Methylphenobarbital (BioDeep_00000002731)

 

Secondary id: BioDeep_00001868112

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione

化学式: C13H14N2O3 (246.1004)
中文名称: 甲基苯巴比妥
谱图信息: 最多检出来源 Mus musculus(urine) 23.68%

分子结构信息

SMILES: CCC1(C(=O)NC(=O)N(C)C1=O)C1=CC=CC=C1
InChI: InChI=1S/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18)

描述信息

Methylphenobarbital is only found in individuals that have used or taken this drug. It is a barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital. [PubChem]Methylphenobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AA - Barbiturates and derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C67084 - Barbiturate
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

27 个代谢物同义名

5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione; 5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trione; Sanofi synthelabo brand OF mephobarbital; 5-Ethyl-1-methyl-5-phenylbarbituric acid; 5-Ethyl-1-methyl-5-phenylbarbitic acid; N-Methylethylphenylbarbituric acid; 5-Ethyl-1-methyl-5-phenylbarbitate; N-Ethylmethylphenylbarbituric acid; Sanofi brand OF mephobarbital; Methylphenylbarbituric acid; N-Methylphenolbarbitol; N-Methylphenobarbital; Methylphenobarbitalum; Methylphenobarbitonum; 1-Methylphenobarbital; Methyl phenobarbitone; Methylphenolbarbital; Methylphenobarbitone; Methylphenobarbital; Metilfenobarbitale; Metilfenobarbital; Mephobarbitone; Mephobarbital; Prominal; Mebaral; Mephobarbital



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 CA1, CYP1A1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, FABP1, PTP4A2
Peripheral membrane protein 3 CYP1A1, CYP2B6, CYP2E1
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 10 CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Nucleus 3 FABP1, NR1I2, PTP4A2
cytosol 4 CA1, CLCN5, FABP1, PTP4A2
dendrite 1 ADORA3
nuclear body 1 NR1I2
nucleoplasm 2 FABP1, NR1I2
Cell membrane 2 ADORA3, CLCN5
Multi-pass membrane protein 2 ADORA3, CLCN5
Golgi apparatus membrane 1 CLCN5
Synapse 1 ADORA3
Golgi apparatus 1 CLCN5
Golgi membrane 2 CLCN5, INS
lysosomal membrane 1 CLCN5
mitochondrial inner membrane 3 CYP1A1, CYP2E1, OTC
presynaptic membrane 1 ADORA3
synaptic vesicle 1 CLCN5
plasma membrane 8 ADORA3, CLCN5, CYP2C19, CYP2C8, CYP2C9, ICAM3, PRSS27, PTP4A2
Membrane 5 CLCN5, CYP2A6, CYP2D6, CYP3A4, ICAM3
extracellular exosome 3 CA1, FABP1, ICAM3
endoplasmic reticulum 1 CYP2D6
extracellular space 1 INS
Schaffer collateral - CA1 synapse 1 ADORA3
mitochondrion 3 CYP1A1, CYP2D6, OTC
protein-containing complex 1 FABP1
intracellular membrane-bounded organelle 10 CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Microsome membrane 7 CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4
Single-pass type I membrane protein 1 ICAM3
Secreted 1 INS
extracellular region 2 INS, PRSS27
Single-pass membrane protein 1 CYP2D6
Mitochondrion matrix 1 OTC
mitochondrial matrix 1 OTC
transcription regulator complex 1 NR1I2
Early endosome 2 CLCN5, PTP4A2
apical part of cell 1 CLCN5
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
peroxisomal matrix 1 FABP1
chromatin 1 NR1I2
endosome lumen 1 INS
intermediate filament cytoskeleton 1 NR1I2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
cytoplasmic microtubule 1 CYP2A6
apical cortex 1 FABP1


文献列表

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