Praziquantel (BioDeep_00000002483)
Secondary id: BioDeep_00000397571
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-one
化学式: C19H24N2O2 (312.18376839999996)
中文名称: 乙腈中吡喹酮溶液
谱图信息:
最多检出来源 Homo sapiens(blood) 95%
分子结构信息
SMILES: C1CCC(CC1)C(=O)N1CC2c3ccccc3CCN2C(=O)C1
InChI: InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
描述信息
Praziquantel is only found in individuals that have used or taken this drug. It is an anthelmintic used in most schistosome and many cestode infestations. [PubChem]Praziquantel works by causing severe spasms and paralysis of the worms muscles. This paralysis is accompanied - and probably caused - by a rapid Ca 2+ influx inside the schistosome. Morphological alterations are another early effect of praziquantel. These morphological alterations are accompanied by an increased exposure of schistosome antigens at the parasite surface. The worms are then either completely destroyed in the intestine or passed in the stool. An interesting quirk of praziquantel is that it is relatively ineffective against juvenile schistosomes. While initially effective, effectiveness against schistosomes decreases until it reaches a minimum at 3-4 weeks. Effectiveness then increases again until it is once again fully effective at 6-7 weeks. Glutathione S-transferase (GST), an essential detoxification enzyme in parasitic helminths, is a major vaccine target and a drug target against schistosomiasis. Schistosome calcium ion channels are currently the only known target of praziquantel.
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02B - Antitrematodals > P02BA - Quinoline derivatives and related substances
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
同义名列表
18 个代谢物同义名
2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-one; Bayer brand OF praziquantel; Merck brand OF praziquantel; Praziquantel, (+-)-isomer; Praziquantel, (S)-isomer; Praziquantel, (R)-isomer; Prasiquantel; praziquantel; Traziquantel; 8440, EMBAY; EMBAY 8440; Biltricide; Cysticide; Pyquiton; Drontsit; Cisticid; Droncit; Cesol
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:91583
- ChEBI: CHEBI:45267
- KEGG: C07367
- KEGGdrug: D00471
- PubChem: 4891
- HMDB: HMDB0015191
- Metlin: METLIN2059
- DrugBank: DB01058
- ChEMBL: CHEMBL976
- Wikipedia: Praziquantel
- MeSH: Praziquantel
- chemspider: 4722
- CAS: 135526-78-2
- CAS: 55268-74-1
- PMhub: MS000002768
- PubChem: 9571
- NIKKAJI: J2.787A
- RefMet: Praziquantel
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Denis Ponomarev, Maria Lvova, Viatcheslav Mordvinov, Irina Chidunchi, Alexander Dushkin, Damira Avgustinovich. Anti-Opisthorchis felineus effects of artemisinin derivatives: An in vitro study.
Acta tropica.
2024 Jun; 254(?):107196. doi:
10.1016/j.actatropica.2024.107196. [PMID: 38521124] - Babatunji Emmanuel Oyinloye, David Ezekiel Shamaki, Emmanuel Ayodeji Agbebi, Sunday Amos Onikanni, Chukwudi Sunday Ubah, Raphael Taiwo Aruleba, Tran Nhat Phong Dao, Olutunmise Victoria Owolabi, Olajumoke Tolulope Idowu, Makhosazana Siduduzile Mathenjwa-Goqo, Deborah Tolulope Esan, Basiru Olaitan Ajiboye, Olaposi Idowu Omotuyi. In Silico Comparison of Bioactive Compounds Characterized from Azadirachta indica with an FDA-Approved Drug against Schistosomal Agents: New Insight into Schistosomiasis Treatment.
Molecules (Basel, Switzerland).
2024 Apr; 29(9):. doi:
10.3390/molecules29091909. [PMID: 38731401] - U D Ukwa, J K Saliu, B Akinsanya. Phytochemical profiling and anthelmintic potential of extracts of selected tropical plants on parasites of fishes in Epe Lagoon.
Scientific reports.
2023 Dec; 13(1):22727. doi:
10.1038/s41598-023-48164-8. [PMID: 38123590] - FatmaA S Anwar, Asmaa R Abdel-Malek, Shimaa H Salem, Mohamed Farouk, Marwa F Ali, Yousef A Abdelrady, Ahmed M Sayed. In vitro and In silico assessment of antischistosomal activities of ethanolic extract of Cornulacamonacantha.
Experimental parasitology.
2023 Oct; 254(?):108631. doi:
10.1016/j.exppara.2023.108631. [PMID: 37820894] - Carine Machado Azevedo, Cássio Santana Meira, Jaqueline Wang da Silva, Danielle Maria Nascimento Moura, Sheilla Andrade de Oliveira, Cícero Jádson da Costa, Emanuelle de Souza Santos, Milena Botelho Pereira Soares. Therapeutic Potential of Natural Products in the Treatment of Schistosomiasis.
Molecules (Basel, Switzerland).
2023 Sep; 28(19):. doi:
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Experimental parasitology.
2023 08; 251(?):108552. doi:
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PLoS neglected tropical diseases.
2023 Jun; 17(6):e0011426. doi:
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ACS infectious diseases.
2023 05; 9(5):1046-1055. doi:
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Journal of ethnopharmacology.
2023 May; ?(?):116607. doi:
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The Egyptian journal of immunology.
2023 Jan; 30(1):57-72. doi:
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Experimental parasitology.
2022 Sep; 240(?):108316. doi:
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International journal of molecular sciences.
2022 Aug; 23(16):. doi:
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Helicobacter.
2022 Aug; 27(4):e12897. doi:
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 Jul; 74(12):2181-2190. doi:
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Acta parasitologica.
2022 Jun; 67(2):773-783. doi:
10.1007/s11686-021-00513-1. [PMID: 35067863] - Yun-Ting He, Xiao-Hong Huang, Yue-Yi Fang, Qing-Sheng Zeng, Lai-De Li, Le Luo, Ying-Si Lai. Cost-effectiveness evaluation of different control strategies for Clonorchis sinensis infection in a high endemic area of China: A modelling study.
PLoS neglected tropical diseases.
2022 05; 16(5):e0010429. doi:
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Ethiopian journal of health sciences.
2022 May; 32(3):631-640. doi:
10.4314/ejhs.v32i3.20. [PMID: 35813666] - Ulrich Membe Femoe, Hermine Boukeng Jatsa, Valentin Greigert, Julie Brunet, Catherine Cannet, Mérimé Christian Kenfack, Nestor Gipwe Feussom, Joseph Bertin Kadji Fassi, Emilenne Tienga Nkondo, Ahmed Abou-Bacar, Alexander Wilhelm Pfaff, Théophile Dimo, Pierre Kamtchouing, Louis-Albert Tchuem Tchuenté. Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection.
PLoS neglected tropical diseases.
2022 04; 16(4):e0010382. doi:
10.1371/journal.pntd.0010382. [PMID: 35446855] - Swarna Bais, Abigail Norwillo, Gordon Ruthel, De'Broski R Herbert, Bruce D Freedman, Robert M Greenberg. Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity.
Biochimie.
2022 Mar; 194(?):108-117. doi:
10.1016/j.biochi.2021.12.018. [PMID: 34990770] - Elias K Asuming-Brempong, Irene Ayi, William van der Puije, Ben A Gyan, Irene A Larbi, Yvonne Ashong, Naa Adjeley Frempong, Joseph K Quartey, Joseph Otchere, Frances M Jones, Shona Wilson, David W Dunne, Daniel A Boakye. Increased ShTAL1 IgE responses post-Praziquantel treatment may be associated with a reduced risk to re-infection in a Ghanaian S. haematobium-endemic community.
PLoS neglected tropical diseases.
2022 03; 16(3):e0010115. doi:
10.1371/journal.pntd.0010115. [PMID: 35263327] - Patience B Tetteh-Quarcoo, Asamoah Ampong, Nicholas T K D Dayie, John Ahenkorah, Emilia A Udofia, Emmanuel Afutu, Robert Aryee, Benjamin P Niriwa, Fleischer C N Kotey, Eric S Donkor, Patrick F Ayeh-Kumi. Dynamics in Morbidity Markers and Cytological Observations Made in Urine of Schistosoma haematobium-Infected Children: Pre- and Post-Praziquantel Treatment in an Endemic Setting.
Medical sciences (Basel, Switzerland).
2022 02; 10(1):. doi:
10.3390/medsci10010014. [PMID: 35225947] - Eglal I Amer, Mervat Z El-Azzouni, Rana T El-Bannan, Thanaa I Shalaby, Samar N El-Achy, Maha M Gomaa. Schistosomiasis mansoni: A new therapeutic target for ubiquinol, a natural inhibitor of neutral magnesium-dependent sphingomyelinase in murine model.
Acta tropica.
2022 Feb; 226(?):106231. doi:
10.1016/j.actatropica.2021.106231. [PMID: 34785184] - Yousef Abdal Jalil Fadladdin. Evaluation of Antischistosomal Activities of Crude Aqueous Extracts of Artemisia annua, Nigella sativa, and Allium sativum against Schistosoma mansoni in Hamsters.
BioMed research international.
2022; 2022(?):5172287. doi:
10.1155/2022/5172287. [PMID: 35313628] - Érica Tex Paulino, Monique Ribeiro de Lima, Alessandra Lifsitch Viçosa, Cleber Hooper da Silva, Claudio Javier Salomon, Daniel Andrés Real, Dario Leonardi, Clélia Christina Mello Silva, Antonio Henrique Almeida de Moraes Neto. The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models.
Frontiers in public health.
2022; 10(?):848633. doi:
10.3389/fpubh.2022.848633. [PMID: 35692307] - Justin Komguep Nono, Severin Donald Kamdem, Fungai Musaigwa, Chukwudi A Nnaji, Frank Brombacher. Influence of schistosomiasis on host vaccine responses.
Trends in parasitology.
2022 01; 38(1):67-79. doi:
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Acta tropica.
2022 Jan; 225(?):106210. doi:
10.1016/j.actatropica.2021.106210. [PMID: 34687644] - Félix Couture, Audrey Desjardins, Patrick O Richard. Urinary schistosomiasis in a child from Central Africa.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
2021 12; 193(48):E1843. doi:
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Trials.
2021 Nov; 22(1):822. doi:
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Food chemistry.
2021 Nov; 362(?):130092. doi:
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The American journal of tropical medicine and hygiene.
2021 11; 106(1):303-311. doi:
10.4269/ajtmh.21-0599. [PMID: 34749308] - C J Opperman, J M N Enslin, J Nuttall, A J Brink, S P Da Fonseca, H D Tootla. Hydatid brain cyst: A delayed diagnosis in a rural setting during COVID-19.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
2021 11; 111(11):1050-1054. doi:
10.7196/samj.2021.v111i11.16043. [PMID: 34949267] - Nitesh Naranbhai, Rochelle A Singh, Bhavani Moodley, Khine Swe Swe Han, Moherndran Archary, Nomonde Mvelase. Case Report: Human Bertiellosis-A Rare Cestode Infection in a South African Child.
The American journal of tropical medicine and hygiene.
2021 10; 106(1):219-221. doi:
10.4269/ajtmh.21-0204. [PMID: 34695801] - Rajabu Hussein Mnkugwe, Eliford Ngaimisi Kitabi, Safari Kinung'hi, Appolinary A R Kamuhabwa, Omary Mashiku Minzi, Eleni Aklillu. Optimal single sampling time-point for monitoring of praziquantel exposure in children.
Scientific reports.
2021 09; 11(1):17955. doi:
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2021 Sep; 31(9):851-865. doi:
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PLoS neglected tropical diseases.
2021 09; 15(9):e0009669. doi:
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PLoS neglected tropical diseases.
2021 09; 15(9):e0009757. doi:
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The American journal of tropical medicine and hygiene.
2021 08; 105(4):1104-1108. doi:
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Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control.
2021 Aug; 33(6):643-646. doi:
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Acta tropica.
2021 Aug; 220(?):105954. doi:
10.1016/j.actatropica.2021.105954. [PMID: 33979641] - Nopparat Songserm, Worawut Namwong, Somkiattiyos Woradet, Banchob Sripa, Akhtar Ali. Public health interventions for preventing re-infection of Opisthorchis viverrini: application of the self-efficacy theory and group process in high-prevalent areas of Thailand.
Tropical medicine & international health : TM & IH.
2021 08; 26(8):962-972. doi:
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PLoS neglected tropical diseases.
2021 08; 15(8):e0009660. doi:
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Molecules (Basel, Switzerland).
2021 Jul; 26(15):. doi:
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Acta tropica.
2021 Jul; 219(?):105916. doi:
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PLoS neglected tropical diseases.
2021 07; 15(7):e0009628. doi:
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Acta tropica.
2021 Jun; 218(?):105871. doi:
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PLoS neglected tropical diseases.
2021 06; 15(6):e0009451. doi:
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Acta tropica.
2021 Jun; 218(?):105909. doi:
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Journal of medical case reports.
2021 May; 15(1):268. doi:
10.1186/s13256-021-02828-z. [PMID: 34022948] - Mahala Livingston, Pavitra Pillay, Siphosenkosi Gift Zulu, Leiv Sandvik, Jane Dene Kvalsvig, Silindile Gagai, Hashini Nilushika Galappaththi-Arachchige, Elisabeth Kleppa, Patricia Ndhlovu, Birgitte Vennervald, Svein Gunnar Gundersen, Myra Taylor, Eyrun F Kjetland. Mapping Schistosoma haematobium for Novel Interventions against Female Genital Schistosomiasis and Associated HIV Risk in KwaZulu-Natal, South Africa.
The American journal of tropical medicine and hygiene.
2021 05; 104(6):2055-2064. doi:
10.4269/ajtmh.20-0679. [PMID: 33939629] - Chenai Sheilla Mutiti, Nyasha Nicole Kapungu, Comfort Ropafadzo Kanji, Nadina Stadler, Julia Stingl, Charles Nhachi, James Hakim, Collen Masimirembwa, Roslyn Stella Thelingwani. Clinically relevant enantiomer specific R- and S-praziquantel pharmacokinetic drug-drug interactions with efavirenz and ritonavir.
Pharmacology research & perspectives.
2021 05; 9(3):e00769. doi:
10.1002/prp2.769. [PMID: 33929078] - Amber M Graham, Amy Davenport, Valentina S Moshnikova, Lindsey J Gilmour, Michelle Fabiani, Micah A Bishop, Audrey K Cook. Heterobilharzia americana infection in dogs: A retrospective study of 60 cases (2010-2019).
Journal of veterinary internal medicine.
2021 May; 35(3):1361-1367. doi:
10.1111/jvim.16127. [PMID: 33934409] - Tatiana S Sokolova, Vyacheslav A Petrov, Irina V Saltykova, Yulia B Dorofeeva, Alexander V Tyakht, Ludmila M Ogorodova, Olga S Fedorova. The impact of Opisthorchis felineus infection and praziquantel treatment on the intestinal microbiota in children.
Acta tropica.
2021 May; 217(?):105835. doi:
10.1016/j.actatropica.2021.105835. [PMID: 33485871] - Harry Cridge, Henrique Lupiano, Julia D Nipper, Andrew J Mackin, Jörg M Steiner. Efficacy of a low-dose praziquantel and fenbendazole protocol in the treatment of asymptomatic schistosomiasis in dogs.
Journal of veterinary internal medicine.
2021 May; 35(3):1368-1375. doi:
10.1111/jvim.16142. [PMID: 33955589] - Wegdan M Abd El Wahab, Ayman A El-Badry, Soheir S Mahmoud, Yaser A El-Badry, Mohamed A El-Badry, Doaa A Hamdy. Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: Hepatoprotective and enhancer of etiological treatment.
PLoS neglected tropical diseases.
2021 05; 15(5):e0009423. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - L P Wang, W P Deng, T W Jia, Z Q Qin, J Xu. [Conversion of serum anti-Schistosoma japonicum antibodies detected by immunological tests following treatment with praziquantel: a meta-analysis].
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control.
2021 Apr; 33(2):138-147. doi:
10.16250/j.32.1374.2020321. [PMID: 34008360] - Adeline Enjema Green, Judith Kuoh Anchang-Kimbi, Godlove Bunda Wepnje, Vicky Daonyle Ndassi, Helen Kuokuo Kimbi. Distribution and factors associated with urogenital schistosomiasis in the Tiko Health District, a semi-urban setting, South West Region, Cameroon.
Infectious diseases of poverty.
2021 Apr; 10(1):49. doi:
10.1186/s40249-021-00827-2. [PMID: 33845904] - Hannah W Wu, Sangshin Park, Sunthorn Pond-Tor, Ron Stuart, Sha Zhou, Yang Hong, Amanda E Ruiz, Luz Acosta, Blanca Jarilla, Jennifer F Friedman, Mario Jiz, Jonathan D Kurtis. Whole-Proteome Differential Screening Identifies Novel Vaccine Candidates for Schistosomiasis japonica.
The Journal of infectious diseases.
2021 04; 223(7):1265-1274. doi:
10.1093/infdis/jiab085. [PMID: 33606021] - Lucas S Queiroz, Everton Allan Ferreira, Ana C Mengarda, Ayla das C Almeida, Priscila de F Pinto, Elaine S Coimbra, Josué de Moraes, Ângelo M L Denadai, Ademar A Da Silva Filho. In vitro and in vivo evaluation of cnicin from blessed thistle (Centaurea benedicta) and its inclusion complexes with cyclodextrins against Schistosoma mansoni.
Parasitology research.
2021 Apr; 120(4):1321-1333. doi:
10.1007/s00436-020-06963-2. [PMID: 33164156] - Susannah Colt, Blanca Jarilla, Palmera Baltazar, Veronica Tallo, Luz P Acosta, Hannah W Wu, Christopher V Barry, Jonathan D Kurtis, Remigio M Olveda, Jennifer F Friedman, Mario A Jiz. Effect of maternal praziquantel treatment for Schistosoma japonicum infection on the offspring susceptibility and immunologic response to infection at age six, a cohort study.
PLoS neglected tropical diseases.
2021 04; 15(4):e0009328. doi:
10.1371/journal.pntd.0009328. [PMID: 33861768] - Abdelrahman R Said, Hager S Zoghroban, Mona F Arafa, Soheir S Mahmoud, Gamal M El Maghraby. Nanostructured lipid carriers for enhanced in vitro and in vivo schistosomicidal activity of praziquantel: effect of charge.
Drug development and industrial pharmacy.
2021 Apr; 47(4):663-672. doi:
10.1080/03639045.2021.1908339. [PMID: 33826458] - Maurice M Nigo, Peter Odermatt, David Wully Nigo, Georgette B Salieb-Beugelaar, Manuel Battegay, Patrick R Hunziker. Patients with severe schistosomiasis mansoni in Ituri Province, Democratic Republic of the Congo.
Infectious diseases of poverty.
2021 Mar; 10(1):39. doi:
10.1186/s40249-021-00815-6. [PMID: 33762007] - Stephen A Spencer, Cortland Linder, James M StJ Penney, Hannah J Russell, Kate Hyde, Caitlin Sheehy, Alice Reid, Emmanuel H Andriamasy, Gina U Raderalazasoa, Daniel A L Rakotomampianina, Anjara M Nandimbiniaina, Tahiry N Ranaivoson, Antsa Andrianiaina, Sheena M Cruickshank, Amaya L Bustinduy, J Russell Stothard, Glenn T Edosoa, Alain M Rahetilahy. Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar.
The American journal of tropical medicine and hygiene.
2021 03; 104(5):1841-1850. doi:
10.4269/ajtmh.20-1433. [PMID: 33684064] - D M El-Nagar, E M Al Olayan, A S Aloufi, A R Khatab. The potent effect of silymarin combination with Praziquantel or mirazid for Schistosoma mansoni treatment in infected male swiss albino mice.
Tropical biomedicine.
2021 Mar; 38(1):22-27. doi:
10.47665/tb.38.1.004. [PMID: 33797519] - Fatimaezzahra Amarir, Abdelkbir Rhalem, Abderrahim Sadak, Marianne Raes, Mohamed Oukessou, Aouatif Saadi, Mohammed Bouslikhane, Charles G Gauci, Marshall W Lightowlers, Nathalie Kirschvink, Tanguy Marcotty. Control of cystic echinococcosis in the Middle Atlas, Morocco: Field evaluation of the EG95 vaccine in sheep and cesticide treatment in dogs.
PLoS neglected tropical diseases.
2021 03; 15(3):e0009253. doi:
10.1371/journal.pntd.0009253. [PMID: 33684115] - Valentin Buchter, Pierre H H Schneeberger, Jennifer Keiser. Validation of a human-serum-based in vitro growth method for drug screening on juvenile development stages of Schistosoma mansoni.
PLoS neglected tropical diseases.
2021 03; 15(3):e0009313. doi:
10.1371/journal.pntd.0009313. [PMID: 33784302] - Liangxiong Xu, Qiuli Liu, Qingren Zeng, Ping Wu, Quan Yu, Kongzhen Gu, Jinghua Xue, Xiaoyi Wei. Radicicol, a Novel Lead Compound against the Migratory-Stage Schistosomula of Schistosoma japonicum.
Antimicrobial agents and chemotherapy.
2021 02; 65(3):. doi:
10.1128/aac.01781-20. [PMID: 33361311] - Lydia Trippler, Shaali Makame Ame, Jan Hattendorf, Saleh Juma, Salum Abubakar, Said Mohammed Ali, Fatma Kabole, David Rollinson, Stefanie Knopp. Impact of seven years of mass drug administration and recrudescence of Schistosoma haematobium infections after one year of treatment gap in Zanzibar: Repeated cross-sectional studies.
PLoS neglected tropical diseases.
2021 02; 15(2):e0009127. doi:
10.1371/journal.pntd.0009127. [PMID: 33577601] - Yousef Abdal Jalil Fadladdin. Antischistosomal Activity of Origanum majorana, Ziziphus spina-christi, and Salvia fruticosa Plant Extracts on Hamster Infected with Schistosoma haematobium.
BioMed research international.
2021; 2021(?):5545331. doi:
10.1155/2021/5545331. [PMID: 34235218] - Mamadou Ouattara, Nana R Diakité, Patrick K Yao, Jasmina Saric, Jean T Coulibaly, Rufin K Assaré, Fidèle K Bassa, Naférima Koné, Négnorogo Guindo-Coulibaly, Jan Hattendorf, Jürg Utzinger, Eliézer K N'Goran. Effectiveness of school-based preventive chemotherapy strategies for sustaining the control of schistosomiasis in Côte d'Ivoire: Results of a 5-year cluster randomized trial.
PLoS neglected tropical diseases.
2021 01; 15(1):e0008845. doi:
10.1371/journal.pntd.0008845. [PMID: 33449924] - Justin Komguep Nono, Thabo Mpotje, Paballo Mosala, Nada Abdel Aziz, Fungai Musaigwa, Lerato Hlaka, Thomas Spangenberg, Frank Brombacher. Praziquantel Treatment of Schistosoma mansoni Infected Mice Renders Them Less Susceptible to Reinfection.
Frontiers in immunology.
2021; 12(?):748387. doi:
10.3389/fimmu.2021.748387. [PMID: 34956183] - Virginie Jacquot, Prescillia Buellet, Laura Letendre, Wei Tong, Henry Li, Eric Tielemans. Pharmacokinetics of a novel endectoparasiticide topical formulation for cats, combining esafoxolaner, eprinomectin and praziquantel.
Parasite (Paris, France).
2021; 28(?):19. doi:
10.1051/parasite/2021014. [PMID: 33812451] - Marta G Cavalcanti, Délia Celser Engel, Aline Fernandes de Araujo Cunha, José Mauro Peralta. Case Report: Diagnosis and Assessment of Cure Approaches for Acute Schistosomiasis in Pre-School Children.
Frontiers in immunology.
2021; 12(?):624736. doi:
10.3389/fimmu.2021.624736. [PMID: 34054799] - Franziska Winkelmann, Marcus Frank, Anne Rabes, Nicole Koslowski, Cindy Schulz, Miriam Bischofsberger, Emil C Reisinger, Martina Sombetzki. Human serum activates the tegument of female schistosomes and supports recovery from Praziquantel.
Parasitology research.
2021 Jan; 120(1):209-221. doi:
10.1007/s00436-020-06968-x. [PMID: 33263166] - Deborah P Sessa, Ana C Mengarda, Paula E Simplicio, Guilherme M Antar, João Henrique G Lago, Josué de Moraes. 15β-Senecioyl-oxy-ent-kaur-16-en-19-oic Acid, a Diterpene Isolated from Baccharis lateralis, as Promising Oral Compound for the Treatment of Schistosomiasis.
Journal of natural products.
2020 12; 83(12):3744-3750. doi:
10.1021/acs.jnatprod.0c01050. [PMID: 33236902] - Maha M Eissa, Mervat Z El-Azzouni, Labiba K El-Khordagui, Amany Abdel Bary, Riham M El-Moslemany, Sara A Abdel Salam. Evaluation of prophylactic efficacy and safety of praziquantel-miltefosine nanocombination in experimental Schistosomiasis mansoni.
Acta tropica.
2020 Dec; 212(?):105714. doi:
10.1016/j.actatropica.2020.105714. [PMID: 32950482] - Pawi Bawitlung Lalthanpuii, Zar Zokimi, Kholhring Lalchhandama. Anthelmintic activity of praziquantel and Spilanthes acmella extract on an intestinal cestode parasite.
Acta pharmaceutica (Zagreb, Croatia).
2020 Dec; 70(4):551-560. doi:
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PLoS neglected tropical diseases.
2020 12; 14(12):e0008866. doi:
10.1371/journal.pntd.0008866. [PMID: 33315875] - Yan Jin, Seungman Cha, Jinmoo Lee, Mousab Siddig Elhag, Sung Tae Hong, Young Ha Lee. Parasitological Observation in Schoolchildren with Urogenital Schistosomiasis Following Treatment with Three Different Brands of Praziquantel.
Journal of Korean medical science.
2020 Nov; 35(46):e394. doi:
10.3346/jkms.2020.35.e394. [PMID: 33258330] - Klodeta Kura, Robert J Hardwick, James E Truscott, Jaspreet Toor, T Deirdre Hollingsworth, Roy M Anderson. The impact of mass drug administration on Schistosoma haematobium infection: what is required to achieve morbidity control and elimination?.
Parasites & vectors.
2020 Nov; 13(1):554. doi:
10.1186/s13071-020-04409-3. [PMID: 33203467] - Pytsje T Hoekstra, Norbert G Schwarz, Ayola A Adegnika, Mala Rakoto Andrianarivelo, Paul L A M Corstjens, Rivo A Rakotoarivelo, Raphaël Rakotozandrindrainy, Elisa Sicuri, Andrea Kreidenweiss, Govert J van Dam. Fast and reliable easy-to-use diagnostics for eliminating bilharzia in young children and mothers: An introduction to the freeBILy project.
Acta tropica.
2020 Nov; 211(?):105631. doi:
10.1016/j.actatropica.2020.105631. [PMID: 32679109] - Atie Moghtadaie, Seyed Amir Miratashi Yazdi, Minoo Mohraz, Hoda Asefi, Effat Razeghi. Medical treatment for an isolated renal multilocular hydatid cyst in an elderly: a case report.
BMC nephrology.
2020 10; 21(1):428. doi:
10.1186/s12882-020-02064-5. [PMID: 33032540] - Chanika Worasith, Chompunoot Wangboon, Kulthida Y Kopolrat, Chutima Homwong, Jiraporn Sithithaworn, Anchalee Techasen, Raynoo Thanan, Narong Khuntikeo, Paiboon Sithithaworn. Application of urine antigen assay to evaluate outcomes of praziquantel treatment and reinfection in opisthorchiasis in northeast Thailand.
Transactions of the Royal Society of Tropical Medicine and Hygiene.
2020 10; 114(10):751-761. doi:
10.1093/trstmh/traa057. [PMID: 32735672] - Mona Magdy, Azza Fahmy, Nashwa Ismail Zaki, Abir Khalil Mohamed. Prophylactic versus therapeutic role of the transplanted CD34+ Umbilical Cord Blood Stem Cells and Wharton Jelly Mesenchymal Stem Cells in early / acute hepatic S. mansoni granulomas reversal in mice; a novel approach.
Experimental parasitology.
2020 Oct; 217(?):107938. doi:
10.1016/j.exppara.2020.107938. [PMID: 32768560] - Alessandra Guidi, Greta Petrella, Valentina Fustaino, Fulvio Saccoccia, Sara Lentini, Roberto Gimmelli, Giulia Di Pietro, Alberto Bresciani, Daniel Oscar Cicero, Giovina Ruberti. Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy.
PLoS neglected tropical diseases.
2020 10; 14(10):e0008767. doi:
10.1371/journal.pntd.0008767. [PMID: 33044962] - Yabo Josiane Honkpehedji, Ayôla Akim Adegnika, Jean Claude Dejon-Agobe, Jeannot Fréjus Zinsou, Romuald Beh Mba, Jacob Gerstenberg, Raphaël Rakotozandrindrainy, Rivo Andry Rakotoarivelo, Tahinamandranto Rasamoelina, Elisa Sicuri, Norbert G Schwarz, Paul L A M Corstjens, Pytsje T Hoekstra, Govert J van Dam, Andrea Kreidenweiss. Prospective, observational study to assess the performance of CAA measurement as a diagnostic tool for the detection of Schistosoma haematobium infections in pregnant women and their child in Lambaréné, Gabon: study protocol of the freeBILy clinical trial in Gabon.
BMC infectious diseases.
2020 Sep; 20(1):718. doi:
10.1186/s12879-020-05445-1. [PMID: 32993559] - Maha M Eissa, Mervat Z El-Azzouni, Labiba K El-Khordagui, Amany Abdel Bary, Riham M El-Moslemany, Sara A Abdel Salam. Single oral fixed-dose praziquantel-miltefosine nanocombination for effective control of experimental schistosomiasis mansoni.
Parasites & vectors.
2020 Sep; 13(1):474. doi:
10.1186/s13071-020-04346-1. [PMID: 32933556] - Paolo Emidio Crisi, Angela Di Cesare, Donato Traversa, Massimo Vignoli, Simone Morelli, Morena Di Tommaso, Francesca De Santis, Fabrizio Pampurini, Roland Schaper, Andrea Boari. Controlled field study evaluating the clinical efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural cat aelurostrongylosis.
The Veterinary record.
2020 Sep; 187(5):e34. doi:
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PLoS neglected tropical diseases.
2020 09; 14(9):e0008653. doi:
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PLoS neglected tropical diseases.
2020 09; 14(9):e0008619. doi:
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Acta parasitologica.
2020 Sep; 65(3):652-660. doi:
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Journal of infection and public health.
2020 Sep; 13(9):1265-1273. doi:
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Infectious diseases of poverty.
2020 Aug; 9(1):121. doi:
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Antimicrobial agents and chemotherapy.
2020 08; 64(9):. doi:
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 07; 71(3):601-613. doi:
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Parasites & vectors.
2020 Jul; 13(1):337. doi:
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Transboundary and emerging diseases.
2020 Jul; 67 Suppl 2(?):69-81. doi:
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The American journal of tropical medicine and hygiene.
2020 07; 103(1):325-333. doi:
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The American journal of tropical medicine and hygiene.
2020 07; 103(1):315-324. doi:
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