Omeprazole (BioDeep_00000002539)

 

Secondary id: BioDeep_00000397479

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1-methyl-1H-benzo[d]imidazole

化学式: C17H19N3O3S (345.11470640000005)
中文名称: (S)-(-)-奥美拉唑, 埃索美拉唑, 奥美拉唑
谱图信息: 最多检出来源 Homo sapiens(blood) 11.61%

分子结构信息

SMILES: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
InChI: InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

描述信息

Omeprazole is a highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers, dyspepsia, peptic ulcer disease , gastroesophageal reflux disease and Zollinger-Ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of Gastric Parietal Cells.--Pubchem. Omeprazole is one of the most widely prescribed drugs internationally and is available over the counter in some countries.
Proton pump inhibitor, inhibits gastric acid secretion. Antiulcer agent. It is used in combination with Amoxicillin for eradication of Helicobacter pylori and for the treatment of gastroesophageal reflux disease (CCD)
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BC - Proton pump inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29723 - Proton Pump Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

同义名列表

114 个代谢物同义名

6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1-methyl-1H-benzo[d]imidazole; 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole; 2,3,5-Trimethylpyridine/Omeprazole; Omeprazole, BAN, INN, JAN, USA; Magnesium, omeprazole; Omeprazole magnesium; Omeprazole pellets; (S)-(-)-Omeprazole; Sodium, omeprazole; Omeprazole sodium; ( -)-Omeprazole; (S)-Omeprazole; (-)-Omeprazole; Prestwick_808; Tedec ulceral; Esomperazole; Esomeprazole; Prilosec otc; Omeprazolum; omeprazole; Antra mups; Demeprazol; Ulcometion; Omebeta 20; Inhibitron; Nexium IV; Nuclosina; Secrepina; Omeprazol; Ceprandal; Epirazole; Omeprazon; Prazentol; Logastric; Omepradex; Emeproton; Dizprazol; Gastroloc; Peptilcer; Sanamidol; Regulacid; Gastrimut; Nopramin; Pepticus; Paprazol; Pepticum; Prilosec; Prazidec; Inhipump; Prazolit; Omezolan; Gibancer; Belmazol; Indurgan; Procelac; Dudencer; Ortanol; Erbolin; Parizac; Ompanyt; Ulcozol; Miracid; Morecon; Audazol; Proclor; Omeprol; Ulceral; Victrix; Omepral; Omegast; Ramezol; Omapren; Ulcesep; Zegerid; Omesek; Omisec; Zefxon; Nilsec; Prysma; Omizac; Zoltum; Ozoken; Danlox; Ulcsep; Mepral; Zepral; Result; Mopral; Olexin; Aulcer; Osiren; Lensor; Omezol; Nexium; Nexiam; Zimor; Exter; Lomac; Desec; Ulsen; Gasec; Ulzol; Antra; Elgam; Losec; Ultop; Omed; Miol; Omid; Omez; Ocid; OMEP; OMZ; H 16868



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ghazal Nabil, Yasmine H Ahmed, Omaima Ahmed, Selvia S Milad, Mohamed Hisham, Mohamed Rafat, Mohamed Atia, Aya A Shokry. Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways. Journal of ethnopharmacology. 2024 Jun; 327(?):117970. doi: 10.1016/j.jep.2024.117970. [PMID: 38428660]
  • N J Menzies-Gow, T Shurlock. The effect of feeding a commercial feedstuff on gastric squamous gastric disease (ESGD) healing and prevention of recurrence. Journal of equine veterinary science. 2024 Feb; 133(?):105015. doi: 10.1016/j.jevs.2024.105015. [PMID: 38281606]
  • Salah Tofik Jalal Balaky. Anti H. pylori, anti-secretory and gastroprotective effects of Thymus vulgaris on ethanol-induced gastric ulcer in Sprague Dawley rats. PloS one. 2024; 19(1):e0287569. doi: 10.1371/journal.pone.0287569. [PMID: 38271407]
  • Monika Singh, Shreshtha Singh, Dinesh Puri, Shalini Kapoor Sawhney, Nitin Kumar, Mohd Yasir, Pankaj Nainwal. The Anti-ulcer Potential of Weissella cibaria Assisted Bio-fermented Product of Citrus limetta Waste Peel in Wistar Albino Rats. Recent patents on biotechnology. 2024; 18(4):344-357. doi: 10.2174/0118722083278152231121173605. [PMID: 38566382]
  • Ruiqi Zhao, Sen Lin, Mengyao Han, Zhimei Lin, Mengjiao Yu, Lisheng Peng. Does proton pump inhibitors use increase risk of digestive tumors?: A 2-sample Mendelian randomization study. Medicine. 2023 Nov; 102(45):e36085. doi: 10.1097/md.0000000000036085. [PMID: 37960715]
  • Doaa R I Abdel-Gawad, Marwa A Ibrahim, Usama K Moawad, Shaimaa Kamel, Hossny A El-Banna, Ahmed H El-Banna, Walid Hamdy Hassan, Fatma I Abo El-Ela. Effectiveness of natural biomaterials in the protection and healing of experimentally induced gastric mucosa Ulcer in rats. Molecular biology reports. 2023 Sep; ?(?):. doi: 10.1007/s11033-023-08776-9. [PMID: 37741810]
  • Sumit Bansal, C Austin Zamarripa, Tory R Spindle, Elise M Weerts, Kenneth E Thummel, Ryan Vandrey, Mary F Paine, Jashvant D Unadkat. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants. Clinical pharmacology and therapeutics. 2023 Jun; ?(?):. doi: 10.1002/cpt.2973. [PMID: 37313955]
  • Faryal Rubab, Hira Ijaz, Shah Hussain, Ans Munir, Stefan Stuppner, Thomas Jakschitz, Günther K Bonn, Saiqa Ishtiaq. Gastroprotective effects of Caragana ambigua stocks on ethanol-induced gastric ulcer in rats supported by LC-MS/MS characterization of formononetin and biochanin A. Journal of the science of food and agriculture. 2022 Dec; 102(15):7030-7038. doi: 10.1002/jsfa.12064. [PMID: 35689485]
  • Hui-Lin Yang, Ying Li, Yi Chen, Si-Ying Chen, Yue-Ting Li, Yong Huang, Lin Zheng, Jing Huang, Yong-Lin Wang, Zi-Peng Gong. [Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(23):6320-6332. doi: 10.19540/j.cnki.cjcmm.20220623.204. [PMID: 36604876]
  • Guoxin Bai, Junyu Yi, Yuanyuan Yu, Hongxing Du. Clinical effect of Anwei Qingyou recipe on peptic ulcer and its effect on the levels of EGF and PGE2: A retrospective study. Medicine. 2022 Oct; 101(40):e30898. doi: 10.1097/md.0000000000030898. [PMID: 36221352]
  • Yue Ma, Shu Li, Hongxi Yang, Yuan Zhang, Huiping Li, Lihui Zhou, Jing Lin, Yanchun Chen, Yabing Hou, Xinyu Zhang, Tong Liu, Xin Zhou, Yaogang Wang. Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adults. Atherosclerosis. 2022 10; 358(?):47-54. doi: 10.1016/j.atherosclerosis.2022.09.001. [PMID: 36113328]
  • Seok Hwee Koo, Gaik Hong Soon, Alain Pruvost, Henri Benech, Tiing Leong Ang, Edmund Jon Deoon Lee, Daphne Shih Wen Ang. Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers. Naunyn-Schmiedeberg's archives of pharmacology. 2022 07; 395(7):815-826. doi: 10.1007/s00210-022-02235-1. [PMID: 35394133]
  • Yiming Cheng, Liangang Liu, Yongjun Xue, Simon Zhou, Yan Li. An Open Label, Phase 1, Randomized, Seven-treatment, Seven-period, Crossover Study to Assess the Relative Bioavailability, pH Effect, Food Effect, and Dose Proportionality of CC-292, a Potent and Orally Available Bruton's Tyrosine Kinase Inhibitor. European journal of drug metabolism and pharmacokinetics. 2022 Jul; 47(4):579-592. doi: 10.1007/s13318-022-00776-7. [PMID: 35657581]
  • Urs Duthaler, Fabio Bachmann, Claudia Suenderhauf, Tanja Grandinetti, Florian Pfefferkorn, Manuel Haschke, Petr Hruz, Jamal Bouitbir, Stephan Krähenbühl. Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently. Clinical pharmacokinetics. 2022 07; 61(7):1039-1055. doi: 10.1007/s40262-022-01119-0. [PMID: 35570253]
  • Roland Heinig, Johannes Nagelschmitz, Stephanie Loewen. Results From Phase I Studies Investigating the Dose Linearity of Finerenone Tablets and the Influence of Food or pH-Modifying Comedications on its Pharmacokinetics in Healthy Male Volunteers. European journal of drug metabolism and pharmacokinetics. 2022 Jul; 47(4):549-559. doi: 10.1007/s13318-022-00770-z. [PMID: 35612708]
  • Huan Gao, Yanqing Song, Jie Ma, Jinghui Zhai, Yueming Zhang, Xiaoyu Qu. Untargeted metabolomics analysis of omeprazole-enhanced chemosensitivity to cisplatin in mice with non-small cell lung cancer. Chemico-biological interactions. 2022 Jun; 360(?):109933. doi: 10.1016/j.cbi.2022.109933. [PMID: 35447140]
  • Shuang Zhou, Ran Xie, Xiaodan Zhang, Xu He, Jie Huang, Yin Jungang, Man Liao, Ying Ding, Dandan Yang, Ying Liu, Qian Zhang, Guoping Yang, Fang Liu, Shengjiang Guan, Qing He, Honggang Lou, Fengyun Gong, Xianmin Meng, Qian Xiang, Xia Zhao, Yimin Cui. Evaluation of the relationship between polymorphisms in CYP2C19 and the single-dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study. Clinical and translational science. 2022 Jun; 15(6):1439-1448. doi: 10.1111/cts.13255. [PMID: 35235711]
  • Slimen Selmi, Dhouha Alimi, Kais Rtibi, Saber Jedidi, Dhekra Grami, Lamjed Marzouki, Karim Hosni, Hichem Sebai. Gastroprotective and Antioxidant Properties of Trigonella foenum graecum Seeds Aqueous Extract (Fenugreek) and Omeprazole Against Ethanol-Induced Peptic Ulcer. Journal of medicinal food. 2022 May; 25(5):513-522. doi: 10.1089/jmf.2020.0217. [PMID: 35561273]
  • Xiaoyu Li, Ying Wang, Xiaohong Zhu, Li Zheng. Clinical study of drug-drug interaction between omeprazole and pyrotinib after meal. British journal of clinical pharmacology. 2022 05; 88(5):2349-2358. doi: 10.1111/bcp.15169. [PMID: 34873745]
  • Larissa Selbach Dries, Rochelli Haefliger, Bruna Sherer Seibert, Angélica Gewehr de Lima, Caroline de Oliveira Cardoso, Magda Susana Perassolo. Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use. The Journal of pharmacy and pharmacology. 2022 Apr; 74(4):547-555. doi: 10.1093/jpp/rgab001. [PMID: 33793790]
  • C Zeng, T Neogi, A T Chan, J Wei, D Misra, N Lu, H K Choi, G Lei, Y Zhang. Proton pump inhibitor therapy and risk of knee replacement surgery: a general population-based cohort study. Osteoarthritis and cartilage. 2022 04; 30(4):559-569. doi: 10.1016/j.joca.2021.12.010. [PMID: 35031493]
  • Amira Hussain, Declan P Naughton, James Barker. Potential Effects of Ibuprofen, Remdesivir and Omeprazole on Dexamethasone Metabolism in Control Sprague Dawley Male Rat Liver Microsomes (Drugs Often Used Together Alongside COVID-19 Treatment). Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072238. [PMID: 35408639]
  • Choki Dorji, Farruk Ahammed Robin, Kesara Na-Bangchang. Omeprazole-induced galactorrhea in kidney transplant patients-a case report. Journal of medical case reports. 2022 Mar; 16(1):121. doi: 10.1186/s13256-022-03337-3. [PMID: 35339194]
  • Yan Zhang, Yiping Yu, Hong Li, Wenge Huang, Ping Wang. Effects of Citri Reticulatae Pericarpium and grapefruit juice on the pharmacokinetics of omeprazole in rats. Journal of food biochemistry. 2022 03; 46(3):e13804. doi: 10.1111/jfbc.13804. [PMID: 34080214]
  • Stephan Schaller, Frederico S Martins, Pavel Balazki, Sonja Böhm, Joachim Baumgart, Ralf A Hilger, Dietrich W Beelen, Claudia Hemmelmann, Arne Ring. Evaluation of the drug-drug interaction potential of treosulfan using a physiologically-based pharmacokinetic modelling approach. British journal of clinical pharmacology. 2022 02; 88(4):1722-1734. doi: 10.1111/bcp.15081. [PMID: 34519068]
  • Zhelong Liu, Jian Xiong, Song Gao, Michael X Zhu, Kai Sun, Min Li, Guohua Zhang, Yi-Ping Li. Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole. Journal of cachexia, sarcopenia and muscle. 2022 02; 13(1):636-647. doi: 10.1002/jcsm.12851. [PMID: 34729960]
  • Lujing Wang, Yang Chen, Wangda Zhou, Xin Miao, Honghui Zhou. Utilization of physiologically-based pharmacokinetic model to assess disease-mediated therapeutic protein-disease-drug interaction in immune-mediated inflammatory diseases. Clinical and translational science. 2022 02; 15(2):464-476. doi: 10.1111/cts.13164. [PMID: 34581012]
  • Wenying Hao, Longfan Piao, Maojie Sun, Fanzhuo Zeng. Clinical effect of combination of octreotide and omeprazole in children with acute upper gastrointestinal bleeding and the levels of serum creatinine and serum urea nitrogen. Pakistan journal of pharmaceutical sciences. 2022 Jan; 35(1(Special)):343-347. doi: NULL. [PMID: 35236645]
  • Ashit Trivedi, Winnie Sohn, Pegah Jafarinasabian, Hanze Zhang, Bianca Terminello, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee. Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Omeprazole, a Proton Pump Inhibitor, in Healthy Subjects. Clinical pharmacology in drug development. 2022 01; 11(1):129-133. doi: 10.1002/cpdd.997. [PMID: 34272833]
  • Antonio Portolés-Pérez, Ana Belén Rivas Paterna, Andrés Sánchez Pernaute, Antonio José Torres García, Carmen Moreno Lopera, Luis M Chicharro, Fernando Bandrés, Amanda López-Picado, Miguel A Rubio, Emilio Vargas Castrillón. Effect of Obesity and Roux-En-Y Gastric Surgery on Omeprazole Pharmacokinetics. Obesity facts. 2022; 15(2):271-280. doi: 10.1159/000521570. [PMID: 34979510]
  • Camille Lenoir, Amine Niederer, Victoria Rollason, Jules Alexandre Desmeules, Youssef Daali, Caroline Flora Samer. Prediction of cytochromes P450 3A and 2C19 modulation by both inflammation and drug interactions using physiologically based pharmacokinetics. CPT: pharmacometrics & systems pharmacology. 2022 01; 11(1):30-43. doi: 10.1002/psp4.12730. [PMID: 34791831]
  • Serafino Fazio, Paolo Bellavite, Elisabetta Zanolin, Peter A McCullough, Sergio Pandolfi, Flora Affuso. Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis of Early COVID-19 and Treated at Home Within 3 Days or After 3 Days of Symptom Onset with Prescribed and Non-Prescribed Treatments Between November 2020 and August 2021. Medical science monitor : international medical journal of experimental and clinical research. 2021 Dec; 27(?):e935379. doi: 10.12659/msm.935379. [PMID: 34966165]
  • Ahmed El-Olemy, Ahmed H Abdelazim, Sherif Ramzy, Mohamed A Hasan, Ahmed W Madkour, Ahmed A Almrasy, Mohamed Shahin. Application of different spectrofluorimetric approaches for quantitative determination of acetylsalicylic acid and omeprazole in recently approved pharmaceutical preparation and human plasma. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Dec; 262(?):120116. doi: 10.1016/j.saa.2021.120116. [PMID: 34217146]
  • Fabio Bachmann, Urs Duthaler, Stephan Krähenbühl. Effect of deglucuronidation on the results of the Basel phenotyping cocktail. British journal of clinical pharmacology. 2021 12; 87(12):4608-4618. doi: 10.1111/bcp.14874. [PMID: 33890704]
  • Joo Young Na, Inseung Jeon, Jangsoo Yoon, Yewon Choi, Seo Hyun Yoon, Kyung-Sang Yu, Jae-Yong Chung. Influence of CYP2C19 Polymorphisms on the Pharmacokinetics of Omeprazole in Elderly Subjects. Clinical pharmacology in drug development. 2021 12; 10(12):1469-1477. doi: 10.1002/cpdd.966. [PMID: 34337876]
  • Chunhua Ma, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu, Yuqin Jiang, Qingjie Ding. Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitors. Journal of medicinal chemistry. 2021 11; 64(21):16242-16270. doi: 10.1021/acs.jmedchem.1c01559. [PMID: 34672559]
  • Ashley Spencer, Jessica M Quimby, Josh M Price, Sally MacLane, Shanna Hillsman, Patty Secoura, Jörg M Steiner, M Katherine Tolbert. Appetite-stimulating effects of once-daily omeprazole in cats with chronic kidney disease: Double-blind, placebo-controlled, randomized, crossover trial. Journal of veterinary internal medicine. 2021 Nov; 35(6):2705-2712. doi: 10.1111/jvim.16268. [PMID: 34590746]
  • Bruna Barbosa da Luz, Daniele Maria-Ferreira, Jorge Luiz Dallazen, Ana Flávia de Oliveira, José Ederaldo Queiroz Telles, Olair Carlos Beltrame, Thales Ricardo Cipriani, Maria Fernanda de Paula Werner. Effectiveness of the polyphenols-rich Sedum dendroideum infusion on gastric ulcer healing in rats: Roles of protective endogenous factors and antioxidant and anti-inflammatory mechanisms. Journal of ethnopharmacology. 2021 Oct; 278(?):114260. doi: 10.1016/j.jep.2021.114260. [PMID: 34062247]
  • Smit S Deliwala, Grigoriy E Gurvits. Acute Esophageal Necrosis in a Patient With COVID-19. The American journal of gastroenterology. 2021 10; 116(10):1977. doi: 10.14309/ajg.0000000000001207. [PMID: 33661144]
  • Mohamed I Zanaty, Adel Abdel-Moneim, Yoichiro Kitani, Toshio Sekiguchi, Nobuo Suzuki. Effect of Omeprazole on Osteoblasts and Osteoclasts in vivo and in the in vitro Model Using Fish Scales. Biochemistry. Biokhimiia. 2021 Oct; 86(10):1192-1200. doi: 10.1134/s0006297921100035. [PMID: 34903151]
  • Koki Kato, Tomohiro Mizuno, Takenao Koseki, Yoshimasa Ito, Masakazu Hatano, Kazuo Takahashi, Shigeki Yamada, Naotake Tsuboi. Concomitant Proton Pump Inhibitors and Immune Checkpoint Inhibitors Increase Nephritis Frequency. In vivo (Athens, Greece). 2021 Sep; 35(5):2831-2840. doi: 10.21873/invivo.12570. [PMID: 34410975]
  • Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi. Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal. Scientific reports. 2021 08; 11(1):16629. doi: 10.1038/s41598-021-96109-w. [PMID: 34404832]
  • Srinivasan Damodharan, Gerard Marshall Raj, M Sakthibalan, Karthikeyan Dakshinamoorthy, P Muraliswaran. Effect of long-term acid suppression therapy with proton pump inhibitors or H2 receptor blockers on serum vitamin B12 levels in elderly population. Irish journal of medical science. 2021 Aug; 190(3):1213-1217. doi: 10.1007/s11845-020-02399-w. [PMID: 33085017]
  • Xiaoshu Dai, Michael D Karol, Matthew Hitron, Marjie L Hard, Matthew T Goulet, Colleen F McLaughlin, Scott J Brantley. Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers. Clinical pharmacology in drug development. 2021 08; 10(8):824-839. doi: 10.1002/cpdd.961. [PMID: 34107166]
  • Theodore W Perry. Abrupt-onset, profound erectile dysfunction in a healthy young man after initiating over-the-counter omeprazole: a case report. Journal of medical case reports. 2021 Jul; 15(1):360. doi: 10.1186/s13256-021-02981-5. [PMID: 34301322]
  • Jiaqi Zhang, Hui Che, Beihua Zhang, Chang Zhang, Bin Zhou, Haijie Ji, Jingyi Xie, Xiaoshuang Shi, Xia Li, Fengyun Wang, Xudong Tang. JianpiQinghua granule reduced PPI dosage in patients with nonerosive reflux disease: A multicenter, randomized, double-blind, double-dummy, noninferiority study. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jul; 88(?):153584. doi: 10.1016/j.phymed.2021.153584. [PMID: 34119741]
  • Luis Francisco Calleja, Belem Yoval-Sánchez, Luz Hernández-Esquivel, Juan Carlos Gallardo-Pérez, Marcela Sosa-Garrocho, Álvaro Marín-Hernández, Ricardo Jasso-Chávez, Marina Macías-Silva, José Salud Rodríguez-Zavala. Activation of ALDH1A1 by omeprazole reduces cell oxidative stress damage. The FEBS journal. 2021 07; 288(13):4064-4080. doi: 10.1111/febs.15698. [PMID: 33400378]
  • Lei Li, Yu-Xia Xiang, Guo-Ping Yang, Xing-Fei Zhang, Xiao-Yan Yang, Shuang Yang, Jie Huang. Pharmacokinetic effects of proton pump inhibitors on the novel PARP inhibitor fluzoparib: a single-arm, fixed-sequence trial in male healthy volunteers. Investigational new drugs. 2021 06; 39(3):796-802. doi: 10.1007/s10637-020-01034-w. [PMID: 33420642]
  • Porfirio Alonso Ruiz-Hurtado, Leticia Garduño-Siciliano, Pilar Dominguez-Verano, Elizdath Martinez-Galero, Maria Margarita Canales-Martinez, Marco Aurelio Rodriguez-Monroy. Evaluation of the gastroprotective effects of Chihuahua propolis on indomethacin- induced gastric ulcers in mouse. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111345. doi: 10.1016/j.biopha.2021.111345. [PMID: 33556873]
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