Candesartan cilexetil (BioDeep_00000002546)
Secondary id: BioDeep_00001867997
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2-(2H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid
化学式: C33H34N6O6 (610.2539704000001)
中文名称: 坎地沙坦酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC(C)OC(=O)OC6CCCCC6
InChI: InChI=1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C66930 - Angiotensin II Receptor Antagonist
D057911 - Angiotensin Receptor Antagonists > D047228 - Angiotensin II Type 1 Receptor Blockers
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure[1][2][3][4][5][6].
同义名列表
17 个代谢物同义名
1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2-(2H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid; 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2-(2H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate; 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-3-{[2-(2H-1,2,3,4-tetrazol-5-yl)-[1,1-biphenyl]-4-yl]methyl}-1,3-benzodiazole-4-carboxylate; 1-Cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid; 1-cyclohexyloxycarbonyloxyethyl2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate; 1-(Cyclohexylocarbonyloxy)ethyl-2-ethoxy-1-(2-(1H-tetrazol-5-yl)biphenyl-4-yl)-1H-benzimidazole-7-carboxylate; Candesartan cilexetil; Candesartan hexetil; Blopress; Parapres; Racanda; TCV-116; Atacand; TCV 116; Kenzen; Amias; Candesartan cilexetil
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:3348
- KEGG: C07709
- KEGGdrug: D00626
- PubChem: 2540
- HMDB: HMDB0249581
- Metlin: METLIN43872
- DrugBank: DB00796
- ChEMBL: CHEMBL1014
- chemspider: 2444
- CAS: 1261393-19-4
- CAS: 145040-37-5
- PMhub: MS000003485
- PubChem: 9911
- NIKKAJI: J1.640.921I
- RefMet: Candesartan cilexetil
- medchemexpress: HY-17505
- KNApSAcK: 3348
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mohammed Abdallah, Aysha Sayed Mohamed, Mina Ibrahim Tadros, Mohamed El-Nabarawi, Mai Ahmed Tawfik. Solusomes (novel soluplus® enriched nano-vesicular carriers) for improving the oral bioavailability of Candesartan cilexetil.
Pharmaceutical development and technology.
2023 Nov; ?(?):1-12. doi:
10.1080/10837450.2023.2289166. [PMID: 38014703] - Noha A T Abbas, Fawkia A Fayed, Rabab Saber El Sebaey, Heba A Hassan. Telmisartan and candesartan promote browning of white adipose tissue and reverse fatty liver changes in high fat diet fed male albino rats.
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10.1007/s00392-009-0011-7. [PMID: 19294444] - Amany Shweta, Luise A Cullen-McEwen, Michelle M Kett, Roger G Evans, Kate M Denton, Sharyn M Fitzgerald, Warwick P Anderson, John F Bertram. Glomerular surface area is normalized in mice born with a nephron deficit: no role for AT1 receptors.
American journal of physiology. Renal physiology.
2009 Mar; 296(3):F583-9. doi:
10.1152/ajprenal.90359.2008. [PMID: 19106212] - Egbert Godehard Schulz, Shadfar Bahri, Volker Schettler, Aron-Frederik Popov, Matthias Hermann. Pharmacokinetics and antihypertensive effects of candesartan cilexetil in patients undergoing haemodialysis: an open-label, single-centre study.
Clinical drug investigation.
2009; 29(11):713-9. doi:
10.2165/11319410-000000000-00000. [PMID: 19813774] - Tsuyoshi Yamane, Yoko Fujii, Kensuke Orito, Kaori Osamura, Takao Kanai, Yoshito Wakao. Comparison of the effects of candesartan cilexetil and enalapril maleate on right ventricular myocardial remodeling in dogs with experimentally induced pulmonary stenosis.
American journal of veterinary research.
2008 Dec; 69(12):1574-9. doi:
10.2460/ajvr.69.12.1574. [PMID: 19046003] - Terry C Major, Bronia Olszewski, Wendy Rosebury, Carlin Okerberg, Tage Carlson, Robert Ostroski, Richard Schroeder, Mark C Kowala, Robert Leadley. A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes.
Cardiovascular drugs and therapy.
2008 Dec; 22(6):469-78. doi:
10.1007/s10557-008-6131-x. [PMID: 18679781] - Yoshifuru Tamura, Masahiro Kosuga, Masahiro Yamashita, Satoru Tomioka, Michiko Sasaki, Tomoyuki Hikita, Hideaki Nakajima, Kenichiro Kojima, Shunya Uchida. Renoprotective effects of angiotensin II receptor blocker, candesartan cilexetil, in patients with stage 4-5 chronic kidney disease.
Clinical and experimental nephrology.
2008 Aug; 12(4):256-263. doi:
10.1007/s10157-008-0040-y. [PMID: 18317875] - Tatsuo Hashimoto, Yoshiyuki Toya, Minoru Kihara, Machiko Yabana, Yoshiaki Inayama, Ken-Ichiro Tanaka, Kousaku Iwatsubo, Mai Yanagi, Jin Oshikawa, Toshiharu Kokuho, Tadashi Kuji, Shin-Ichiro Yoshida, Kouichi Tamura, Satoshi Umemura. Behçet's disease complicated by IgA nephropathy with nephrotic syndrome.
Clinical and experimental nephrology.
2008 Jun; 12(3):224-7. doi:
10.1007/s10157-008-0029-6. [PMID: 18224274] - Urara Mori-Takeyama, Shinya Minatoguchi, Ichijirou Murata, Hisayoshi Fujiwara, Yoko Ozaki, Michiya Ohno, Hiroshi Oda, Hiroshige Ohashi. Dual blockade of the rennin-angiotensin system versus maximal recommended dose of angiotensin II receptor blockade in chronic glomerulonephritis.
Clinical and experimental nephrology.
2008 Feb; 12(1):33-40. doi:
10.1007/s10157-007-0013-6. [PMID: 18175062] - P Bramlage, E Schönrock, P Odoj, W-P Wolf, C Funken. [Importance of a fixed combination of AT1-receptor blockade and hydrochlorothiazide for blood pressure lowering in cardiac risk patients. A postmarketing surveillance study with Candesartan/HCTZ].
MMW Fortschritte der Medizin.
2008 Jan; 149 Suppl 4(?):172-81. doi:
NULL. [PMID: 18402243] - Tetsuya Sugiyama, Takashi Okuno, Masayuki Fukuhara, Hidehiro Oku, Tsunehiko Ikeda, Hiroshi Obayashi, Mitsuhiro Ohta, Michiaki Fukui, Goji Hasegawa, Naoto Nakamura. Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes.
Experimental eye research.
2007 Sep; 85(3):406-12. doi:
10.1016/j.exer.2007.06.008. [PMID: 17678894] - Eduardo Podjarny, Joelle Bernheim, Galit Hasdan, Dorit Karsh, Gloria Rashid, Janice Green, Bernardo Katz, Jacques Bernheim. Additive renoprotective effect of candesartan and tetrahydrobiopterin in rats after 5/6 nephrectomy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2007 Jul; 22(7):1864-72. doi:
10.1093/ndt/gfm129. [PMID: 17442743] - Wilma Debernardi-Venon, Silvia Martini, Fiorella Biasi, Barbara Vizio, Angela Termine, Giuseppe Poli, Franco Brunello, Carlo Alessandria, Renato Bonardi, Giorgio Saracco, Mario Rizzetto, Alfredo Marzano. AT1 receptor antagonist Candesartan in selected cirrhotic patients: effect on portal pressure and liver fibrosis markers.
Journal of hepatology.
2007 Jun; 46(6):1026-33. doi:
10.1016/j.jhep.2007.01.017. [PMID: 17336417] - Chiara M Meier, Giacomo D Simonetti, Silvia Ghiglia, Emilio Fossali, Patrizia Salice, Costanzo Limoni, Mario G Bianchetti. Palatability of angiotensin II antagonists among nephropathic children.
British journal of clinical pharmacology.
2007 May; 63(5):628-31. doi:
10.1111/j.1365-2125.2006.02814.x. [PMID: 17302913] - Kimiko Ishiguro, Hiroyuki Sasamura, Yusuke Sakamaki, Hiroshi Itoh, Takao Saruta. Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury.
Hypertension research : official journal of the Japanese Society of Hypertension.
2007 Jan; 30(1):63-75. doi:
10.1291/hypres.30.63. [PMID: 17460373] - Stefan Zorad, Jing-tao Dou, Julius Benicky, Daniel Hutanu, Katarina Tybitanclova, Jin Zhou, Juan M Saavedra. Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma.
European journal of pharmacology.
2006 Dec; 552(1-3):112-22. doi:
10.1016/j.ejphar.2006.08.062. [PMID: 17064684] - M Saito, D Nakayama, M Takada, K Hirooka, Y Yasumura. Carvedilol accelerate elevation of serum potassium in chronic heart failure patients administered spironolactone plus furosemide and either enalapril maleate or candesartan cilexetil.
Journal of clinical pharmacy and therapeutics.
2006 Dec; 31(6):535-40. doi:
10.1111/j.1365-2710.2006.00772.x. [PMID: 17176359] - Fumiaki Yamashita, Hisakazu Ohtani, Noriko Koyabu, Fumihiko Ushigome, Hiroki Satoh, Hideyasu Murakami, Takeshi Uchiumi, Takanori Nakamura, Michihiko Kuwano, Masayuki Tsujimoto, Yasufumi Sawada. Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4.
The Journal of pharmacy and pharmacology.
2006 Nov; 58(11):1499-505. doi:
10.1211/jpp.58.11.0011. [PMID: 17132213] - Giacomo D Simonetti, Rodo O von Vigier, Martin Konrad, Mattia Rizzi, Emilio Fossali, Mario G Bianchetti. Candesartan cilexetil in children with hypertension or proteinuria: preliminary data.
Pediatric nephrology (Berlin, Germany).
2006 Oct; 21(10):1480-2. doi:
10.1007/s00467-006-0144-0. [PMID: 16802178] - Karlene Maitland, Lakeesha Bridges, Wendell P Davis, Joseph Loscalzo, Mildred A Pointer. Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension.
Circulation.
2006 Aug; 114(9):905-11. doi:
10.1161/circulationaha.106.622316. [PMID: 16923758] - Hiroyuki Sasamura, Yudai Kitamura, Mari Nakamura, Munekazu Ryuzaki, Takao Saruta. Effects of the angiotensin receptor blocker candesartan on arterial stiffness and markers of extracellular matrix metabolism in patients with essential hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2006 Jul; 28(5):511-20. doi:
10.1080/10641960600798721. [PMID: 16820347] - Hidehisa Sasaki, Saburo Kanai, Tomokazu Oyama, Yoh Miyashita, Shigeo Yamamura, Kohji Shirai. Effect of combination therapy of benidipine hydrochloride and candesartan cilexetil on serum lipid metabolism and blood pressure in elderly hypertensive patients with type 2 diabetes mellitus.
Journal of atherosclerosis and thrombosis.
2006 Jun; 13(3):149-57. doi:
10.5551/jat.13.149. [PMID: 16835470] - Nathalie Sturm, Marie-Noëlle Hilleret, Thierry Dreyfus, Didier Barnoud, Vincent Leroy, Jean-Pierre Zarski. [Candesartan Cilexetil (Atacand) induced prolonged severe cholestasis improved by extracorporeal albumin dialysis].
Gastroenterologie clinique et biologique.
2005 Dec; 29(12):1299-301. doi:
10.1016/s0399-8320(05)82229-8. [PMID: 16518295] - Tsukasa Nakamura, Takeshi Sugaya, Yasuhiro Kawagoe, Yoshihiko Ueda, Shiwori Osada, Hikaru Koide. Candesartan reduces urinary fatty acid-binding protein excretion in patients with autosomal dominant polycystic kidney disease.
The American journal of the medical sciences.
2005 Oct; 330(4):161-5. doi:
10.1097/00000441-200510000-00002. [PMID: 16234607] - Shuichi Tsuruoka, Michi Wakaumi, Takashi Ioka, Hisashi Yamamoto, Hitoshi Ando, Kohichi Sugimoto, Akio Fujimura. Angiotensin II receptor blocker-induces blunted taste sensitivity: comparison of candesartan and valsartan.
British journal of clinical pharmacology.
2005 Aug; 60(2):204-7. doi:
10.1111/j.1365-2125.2005.02394.x. [PMID: 16042674] - Frank Pietruck, Gerhard Kiel, Manfred Birkel, Bodo Stahlheber-Dilg, Thomas Philipp. Evaluation of the effect of candesartan cilexetil on the steady-state pharmacokinetics of tacrolimus in renal transplant patients.
Biopharmaceutics & drug disposition.
2005 May; 26(4):135-41. doi:
10.1002/bdd.440. [PMID: 15768377] - Hiroaki Nakamura, Tatsuya Inoue, Naohisa Arakawa, Yuki Shimizu, Yasushi Yoshigae, Izumi Fujimori, Emi Shimakawa, Tohru Toyoshi, Tomihisa Yokoyama. Pharmacological and pharmacokinetic study of olmesartan medoxomil in animal diabetic retinopathy models.
European journal of pharmacology.
2005 Apr; 512(2-3):239-46. doi:
10.1016/j.ejphar.2005.02.047. [PMID: 15840410] - Enrico Agabiti Rosei, Damiano Rizzoni, Maria Lorenza Muiesan, Intissar Sleiman, Massimo Salvetti, Cristina Monteduro, Enzo Porteri. Effects of candesartan cilexetil and enalapril on inflammatory markers of atherosclerosis in hypertensive patients with non-insulin-dependent diabetes mellitus.
Journal of hypertension.
2005 Feb; 23(2):435-44. doi:
10.1097/00004872-200502000-00027. [PMID: 15662233] - Rayaz A Malik, Ian J Schofield, Ashley Izzard, Clare Austin, Georgina Bermann, Anthony M Heagerty. Effects of angiotensin type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus.
Hypertension (Dallas, Tex. : 1979).
2005 Feb; 45(2):264-9. doi:
10.1161/01.hyp.0000153305.50128.a1. [PMID: 15630048] - Sabine Leh, Øyvind Vaagnes, Solomon B Margolin, Bjarne M Iversen, Terje Forslund. Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2005 Jan; 20(1):71-82. doi:
10.1093/ndt/gfh562. [PMID: 15561744] - J M Willemsen, T J Rabelink, P Boer, C A Gaillard. Disparate systemic and renal blocking properties of angiotensin II antagonists during exogenous angiotensin II administration: implications for treatment.
Journal of human hypertension.
2004 Dec; 18(12):857-63. doi:
10.1038/sj.jhh.1001769. [PMID: 15361886] - K Homma, K Hayashi, T Kanda, K Yoshioka, I Takamatsu, S Tatematsu, H Kumagai, S Wakino, T Saruta. Beneficial action of candesartan cilexetil plus amlodipine or ACE inhibitors in chronic nondiabetic renal disease.
Journal of human hypertension.
2004 Dec; 18(12):879-84. doi:
10.1038/sj.jhh.1001761. [PMID: 15295613] - H Kakizawa, Y Itoh, S Imamura, T Matsumoto, Y Ishiwata, Y Ono, K Yamamoto, T Kato, N Hayakawa, N Oda, Y Goto, Y Goto, A Nagasaka, T Senda, M Itoh. Possible role of VEGF in the progression of kidney disease in streptozotocin (STZ)-induced diabetic rats: effects of an ACE inhibitor and an angiotensin II receptor antagonist.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2004 Jul; 36(7):458-64. doi:
10.1055/s-2004-825725. [PMID: 15305228] - Michel Azizi, Alvine Bissery, Maxime Lamarre-Cliche, Joël Ménard. Integrating drug pharmacokinetics for phenotyping individual renin response to angiotensin II blockade in humans.
Hypertension (Dallas, Tex. : 1979).
2004 Apr; 43(4):785-90. doi:
10.1161/01.hyp.0000125698.00128.64. [PMID: 15023936] - Akira Nishiyama, Masanori Yoshizumi, Matlubur Rahman, Hiroyuki Kobori, Dale M Seth, Akira Miyatake, Guo-Xing Zhang, Li Yao, Hirofumi Hitomi, Takatomi Shokoji, Hideyasu Kiyomoto, Shoji Kimura, Toshiaki Tamaki, Masakazu Kohno, Youichi Abe. Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats.
Kidney international.
2004 Mar; 65(3):972-81. doi:
10.1111/j.1523-1755.2004.00476.x. [PMID: 14871417] - Kazuya Omoto, Kazunari Tanabe, Tadahiko Tokumoto, Hiroaki Shimmura, Hideki Ishida, Hiroshi Toma. Use of candesartan cilexetil decreases proteinuria in renal transplant patients with chronic allograft dysfunction.
Transplantation.
2003 Oct; 76(8):1170-4. doi:
10.1097/01.tp.0000073615.57523.ac. [PMID: 14578748] - Osamu Iimura, Eiji Kusano, Kaichiro Tanba, Satoru Yanagiba, Morimasa Amemiya, Yasuhiro Ando, Sumiko Honma, Shigeaki Muto, Yasushi Asano. [Additive antiproteinuric effect of angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitor in patients with chronic glomerulonephritis].
Nihon Jinzo Gakkai shi.
2003 Jul; 45(5):439-44. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2003 Jun; 26(6):453-8. doi:
10.1291/hypres.26.453. [PMID: 12862201] - Hisao Ando, Kazunori Furugori, Daijiro Shibata, Toko Harata, Yasutaka Murata, Shigehiko Mizutani. Dual renin-angiotensin blockade therapy in patients at high risk of early ovarian hyperstimulation syndrome receiving IVF and elective embryo cryopreservation: a case series.
Human reproduction (Oxford, England).
2003 Jun; 18(6):1219-22. doi:
10.1093/humrep/deg268. [PMID: 12773449] - Giorgio Basile, Daniela Villari, Sebastiano Gangemi, Tiziana Ferrara, Maria G Accetta, Vittorio Nicita-Mauro. Candesartan cilexetil-induced severe hepatotoxicity.
Journal of clinical gastroenterology.
2003 Mar; 36(3):273-5. doi:
10.1097/00004836-200303000-00017. [PMID: 12590242] - V Mitrovic, R Willenbrock, M Miric, P Seferovic, J Spinar, M Dabrowski, W Kiowski, D S Marks, E Alegria, A Dukát, K Lenz, H A Arens. Acute and 3-month treatment effects of candesartan cilexetil on hemodynamics, neurohormones, and clinical symptoms in patients with congestive heart failure.
American heart journal.
2003 Mar; 145(3):E14. doi:
10.1067/mhj.2003.161. [PMID: 12660683] - Hiroaki Mukawa, Yukio Toki, Yutaka Miyazaki, Hideo Matsui, Kenji Okumura, Takayuki Ito. Angiotensin II type 2 receptor blockade partially negates antihypertrophic effects of type 1 receptor blockade on pressure-overload rat cardiac hypertrophy.
Hypertension research : official journal of the Japanese Society of Hypertension.
2003 Jan; 26(1):89-95. doi:
10.1291/hypres.26.89. [PMID: 12661917] - Francisco Fernández-Vega, José Abellán, Onofre Vegazo, Soledad García De Vinuesa, José Carlos Rodríguez, Benito Maceira, Saturnino Sanz de Castro, Roberto Robles Nicolás, José Luño. Angiotensin II type 1 receptor blockade to control blood pressure in postmenopausal women: influence of hormone replacement therapy.
Kidney international. Supplement.
2002 Dec; ?(82):S36-41. doi:
10.1046/j.1523-1755.62.s82.8.x. [PMID: 12410853] - Yasutaka Nagisa, Asae Shintani, Shizue Nakagawa. [Ameliorative effects on retinal disorder in diabetic SHRSP (stroke-prone spontaneously hypertensive rat)].
Nihon rinsho. Japanese journal of clinical medicine.
2002 Oct; 60(10):1975-80. doi:
. [PMID: 12397694] - Kiyoshi Kurokawa, Keishi Abe, Takao Saruta, Masaaki Arakawa, Ryuichi Kikkawa, Naohiko Ueda, Kaoru Onoyama, Kimio Tomita, Nobuya Ogawa. Antiproteinuric effect of candesartan cilexetil in patients with chronic glomerulonephritis.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2002 Sep; 3(3):167-75. doi:
10.3317/jraas.2002.037. [PMID: 12563567] - Hideaki Nakaya, Hiroyuki Sasamura, Mizuo Mifune, Ryoko Shimizu-Hirota, Mari Kuroda, Matsuhiko Hayashi, Takao Saruta. Prepubertal treatment with angiotensin receptor blocker causes partial attenuation of hypertension and renal damage in adult Dahl salt-sensitive rats.
Nephron.
2002 Aug; 91(4):710-8. doi:
10.1159/000065035. [PMID: 12138277] - Mitsuhide Naruse, Akiyo Tanabe, Atsuhisa Sato, Sachiko Takagi, Ken Tsuchiya, Toshihiro Imaki, Kazue Takano. Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2002 Jul; 40(1):28-33. doi:
10.1161/01.hyp.0000022606.52221.2f. [PMID: 12105134] - Takanori Matsuo, Eiichiro Ishikawa, Masayuki Ohta, Yumiko Shibouta, Yoshimasa Ishimura, Yoshimi Imura, Yasuo Sugiyama. Renal protective effect of candesartan cilexetil in spontaneously hypercholesterolemic rats.
Japanese journal of pharmacology.
2002 Mar; 88(3):300-6. doi:
10.1254/jjp.88.300. [PMID: 11949885] - Jun Araya, Tetsuhiro Tsuruma, Koichi Hirata, Atsuhito Yagihashi, Naoki Watanabe. TCV-116, an angiotensin II type 1 receptor antagonist, reduces hepatic ischemia-reperfusion injury in rats.
Transplantation.
2002 Feb; 73(4):529-34. doi:
10.1097/00007890-200202270-00006. [PMID: 11889423] - Kohji Takara, Mikio Kakumoto, Yusuke Tanigawara, Junko Funakoshi, Toshiyuki Sakaeda, Katsuhiko Okumura. Interaction of digoxin with antihypertensive drugs via MDR1.
Life sciences.
2002 Feb; 70(13):1491-500. doi:
10.1016/s0024-3205(01)01494-1. [PMID: 11895100]