Naloxone (BioDeep_00000002559)

 

Secondary id: BioDeep_00000411060

human metabolite blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


(1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-one

化学式: C19H21NO4 (327.14705060000006)
中文名称: 纳洛酮
谱图信息: 最多检出来源 Homo sapiens(general) 7.38%

分子结构信息

SMILES: C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O
InChI: InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1

描述信息

Naloxone is only found in individuals that have used or taken this drug. It is a specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. [PubChem]While the mechanism of action of naloxone is not fully understood, the preponderance of evidence suggests that naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AH - Peripheral opioid receptor antagonists
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
C78272 - Agent Affecting Nervous System > C681 - Opiate Antagonist

同义名列表

48 个代谢物同义名

(1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-one; (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one; Naloxone hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-isomer; 17-Allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one; Bristol myers squibb brand OF naloxone hydrochloride; Bristol-myers squibb brand OF naloxone hydrochloride; Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-isomer; 17-Allyl-3,14-dihydroxy-4,5α-epoxymorphinan-6-one; 17-Allyl-3,14-dihydroxy-4,5a-epoxymorphinan-6-one; United drug brand OF naloxone hydrochloride; Ratiopharm brand OF naloxone hydrochloride; 1-N-Allyl-14-hydroxynordihydromorphinone; Curamed brand OF naloxone hydrochloride; Lamepro brand OF naloxone hydrochloride; Abello brand OF naloxone hydrochloride; Boots brand OF naloxone hydrochloride; endo Brand OF naloxone hydrochloride; SERB brand OF naloxone hydrochloride; Hydrochloride dihydride, naloxone; Dihydride, naloxone hydrochloride; Naloxone hydrochloride dihydride; Hydrochloride, naloxone; Naloxone hydrochloride; Hydrobromide, naloxone; N-Allylnoroxymorphone; Naloxone hydrobromide; Naloxon ratiopharm; Naloxon-ratiopharm; Naloxonratiopharm; Abello, naloxone; Curamed, naloxon; Naloxon curamed; Naloxone abello; DBL Naloxone; (-)-Naloxone; EN 1530 base; MRZ 2593 BR; MRZ 2593-BR; L-Naloxone; MRZ 2593BR; Nalossone; Naloxonum; Narcanti; Naloxona; Naloxone; Nalone; Narcan; Naloxone



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Minghong Li, Zilei Tang, Liuyan Yu, Yingming Li, Wenyu Ma, Jincun Li, Gang Li, Lei Xiong, Na Lei, Peixin Guo, Yuhuan Xie. The arousal effect of An-Gong-Niu-Huang-Wan on alcoholic-induced coma rats: A research based on EEG. Journal of ethnopharmacology. 2024 Jun; 328(?):117974. doi: 10.1016/j.jep.2024.117974. [PMID: 38467317]
  • Xiangzhen Min, Yan Ma, Yufang Leng, Xiaoxi Li, Jianmin Zhang, Shoucai Xu, Xiuqin Wang, Renjun Lv, Jie Guo, Huaixin Xing. Effects of perioperative low-dose naloxone on the immune system in patients undergoing laparoscopic-assisted total gastrectomy: a randomized controlled trial. BMC anesthesiology. 2024 May; 24(1):172. doi: 10.1186/s12871-024-02524-7. [PMID: 38720250]
  • Ben A Chindo, Melanie-Jayne R Howes, Sawsan Abuhamdah, Danjuma Mallam, Timothy Micah, Rosemary I Awotula, Robin Battison, Paul L Chazot. Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models. Journal of ethnopharmacology. 2024 Mar; 321(?):117500. doi: 10.1016/j.jep.2023.117500. [PMID: 38030022]
  • M Oqal, E Qnais, A Alqudah, O Gammoh. Analgesic effect of the flavonoid herbacetin in nociception animal models. European review for medical and pharmacological sciences. 2023 Dec; 27(23):11236-11248. doi: 10.26355/eurrev_202312_34563. [PMID: 38095373]
  • Gowhar Ali, Nazar Ul Islam, Muhammad Qaim, Rahim Ullah, Muhammad Saeed Jan, Khadija Shabbiri, Muhammad Shafique, Muhammad Ayaz. 2-Hydroxybenzohydrazide as a novel potential candidate against nociception, inflammation, and pyrexia: in vitro, in vivo, and computational approaches. Inflammopharmacology. 2023 Oct; ?(?):. doi: 10.1007/s10787-023-01356-0. [PMID: 37864684]
  • Shahrzad Molavinia, Mehrad Nikravesh, Marzieh Pashmforoosh, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar. Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation. Neurochemical research. 2023 Oct; ?(?):. doi: 10.1007/s11064-023-04043-2. [PMID: 37864024]
  • Adriana Jesus Souza, Francisco S Guimarães, Felipe V Gomes. Cannabidiol attenuates the expression of conditioned place aversion induced by naloxone-precipitated morphine withdrawal through the activation of 5-HT1A receptors. Behavioural brain research. 2023 May; 450(?):114504. doi: 10.1016/j.bbr.2023.114504. [PMID: 37209879]
  • David Peran, Michael Stern, Petr Cernohorsky, Roman Sykora, Stanislav Popela, Frantisek Duska. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon : official journal of the International Society on Toxinology. 2023 Feb; 225(?):107054. doi: 10.1016/j.toxicon.2023.107054. [PMID: 36801215]
  • Geun Joo Choi, Hyun Kang, Oh Haeng Lee, Ji Wung Kwon. Effect of Immature Rubus occidentalis on Postoperative Pain in a Rat Model. Medicina (Kaunas, Lithuania). 2023 Jan; 59(2):. doi: 10.3390/medicina59020264. [PMID: 36837466]
  • Rodrigo Vargas-Ruiz, Rosa Mariana Montiel-Ruiz, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Maribel Lucila Herrera-Ruiz, Jaqueline Molina-Cabrera, María Cruz Juárez-Aragón, Francisco Javier Flores-Murrieta. Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception. Journal of ethnopharmacology. 2023 Jan; 300(?):115756. doi: 10.1016/j.jep.2022.115756. [PMID: 36170958]
  • Zahra Rahimian, SeyedHassan Sadrian, Mina Shahisavandi, Hadi Aligholi, Mohammad M Zarshenas, Alireza Abyar, Zahra Zeraatpisheh, Ali A Asadi-Pooya. Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia. BioMed research international. 2023; 2023(?):4121998. doi: 10.1155/2023/4121998. [PMID: 38089644]
  • Andreza Larissa do Nascimento, Joyce Bezerra Guedes, Wêndeo Kennedy Costa, Bruno Oliveira de Veras, Júlio César Ribeiro de Oliveira Farias de Aguiar, Daniela Maria do Amaral Ferraz Navarro, Maria Tereza Dos Santos Correia, Thiago Henrique Napoleão, Alisson Macário de Oliveira, Márcia Vanusa da Silva. Essential oil from the leaves of Eugenia pohliana DC. (Myrtaceae) alleviate nociception and acute inflammation in mice. Inflammopharmacology. 2022 Dec; 30(6):2273-2284. doi: 10.1007/s10787-022-01067-y. [PMID: 36094726]
  • Yi Zhou, Xihua Lu, Yunfei Zhang, Changsheng Li, Yu Bai, Zhen Zhang. Investigation of the effects of opioids on microglial nitrite and nitric oxide synthase (iNOS) production and phagocytosis during inflammation. Combinatorial chemistry & high throughput screening. 2022 Nov; ?(?):. doi: 10.2174/1386207326666221111093915. [PMID: 36372918]
  • Glenda Laíssa Oliveira de Melo Candeia, Wêndeo Kennedy Costa, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares. Anti-inflammatory, antinociceptive effects and involvement of opioid receptors in the antinociceptive activity of Eugenia uniflora leaves obtained with water, ethanol, and propylene glycol mixture. Journal of ethnopharmacology. 2022 Oct; 296(?):115508. doi: 10.1016/j.jep.2022.115508. [PMID: 35779820]
  • Yingfu Jiao, Fugui Li, Mo Chen, Zhijian He, Zhangxiang Huang, Weifeng Yu, Kangjie Xie. Pre-treatment with morphine prevents lipopolysaccharide-induced acute respiratory distress syndrome in rats via activation of opioid receptors. Experimental cell research. 2022 09; 418(1):113224. doi: 10.1016/j.yexcr.2022.113224. [PMID: 35643178]
  • David Dadiomov, Maria Bolshakova, Melania Mikhaeilyan, Rebecca Trotzky-Sirr. Buprenorphine and naloxone access in pharmacies within high overdose areas of Los Angeles during the COVID-19 pandemic. Harm reduction journal. 2022 Jun; 19(1):69. doi: 10.1186/s12954-022-00651-3. [PMID: 35768817]
  • Leila Mohammadzadeh, Amir Mohammad Alizadeh, Mohammad Sadegh Feiz, Shole Jamali, Mohaddeseh Abedi, Hamid Latifi, Abbas Haghparast. Acute morphine administration, morphine dependence, and naloxone-induced withdrawal syndrome affect the resting-state functional connectivity and Local Field Potentials of the rat prefrontal cortex. Behavioural brain research. 2022 06; 427(?):113859. doi: 10.1016/j.bbr.2022.113859. [PMID: 35337941]
  • Chayanin Kiratipaiboon, Peththa Wadu Dasuni Wasana, Hasriadi, Suchada Sukrong, Nijsiri Ruangrungsri, Pasarapa Towiwat. Herbal root extracts in Ben-Cha-Moon-Yai remedy attenuated pain-like behaviors and inflammation through the opioid and prostaglandin systems. Journal of ethnopharmacology. 2022 May; 290(?):115088. doi: 10.1016/j.jep.2022.115088. [PMID: 35149131]
  • Randa Abdelal, A Raja Banerjee, Suzanne Carlberg-Racich, Neyla Darwaza, Diane Ito, Jessica Shoaff, Josh Epstein. Real-world study of multiple naloxone administration for opioid overdose reversal among bystanders. Harm reduction journal. 2022 05; 19(1):49. doi: 10.1186/s12954-022-00627-3. [PMID: 35596213]
  • M Duska, D Goodman. Implementation of a Prenatal Naloxone Distribution Program to Decrease Maternal Mortality from Opioid Overdose. Maternal and child health journal. 2022 May; 26(5):985-993. doi: 10.1007/s10995-021-03307-z. [PMID: 35029805]
  • Phil Skolnick. Treatment of overdose in the synthetic opioid era. Pharmacology & therapeutics. 2022 05; 233(?):108019. doi: 10.1016/j.pharmthera.2021.108019. [PMID: 34637841]
  • Carly A Baehr, Mariah M Wu, Sujata G Pandit, Jose Arias-Umana, David AuCoin, Marco Pravetoni. Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity. The Journal of pharmacology and experimental therapeutics. 2022 05; 381(2):129-136. doi: 10.1124/jpet.121.001048. [PMID: 35153198]
  • Katherine L Potaka, Rebecca Freeman, Danny Soo, Nam-Anh Nguyen, Tin Fei Sim, Joanna C Moullin. Retrospective analysis of patterns of opioid overdose and interventions delivered at a tertiary hospital emergency department: impact of COVID-19. BMC emergency medicine. 2022 04; 22(1):62. doi: 10.1186/s12873-022-00604-w. [PMID: 35397487]
  • Aaron Dora-Laskey, Joan Kellenberg, Chin Hwa Dahlem, Elizabeth English, Monica Gonzalez Walker, Chad M Brummett, Keith E Kocher. Piloting a statewide emergency department take-home naloxone program: Improving the quality of care for patients at risk of opioid overdose. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2022 04; 29(4):442-455. doi: 10.1111/acem.14435. [PMID: 34962682]
  • Piyusha P Pagare, Mengchu Li, Yi Zheng, Abhishek S Kulkarni, Samuel Obeng, Boshi Huang, Christian Ruiz, James C Gillespie, Rolando E Mendez, David L Stevens, Justin L Poklis, Matthew S Halquist, William L Dewey, Dana E Selley, Yan Zhang. Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists. Journal of medicinal chemistry. 2022 03; 65(6):5095-5112. doi: 10.1021/acs.jmedchem.2c00087. [PMID: 35255685]
  • Tara Gomes, Tonya J Campbell, Sophie A Kitchen, Ria Garg, Nikki Bozinoff, Siyu Men, Mina Tadrous, Charlotte Munro, Tony Antoniou, Dan Werb, Jennifer Wyman. Association Between Increased Dispensing of Opioid Agonist Therapy Take-Home Doses and Opioid Overdose and Treatment Interruption and Discontinuation. JAMA. 2022 03; 327(9):846-855. doi: 10.1001/jama.2022.1271. [PMID: 35230394]
  • Kai Yue, Jonathan L Katz, Xiji Shu. Physiological dependence to mitragynine indicated by a rapid cross-dependence procedure with heroin-dependent mice. Psychopharmacology. 2022 Mar; 239(3):897-908. doi: 10.1007/s00213-022-06080-1. [PMID: 35107609]
  • Akshat Khare, Arsh Sidana, Ammar Mohemmed, Denisha Markelle Allicock, Anna Waterstone, Matthew Aaron Zimmer, Dora Il'yasova. Acceleration of opioid-related EMS runs in the spring of 2020: The National Emergency Medical Services Information System data for 2018-2020. Drug and alcohol dependence. 2022 Mar; 232(?):109271. doi: 10.1016/j.drugalcdep.2022.109271. [PMID: 35051696]
  • Laura J Cremer, Amy Board, Gery P Guy, Lyna Schieber, Alice Asher, Erin M Parker. Trends in pharmacy-based dispensing of buprenorphine, extended-release naltrexone, and naloxone during the COVID-19 pandemic by age and sex - United States, March 2019 - December 2020. Drug and alcohol dependence. 2022 03; 232(?):109192. doi: 10.1016/j.drugalcdep.2021.109192. [PMID: 35065513]
  • Mohammad-Ali Sobhanifar, Roghayeh Rashidi, Arezoo Rajabian, Fatemeh Forouzanfar, Maede Hasanpour, Mehrdad Iranshahi, Hassan Rakhshandeh, Azar Hosseini. The possible mechanism of Datura stramonium on pentobarbital-induced sleep in mice. The International journal of neuroscience. 2022 Feb; ?(?):1-9. doi: 10.1080/00207454.2021.1998045. [PMID: 35213269]
  • Sacha Uljon. An Adulterated Urine Buprenorphine Specimen. The primary care companion for CNS disorders. 2022 Feb; 24(2):. doi: 10.4088/pcc.21cr03007. [PMID: 35213940]
  • Elizabeth Dogherty, Carlin Patterson, Marilou Gagnon, Scott Harrison, Jocelyn Chase, Jill Boerstler, Jennifer Gibson, Sam Gill, Seonaid Nolan, Andy Ryan. Implementation of a nurse-led overdose prevention site in a hospital setting: lessons learned from St. Paul's Hospital, Vancouver, Canada. Harm reduction journal. 2022 02; 19(1):13. doi: 10.1186/s12954-022-00596-7. [PMID: 35120536]
  • Mark G Papich, Roger J Narayan. Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection. Drug delivery and translational research. 2022 02; 12(2):376-383. doi: 10.1007/s13346-021-01096-0. [PMID: 34817831]
  • Piotr Niezgoda, Malwina A Barańska, Joanna Sikora, Przemysław Sobczak, Katarzyna Buszko, Adam Sikora, Michał P Marszałł, Eliano P Navarese, Bernd Jilma, Jacek Kubica. Oral NAloxone to overcome the moRphine effect in acute COronary syndrome patients treated with TICagrelor - NARCOTIC trial. Cardiology journal. 2022; 29(3):432-440. doi: 10.5603/cj.a2020.0040. [PMID: 32207836]
  • Traci C Green, Jeffrey Bratberg, Adriane N Irwin, Jesse Boggis, Mary Gray, Gillian Leichtling, Derek Bolivar, Anthony Floyd, Zain Al-Jammali, Jenny Arnold, Ryan Hansen, Daniel Hartung. Study protocol for the Respond to Prevent Study: a multi-state randomized controlled trial to improve provision of naloxone, buprenorphine and nonprescription syringes in community pharmacies. Substance abuse. 2022; 43(1):901-905. doi: 10.1080/08897077.2021.2010162. [PMID: 35213293]
  • Albert J Burgess-Hull, Kirsten E Smith, Leigh V Panlilio, Destiny Schriefer, Kenzie L Preston, Aliese Alter, Christopher Yeager, Timothy Chizmar, Ted Delbridge, Kenan Zamore, Jeff Beeson, David H Epstein. Nonfatal opioid overdoses before and after Covid-19: Regional variation in rates of change. PloS one. 2022; 17(3):e0263893. doi: 10.1371/journal.pone.0263893. [PMID: 35263326]
  • Claudia C Tussey, Margaret D Reyes, Rosalinda B Thomas, Charlotte T Boyd, John G Spangler, Julienne K Kirk. Utility of the group medical visit model for medication-assisted therapy. Journal of opioid management. 2022 Jan; 18(1):69-74. doi: 10.5055/jom.2022.0696. [PMID: 35238015]
  • Terence M Hughes, Alexander Kalicki, Zina Huxley-Reicher, Wilma Toribio, Don L Samuels, Jeffrey J Weiss, Michael Herscher, Linda Wang. A medical student-led model for telephone-based opioid overdose education and naloxone distribution during the COVID-19 pandemic. Substance abuse. 2022; 43(1):988-992. doi: 10.1080/08897077.2022.2060426. [PMID: 35435812]
  • Christine Ramdin, Marshall Guo, Scott Fabricant, Cynthia Santos, Lewis Nelson. The Impact of a Peer-Navigator Program on Naloxone Distribution and Buprenorphine Utilization in the Emergency Department. Substance use & misuse. 2022; 57(4):581-587. doi: 10.1080/10826084.2021.2023187. [PMID: 34970942]
  • Matthew S Ellis, Zachary A Kasper, Theodore J Cicero. Polysubstance use trends and variability among individuals with opioid use disorder in rural versus urban settings. Preventive medicine. 2021 11; 152(Pt 2):106729. doi: 10.1016/j.ypmed.2021.106729. [PMID: 34293380]
  • Manuel P Pereira, Claudia Zeidler, Sonja Ständer. Improvement of Chronic Kidney Disease-Associated Pruritus After Treatment With Intravenous Naloxone. JAMA dermatology. 2021 11; 157(11):1380-1381. doi: 10.1001/jamadermatol.2021.3829. [PMID: 34586358]
  • Illa S Johari, Norsyifa Harun, Zarif M Sofian, Mohammed Shoaib. Pentylenetetrazol-like stimulus is not produced following naloxone-precipitated mitragynine withdrawal in rats. Psychopharmacology. 2021 Nov; 238(11):3183-3191. doi: 10.1007/s00213-021-05934-4. [PMID: 34333672]
  • Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Masoumeh Askari, Alireza Amirabadizadeh, Mohsen Foadoddini, Omid Mehrpour. Effects of naloxone and diazepam on blood glucose levels in tramadol overdose using generalized estimating equation (GEE) model; (an experimental study). BMC endocrine disorders. 2021 Sep; 21(1):180. doi: 10.1186/s12902-021-00847-x. [PMID: 34488743]
  • Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter. Prostaglandins, leukotrienes, and essential fatty acids. 2021 09; 172(?):102323. doi: 10.1016/j.plefa.2021.102323. [PMID: 34392133]
  • Claudia Mariottini, Merja Gergov, Ilkka Ojanperä. Determination of buprenorphine, norbuprenorphine, naloxone, and their glucuronides in urine by liquid chromatography-tandem mass spectrometry. Drug testing and analysis. 2021 Sep; 13(9):1658-1667. doi: 10.1002/dta.3104. [PMID: 34047070]
  • Michael Levine, Frank Lovecchio. New Designer Drugs. Emergency medicine clinics of North America. 2021 Aug; 39(3):677-687. doi: 10.1016/j.emc.2021.04.013. [PMID: 34215409]
  • Luying Cui, Hele Cai, Fazhuang Sun, Yali Wang, Yang Qu, Junsheng Dong, Heng Wang, Jun Li, Chen Qian, Jianji Li. Beta-endorphin inhibits the inflammatory response of bovine endometrial cells through δ opioid receptor in vitro. Developmental and comparative immunology. 2021 08; 121(?):104074. doi: 10.1016/j.dci.2021.104074. [PMID: 33775662]
  • Richard S Schottenfeld, Marek C Chawarski, Mahmud Mazlan. Behavioral counseling and abstinence-contingent take-home buprenorphine in general practitioners' offices in Malaysia: a randomized, open-label clinical trial. Addiction (Abingdon, England). 2021 08; 116(8):2135-2149. doi: 10.1111/add.15399. [PMID: 33404150]
  • Elizabeth M Oliva, John Richardson, Michael A Harvey, Pamela Bellino. Saving Lives: The Veterans Health Administration (VHA) Rapid Naloxone Initiative. Joint Commission journal on quality and patient safety. 2021 08; 47(8):469-480. doi: 10.1016/j.jcjq.2021.06.004. [PMID: 34330409]
  • Rachel French, Jamie Favaro, Shoshana V Aronowitz. A free mailed naloxone program in Philadelphia amidst the COVID-19 pandemic. The International journal on drug policy. 2021 08; 94(?):103199. doi: 10.1016/j.drugpo.2021.103199. [PMID: 33765515]
  • Katie Kanter, Ryan Gallagher, Feyisope Eweje, Alexander Lee, David Gordon, Stephen Landy, Julia Gasior, Haideliza Soto-Calderon, Peter F Cronholm, Ben Cocchiaro, James Weimer, Alexis Roth, Stephen Lankenau, Jacob Brenner. Willingness to use a wearable device capable of detecting and reversing overdose among people who use opioids in Philadelphia. Harm reduction journal. 2021 07; 18(1):75. doi: 10.1186/s12954-021-00522-3. [PMID: 34301246]
  • Ashana Puri, Dorcas Frempong, Dhruv Mishra, Prashant Dogra. Microneedle-mediated transdermal delivery of naloxone hydrochloride for treatment of opioid overdose. International journal of pharmaceutics. 2021 Jul; 604(?):120739. doi: 10.1016/j.ijpharm.2021.120739. [PMID: 34048932]
  • Xavier Mas-Orea, Morgane Sebert, Mehdi Benamar, Camille Petitfils, Catherine Blanpied, Abdelhadi Saoudi, Céline Deraison, Frederick Barreau, Nicolas Cenac, Gilles Dietrich. Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice. International journal of molecular sciences. 2021 Jul; 22(14):. doi: 10.3390/ijms22147387. [PMID: 34299013]
  • Amjad Ali, Abdul Nasir, Syed Wadood Ali Shah, Atif Ali Khan Khalil, Mi-Jeong Ahn, Syed Muhammad Mukarram Shah, Fazli Subhan, Muhammad Faheem, Wasim Sajjad, Mohammad Shoaib, Saeed Ahmad, Nausheen Nazir, Mohammad Nisar. Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice. BMC complementary medicine and therapies. 2021 Jul; 21(1):184. doi: 10.1186/s12906-021-03357-4. [PMID: 34210323]
  • Michael Fairley, Keith Humphreys, Vilija R Joyce, Mark Bounthavong, Jodie Trafton, Ann Combs, Elizabeth M Oliva, Jeremy D Goldhaber-Fiebert, Steven M Asch, Margaret L Brandeau, Douglas K Owens. Cost-effectiveness of Treatments for Opioid Use Disorder. JAMA psychiatry. 2021 07; 78(7):767-777. doi: 10.1001/jamapsychiatry.2021.0247. [PMID: 33787832]
  • Safy Badr, Samar Rezq, Rasha H Abdelghany. Endogenous β-endorphin plays a pivotal role in angiotensin II-mediated central neurochemical changes and pressor response. Chemico-biological interactions. 2021 Jun; 342(?):109475. doi: 10.1016/j.cbi.2021.109475. [PMID: 33872574]
  • Brian S Barnett, Sarah E Wakeman, Corey S Davis, Jamie Favaro, Josiah D Rich. Expanding Mail-Based Distribution of Drug-Related Harm Reduction Supplies Amid COVID-19 and Beyond. American journal of public health. 2021 06; 111(6):1013-1017. doi: 10.2105/ajph.2021.306228. [PMID: 33950718]
  • Eva Malmros Olsson, Per-Arne Lönnqvist, Carl-Olav Stiller, Staffan Eksborg, Stefan Lundeberg. Rapid systemic uptake of naloxone after intranasal administration in children. Paediatric anaesthesia. 2021 06; 31(6):631-636. doi: 10.1111/pan.14175. [PMID: 33687794]
  • Dalia Khoury, Alexander Preiss, Paul Geiger, Mohd Anwar, Kevin Paul Conway. Increases in Naloxone Administrations by Emergency Medical Services Providers During the COVID-19 Pandemic: Retrospective Time Series Study. JMIR public health and surveillance. 2021 05; 7(5):e29298. doi: 10.2196/29298. [PMID: 33999828]
  • Elizabeth Noyes, Ellis Yeo, Megan Yerton, Isabel Plakas, Susan Keyes, Aura Obando, Jessie M Gaeta, Elsie M Taveras, Avik Chatterjee. Harm Reduction for Adolescents and Young Adults During the COVID-19 Pandemic: A Case Study of Community Care in Reach. Public health reports (Washington, D.C. : 1974). 2021 05; 136(3):301-308. doi: 10.1177/0033354921999396. [PMID: 33673755]
  • Lucas Dos Reis Izolan, Douglas Marques da Silva, Helena Beatriz Larrosa Oliveira, Janaína Lucas de Oliveira Salomon, Caroline Portela Peruzzi, Solange C Garcia, Eliane Dallegrave, Caroline Zanotto, Elaine Elisabetsky, Carlos Alberto Gonçalves, Marcelo Dutra Arbo, Eduardo Luis Konrath, Mirna Bainy Leal. Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice. Neurochemical research. 2021 May; 46(5):1092-1100. doi: 10.1007/s11064-021-03237-w. [PMID: 33544325]
  • Mariana A Freitas, Amanda Vasconcelos, Elaine C D Gonçalves, Eduarda G Ferrarini, Gabriela B Vieira, Donatella Cicia, Maíra Cola, Raffaele Capasso, Rafael C Dutra. Involvement of Opioid System and TRPM8/TRPA1 Channels in the Antinociceptive Effect of Spirulina platensis. Biomolecules. 2021 04; 11(4):. doi: 10.3390/biom11040592. [PMID: 33920609]
  • Nazeer Hasan, Mohammad Imran, Prashant Kesharwani, Kushagra Khanna, Ritu Karwasra, Nitin Sharma, Sonalika Rawat, Deeksha Sharma, Farhan Jalees Ahmad, Gaurav Kumar Jain, Aseem Bhatnagar, Sushama Talegaonkar. Intranasal delivery of Naloxone-loaded solid lipid nanoparticles as a promising simple and non-invasive approach for the management of opioid overdose. International journal of pharmaceutics. 2021 Apr; 599(?):120428. doi: 10.1016/j.ijpharm.2021.120428. [PMID: 33662465]
  • Brendan P Jacka, Tim Janssen, Bryan R Garner, Julia Yermash, Kimberly R Yap, Elizabeth L Ball, Bryan Hartzler, Sara J Becker. Impacts of the COVID-19 pandemic on healthcare access among patients receiving medication for opioid use disorder. Drug and alcohol dependence. 2021 04; 221(?):108617. doi: 10.1016/j.drugalcdep.2021.108617. [PMID: 33647590]
  • Valeria Itzel Reyes-Pérez, Vinicio Granados-Soto, Manuel Rangel-Grimaldo, Myrna Déciga-Campos, Rachel Mata. Pharmacological Analysis of the Anti-inflammatory and Antiallodynic Effects of Zinagrandinolide E from Zinnia grandiflora in Mice. Journal of natural products. 2021 03; 84(3):713-723. doi: 10.1021/acs.jnatprod.0c00793. [PMID: 32870011]
  • Matthew W Courser, Holly Raffle. With crisis comes opportunity: Unanticipated benefits resulting from pivots to take-home naloxone (THN) programs during the COVID-19 pandemic. Journal of substance abuse treatment. 2021 03; 122(?):108220. doi: 10.1016/j.jsat.2020.108220. [PMID: 33309390]
  • Diniz M Sena, Xiaojing Cong, Alejandro Giorgetti. Ligand based conformational space studies of the μ-opioid receptor. Biochimica et biophysica acta. General subjects. 2021 03; 1865(3):129838. doi: 10.1016/j.bbagen.2020.129838. [PMID: 33373630]
  • Amanda Roxburgh, Marianne Jauncey, Carolyn Day, Mark Bartlett, Shelley Cogger, Paul Dietze, Suzanne Nielsen, Julie Latimer, Nico Clark. Adapting harm reduction services during COVID-19: lessons from the supervised injecting facilities in Australia. Harm reduction journal. 2021 02; 18(1):20. doi: 10.1186/s12954-021-00471-x. [PMID: 33596940]
  • Christopher M Jones, Gery P Guy, Amy Board. Comparing actual and forecasted numbers of unique patients dispensed select medications for opioid use disorder, opioid overdose reversal, and mental health, during the COVID-19 pandemic, United States, January 2019 to May 2020. Drug and alcohol dependence. 2021 02; 219(?):108486. doi: 10.1016/j.drugalcdep.2020.108486. [PMID: 33421802]
  • Philip DiSalvo, Gail Cooper, Jessica Tsao, Michelle Romeo, Larissa K Laskowski, Gregg Chesney, Mark K Su. Fentanyl-contaminated cocaine outbreak with laboratory confirmation in New York City in 2019. The American journal of emergency medicine. 2021 02; 40(?):103-105. doi: 10.1016/j.ajem.2020.12.002. [PMID: 33360606]
  • Wangjun Qin, Hong Qu, Lin Pan, Weiliang Sun, Yuzhen Chen, Caihong Wu. Possible mechanism and potential application of anti-opioid effect of diazepam-binding inhibitor. Life sciences. 2021 Jan; 265(?):118836. doi: 10.1016/j.lfs.2020.118836. [PMID: 33259865]
  • Austin O'Carroll, Tony Duffin, John Collins. Harm reduction in the time of COVID-19: Case study of homelessness and drug use in Dublin, Ireland. The International journal on drug policy. 2021 01; 87(?):102966. doi: 10.1016/j.drugpo.2020.102966. [PMID: 33166825]
  • Zhijia Tang, Xiaobao Shao, Jun Wu, Hucheng Chen, Anyu Zhang, Fei Xu, He Ping, Shiwei Li, Chunyan Liu, Yijun Li, Xue Xue, Binbin Yuan. Naloxone Protects against Lipopolysaccharide-Induced Neuroinflammation and Microglial Activation via Inhibiting ATP-Sensitive Potassium Channel. Computational and mathematical methods in medicine. 2021; 2021(?):7731528. doi: 10.1155/2021/7731528. [PMID: 34373698]
  • Nazila Jamshidi, Akshay Athavale, Bridin Murnion. Buprenorphine not detected on urine drug screening in supervised treatment. Journal of opioid management. 2021; 17(7):69-76. doi: 10.5055/jom.2021.0644. [PMID: 34520028]
  • Andrew W Roberts, Kevin A Look, Grace Trull, Delesha M Carpenter. Medicaid prescription limits and their implications for naloxone accessibility. Drug and alcohol dependence. 2021 01; 218(?):108355. doi: 10.1016/j.drugalcdep.2020.108355. [PMID: 33309522]
  • Oluwaseyi K Wakeel, Abraham I Abe, Oluropo B Awosan, Mokaila K Olapade, Temitope J Olatoyan-Layonu, Olugbenga A Olowe, Oluwaseyi A Adeyeba. Anti-Nociceptive and Anti-Inflammatory Effects of Stem Bark Extract of Ficus Capensis Thunb (Moraceae) by Bioactivity Fractionation. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2021; 20(2):206-218. doi: 10.2174/1871523019666200825194616. [PMID: 32842947]
  • Sahar Nasim, Mohib Shah, Syed Wadood Ali Shah, Muhammad Naeem Ahmed, Mubashir Ahmad, Natasha Anwar, Mehreen Ghias. Activity guided isolation and mechanistic approach towards analgesic potential of Chenopodium mediated through opioidergic pathway. Pakistan journal of pharmaceutical sciences. 2021 Jan; 34(1(Supplementary)):197-203. doi: ". [PMID: 34275843]
  • Jamie Lei, Amy Butz, Natalie Valentino. Management of kratom dependence with buprenorphine/naloxone in a veteran population. Substance abuse. 2021; 42(4):497-502. doi: 10.1080/08897077.2021.1878086. [PMID: 33617752]
  • Melody J Glenn, Amber D Rice, Keith Primeau, Adrienne Hollen, Isrealia Jado, Philipp Hannan, Sharon McDonough, Brittany Arcaris, Daniel W Spaite, Joshua B Gaither. Refusals After Prehospital Administration of Naloxone during the COVID-19 Pandemic. Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors. 2021 Jan; 25(1):46-54. doi: 10.1080/10903127.2020.1834656. [PMID: 33054530]
  • Zhiqi Shi, Shugang Pan, Luolin Wang, Sha Li. Oleanolic Acid Attenuates Morphine Withdrawal Symptoms in Rodents: Association with Regulation of Dopamine Function. Drug design, development and therapy. 2021; 15(?):3685-3696. doi: 10.2147/dddt.s326583. [PMID: 34465980]
  • Francisca Crislândia Oliveira Silva, Jane Eire Silva Alencar de Menezes, Maria Kueirislene Amâncio Ferreira, Antonio Wlisses da Silva, Carlos Leone Alves Holanda, Joyce Dos Reis Lima, Adriana Rolim Campos, Francisco Flávio Vasconcelos Evaristo, Edson Holanda Teixeira, Francisco Ernani Alves Magalhães, Paulo Nogueira Bandeira, Hélcio Silva Dos Santos. Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio). Biochemical and biophysical research communications. 2020 12; 533(3):362-367. doi: 10.1016/j.bbrc.2020.07.107. [PMID: 32962857]
  • Nancy Glober, George Mohler, Philip Huynh, Tom Arkins, Dan O'Donnell, Jeremy Carter, Brad Ray. Impact of COVID-19 Pandemic on Drug Overdoses in Indianapolis. Journal of urban health : bulletin of the New York Academy of Medicine. 2020 12; 97(6):802-807. doi: 10.1007/s11524-020-00484-0. [PMID: 33005988]
  • Jill S Warrington, Gregory S Warrington, Samuel Francis-Fath, John Brooklyn. Urinary Buprenorphine, Norbuprenorphine and Naloxone Concentrations and Ratios: Review and Potential Clinical Implications. Journal of addiction medicine. 2020 12; 14(6):e344-e349. doi: 10.1097/adm.0000000000000676. [PMID: 32530884]
  • David C Cone, Sandy Bogucki, Kevin Burns, Gail D'Onofrio, Kathryn Hawk, Daniel Joseph, David A Fiellin. Naloxone Use by Emergency Medical Services During the COVID-19 Pandemic: A National Survey. Journal of addiction medicine. 2020 12; 14(6):e369-e371. doi: 10.1097/adm.0000000000000746. [PMID: 33031212]
  • Lisa L Wilson, Hannah M Harris, Shainnel O Eans, Ariana C Brice-Tutt, Thomas J Cirino, Heather M Stacy, Chloe A Simons, Francisco León, Abhisheak Sharma, Edward W Boyer, Bonnie A Avery, Jay P McLaughlin, Christopher R McCurdy. Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence. Drug and alcohol dependence. 2020 11; 216(?):108310. doi: 10.1016/j.drugalcdep.2020.108310. [PMID: 33017752]
  • Yuen Chin Leong, P Richard Verbeek. Does intranasal naloxone administration increase the risk of 2019 coronavirus disease transmission?. CJEM. 2020 11; 22(6):e20. doi: 10.1017/cem.2020.395. [PMID: 32393409]
  • Theresa Winhusen, Christine Wilder, Frankie Kropp, Jeff Theobald, Michael S Lyons, Daniel Lewis. A brief telephone-delivered peer intervention to encourage enrollment in medication for opioid use disorder in individuals surviving an opioid overdose: Results from a randomized pilot trial. Drug and alcohol dependence. 2020 11; 216(?):108270. doi: 10.1016/j.drugalcdep.2020.108270. [PMID: 32911132]
  • Luca Docci, Kenichi Umehara, Stephan Krähenbühl, Stephen Fowler, Neil Parrott. Construction and Verification of Physiologically Based Pharmacokinetic Models for Four Drugs Majorly Cleared by Glucuronidation: Lorazepam, Oxazepam, Naloxone, and Zidovudine. The AAPS journal. 2020 10; 22(6):128. doi: 10.1208/s12248-020-00513-5. [PMID: 33033903]
  • L Niu, G Yang, C-X Liu, X-Z Zhao, X-Y Li, M Yu. Observation of the efficacy of naloxone combined with acyclovir in the treatment of children viral encephalitis and its impacts on IL-1 and IL-6. European review for medical and pharmacological sciences. 2020 10; 24(20):10736-10744. doi: 10.26355/eurrev_202010_23434. [PMID: 33155234]
  • H Z Rosa, H J Segat, R C S Barcelos, Kr Roversi, D R Rossato, G F de Brum, M E Burger. Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction parameters. Pharmacology, biochemistry, and behavior. 2020 10; 197(?):173000. doi: 10.1016/j.pbb.2020.173000. [PMID: 32702398]
  • R Brar, C Grant, K DeBeck, M-J Milloy, N Fairbairn, E Wood, T Kerr, Kanna Hayashi. Changes in drug use behaviors coinciding with the emergence of illicit fentanyl among people who use drugs in Vancouver, Canada. The American journal of drug and alcohol abuse. 2020 09; 46(5):625-631. doi: 10.1080/00952990.2020.1771721. [PMID: 32689810]
  • Alexandra B Collins, Colleen Daley Ndoye, Diego Arene-Morley, Brandon D L Marshall. Addressing co-occurring public health emergencies: The importance of naloxone distribution in the era of COVID-19. The International journal on drug policy. 2020 09; 83(?):102872. doi: 10.1016/j.drugpo.2020.102872. [PMID: 32713765]
  • Robert Root-Bernstein, Beth Churchill, Miah Turke. Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse. International journal of molecular sciences. 2020 Aug; 21(17):. doi: 10.3390/ijms21176230. [PMID: 32872204]
  • Anna Mas-Capdevila, Lisard Iglesias-Carres, Anna Arola-Arnal, Gerard Aragonès, Begoña Muguerza, Francisca Isabel Bravo. Implication of Opioid Receptors in the Antihypertensive Effect of a Novel Chicken Foot-Derived Peptide. Biomolecules. 2020 07; 10(7):. doi: 10.3390/biom10070992. [PMID: 32630658]
  • Elena Martínez-Laorden, Javier Navarro-Zaragoza, María-Victoria Milanés, Maria-Luisa Laorden, Pilar Almela. Conditioned aversive memory associated with morphine withdrawal increases brain-derived neurotrophic factor in dentate gyrus and basolateral amygdala. Addiction biology. 2020 07; 25(4):e12792. doi: 10.1111/adb.12792. [PMID: 31282111]
  • Nathan Mullins, Shelley L Galvin, Melinda Ramage, Marie Gannon, Kathleen Lorenz, Brent Sager, Carol C Coulson. Buprenorphine and Naloxone Versus Buprenorphine for Opioid Use Disorder in Pregnancy: A Cohort Study. Journal of addiction medicine. 2020 May; 14(3):185-192. doi: 10.1097/adm.0000000000000562. [PMID: 31567599]
  • Jinlong Chen, Lining Liang, Yuan Li, Yixin Zhang, Mengdan Zhang, Tingting Yang, Fei Meng, Xiaowei Lai, Changpeng Li, Jingcai He, Meiai He, Qiaoran Xu, Qian Li, Ping-Yee Law, Horace H Loh, Duanqing Pei, Hao Sun, Hui Zheng. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 04; 34(4):5917-5930. doi: 10.1096/fj.201902873r. [PMID: 32154623]
  • Juleigh Nowinski Konchak, Kevin McGurk, Keiki Hinami, Margaret Vacchiano, Steven Aks. Effect of positive urine fentanyl screen on attitudes toward heroin use. Drug and alcohol dependence. 2020 04; 209(?):107934. doi: 10.1016/j.drugalcdep.2020.107934. [PMID: 32126456]
  • Cheng-Yuan Lin, Wei-Cheng Liu, Min-Hsien Chiang, I-Ting Tsai, Jen-Yin Chen, Wan-Jung Cheng, Chun-Ning Ho, Shu-Wei Liao, Chin-Chen Chu, Cheuk-Kwan Sun, Kuo-Chuan Hung. Myasthenic crisis and late deep vein thrombosis following thymectomy in a patient with myasthenia gravis: A case report. Medicine. 2020 Apr; 99(15):e19781. doi: 10.1097/md.0000000000019781. [PMID: 32282741]