Adrenic acid (BioDeep_00000002672)

 

Secondary id: BioDeep_00001871871

human metabolite Endogenous blood metabolite


代谢物信息卡片


7,10,13,16-Docosatetraenoic acid (van) adrenic acid

化学式: C22H36O2 (332.2715)
中文名称: 廿二碳四烯酸, 7Z,10Z,13Z,16Z-二十二碳四烯酸, 顺-7,10,13,16-二十二碳四烯酸
谱图信息: 最多检出来源 Homo sapiens(blood) 20.65%

分子结构信息

SMILES: C(CC(=O)O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC
InChI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)

描述信息

Adrenic acid, also known as 7,10,13,16-docosatetraenoic acid or adrenate, is a member of the class of compounds known as very long-chain fatty acids. Very long-chain fatty acids are fatty acids with an aliphatic tail that contains at least 22 carbon atoms. Adrenic acid is practically insoluble (in water) and a weakly acidic compound (based on its pKa). Adrenic acid can be found in blood and in human myelin tissue. Within the cell, adrenic acid is primarily located in the cytoplasm, in the membrane (predicted from logP), and in the peroxisome. It can also be found in the extracellular space. In humans, adrenic acid is involved in alpha-linolenic acid and linoleic acid metabolism. Docosatetraenoic acid designates any straight chain 22:4 fatty acid. In particular, all-cis-7,10,13,16-docosatetraenoic acid is an ω-6 fatty acid with the trivial name adrenic acid (AdA). This is a naturally occurring polyunsaturated fatty acid formed through a 2-carbon chain elongation of arachidonic acid. It is one of the most abundant fatty acids in the early human brain. This unsaturated fatty acid is also metabolized by cells into biologically active products, such as dihomoprostaglandins and dihomo-epoxyeicosatrienoic acids (dihomo-EETs) (Wikipedia). Adrenic acid, which is a prostacyclin inhibitor, appears to be a potential prothrombotic agent (PMID: 1642692).
Adrenic acid, which is a prostacyclin inhibitor, appears to be potential prothrombotic agent. (PMID 1642692) [HMDB]

同义名列表

23 个代谢物同义名

7,10,13,16-Docosatetraenoic acid (van) adrenic acid; (7Z,10Z,13Z,16Z)-Docosa-7,10,13,16-tetraenoic acid; cis,cis,cis,cis-Docosa-7,10,13,16-tetraensaeure; 7,10,13,16-Docosatetraenoic acid (van) adrenate; (7Z,10Z,13Z,16Z)-Docosa-7,10,13,16-tetraenoate; all-cis-7,10,13,16-Docosatetraenoic acid; all-cis-7,10,13,16-Docosatetraenoate; 7Z,10Z,13Z,16Z-docosatetraenoic acid; (7Z,10Z,13Z,16Z)-Docosatetraenoate; Docosa-7,10,13,16-tetraenoic acid; 7Z,10Z,13Z,16Z-Docosatetraenoate; 7,10,13,16-docosatetraenoic acid; 7,10,13,16-Docosatetraenoate; FA(22:4(7Z,10Z,13Z,16Z)); Adrenic acid, (Z)-isomer; docosatetraenoic acid; C22:4n-6,9,12,15; adrenic acid; Adrenate; FA 22:4; 22:4n6; 7Z,10Z,13Z,16Z-Docosatetraenoic acid; Adrenic acid



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

7 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(6)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ACSL4, GPX1, PLA2G12A
Endoplasmic reticulum membrane 8 ACSL4, CD4, DEGS1, ELOVL2, ELOVL5, FADS1, FADS2, SCD
Mitochondrion membrane 1 DEGS1
Nucleus 1 PPARA
cytosol 3 ACOX1, GPX1, IL1B
dendrite 2 ELOVL2, ELOVL5
mitochondrial membrane 1 DEGS1
nucleoplasm 1 PPARA
Cell membrane 3 ACSL4, CD4, CD8A
Multi-pass membrane protein 6 DEGS1, ELOVL2, ELOVL5, FADS1, FADS2, SCD
cell surface 1 F3
Golgi membrane 1 INS
neuronal cell body 2 ELOVL2, ELOVL5
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
plasma membrane 7 ACSL4, CD4, CD8A, DEGS1, F2, F3, FADS2
terminal bouton 1 GHRH
Membrane 9 ACOX1, ACSL4, DEGS1, ELOVL2, ELOVL5, F3, FADS1, FADS2, SCD
extracellular exosome 3 ACSL4, F2, SOD2
endoplasmic reticulum 5 ACSL4, DEGS1, ELOVL2, ELOVL5, SCD
extracellular space 6 F2, F3, GHRH, IL1B, IL6, INS
mitochondrion 5 ACSL4, DEGS1, FADS1, GPX1, SOD2
intracellular membrane-bounded organelle 1 FADS1
Microsome membrane 1 ACSL4
Single-pass type I membrane protein 3 CD4, CD8A, F3
Secreted 5 F2, IL1B, IL6, INS, PLA2G12A
extracellular region 7 CD8A, F2, GHRH, IL1B, IL6, INS, PLA2G12A
Mitochondrion outer membrane 1 ACSL4
mitochondrial outer membrane 1 ACSL4
[Isoform 1]: Membrane 1 F3
[Isoform 2]: Secreted 2 CD8A, F3
Mitochondrion matrix 1 SOD2
mitochondrial matrix 2 GPX1, SOD2
external side of plasma membrane 3 CD4, CD8A, F3
perikaryon 1 GHRH
nucleolus 1 SCD
Early endosome 1 CD4
Membrane raft 1 CD4
mitochondrial nucleoid 1 SOD2
Peroxisome 1 ACOX1
peroxisomal matrix 1 ACOX1
peroxisomal membrane 2 ACOX1, ACSL4
collagen-containing extracellular matrix 2 F2, F3
secretory granule 1 IL1B
receptor complex 1 CD8A
chromatin 1 PPARA
blood microparticle 1 F2
Endomembrane system 1 DEGS1
endosome lumen 1 INS
Lipid droplet 1 ACSL4
mitochondria-associated endoplasmic reticulum membrane contact site 1 ACSL4
[Isoform 1]: Endoplasmic reticulum membrane 1 FADS1
Cell projection, dendrite 2 ELOVL2, ELOVL5
specific granule membrane 1 DEGS1
Peroxisome membrane 1 ACSL4
plasma membrane raft 1 CD8A
secretory granule lumen 1 INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 4 CD4, F2, IL6, INS
transport vesicle 1 INS
Single-pass type III membrane protein 1 ACSL4
Secreted, extracellular exosome 1 IL1B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 CD4
[Isoform 1]: Cell membrane 1 CD8A
[Isoform 2]: Endoplasmic reticulum membrane 1 FADS1
T cell receptor complex 2 CD4, CD8A
interleukin-6 receptor complex 1 IL6
serine-type peptidase complex 1 F3
dendritic tree 2 ELOVL2, ELOVL5


文献列表

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