li, Qi Zhang, Jianzhong Shen, Kui Zhu. Synergy of outer membrane disruptor SLAP-S25 with hydrophobic antibiotics against Gram-negative pathogens.
The Journal of antimicrobial chemotherapy.
2022 12; 78(1):263-271. doi:
10.1093/jac/dkac387. [PMID: 36385317] - Nishita Mistry, Rajdip Bandyopadhyaya, Sarika Mehra. Enhancement of Antimycobacterial Activity of Rifampicin Using Mannose-Anchored Lipid Nanoparticles against Intramacrophage Mycobacteria.
ACS applied bio materials.
2022 12; 5(12):5779-5789. doi:
10.1021/acsabm.2c00796. [PMID: 36441965] - Milan Milenovic, Antoine Gouttepifre, Michael Eickermann, Jürgen Junk, Carmelo Rapisarda. Plant-mediated rifampicin treatment of Bemisia tabaci disrupts but does not eliminate endosymbionts.
Scientific reports.
2022 12; 12(1):20766. doi:
10.1038/s41598-022-24788-0. [PMID: 36456664] - Yanqing Song, Xiaoyu Qu, Lina Tao, Huan Gao, Yueming Zhang, Jinghui Zhai, Jiawei Gong, Tingting Hu. Exploration of the underlying mechanisms of isoniazid/rifampicin-induced liver injury in mice using an integrated proteomics and metabolomics approach.
Journal of biochemical and molecular toxicology.
2022 Dec; 36(12):e23217. doi:
10.1002/jbt.23217. [PMID: 36111668] - Mohd Hafidz Mahamad Maifiah, Yan Zhu, Brian T Tsuji, Darren J Creek, Tony Velkov, Jian Li. Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin-rifampicin combination against Pseudomonas aeruginosa.
Journal of biomedical science.
2022 Oct; 29(1):89. doi:
10.1186/s12929-022-00874-3. [PMID: 36310165] - Kristina Klobucar, Emily Jardine, Maya A Farha, Marc R MacKinnon, Meghan Fragis, Brenda Nkonge, Timsy Bhando, Louis Borrillo, Caressa N Tsai, Jarrod W Johnson, Brian K Coombes, Jakob Magolan, Eric D Brown. Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.
ACS infectious diseases.
2022 10; 8(10):2187-2197. doi:
10.1021/acsinfecdis.2c00357. [PMID: 36098580] - Susan M Britza, Ian F Musgrave, Roger W Byard. Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I.
Toxicology mechanisms and methods.
2022 Oct; 32(8):606-615. doi:
10.1080/15376516.2022.2057267. [PMID: 35354423] - Karine Soetaert, Pieter-Jan Ceyssens, Samira Boarbi, Bert Bogaerts, Thomas Delcourt, Kevin Vanneste, Sigrid C J De Keersmaecker, Nancy H C Roosens, Alexandra Vodolazkaia, Marina Mukovnikova, Vanessa Mathys. Retrospective evaluation of routine whole genome sequencing of Mycobacterium tuberculosis at the Belgian National Reference Center, 2019.
Acta clinica Belgica.
2022 Oct; 77(5):853-860. doi:
10.1080/17843286.2021.1999588. [PMID: 34751641] - Cong Wang, Jun Yang, Enliang Li, Shuaiwu Luo, Chi Sun, Yuting Liao, Min Li, Jin Ge, Jun Lei, Fan Zhou, Linquan Wu, Wenjun Liao. Metabolic signatures of hepatolithiasis using ultra-high performance liquid chromatography-tandem mass spectrometry.
Metabolomics : Official journal of the Metabolomic Society.
2022 08; 18(9):69. doi:
10.1007/s11306-022-01927-2. [PMID: 35976530] - Ming-Min Cai, Ting Dou, Lu Tang, Qiu-Yue Sun, Zi-Hong Zhai, Hui-Ping Wang, Wei Qian. Effects of rifampicin on antineoplastic drug pyrotinib maleate pharmacokinetics in healthy subjects.
Investigational new drugs.
2022 08; 40(4):756-761. doi:
10.1007/s10637-022-01241-7. [PMID: 35435627] - Min Lin, Ying-Wen Chen, Yun-Ran Li, Li-Jun Long, Le-Yao Qi, Ting-Ting Cui, Shao-Yong Wu, Jia-Yuan Lin, Tong Wu, Yi-Chen Yang, Wei-Hua Yuan, Ge-Yuan Wu, Qi-Wen Lan, Jia-Qi Liu, Ya-Ping Li, Zi-Yuan Yu, Xu-Guang Guo. Systematic evaluation of line probe assays for the diagnosis of tuberculosis and drug-resistant tuberculosis.
Clinica chimica acta; international journal of clinical chemistry.
2022 Aug; 533(?):183-218. doi:
10.1016/j.cca.2022.06.020. [PMID: 35792161] - Richard Court, Kamunkhwala Gausi, Buyisile Mkhize, Lubbe Wiesner, Catriona Waitt, Helen McIlleron, Gary Maartens, Paolo Denti, Marian Loveday. Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin-resistant tuberculosis.
British journal of clinical pharmacology.
2022 Aug; 88(8):3548-3558. doi:
10.1111/bcp.15380. [PMID: 35526837] - Xiaocui Wu, Guangkun Tan, Jinghui Yang, Yinjuan Guo, Chengchen Huang, Wei Sha, Fangyou Yu. Prediction of Mycobacterium tuberculosis drug resistance by nucleotide MALDI-TOF-MS.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Aug; 121(?):47-54. doi:
10.1016/j.ijid.2022.04.061. [PMID: 35523300] - Christo Tsilifis, Ina Schim van der Loeff, Eleri Williams, Stephen Owens, Steven Powell, Andrew Gennery, Mary Slatter. BCG lymphadenitis: a potential complication of immune reconstitution following haematopoietic stem cell transplant.
Archives of disease in childhood. Education and practice edition.
2022 08; 107(4):274-275. doi:
10.1136/archdischild-2020-320883. [PMID: 33355234] - Wan-Mei Song, Shi-Jin Li, Jin-Yue Liu, Qi Fu, Ting-Ting Xu, Ning Ning Tao, Qian-Yun Zhang, Si-Qi Liu, Qi-Qi An, Xue-Han Zhu, Yao Liu, Chun-Bao Yu, Yi-Fan Li, Jihua Dong, Huai-Chen Li. Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004-2020.
BMJ open.
2022 07; 12(7):e059149. doi:
10.1136/bmjopen-2021-059149. [PMID: 35902191] - Alessandro Brancatella, Daniele Cappellani, Martin Kaufmann, Antonella Semeraro, Simona Borsari, Chiara Sardella, Fulvia Baldinotti, Maria Adelaide Caligo, Glenville Jones, Claudio Marcocci, Filomena Cetani. Long-term Efficacy and Safety of Rifampin in the Treatment of a Patient Carrying a CYP24A1 Loss-of-Function Variant.
The Journal of clinical endocrinology and metabolism.
2022 07; 107(8):e3159-e3166. doi:
10.1210/clinem/dgac315. [PMID: 35569070] - Ryuta Asaumi, Ken-Ichi Nunoya, Yoshiyuki Yamaura, Kunal S Taskar, Yuichi Sugiyama. Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney.
CPT: pharmacometrics & systems pharmacology.
2022 07; 11(7):919-933. doi:
10.1002/psp4.12807. [PMID: 35570332] - Anna S Dean, Olga Tosas Auguet, Philippe Glaziou, Matteo Zignol, Nazir Ismail, Tereza Kasaeva, Katherine Floyd. 25 years of surveillance of drug-resistant tuberculosis: achievements, challenges, and way forward.
The Lancet. Infectious diseases.
2022 07; 22(7):e191-e196. doi:
10.1016/s1473-3099(21)00808-2. [PMID: 35248168] - Medha Bargaje, Sandeep Bharaswadkar, Sathiyanarayanan Lohidasan, Bijoy Kumar Panda. Plasma drug concentrations of 4-drug fixed-dose combination regimen and its efficacy for treatment of pulmonary tuberculosis under National Tuberculosis Elimination Programme: A prospective pilot study.
The Indian journal of tuberculosis.
2022 Jul; 69(3):311-319. doi:
10.1016/j.ijtb.2021.04.002. [PMID: 35760480] - Tao Ji, Xuejun Chen, Swamy Yeleswaram. Evaluation of drug-drug interaction potential for pemigatinib using physiologically based pharmacokinetic modeling.
CPT: pharmacometrics & systems pharmacology.
2022 07; 11(7):894-905. doi:
10.1002/psp4.12805. [PMID: 35506332] - İlknur Yurtsever, Ünsal Veli Üstündağ, İsmail Ünal, Perihan Seda Ateş, Ebru Emekli-Alturfan. Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish.
Drug and chemical toxicology.
2022 Jul; 45(4):1544-1551. doi:
10.1080/01480545.2020.1846549. [PMID: 33187454] - Martina Gruppuso, Benedetta Guagnini, Luigi Musciacchio, Francesca Bellemo, Gianluca Turco, Davide Porrelli. Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core-Shell Electrospun Membranes: A Proof of Concept.
ACS applied materials & interfaces.
2022 Jun; 14(24):27599-27612. doi:
10.1021/acsami.2c04849. [PMID: 35671365] - Amedeo De Nicolò, Andrea Calcagno, Ilaria Motta, Elisa De Vivo, Antonio D'Avolio, Giovanni Di Perri, Lubbe Wiesner, Isma-Eel Ebrahim, Gary Maartens, Catherine Orrell, Helen McIlleron. The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study.
Antimicrobial agents and chemotherapy.
2022 06; 66(6):e0013622. doi:
10.1128/aac.00136-22. [PMID: 35583344] - Aida N Kawuma, Roeland E Wasmann, Kelly E Dooley, Marta Boffito, Gary Maartens, Paolo Denti. Population Pharmacokinetic Model and Alternative Dosing Regimens for Dolutegravir Coadministered with Rifampicin.
Antimicrobial agents and chemotherapy.
2022 06; 66(6):e0021522. doi:
10.1128/aac.00215-22. [PMID: 35604212] - Catherine Berry, Philipp du Cros, Katherine Fielding, Suzanne Gajewski, Emil Kazounis, Timothy D McHugh, Corinne Merle, Ilaria Motta, David A J Moore, Bern-Thomas Nyang'wa. TB-PRACTECAL: study protocol for a randomised, controlled, open-label, phase II-III trial to evaluate the safety and efficacy of regimens containing bedaquiline and pretomanid for the treatment of adult patients with pulmonary multidrug-resistant tuberculosis.
Trials.
2022 Jun; 23(1):484. doi:
10.1186/s13063-022-06331-8. [PMID: 35698158] - David Fage, Reda Brilleman, Guillaume Deprez, Marie-Christine Payen, Frédéric Cotton. Development, validation and clinical use of a LC-MS/MS method for the simultaneous determination of the nine main antituberculosis drugs in human plasma.
Journal of pharmaceutical and biomedical analysis.
2022 Jun; 215(?):114776. doi:
10.1016/j.jpba.2022.114776. [PMID: 35462286] - Vishal Sharma, Anoop Singh, Mohita Gaur, Deepti Rawat, Anjali Yadav, Rajan, Chanchal Kumar, Mandira Varma-Basil, Sheelu Lohiya, Vishal Khanna, Ashwani Khanna, Anil Chaudhry, Yogendra Singh, Richa Misra. Evaluating the efficacy of stool sample on Xpert MTB/RIF Ultra and its comparison with other sample types by meta-analysis for TB diagnostics.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2022 Jun; 41(6):893-906. doi:
10.1007/s10096-022-04449-w. [PMID: 35508741] - Akemi Oshiro Guirelli, Thayná Rosa Bispo, Daniela Rodrigues Colpas, Ivana Barros de Campos, Erica Chimara, Maria Cecília Cergole-Novella, Itatiana Ferreira Rodart, Valéria Dos Santos Candido, Paula Jimena Segura-Ramírez, Vilma Dos Santos Menezes Gaiotto Daros, Andreia Moreira Dos Santos Carmo. Tuberculosis/COVID-19 co-infection detected in a single sputum sample using a rapid molecular test.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].
2022 Jun; 53(2):633-639. doi:
10.1007/s42770-021-00677-y. [PMID: 35107805] - Daniel Van Aartsen, Museveni Justine, Estomih Mduma, Stellah G Mpagama, Mohammad H Alshaer, Charles A Peloquin, Buliga Mujaga, Athanasia Maro, Jean Gratz, Margaret Kosek, Jie Liu, Elizabeth T Rogawski McQuade, Eric R Houpt, Tania A Thomas, Scott K Heysell. Enteropathogen spectrum and effect on antimycobacterial pharmacokinetics among children with tuberculosis in rural Tanzania: a prospective cohort study.
The Lancet. Microbe.
2022 Jun; 3(6):e408-e416. doi:
10.1016/s2666-5247(21)00308-6. [PMID: 35659902] - Jatinder K Mukker, George Dukes, Max Tolkoff, Lisi Wang, Cristina Almansa, Susanna Y Huh, Mitsuhiro Nishihara, Diane Ramsden, Chunlin Chen. The pharmacokinetics of oral trazpiroben (TAK-906) after organic anion transporting polypeptide 1B1/1B3 inhibition: A phase I, randomized study.
Clinical and translational science.
2022 06; 15(6):1532-1543. doi:
10.1111/cts.13274. [PMID: 35460165] - Heidi Dahl Christensen, Ann Brinch Madelung, Anne Lerberg Nielsen, Fredrikke Christie Knudtzen. Severe Bartonella henselae bone infection in a kidney transplanted young man.
BMJ case reports.
2022 May; 15(5):. doi:
10.1136/bcr-2021-247805. [PMID: 35584856] - Saki Izumi, Yoshitane Nozaki, Wooin Lee, Yuichi Sugiyama. Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A.
Drug metabolism and disposition: the biological fate of chemicals.
2022 05; 50(5):541-551. doi:
10.1124/dmd.121.000783. [PMID: 35241487] - Lu Liu, Le Yang, Wei Li, Xiaoyan Chen. Simultaneous determination of almonertinib and its active metabolite HAS-719 in human plasma by LC-MS/MS: Evaluation of pharmacokinetic interactions.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 May; 1197(?):123231. doi:
10.1016/j.jchromb.2022.123231. [PMID: 35344780] - Xiaoxing Wang, Martin E Dowty, Ann Wouters, Svitlana Tatulych, Carol A Connell, Vu H Le, Sakambari Tripathy, Melissa T O'Gorman, Jennifer A Winton, Natalie Yin, Hernan Valdez, Bimal K Malhotra. Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals.
European journal of drug metabolism and pharmacokinetics.
2022 May; 47(3):419-429. doi:
10.1007/s13318-021-00745-6. [PMID: 35226304] - Xiaocui Wu, Guangkun Tan, Wei Sha, Haican Liu, Jinghui Yang, Yinjuan Guo, Xin Shen, Zheyuan Wu, Hongbo Shen, Fangyou Yu. Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures.
Microbiology spectrum.
2022 04; 10(2):e0251621. doi:
10.1128/spectrum.02516-21. [PMID: 35311541] - Clara Bay, Hisham A El-Masri. A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis.
Toxicology letters.
2022 Apr; 359(?):46-54. doi:
10.1016/j.toxlet.2022.02.002. [PMID: 35143881] - Yuliia Sereda, Oleksandr Korotych, Dzmitry Klimuk, Dzmitry Zhurkin, Varvara Solodovnikova, Malgorzata Grzemska, Viatcheslav Grankov, Hennadz Hurevich, Askar Yedilbayev, Alena Skrahina. Tuberculosis Co-Infection Is Common in Patients Requiring Hospitalization for COVID-19 in Belarus: Mixed-Methods Study.
International journal of environmental research and public health.
2022 04; 19(7):. doi:
10.3390/ijerph19074370. [PMID: 35410048] - Yan Cao, Tao Wang, Ke He, Juanmin Xue, Xinjing Wang, Jianqin Liang. High-dose rifampicin for the treatment of tuberculous meningitis: a meta-analysis of randomized controlled trials.
Journal of clinical pharmacy and therapeutics.
2022 Apr; 47(4):445-454. doi:
10.1111/jcpt.13555. [PMID: 34897758] - Vivek Kumar Singh, Vikrant Nain, Mullapudi Lakshmi Venkata Phanindra, Sellamuthu Gothandapani, Sushil Satish Chhapekar, Rohini Sreevathsa, K R S Sambasiva Rao, Polumetla Ananda Kumar, Awanish Kumar. Rifampicin Increases Expression of Plant Codon-Optimized Bacillus thuringiensis δ-Endotoxin Genes in Escherichia coli.
The protein journal.
2022 04; 41(2):327-336. doi:
10.1007/s10930-022-10043-y. [PMID: 35119603] - Hiroaki Takubo, Koji Bessho, Ryosuke Watari, Ryota Shigemi. Quantitative prediction of OATP1B-mediated drug-drug interactions using endogenous biomarker coproporphyrin I.
Xenobiotica; the fate of foreign compounds in biological systems.
2022 Apr; 52(4):397-404. doi:
10.1080/00498254.2022.2085210. [PMID: 35638858] - Lu Liu, Wei Li, Le Yang, Zi-Tao Guo, Hao Xue, Ning-Jie Xie, Xiao-Yan Chen. Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers.
Acta pharmacologica Sinica.
2022 Apr; 43(4):1082-1090. doi:
10.1038/s41401-021-00710-8. [PMID: 34267345] - Roosa Rahunen, Outi Kummu, Vesa Koivukangas, Heidi Hautajärvi, Jukka Hakkola, Jaana Rysä, Janne Hukkanen. Pregnane X Receptor‒4β-Hydroxycholesterol Axis in the Regulation of Overweight- and Obesity-Induced Hypertension.
Journal of the American Heart Association.
2022 03; 11(6):e023492. doi:
10.1161/jaha.121.023492. [PMID: 35229613] - David Ekqvist, Anna Bornefall, Daniel Augustinsson, Martina Sönnerbrandt, Michaela Jonsson Nordvall, Mats Fredrikson, Björn Carlsson, Mårten Sandstedt, Ulrika S H Simonsson, Jan-Willem C Alffenaar, Jakob Paues, Katarina Niward. Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP).
BMJ open.
2022 03; 12(3):e054788. doi:
10.1136/bmjopen-2021-054788. [PMID: 35273049] - Maiara Camotti Montanha, Francesc Fabrega, Alice Howarth, Nicolas Cottura, Hannah Kinvig, Fazila Bunglawala, Andrew Lloyd, Paolo Denti, Catriona Waitt, Marco Siccardi. Predicting Drug-Drug Interactions between Rifampicin and Ritonavir-Boosted Atazanavir Using PBPK Modelling.
Clinical pharmacokinetics.
2022 03; 61(3):375-386. doi:
10.1007/s40262-021-01067-1. [PMID: 34635995] - Rasoul Mirzaei, Mohammad Yousef Alikhani, Carla Renata Arciola, Iraj Sedighi, Rasoul Yousefimashouf, Kamran Pooshang Bagheri. Prevention, inhibition, and degradation effects of melittin alone and in combination with vancomycin and rifampin against strong biofilm producer strains of methicillin-resistant Staphylococcus epidermidis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Mar; 147(?):112670. doi:
10.1016/j.biopha.2022.112670. [PMID: 35123230] - Darya V Urusova, Joseph A Merriman, Ananya Gupta, Liang Chen, Barun Mathema, Michael G Caparon, Shabaana A Khader. Rifampin resistance mutations in the rpoB gene of Enterococcus faecalis impact host macrophage cytokine production.
Cytokine.
2022 03; 151(?):155788. doi:
10.1016/j.cyto.2021.155788. [PMID: 35030469] - Kenedy Kiyimba, Emmanuel Tiyo Ayikobua, Daniel Chans Mwandah, Samuel Baker Obakiro. Assessing the protective effect of Crassocephalum vitellinum against Rifampicin-induced hepatotoxicity in Wistar rats.
African health sciences.
2022 Mar; 22(1):352-360. doi:
10.4314/ahs.v22i1.43. [PMID: 36032444] - Carlijn H C Litjens, Laurens F M Verscheijden, Celine Bolwerk, Rick Greupink, Jan B Koenderink, Petra H H van den Broek, Jeroen J M W van den Heuvel, Elin M Svensson, Martin J Boeree, Cecile Magis-Escurra, Wouter Hoefsloot, Reinout van Crevel, Arjan van Laarhoven, Jakko van Ingen, Saskia Kuipers, Rovina Ruslami, David M Burger, Frans G M Russel, Rob E Aarnoutse, Lindsey H M Te Brake. Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling.
Journal of clinical pharmacology.
2022 03; 62(3):385-396. doi:
10.1002/jcph.1972. [PMID: 34554580] - Rong Ma, Jianqun Zhang, Zhen Chen, He Ma, Xiaoyin Liu, Simin Liang, Peng Wu, Zhaohui Ge. Treatment of spinal tuberculosis in rabbits using bovine serum albumin nanoparticles loaded with isoniazid and rifampicin.
Neurological research.
2022 Mar; 44(3):268-274. doi:
10.1080/01616412.2021.1979749. [PMID: 34581255] - A David Rodrigues, Linda S Wood, Manoli Vourvahis, Andrew Rowland. Leveraging Human Plasma-Derived Small Extracellular Vesicles as Liquid Biopsy to Study the Induction of Cytochrome P450 3A4 by Modafinil.
Clinical pharmacology and therapeutics.
2022 02; 111(2):425-434. doi:
10.1002/cpt.2440. [PMID: 34623637] - Jing Chen, Hongbo Wu, Xudong Tang, Lei Chen. 4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress.
Bioengineered.
2022 02; 13(2):2866-2877. doi:
10.1080/21655979.2021.2024970. [PMID: 35045794] - Song Ren, Karthick Vishwanathan, Mireille Cantarini, Paul Frewer, Indira Hara, Graeme Scarfe, Wendy Burke, Stein Schalkwijk, Yan Li, David Han, Ronald Goldwater. Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.
British journal of clinical pharmacology.
2022 02; 88(2):655-668. doi:
10.1111/bcp.14994. [PMID: 34322894] - Glauco Henrique Balthazar Nardotto, Valdes Roberto Bollela, Adriana Rocha, Oscar Della Pasqua, Vera Lucia Lanchote. No implication of HIV coinfection on the plasma exposure to rifampicin, pyrazinamide, and ethambutol in tuberculosis patients.
Clinical and translational science.
2022 02; 15(2):514-523. doi:
10.1111/cts.13169. [PMID: 34670022] - Vinay Bharadwaj Tatipamula, Satya Sowbhagya Priya Annam. Antimycobacterial activity of acetone extract and isolated metabolites from folklore medicinal lichen Usnea laevis Nyl. against drug-sensitive and multidrug-resistant tuberculosis strains.
Journal of ethnopharmacology.
2022 Jan; 282(?):114641. doi:
10.1016/j.jep.2021.114641. [PMID: 34536516] - Josefine Slater, Maiken Stilling, Pelle Hanberg, Mathias Alrø Fichtner Bendtsen, Andrea René Jørgensen, Kjeld Søballe, Nis Pedersen Jørgensen, Mats Bue. Moxifloxacin Concentrations in the Knee Joint, Tibial Bone, and Soft Tissue When Combined with Rifampicin: A Randomized Porcine Microdialysis Study.
The Journal of bone and joint surgery. American volume.
2022 01; 104(1):49-54. doi:
10.2106/jbjs.21.00549. [PMID: 34731098] - Heba Nabil, Outi Kummu, Petri Lehenkari, Jaana Rysä, Juha Risteli, Jukka Hakkola, Janne Hukkanen. Rifampicin induces the bone form of alkaline phosphatase in humans.
Basic & clinical pharmacology & toxicology.
2022 Jan; 130 Suppl 1(?):81-94. doi:
10.1111/bcpt.13586. [PMID: 33851518] - Luiz Roberto de Sousa Ulisses, Helen Souto Siqueira Cardoso, Inara Creão Costa Alves, Isabela Novais Medeiros, Camilla Garcia de Oliveira, Tiago Martins de Almeida, Fabíola Fernandes Dos Santos Castro, Claudia Neto Gonçalves Neves da Silva, Laura Viana de Lima, Renata Pereira Fontoura, Eduardo Resende Sousa E Silva, Pollyana Lopes de Araújo, Gustavo de Sousa Arantes Ferreira. Donor-derived TB after kidney transplantation: a case report.
Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia.
2022 Jan; 44(1):126-129. doi:
10.1590/2175-8239-jbn-2020-0117. [PMID: 33836038] - Joung Ha Park, Bonhan Koo, Min Jae Kim, Hyo Joo Lee, Hye-Hee Cha, Ji Yeun Kim, Sei Won Lee, Yong Shin, Sung-Han Kim. Utility of plasma cell-free DNA detection using homobifunctional imidoesters using a microfluidic system for diagnosing active tuberculosis.
Infectious diseases (London, England).
2022 Jan; 54(1):46-52. doi:
10.1080/23744235.2021.1963839. [PMID: 34405761] - Akiko Watanabe, Tomoko Ishizuka, Makiko Yamada, Yoshiyuki Igawa, Takako Shimizu, Hitoshi Ishizuka. Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment.
European journal of clinical pharmacology.
2022 Jan; 78(1):65-73. doi:
10.1007/s00228-021-03194-x. [PMID: 34415382] - L Liu, Y Yang, W Li, Y Li, X Jiang, L Wang. Tanshinone IIA alleviate rifampicin-induced cholestasis by regulating the expression and function of bile salt export pump.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221097365. doi:
10.1177/09603271221097365. [PMID: 35544702] - Osamu Iketani, Akari Komeya, Yuki Enoki, Kazuaki Taguchi, Shunsuke Uno, Yoshifumi Uwamino, Kazuaki Matsumoto, Junko Kizu, Naoki Hasegawa. Impact of rifampicin on the pharmacokinetics of clarithromycin and 14-hydroxy clarithromycin in patients with multidrug combination therapy for pulmonary Mycobacterium avium complex infection.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Jan; 28(1):61-66. doi:
10.1016/j.jiac.2021.10.003. [PMID: 34706852] - David W Haas, Rosie Mngqibisa, Jose Francis, Helen McIlleron, Jennifer A Robinson, Michelle A Kendall, Paxton Baker, Sajeeda Mawlana, Sharlaa Badal-Faesen, Francis Angira, Ayotunde Omoz-Oarhe, Wadzanai P Samaneka, Paolo Denti, Susan E Cohn. Pharmacogenetics of interaction between depot medroxyprogesterone acetate and efavirenz, rifampicin, and isoniazid during treatment of HIV and tuberculosis.
Pharmacogenetics and genomics.
2022 01; 32(1):24-30. doi:
10.1097/fpc.0000000000000448. [PMID: 34369424] - Michael Desch, Glen Wunderlich, Markus Goettel, Sophia Goetz, Karl-Heinz Liesenfeld, Tom S Chan, Holger Rosenbrock, Regina Sennewald, Jasmin Link, Sascha Keller, Sven Wind. Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor.
European journal of drug metabolism and pharmacokinetics.
2022 Jan; 47(1):91-103. doi:
10.1007/s13318-021-00723-y. [PMID: 34716565] - Yaogeng Wang, Rolf W Sparidans, Jing Wang, Wenlong Li, Maria C Lebre, Jos H Beijnen, Alfred H Schinkel. Rifampin and ritonavir increase oral availability and elacridar enhances overall exposure and brain accumulation of the NTRK inhibitor larotrectinib.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2022 Jan; 170(?):197-207. doi:
10.1016/j.ejpb.2021.12.007. [PMID: 34952136] - M A Buabeid, E-S A Arafa, T Rani, F U D Ahmad, H Ahmed, W Hassan, G Murtaza. Effects of Solanum lycopersicum L. (tomato) against isoniazid and rifampicin induced hepatotoxicity in wistar albino rats.
Brazilian journal of biology = Revista brasleira de biologia.
2022; 84(?):e254552. doi:
10.1590/1519-6984.254552. [PMID: 35137848] - Rovina Ruslami, Fajri Gafar, Vycke Yunivita, Ida Parwati, Ahmad R Ganiem, Rob E Aarnoutse, Bob Wilffert, Jan-Willem C Alffenaar, Heda M Nataprawira. Pharmacokinetics and safety/tolerability of isoniazid, rifampicin and pyrazinamide in children and adolescents treated for tuberculous meningitis.
Archives of disease in childhood.
2022 01; 107(1):70-77. doi:
10.1136/archdischild-2020-321426. [PMID: 34183327] - Wenkai Chen, Wenping Lin, Naichun Yu, Linlin Zhang, Zuoxing Wu, Yongjie Chen, Zongguang Li, Fengqing Gong, Na Li, Xiaohui Chen, Xu He, Yue Wu, Xiangchen Zeng, Yuting Yueh, Ren Xu, Guangrong Ji. Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect.
International journal of nanomedicine.
2022; 17(?):5431-5446. doi:
10.2147/ijn.s379917. [PMID: 36426375] - Natalia E Castillo Almeida, Ryan W Stevens, Pooja Gurram, Christina G Rivera, Gina A Suh. Cefazolin and rifampin: A coagulopathy-inducing combination.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2021 12; 78(24):2204-2208. doi:
10.1093/ajhp/zxab210. [PMID: 34000006] - Deepak Yadav, Sumanpreet Kaur, Dibyajyoti Banerjee, Rajasri Bhattacharyya. Metformin and Rifampicin combination augments active to latent tuberculosis conversion: A computational study.
Biotechnology and applied biochemistry.
2021 Dec; 68(6):1307-1312. doi:
10.1002/bab.2052. [PMID: 33059386] - Xian Pan, Shinji Yamazaki, Sibylle Neuhoff, Mian Zhang, Venkatesh Pilla Reddy. Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P-glycoprotein-cytochrome P450 3A4 dual substrates.
CPT: pharmacometrics & systems pharmacology.
2021 12; 10(12):1485-1496. doi:
10.1002/psp4.12717. [PMID: 34729944] - Valérie Zeller, Sophie Magreault, Beate Heym, Dominique Salmon, Marie-Dominique Kitzis, Eliane Billaud, Simon Marmor, Anne-Sophie Jannot, Laurence Salomon, Vincent Jullien. Influence of the clindamycin administration route on the magnitude of clindamycin-rifampicin interaction: a prospective pharmacokinetic study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2021 Dec; 27(12):1857.e1-1857.e7. doi:
10.1016/j.cmi.2021.04.017. [PMID: 33915288] - Oren Gordon, Donald E Lee, Bessie Liu, Brooke Langevin, Alvaro A Ordonez, Dustin A Dikeman, Babar Shafiq, John M Thompson, Paul D Sponseller, Kelly Flavahan, Martin A Lodge, Steven P Rowe, Robert F Dannals, Camilo A Ruiz-Bedoya, Timothy D Read, Charles A Peloquin, Nathan K Archer, Lloyd S Miller, Kimberly M Davis, Jogarao V S Gobburu, Sanjay K Jain. Dynamic PET-facilitated modeling and high-dose rifampin regimens for Staphylococcus aureus orthopedic implant-associated infections.
Science translational medicine.
2021 12; 13(622):eabl6851. doi:
10.1126/scitranslmed.abl6851. [PMID: 34851697] - Stephanie Minnies, Byron W P Reeve, Loren Rockman, Georgina Nyawo, Charissa C Naidoo, Natasha Kitchin, Cornelia Rautenbach, Colleen A Wright, Andrew Whitelaw, Pawel Schubert, Robin M Warren, Grant Theron. Xpert MTB/RIF Ultra Is Highly Sensitive for the Diagnosis of Tuberculosis Lymphadenitis in a High-HIV Setting.
Journal of clinical microbiology.
2021 11; 59(12):e0131621. doi:
10.1128/jcm.01316-21. [PMID: 34469182] - Anna Olsson, Marcus Hong, Hissa Al-Farsi, Christian G Giske, Pernilla Lagerbäck, Thomas Tängdén. Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases.
Antimicrobial agents and chemotherapy.
2021 11; 65(12):e0106521. doi:
10.1128/aac.01065-21. [PMID: 34516251] - Temidayo Ogunmoyole, Ayomide Micheal Ola-Awe, Omotola Grace Fatile. Ethanolic extract of Mucuna pruriens leaves ameliorates carbon tetrachloride and rifampicin-induced hepatotoxicity and nephrotoxicity in wistar albino rat.
BMC complementary medicine and therapies.
2021 Nov; 21(1):282. doi:
10.1186/s12906-021-03455-3. [PMID: 34789221] - Agnija Kivrane, Solveiga Grinberga, Eduards Sevostjanovs, Viktorija Igumnova, Ilva Pole, Anda Viksna, Dace Bandere, Alvils Krams, Andra Cirule, Osvalds Pugovics, Renate Ranka. LC-MS/MS method for simultaneous quantification of the first-line anti-tuberculosis drugs and six primary metabolites in patient plasma: Implications for therapeutic drug monitoring.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Nov; 1185(?):122986. doi:
10.1016/j.jchromb.2021.122986. [PMID: 34688197] - Bo-Huang Liou, Chih-Ning Cheng, Ya-Ting Lin, Yu-Jou Lin, Yu-Chung Chuang, Kuan-Yin Lin, Wen-Chun Liu, Shu-Wen Lin, Ching-Hua Kuo, Hsin-Yun Sun, Chien-Ching Hung. Short-course daily isoniazid and rifapentine for latent tuberculosis infection in people living with HIV who received coformulated bictegravir/emtricitabine/tenofovir alafenamide.
Journal of the International AIDS Society.
2021 11; 24(11):e25844. doi:
10.1002/jia2.25844. [PMID: 34822220] - Sarit Cohen-Rabbie, Li Zhou, Karthick Vishwanathan, Martin Wild, Sherrie Xu, Tomoko Freshwater, Lokesh Jain, Stein Schalkwijk, Helen Tomkinson, Diansong Zhou. Physiologically Based Pharmacokinetic Modeling for Selumetinib to Evaluate Drug-Drug Interactions and Pediatric Dose Regimens.
Journal of clinical pharmacology.
2021 11; 61(11):1493-1504. doi:
10.1002/jcph.1935. [PMID: 34196005] - Lloyd Tanner, Gabriel T Mashabela, Charles C Omollo, Timothy J de Wet, Christopher J Parkinson, Digby F Warner, Richard K Haynes, Lubbe Wiesner. Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy.
Microbiology spectrum.
2021 10; 9(2):e0043421. doi:
10.1128/spectrum.00434-21. [PMID: 34585951]