Sufentanil (BioDeep_00000002525)
Secondary id: BioDeep_00000398460
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
N-[4-(methoxymethyl)-1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl]-N-phenylpropanamide
化学式: C22H30N2O2S (386.202788)
中文名称: 舒芬太尼
谱图信息:
最多检出来源 Homo sapiens(blood) 9.57%
分子结构信息
SMILES: CCC(=O)N(C1=CC=CC=C1)C1(COC)CCN(CCC2=CC=CS2)CC1
InChI: InChI=1S/C22H30N2O2S/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20/h4-10,17H,3,11-16,18H2,1-2H3
描述信息
Sufentanil is only found in individuals that have used or taken this drug. It is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. [PubChem]Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Sufentanils analgesic activity is, most likely, due to its conversion to morphine. Opioids open calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AH - Opioid anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
24 个代谢物同义名
N-[4-(methoxymethyl)-1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl]-N-phenylpropanamide; N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide; N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide; Ratiopharm brand OF sufentanil citrate; Curasan brand OF sufentanil citrate; Janssen brand OF sufentanil citrate; Taylor brand OF sufentanil citrate; Hameln brand OF sufentanil citrate; Sufentanil-ratiopharm; Sufentanil ratiopharm; SufentanilRatiopharm; Curasan, sufentanil; Citrate, sufentanil; Sufentanil curasan; sufentanil citrate; Sufentanil-hameln; Sufentanil hameln; SufentanilHameln; Sufentanilum; Sulfentanil; Sulfentanyl; SUFENTANIL; Sufentanyl; Sufenta
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:9316
- KEGG: C08022
- KEGGdrug: D05938
- PubChem: 41693
- HMDB: HMDB0014846
- Metlin: METLIN2524
- DrugBank: DB00708
- ChEMBL: CHEMBL658
- Wikipedia: Sufentanil
- MeSH: Sufentanil
- chemspider: 38043
- CAS: 56030-54-7
- PMhub: MS000003394
- PubChem: 10222
- NIKKAJI: J11.105H
- RefMet: Sufentanil
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Boran Deng, Dingding Wang, Zifeng Xie, Yongqin Wang, Li Huang, Manlin Jiang, Tu Shen. Comparison of the analgesic effect of dezocine and esketamine in combination with sufentanil respectively after laparoscopic cholecystectomy: a prospective randomized controlled study.
BMC anesthesiology.
2024 Feb; 24(1):51. doi:
10.1186/s12871-024-02430-y. [PMID: 38317099] - Runan Pan, Bing Xu, Chengjie Tang, Junyan Cui. Exploring the effects of different dosages of sufentanil on postoperative VAS scores and recovery time in elderly patients with tibia-fibula fracture.
Minerva gastroenterology.
2023 12; 69(4):589-591. doi:
10.23736/s2724-5985.23.03414-9. [PMID: 37162470] - Kangjie Xie, Jinyan Chen, Lili Tian, Fulei Gu, Yafei Pan, Zhangxiang Huang, Jun Fang, Weifeng Yu, Huidan Zhou. Postoperative infusion of dexmedetomidine via intravenous patient-controlled analgesia for prevention of postoperative delirium in elderly patients undergoing surgery.
Aging clinical and experimental research.
2023 Jul; ?(?):. doi:
10.1007/s40520-023-02497-6. [PMID: 37470916] - Fei Liu, Liu-Lin Xiong, Ting-Ting Li, Yan-Jun Chen, Wei Ma, Qi-Jun Li, Qian Li, Ting-Hua Wang. Analgesic Effects and Adverse Reactions of Lidocaine for Patient-Controlled Intravenous Analgesia on Patients Undergoing Open Hepatectomy: A Retrospective Analysis.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses.
2023 Feb; 38(1):39-44. doi:
10.1016/j.jopan.2022.05.069. [PMID: 35989234] - Yi Zhou, Xiaoyan Liu, Chuan Ding, Bingyan Xiang, Ling Yan. Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study.
Pain research & management.
2023; 2023(?):7088004. doi:
10.1155/2023/7088004. [PMID: 36686371] - Yan Lu, Zongfang Piao, Jianling Li, Ling Li, Ruhong Li. Sufentanil promotes autophagy and improves ischemia-reperfusion-induced acute kidney injury via up-regulating microRNA-145.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2022 Oct; 47(10):1315-1323. doi:
10.11817/j.issn.1672-7347.2022.210602. [PMID: 36411682] - ShiFang Wang, WeiBing Wang, JinBo Xiao, HongPing Yu, Hui Zhou, Huang Xu. Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose-response trial.
BMC anesthesiology.
2022 Jul; 22(1):216. doi:
10.1186/s12871-022-01758-7. [PMID: 35820840] - Zhenming Kang, Guoshao Zhu, Changsheng Su, Kai Zeng, Shunyuan Li, Xiaodan Wu. Differential effects of remifentanil and sufentanil anesthesia on post-operative pain and cognitive functions.
International immunopharmacology.
2022 Jul; 108(?):108888. doi:
10.1016/j.intimp.2022.108888. [PMID: 35729829] - Jianing Li, Shuo Li, Ling Yu, Jin Wei, Hongwei Sun, Caixia Yang, Hongyu Tan. Identification of Preoperative Serum Metabolites Associated With Postoperative Opioid Consumption in Gastric Cancer Patients by Extreme Phenotype Sampling.
Pain physician.
2022 03; 25(2):E385-E396. doi:
. [PMID: 35322994] - Sarang S Koushik, Ruben H Schwartz, Denis Cherkalin, Vignesh Sankar, Naum Shaparin, Omar Viswanath. A Review of Sublingual Sufentanil Tablet (SST) and its Utility as an Analgesic Agent for Pain Procedures.
Current pain and headache reports.
2022 Feb; 26(2):145-149. doi:
10.1007/s11916-022-01014-0. [PMID: 35076875] - Zhong-Biao Nie, Zhi-Hong Li, Bin Lu, Yao-Yao Guo, Ran Zhang. Hydromorphone vs sufentanil in patient-controlled analgesia for postoperative pain management: A meta-analysis.
Medicine.
2022 Jan; 101(3):e28615. doi:
10.1097/md.0000000000028615. [PMID: 35060534] - Shenglan Mei, Yifan Jia, Jinjian Zhou, Ling Zhan, Jin Liu, Hao Ming, Huagang Liu. Effects of Different Anesthetics on Perioperative Organ Protection and Postoperative Cognitive Function in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass.
Computational intelligence and neuroscience.
2022; 2022(?):8994946. doi:
10.1155/2022/8994946. [PMID: 35676968] - Liuji Qiu, Guochen Zhong, Zhiqi Hou, Jiayin Lin, Laibao Sun. Protective Effect of Sufentanil on Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting Endoplasmic Reticulum Stress.
Computational and mathematical methods in medicine.
2022; 2022(?):6267720. doi:
10.1155/2022/6267720. [PMID: 35356663] - Yue Wu, Lina Tian, Chunye Li, Minjun Liu, Shina Qiao, Weibo Zhang, Suming Tian, Gang Chen. Factors affecting sufentanil consumption for intravenous controlled analgesia after hepatectomy: retrospective analysis.
BMC anesthesiology.
2021 12; 21(1):308. doi:
10.1186/s12871-021-01526-z. [PMID: 34876004] - Marcin Zawadzki, Grzegorz Kowalski, Agnieszka Chłopaś-Konowałek, Marta Siczek, Małgorzata Sobieszczańska, Wojciech Leppert, Katarzyna Wieczorowska-Tobis, Paweł Szpot. Rapid Determination of Sufentanil in Human Plasma by UHPLC-QqQ-MS-MS.
Journal of analytical toxicology.
2021 Jul; 45(6):605-611. doi:
10.1093/jat/bkaa123. [PMID: 32901795] - Yang Zhang, Haixia Gong, Biming Zhan, Shibiao Chen. Effects of bilateral Pecto-intercostal Fascial Block for perioperative pain management in patients undergoing open cardiac surgery: a prospective randomized study.
BMC anesthesiology.
2021 06; 21(1):175. doi:
10.1186/s12871-021-01391-w. [PMID: 34157970] - Grzegorz Kowalski, Marcin Zawadzki, Wojciech Leppert, Paweł Szpot, Marta Siczek, Krzysztof Słowiński, Małgorzata Sobieszczańska, Agata Gawłowska, Katarzyna Wieczorowska-Tobis. Analgesic efficacy of sufentanil in dressings after surgical treatment of burn wounds.
Burns : journal of the International Society for Burn Injuries.
2021 06; 47(4):880-887. doi:
10.1016/j.burns.2020.10.006. [PMID: 33293157] - Xingfeng Sun, Qun Zhou, Min Zhou, Rong Cao, Zuolei Chen, Songjiang Tang, Shaoqiang Huang. The Effect of Epidural Nalbuphine Combined With Ropivacaine on Epidural Analgesia During Labor: A Multicenter, Randomized, Double-blind, Controlled Study.
The Clinical journal of pain.
2021 06; 37(6):437-442. doi:
10.1097/ajp.0000000000000928. [PMID: 33758132] - Zhengzuo Wan, Chunhua Chu, Rong Zhou, Bin Que. Effects of Oxycodone Combined With Flurbiprofen Axetil on Postoperative Analgesia and Immune Function in Patients Undergoing Radical Resection of Colorectal Cancer.
Clinical pharmacology in drug development.
2021 03; 10(3):251-259. doi:
10.1002/cpdd.818. [PMID: 32567233] - Jia-Wei Chen, Lin Tian, Le Zhang, Jian-Ying Hu, Shao-Qiang Huang, Jing Jiao. Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies: A randomized controlled trial.
Clinical and experimental pharmacology & physiology.
2021 02; 48(2):170-176. doi:
10.1111/1440-1681.13421. [PMID: 33063882] - Jean Jung, Allan Kolodziej, Elise Pape, Michael Bisch, Lucie Javot, Valérie Gibaja, Jean-Yves Jouzeau, Julien Scala-Bertola, Nicolas Gambier. Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients.
Forensic science international.
2020 Dec; 317(?):110437. doi:
10.1016/j.forsciint.2020.110437. [PMID: 33007729] - Robert J Brosnan, Bruno H Pypendop, Scott D Stanley. Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats.
Journal of veterinary pharmacology and therapeutics.
2020 Nov; 43(6):533-537. doi:
10.1111/jvp.12886. [PMID: 32557697] - Yi-Heng Liu, Xiao-Bing Hu, Xia-Min Yang, Ying-Wei Wang, Meng Deng. Comparing remifentanil and sufentanil in stress reduction during neurosurgery: a randomised controlled trial.
International journal of clinical pharmacy.
2020 Oct; 42(5):1326-1334. doi:
10.1007/s11096-020-01094-1. [PMID: 32686050] - Yanxia Guo, Dan Wang, Xiaolin Yang, Pingping Jiang, Juan Xu, Guoyuan Zhang. Effects of different sufentanil target concentrations on the MACBAR of sevoflurane in patients with carbon dioxide pneumoperitoneum stimulus.
BMC anesthesiology.
2020 09; 20(1):239. doi:
10.1186/s12871-020-01160-1. [PMID: 32957929] - Yanhua Peng, Jinfeng Yang, Duo Guo, Chumei Zheng, Huiping Sun, Qinya Zhang, Shuangfa Zou, Yanping Zhang, Ke Luo, Keith A Candiotti. Sufentanil postoperative analgesia reduce the increase of T helper 17 (Th17) cells and FoxP3+ regulatory T (Treg) cells in rat hepatocellular carcinoma surgical model: A randomised animal study.
BMC anesthesiology.
2020 08; 20(1):212. doi:
10.1186/s12871-020-01129-0. [PMID: 32847505] - Susanna Porela-Tiihonen, Hannu Kokki, Merja Kokki. An up-to-date overview of sublingual sufentanil for the treatment of moderate to severe pain.
Expert opinion on pharmacotherapy.
2020 Aug; 21(12):1407-1418. doi:
10.1080/14656566.2020.1766025. [PMID: 32486875] - Chaoliang Tang, Yida Hu, Zhetao Zhang, Zeyuan Wei, Hongtao Wang, Qingtian Geng, Si Shi, Song Wang, Jiawu Wang, Xiaoqing Chai. Dexmedetomidine with sufentanil in intravenous patient-controlled analgesia for relief from postoperative pain, inflammation and delirium after esophageal cancer surgery.
Bioscience reports.
2020 05; 40(5):. doi:
10.1042/bsr20193410. [PMID: 32343308] - Jian Zhang, Qing Tu, Jianhui Gan, Shuai Miao, Ying Zhou, Qiang Li, Chuandong Zheng. Preemptive Anti-Stress Response Effects of Oxycodone Versus Sufentanil for Patients Undergoing Cardiac Valve Replacement-A Randomized Controlled Trial.
Clinical pharmacology in drug development.
2020 04; 9(3):321-329. doi:
10.1002/cpdd.764. [PMID: 31820593] - Meng Ying Xi, Si Si Li, Chao Zhang, Lin Zhang, Tao Wang, Cong Yu. Nalbuphine for Analgesia After Orthognathic Surgery and Its Effect on Postoperative Inflammatory and Oxidative Stress: A Randomized Double-Blind Controlled Trial.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2020 Apr; 78(4):528-537. doi:
10.1016/j.joms.2019.10.017. [PMID: 31785250] - Jianhui Gan, Qing Tu, Shuai Miao, Tiantian Lei, Xiaoyan Cui, Jinyin Yan, Jian Zhang. Effects of oxycodone applied for patient-controlled analgesia on postoperative cognitive function in elderly patients undergoing total hip arthroplasty: a randomized controlled clinical trial.
Aging clinical and experimental research.
2020 Feb; 32(2):329-337. doi:
10.1007/s40520-019-01202-w. [PMID: 30993660] - Jiang Wu, Qi Gui, Jinlin Wang, Jingjing Ye, Zhongfang Xia, Shufen Wang, Feng Liu, Fanli Kong, Liang Zhong. Oxycodone preemptive analgesia after endoscopic plasma total adenotonsillectomy in children: A randomized controlled trial.
Medicine.
2020 Feb; 99(6):e19004. doi:
10.1097/md.0000000000019004. [PMID: 32028411] - H Zhou, Z-H Zhu, Y Liu, Y-Y Liu. Effects of midazolam combined with sufentanil on injury and expression of HMGB1 and NF-κB in rats with pancreatitis.
European review for medical and pharmacological sciences.
2020 02; 24(4):2102-2109. doi:
10.26355/eurrev_202002_20390. [PMID: 32141580] - Ru Ouyang, Haijing Ren, Wei Liu, Xi Yuan, Enjun Lei. Remifentanil inhibits the traumatic stress response in emergent trauma surgery.
Journal of clinical laboratory analysis.
2019 Oct; 33(8):e22971. doi:
10.1002/jcla.22971. [PMID: 31373418] - Li-Yun Zhang, Yu-Hao Zhang, Jie Shen, Yan Luo. Effects of dexmedetomidine on post-operative recovery and mental status in patients receiving robotic-assisted thoracic surgery.
Annals of palliative medicine.
2019 Sep; 8(4):469-475. doi:
10.21037/apm.2019.08.09. [PMID: 31594375] - Jongsung Hahn, Seungwon Yang, Kyoung Lok Min, Dasohm Kim, Byung Hak Jin, Changhun Park, Min Soo Park, Jin Wi, Min Jung Chang. Population pharmacokinetics of intravenous sufentanil in critically ill patients supported with extracorporeal membrane oxygenation therapy.
Critical care (London, England).
2019 07; 23(1):248. doi:
10.1186/s13054-019-2508-4. [PMID: 31288863] - Pavla Pokorná, Martin Šíma, Václav Vobruba, Martina Bašková, Lenka Posch, Ondřej Slanař. Sufentanil pharmacokinetics in a full-term neonate treated with extracorporeal membrane oxygenation: a case report.
Perfusion.
2019 07; 34(5):433-436. doi:
10.1177/0267659118824011. [PMID: 30632944] - Yi An, Lei Zhao, Tianlong Wang, Jiapeng Huang, Wei Xiao, Ping Wang, Lixia Li, Zhongjia Li, Xiaoxu Chen. Preemptive oxycodone is superior to equal dose of sufentanil to reduce visceral pain and inflammatory markers after surgery: a randomized controlled trail.
BMC anesthesiology.
2019 06; 19(1):96. doi:
10.1186/s12871-019-0775-x. [PMID: 31185942] - Ulrich H Frey, Marina Klaassen, Crista Ochsenfarth, Florian Murke, Matthias Thielmann, Eva Kottenberg, Petra Kleinbongard, Stefanie Klenke, Andrea Engler, Gerd Heusch, Bernd Giebel, Jürgen Peters. Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro-RNA signature in CABG patients.
Acta anaesthesiologica Scandinavica.
2019 04; 63(4):483-492. doi:
10.1111/aas.13296. [PMID: 30548252] - Lian Liu, Quan Yuan, Yafeng Wang, Wenwei Gao, Jiabao Hou, Yang Wu, Bo Zhao, Zhongyuan Xia. Effects of Dexmedetomidine Combined with Sufentanil on Postoperative Delirium in Young Patients After General Anesthesia.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Dec; 24(?):8925-8932. doi:
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Pain medicine (Malden, Mass.).
2018 10; 19(10):2058-2068. doi:
10.1093/pm/pnx248. [PMID: 29126259] - Wangda Zhou, Trevor N Johnson, Khanh H Bui, S Y Amy Cheung, Jianguo Li, Hongmei Xu, Nidal Al-Huniti, Diansong Zhou. Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children.
Clinical pharmacology and therapeutics.
2018 07; 104(1):188-200. doi:
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Anesthesiology.
2018 05; 128(5):912-920. doi:
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Anesthesiology.
2018 05; 128(5):943-952. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2018 03; 43(4):801-809. doi:
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Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2017 Jul; 37(7):705-709. doi:
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Acta anaesthesiologica Scandinavica.
2017 Jul; 61(6):636-640. doi:
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Pain physician.
2017 02; 20(2S):SE23-SE31. doi:
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European review for medical and pharmacological sciences.
2016 Apr; 20(7):1411-22. doi:
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Journal of pharmaceutical and biomedical analysis.
2016 Jan; 117(?):485-91. doi:
10.1016/j.jpba.2015.10.002. [PMID: 26469297] - Alicja Bartkowska-Śniatkowska, Agnieszka Bienert, Paweł Wiczling, Jowita Rosada-Kurasińska, Marzena Zielińska, Justyna Warzybok, Agnieszka Borsuk, Dick Tibboel, Roman Kaliszan, Edmund Grześkowiak. Pharmacokinetics of sufentanil during long-term infusion in critically ill pediatric patients.
Journal of clinical pharmacology.
2016 Jan; 56(1):109-15. doi:
10.1002/jcph.577. [PMID: 26105145] - Xing Liu, Shuqin Li, Baoguo Wang, Lixin An, Xiujun Ren, Haifeng Wu. Intraoperative and postoperative anaesthetic and analgesic effect of multipoint transcutaneous electrical acupuncture stimulation combined with sufentanil anaesthesia in patients undergoing supratentorial craniotomy.
Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2015 Aug; 33(4):270-6. doi:
10.1136/acupmed-2014-010749. [PMID: 25926298] - In-Kyung Song, Ji-Hyun Lee, SungAe Jung, Jin-Tae Kim, Hee-Soo Kim. Estimation of the plasma effect site equilibration rate constant of sufentanil in children using the time to peak effect of heart rate and blood pressure.
Indian journal of pharmacology.
2015 Jul; 47(4):360-4. doi:
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Medizinische Klinik, Intensivmedizin und Notfallmedizin.
2015 Apr; 110(2):145-9. doi:
10.1007/s00063-014-0416-6. [PMID: 25253578] - Fei Xiao, Wen-Ping Xu, Xiao-Min Zhang, Yin-Fa Zhang, Li-Zhong Wang, Xin-Zhong Chen. ED 50 and ED 95 of intrathecal bupivacaine coadministered with sufentanil for cesarean delivery under combined spinal-epidural in severely preeclamptic patients.
Chinese medical journal.
2015 Feb; 128(3):285-90. doi:
10.4103/0366-6999.150083. [PMID: 25635420] - Shangkun Li, Su Min, Bin Wu, Wanbi Tang. [Application of patient-controlled intravenous analgesia of dezocine combined with sufentanil in burn patients after surgery].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2015 Feb; 31(1):48-51. doi:
. [PMID: 25876640] - Harold S Minkowitz. A review of sufentanil and the sufentanil sublingual tablet system for acute moderate to severe pain.
Pain management.
2015; 5(4):237-50. doi:
10.2217/pmt.15.22. [PMID: 26088280] - Sandra K Willsie, Mark A Evashenk, Lawrence G Hamel, Stephen S Hwang, Yu-Kun Chiang, Pamela P Palmer. Pharmacokinetic properties of single- and repeated-dose sufentanil sublingual tablets in healthy volunteers.
Clinical therapeutics.
2015 Jan; 37(1):145-55. doi:
10.1016/j.clinthera.2014.11.001. [PMID: 25544247] - Youmei Zuo, Xinqi Cheng, Erwei Gu, Xunqin Liu, Lei Zhang, Yuanyuan Cao. Effect of aortic root infusion of sufentanil on ischemia-reperfusion injury in patients undergoing mitral valve replacement.
Journal of cardiothoracic and vascular anesthesia.
2014 Dec; 28(6):1474-8. doi:
10.1053/j.jvca.2014.04.023. [PMID: 25312265] - Hongjun Li, Hui Qiao, Hongjie Lu, Changqi Liu. Evaluation of the peripheral analgesic effect of sufentanil lipid nanoparticles.
Journal of anesthesia.
2014 Oct; 28(5):702-7. doi:
10.1007/s00540-014-1795-9. [PMID: 24604021] - Maria Gerou, Antonia Steves, Michael Musch, Franz-Josef Wittstamm, Darko Kröpfl, Harald Groeben. Age and bupivacaine plasma concentrations following radical cystectomy.
Journal of anesthesia.
2014 Oct; 28(5):716-20. doi:
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British journal of anaesthesia.
2014 Oct; 113(4):677-87. doi:
10.1093/bja/aeu160. [PMID: 25001621] - Shan-Wu Feng, Shi-Qin Xu, Li Ma, Cai-Juan Li, Xian Wang, Hong-Mei Yuan, Fu-Zhou Wang, Xiao-Feng Shen, Zheng-Nian Ding. Regular intermittent bolus provides similar incidence of maternal fever compared with continuous infusion during epidural labor analgesia.
Saudi medical journal.
2014 Oct; 35(10):1237-42. doi:
NULL. [PMID: 25316469] - T Schaaf, M Lyutenska, B W Urban, M Wittmann. Direct effects of morphine but not of fentanyl-type opioids on human 5-HT3A receptors in outside-out patch-clamp studies.
European journal of pain (London, England).
2014 Sep; 18(8):1165-72. doi:
10.1002/j.1532-2149.2014.00463.x. [PMID: 24590579] - Bogumila Woloszczuk-Gebicka, Tomasz Grabowski, Beata Borucka, Magdalena Karas-Trzeciak. Pharmacokinetics of sufentanil administered with 0.2\% ropivacaine as a continuous epidural infusion for postoperative pain relief in infants.
Paediatric anaesthesia.
2014 Sep; 24(9):962-7. doi:
10.1111/pan.12440. [PMID: 24824135] - Young-Chul Yoo, Jae-Kwang Shim, Young Song, So-Young Yang, Young-Lan Kwak. Anesthetics influence the incidence of acute kidney injury following valvular heart surgery.
Kidney international.
2014 Aug; 86(2):414-22. doi:
10.1038/ki.2013.532. [PMID: 24429400] - Patricia Hedenqvist, Anna Edner, Marianne Jensen-Waern. Anaesthesia in medetomidine premedicated New Zealand White rabbits: a comparison between intravenous sufentanil-midazolam and isoflurane anaesthesia for orthopaedic surgery.
Laboratory animals.
2014 Apr; 48(2):155-63. doi:
10.1177/0023677213516311. [PMID: 24464922] - Xiang Liu, Guixia Jing, Juan Bai, Hui Yuan. [Effect of sufentanil preconditioning on myocardial P-Akt expression in rats during myocardial ischemia-reperfusion].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2014 Mar; 34(3):335-40. doi:
. [PMID: 24670444] - Caetano Nigro Neto, Jose Luiz Gomes do Amaral, Renato Arnoni, Maria Angela Tardelli, Giovanni Landoni. Intrathecal sufentanil for coronary artery bypass grafting.
Brazilian journal of anesthesiology (Elsevier).
2014 Mar; 64(2):73-8. doi:
10.1016/j.bjane.2012.12.004. [PMID: 24794447] - Christian Jeleazcov, Teijo I Saari, Harald Ihmsen, Jan Mell, Katharina Fröhlich, Ljubica Krajinovic, Jörg Fechner, Jürgen Schüttler. Population pharmacokinetic modeling of hydromorphone in cardiac surgery patients during postoperative pain therapy.
Anesthesiology.
2014 Feb; 120(2):378-91. doi:
10.1097/aln.0b013e3182a76d05. [PMID: 23958818] - B H Pypendop, R J Brosnan, C R Majewski-Tiedeken, S D Stanley, J E Ilkiw. Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats.
Journal of veterinary pharmacology and therapeutics.
2014 Feb; 37(1):13-7. doi:
10.1111/jvp.12047. [PMID: 23895731] - Bettina N Nielsen, Susanne M Friis, Janne Rømsing, Kjeld Schmiegelow, Brian J Anderson, Nerea Ferreirós, Sandra Labocha, Steen W Henneberg. Intranasal sufentanil/ketamine analgesia in children.
Paediatric anaesthesia.
2014 Feb; 24(2):170-80. doi:
10.1111/pan.12268. [PMID: 24118506] - She-Liang Shen, Yi-hong Xie, Wen-Yuan Wang, Shuang-Fei Hu, Yun-Long Zhang. Comparison of dexmedetomidine and sufentanil for conscious sedation in patients undergoing awake fibreoptic nasotracheal intubation: a prospective, randomised and controlled clinical trial.
The clinical respiratory journal.
2014 Jan; 8(1):100-7. doi:
10.1111/crj.12045. [PMID: 23906186] - J L Manfio, L M Santos, M J C Carmona, M B Dos Santos, S Rcj Santos. Pharmacokinetic assessment of sufentanil in cardiac surgery.
Drug research.
2013 Oct; 63(10):495-500. doi:
10.1055/s-0033-1343470. [PMID: 23780500] - Ali Reza Fakhari, Hadi Tabani, Saeed Nojavan. Miniaturized hollow fibre assisted liquid-phase microextraction and gas chromatography for determination of trace concentration of sufentanil and alfentanil in biological samples.
Drug testing and analysis.
2013 Jul; 5(7):589-95. doi:
10.1002/dta.1387. [PMID: 22786780] - B Frossard, C Combret, D Benhamou. [Analgesia for labour and delivery in a parturient with paramytonia congenita].
Annales francaises d'anesthesie et de reanimation.
2013 May; 32(5):372-4. doi:
10.1016/j.annfar.2013.03.007. [PMID: 23648013] - S Karason, T A Olafsson. Avoiding bladder catheterisation in total knee arthroplasty: patient selection criteria and low-dose spinal anaesthesia.
Acta anaesthesiologica Scandinavica.
2013 May; 57(5):639-45. doi:
10.1111/aas.12089. [PMID: 23432613] - J Fechner, H Ihmsen, J Schüttler, C Jeleazcov. The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery.
European journal of pain (London, England).
2013 Apr; 17(4):562-70. doi:
10.1002/j.1532-2149.2012.00211.x. [PMID: 22927230] - Harold S Minkowitz, Neil K Singla, Mark A Evashenk, Stephen S Hwang, Yu-Kun Chiang, Lawrence G Hamel, Pamela P Palmer. Pharmacokinetics of sublingual sufentanil tablets and efficacy and safety in the management of postoperative pain.
Regional anesthesia and pain medicine.
2013 Mar; 38(2):131-9. doi:
10.1097/aap.0b013e3182791157. [PMID: 23271030] - C Jeleazcov, T I Saari, H Ihmsen, J Schüttler, J Fechner. Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass.
British journal of anaesthesia.
2012 Nov; 109(5):698-706. doi:
10.1093/bja/aes253. [PMID: 22831891] - Ma Jiahai, Wang Xueyan, Xie Yonggang, Yu Jianhong, He Qunhui, Li Zhi, Du Juan, Jiang Xiuliang. Spectral entropy monitoring reduces anesthetic dosage for patients undergoing off-pump coronary artery bypass graft surgery.
Journal of cardiothoracic and vascular anesthesia.
2012 Oct; 26(5):818-21. doi:
10.1053/j.jvca.2012.01.028. [PMID: 22502772] - Marija Bosilkovska, Bernhard Walder, Marie Besson, Youssef Daali, Jules Desmeules. Analgesics in patients with hepatic impairment: pharmacology and clinical implications.
Drugs.
2012 Aug; 72(12):1645-69. doi:
10.2165/11635500-000000000-00000. [PMID: 22867045] - T Lescot, F Boroli, V Reina, D Chauvet, A-L Boch, L Puybasset. Effect of continuous cerebrospinal fluid drainage on therapeutic intensity in severe traumatic brain injury.
Neuro-Chirurgie.
2012 Aug; 58(4):235-40. doi:
10.1016/j.neuchi.2012.03.010. [PMID: 22613876] - Teijo I Saari, Jörg Fechner, Harald Ihmsen, Jürgen Schüttler, Christian Jeleazcov. Determination of total and unbound sufentanil in human plasma by ultrafiltration and LC-MS/MS: application to clinical pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2012 Jul; 66(?):306-13. doi:
10.1016/j.jpba.2012.03.050. [PMID: 22522038] - P Akkamahadevi, Ht Srinivas, Anjali Siddesh, Naveen Kadli. Comparision of efficacy of sufentanil and fentanyl with low-concentration bupivacaine for combined spinal epidural labour analgesia.
Indian journal of anaesthesia.
2012 Jul; 56(4):365-9. doi:
10.4103/0019-5049.100819. [PMID: 23087459] - Se-Young Oh, Jong Chan Kim, Yong Seon Choi, Woo Kyung Lee, Yeong-Kyu Lee, Young Lan Kwak. Effects of ulinastatin treatment on myocardial and renal injury in patients undergoing aortic valve replacement with cardiopulmonary bypass.
Korean journal of anesthesiology.
2012 Feb; 62(2):148-53. doi:
10.4097/kjae.2012.62.2.148. [PMID: 22379570] - Yan Wang, Hong-bin Zhang, Bin Xia, Gong-ming Wang, Meng-yuan Zhang. Preemptive analgesic effects of flurbiprofen axetil in patients undergoing radical resection of esophageal carcinoma via the left thoracic approach.
Chinese medical journal.
2012 Feb; 125(4):579-82. doi:
. [PMID: 22490477] - Petrus R de Jong, Alvin W L Schadenberg, Theo van den Broek, Jeffrey M Beekman, Femke van Wijk, Paul J Coffer, Berent J Prakken, Nicolaas J G Jansen. STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass.
PloS one.
2012; 7(4):e35070. doi:
10.1371/journal.pone.0035070. [PMID: 22506067] - Allison Greening, Letha Mathews, James Blair. Apparent dexmedetomidine-induced polyuric syndrome in an achondroplastic patient undergoing posterior spinal fusion.
Anesthesia and analgesia.
2011 Dec; 113(6):1381-3. doi:
10.1213/ane.0b013e31823299c1. [PMID: 22003216] - Derek J Roberts, Richard I Hall, Andreas H Kramer, Helen Lee Robertson, Clare N Gallagher, David A Zygun. Sedation for critically ill adults with severe traumatic brain injury: a systematic review of randomized controlled trials.
Critical care medicine.
2011 Dec; 39(12):2743-51. doi:
10.1097/ccm.0b013e318228236f. [PMID: 22094498] - Sabina Strano-Rossi, Iván Alvarez, María Jesús Tabernero, Pamela Cabarcos, Purificación Fernández, Ana María Bermejo. Determination of fentanyl, metabolite and analogs in urine by GC/MS.
Journal of applied toxicology : JAT.
2011 Oct; 31(7):649-54. doi:
10.1002/jat.1613. [PMID: 21132842] - Li-xin An, Yong Ji, Li-li Wang. [The application of electro-acupuncture combined with sevoflurane anesthesia in neurosurgery].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2011 Sep; 31(9):1181-6. doi:
. [PMID: 22013791] - Kinge van der Heide, Ann de Haes, Götz Jk Wietasch, Ans Cp Wiesfeld, Herman Gd Hendriks. Torsades de pointes during laparoscopic adrenalectomy of a pheochromocytoma: a case report.
Journal of medical case reports.
2011 Aug; 5(?):368. doi:
10.1186/1752-1947-5-368. [PMID: 21838875] - Cédric Daubin, Charlotte Quentin, Stéphane Allouche, Olivier Etard, Cathy Gaillard, Amélie Seguin, Xavier Valette, Jean-Jacques Parienti, Fabrice Prevost, Michel Ramakers, Nicolas Terzi, Pierre Charbonneau, Damien du Cheyron. Serum neuron-specific enolase as predictor of outcome in comatose cardiac-arrest survivors: a prospective cohort study.
BMC cardiovascular disorders.
2011 Aug; 11(?):48. doi:
10.1186/1471-2261-11-48. [PMID: 21824428] - Thierry V Scohy, Hanna D Golab, Mohamud Egal, Johanna J M Takkenberg, Ad J J C Bogers. Intraoperative glycemic control without insulin infusion during pediatric cardiac surgery for congenital heart disease.
Paediatric anaesthesia.
2011 Aug; 21(8):872-9. doi:
10.1111/j.1460-9592.2011.03571.x. [PMID: 21463390] - Youn Yi Jo, Young Lan Kwak, Jonghoon Lee, Yong Seon Choi. Relationship between N-terminal pro-B-type natriuretic peptide and renal function: the effects on predicting early outcome after off-pump coronary artery bypass surgery.
Korean journal of anesthesiology.
2011 Jul; 61(1):35-41. doi:
10.4097/kjae.2011.61.1.35. [PMID: 21860749] - Mohammad Saraji, Malihe Khalili Boroujeni, Ali Akbar Hajialiakbari Bidgoli. Comparison of dispersive liquid-liquid microextraction and hollow fiber liquid-liquid-liquid microextraction for the determination of fentanyl, alfentanil, and sufentanil in water and biological fluids by high-performance liquid chromatography.
Analytical and bioanalytical chemistry.
2011 Jun; 400(7):2149-58. doi:
10.1007/s00216-011-4874-x. [PMID: 21442368] - Valérie Renauld, Véronique Goudet, Claudie Mouton-Faivre, Bertrand Debaene, Pascale Dewachter. Case Report: perioperative immediate hypersensitivity involves not only allergy but also mastocytosis.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2011 May; 58(5):456-9. doi:
10.1007/s12630-011-9472-z. [PMID: 21347740] - Ruimei Yuan, Xianwei Zhang, Qian Deng, Yuan Wu, Guifang Xiang. Impact of CYP3A4*1G polymorphism on metabolism of fentanyl in Chinese patients undergoing lower abdominal surgery.
Clinica chimica acta; international journal of clinical chemistry.
2011 Apr; 412(9-10):755-60. doi:
10.1016/j.cca.2010.12.038. [PMID: 21223952] - Maria Cusato, Massimo Allegri, Tekla Niebel, Pablo Ingelmo, Monica Broglia, Antonio Braschi, Mario Regazzi. Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate.
European journal of clinical pharmacology.
2011 Apr; 67(4):399-406. doi:
10.1007/s00228-010-0927-x. [PMID: 21079936]