Perindopril (BioDeep_00000002478)

human metabolite blood metabolite

代谢物信息卡片

(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

化学式: C19H32N2O5 (368.2311)
中文名称: 培哚普利
谱图信息: 最多检出来源 Homo sapiens(plant) 9.98%

分子结构信息

SMILES: CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
InChI: InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)

描述信息

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Perindopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Perindopril (S-9490) is an orally available, long-acting angiotensin-converting enzyme (ACE) inhibitor. Perindopril inhibits inflammatory cell influx and intimal thickening, preserving elastin on the inside of the aorta. Perindopril effectively inhibits experimental abdominal aortic aneurysm (AAA) formation in a rat model and reduces pulmonary vasoconstriction in rats with pulmonary hypertension[1][2][3][4].

同义名列表

13 个代谢物同义名

(2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid; (2S,3AS,7as)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid; (2S,3AS,7as)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylate; 1-(2-((1-(Ethoxycarbonyl)butyl)amino)propionyl)octahydro-1H-indole-2-carboxylic acid; Erbumine, perindopril; Perindopril erbumine; Perindoprilum; Pirindopril; Perindopril; Perstarium; S-9490; Perindopril; Perindopril erbumine

数据库引用编号

24 个数据库交叉引用编号

ChEBI: CHEBI:8024
KEGG: C07706
KEGGdrug: D03753
PubChem: 4169159
PubChem: 107807
HMDB: HMDB0014928
Metlin: METLIN1795
DrugBank: DB00790
ChEMBL: CHEMBL1581
Wikipedia: Perindopril
MeSH: Perindopril
chemspider: 96956
CAS: 107133-36-8
CAS: 82834-16-0
CAS: 82978-68-5
PMhub: MS000002759
PubChem: 9908
NIKKAJI: J23.744B
RefMet: Perindopril
medchemexpress: HY-B0130
KNApSAcK: 8024
KEGG: C07707
PubChem: 9909
KNApSAcK: 8025

分类词条

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

Perindopril Action Pathway: Perindopril ⟶ Perindoprilat

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	6	ACE, BCL2, EDN1, NOS3, TLR4, VEGFA
Peripheral membrane protein	1	GORASP1
Endosome membrane	1	TLR4
Endoplasmic reticulum membrane	1	BCL2
Nucleus	3	BCL2, NOS3, VEGFA
cytosol	3	BCL2, LEP, NOS3
nucleoplasm	1	NOS3
Cell membrane	4	ACE, AGTR1, AGTR2, TLR4
Cytoplasmic side	1	GORASP1
Multi-pass membrane protein	3	AGTR1, AGTR2, CACNA1I
Golgi apparatus membrane	1	GORASP1
cell surface	2	TLR4, VEGFA
Golgi apparatus	3	GORASP1, NOS3, VEGFA
Golgi membrane	3	GORASP1, INS, NOS3
Lysosome	1	ACE
endosome	1	ACE
plasma membrane	8	ACE, AGTR1, AGTR2, CACNA1I, KNG1, NOS3, REN, TLR4
Membrane	7	ACE, AGTR1, BCL2, CACNA1I, REN, TLR4, VEGFA
caveola	1	NOS3
extracellular exosome	4	ACE, AGT, KNG1, VWF
endoplasmic reticulum	3	BCL2, VEGFA, VWF
extracellular space	12	ACE, AGT, CRP, EDN1, IL10, IL6, INS, KNG1, LEP, REN, VEGFA, VWF
perinuclear region of cytoplasm	2	NOS3, TLR4
adherens junction	1	VEGFA
mitochondrion	1	BCL2
protein-containing complex	1	BCL2
Single-pass type I membrane protein	2	ACE, TLR4
Secreted	11	ACE, AGT, CRP, EDN1, IL10, IL6, INS, LEP, REN, VEGFA, VWF
extracellular region	13	ACE, AGT, CRP, EDN1, ELN, IL10, IL6, INS, KNG1, LEP, REN, VEGFA, VWF
Mitochondrion outer membrane	1	BCL2
Single-pass membrane protein	1	BCL2
mitochondrial outer membrane	1	BCL2
basal part of cell	1	EDN1
Nucleus membrane	1	BCL2
Bcl-2 family protein complex	1	BCL2
nuclear membrane	1	BCL2
external side of plasma membrane	2	ACE, TLR4
Secreted, extracellular space, extracellular matrix	3	ELN, VEGFA, VWF
Cytoplasm, P-body	1	NOS3
P-body	1	NOS3
Early endosome	1	TLR4
apical part of cell	1	REN
pore complex	1	BCL2
cis-Golgi network	1	GORASP1
extracellular matrix	3	ELN, VEGFA, VWF
collagen-containing extracellular matrix	4	AGT, ELN, KNG1, VWF
secretory granule	1	VEGFA
Cell projection, ruffle	1	TLR4
ruffle	1	TLR4
receptor complex	1	TLR4
phagocytic cup	1	TLR4
cytoskeleton	1	NOS3
Secreted, extracellular space	1	KNG1
brush border membrane	1	ACE
blood microparticle	2	AGT, KNG1
sperm midpiece	1	ACE
endosome lumen	1	INS
Cytoplasm, Stress granule	1	NOS3
cytoplasmic stress granule	1	NOS3
myelin sheath	1	BCL2
basal plasma membrane	1	ACE
platelet alpha granule	1	VWF
lipopolysaccharide receptor complex	1	TLR4
secretory granule lumen	1	INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	3	IL6, INS, KNG1
platelet alpha granule lumen	3	KNG1, VEGFA, VWF
voltage-gated calcium channel complex	1	CACNA1I
endocytic vesicle membrane	1	NOS3
transport vesicle	2	EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	2	GORASP1, INS
Golgi apparatus, cis-Golgi network membrane	1	GORASP1
elastic fiber	1	ELN
rough endoplasmic reticulum lumen	1	EDN1
Weibel-Palade body	2	EDN1, VWF
interleukin-6 receptor complex	1	IL6
BAD-BCL-2 complex	1	BCL2
[Angiotensin-converting enzyme, soluble form]: Secreted	1	ACE
[Isoform Testis-specific]: Cell membrane	1	ACE
[N-VEGF]: Cytoplasm	1	VEGFA
[VEGFA]: Secreted	1	VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum	1	VEGFA
[Isoform VEGF121]: Secreted	1	VEGFA
[Isoform VEGF165]: Secreted	1	VEGFA
VEGF-A complex	1	VEGFA

文献列表

Nural Pastacı Özsobacı, Metehan Karataş, Matem Tunçdemir, Derviş Özcelik. Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker on oxidative stress and metabolism of elements in kidney of STZ-induced diabetic rats. Archives of biochemistry and biophysics. 2024 Jan; 751(?):109851. doi: 10.1016/j.abb.2023.109851. [PMID: 38065251]
Kylie Connolly, Romeo Batacan, Douglas Jackson, Rebecca Vella, Andrew Fenning. Perindopril prevents development of obesity and hypertension in middle aged diet-induced obese rat models of metabolic syndrome. Life sciences. 2023 Feb; 314(?):121291. doi: 10.1016/j.lfs.2022.121291. [PMID: 36535403]
Marta Kus, Klaudia Gorniak, Piotr Czaklosz, Anna Olejnik, Paulina Skupin-Mrugalska, Izabela Ibragimow, Hanna Piotrowska-Kempisty. Permeability of the Perindopril Arginine under In Vitro Conditions across Caco-2 Monolayer and Biomimetic Phospholipid Membrane. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072232. [PMID: 35408631]
E A Privalova, Yu N Belenkov, Yu A Danilogorskaya, E A Zheleznykh, M V Kozhevnikova, V Y Zektser, A S Lishuta, I S Ilgisonis. To study the dynamics of serum levels of vascular remodeling in patients with hypertension, including in combination with type 2 diabetes mellitus during 12‑month therapy with perindopril A. Kardiologiia. 2022 Jan; 62(1):24-31. doi: 10.18087/cardio.2022.1.n1890. [PMID: 35168530]
Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš, Yvona Mazurová, Michaela Adamcová, Magdalena Holečková, Vladimír Palička, Tomáš Šimůnek, Martin Štěrba. Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up. Clinical science (London, England : 1979). 2022 01; 136(1):139-161. doi: 10.1042/cs20210836. [PMID: 34878093]
Harin Rhee, Sungmi Kim, Wanhee Lee, Hakeong Jeon, Da Woon Kim, Byung-Min Ye, Hyo Jin Kim, Min Jeong Kim, Seo Rin Kim, Il Young Kim, Sang Heon Song, Eun Young Seong, Dong Won Lee, Soo Bong Lee. Immunoglobulin A nephropathy in a patient with neurofibromatosis type 1: A case report and literature review. Medicine. 2021 Oct; 100(42):e27572. doi: 10.1097/md.0000000000027572. [PMID: 34678898]
N N Pribylova, M V Yakovleva, C A Pribylov, T A Barbashina, E V Gavriljuk, G S Mal, V S Pribylov. [Vasoprotective effects hypotensive therapy in patients with coronary heart disease combined with chronic kidney disease stage 2-3 after coronary stenting]. Kardiologiia. 2021 Aug; 61(8):14-22. doi: 10.18087/cardio.2021.8.n1525. [PMID: 34549689]
O D Ostroumova, A I Kochetkov, N A Arablincky, N A Shatalova, R R Romanovsky, A A Kirichenko. [What do we Mean by "Ideal" Blood Pressure Control?]. Kardiologiia. 2021 Jul; 61(7):68-78. doi: 10.18087/cardio.2021.7.n1662. [PMID: 34397344]
Mamdouh R Rezk, Kamal A Badr. Determination of amlodipine, indapamide and perindopril in human plasma by a novel LC-MS/MS method: Application to a bioequivalence study. Biomedical chromatography : BMC. 2021 May; 35(5):e5048. doi: 10.1002/bmc.5048. [PMID: 33314205]
Xin Zheng, Huitao Gao, Xinge Cui, Yanbao Zhang, Rui Chen, Yaqin Wang, Pauline Lauruol, Hongyun Wang. Simultaneous determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma using UPLC-MS/MS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Apr; 1169(?):122585. doi: 10.1016/j.jchromb.2021.122585. [PMID: 33706186]
Qiuying Li, Zhen Hao, Yan Yu, Yunbiao Tang. Bioequivalence study of two perindopril tert-butylamine tablet formulations in healthy Chinese subjects under fasting and fed conditions: A randomized, open-label, single-dose, crossover trial. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Mar; 135(?):111221. doi: 10.1016/j.biopha.2021.111221. [PMID: 33433351]
Ugur Kostakoglu, Tolga Mercantepe, Hulya Kilic Yilmaz, Levent Tumkaya, Sule Batcik, Esra Pinarbas, Huseyin Avni Uydu. The Protective Effects of Perindopril Against Acute Kidney Damage Caused by Septic Shock. Inflammation. 2021 Feb; 44(1):148-159. doi: 10.1007/s10753-020-01316-8. [PMID: 32803666]
Tlili Barhoumi, Bandar Alghanem, Hayat Shaibah, Fatmah A Mansour, Hassan S Alamri, Maaged A Akiel, Fayhan Alroqi, Mohammad Boudjelal. SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril). Frontiers in immunology. 2021; 12(?):728896. doi: 10.3389/fimmu.2021.728896. [PMID: 34616396]
Naif Aljuhani, Raed S Ismail, Mohammed S El-Awady, Memy H Hassan. Modulatory effects of perindopril on cisplatin-induced nephrotoxicity in mice: Implication of inflammatory cytokines and caspase-3 mediated apoptosis. Acta pharmaceutica (Zagreb, Croatia). 2020 Dec; 70(4):515-525. doi: 10.2478/acph-2020-0033. [PMID: 32412432]
Hyunju Kim, Dan Wang, John Chalmers, Min Jun, Sophia Zoungas, Michel Marre, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Neil R Poulter, Mark E Cooper, Mark Woodward, Elizabeth Selvin, Casey M Rebholz. Alternative kidney filtration markers and the risk of major macrovascular and microvascular events, and all-cause mortality in individuals with type 2 diabetes in the ADVANCE trial. Journal of diabetes. 2020 Dec; 12(12):929-941. doi: 10.1111/1753-0407.13083. [PMID: 32609422]
Basim A S Messiha, Mohammed R A Ali, Mahmoud M Khattab, Amira M Abo-Youssef. Perindopril ameliorates experimental Alzheimer's disease progression: role of amyloid β degradation, central estrogen receptor and hyperlipidemic-lipid raft signaling. Inflammopharmacology. 2020 Oct; 28(5):1343-1364. doi: 10.1007/s10787-020-00724-4. [PMID: 32488543]
Rehab Werida, Ibtsam Khairat, Lamiaa Khedr, Alaa El-Din El-Sisi. Comparative effects of enalapril versus perindopril on serum levels of leptin and adiponectin in hypertensive patients. Acta cardiologica. 2020 Oct; 75(6):551-556. doi: 10.1080/00015385.2019.1636533. [PMID: 31345107]
V Yu Mareev, Yu V Minina, Yu L Begrambekova, A M Levin. [Therapeutic approaches to the Rational Use of trip-le combination therapy with a fixed combination of amlodipine, indapamide and perindopril arginine (TRIPLE COMBINATION) in patients with hypertension who do not control blood pressure on conventional treatment. (Description and main results of the TRIO program)]. Kardiologiia. 2020 Jun; 60(5):1149. doi: 10.18087/cardio.2020.5.n1149. [PMID: 32515706]
Jinhai Lin, Bin Zhong, Jinling Yan, Lili Chen. Effect of trimetazidine combined with perindopril on NT-proBNP level in rats with dilated cardiomyopathy. Cellular and molecular biology (Noisy-le-Grand, France). 2020 May; 66(2):198-203. doi: . [PMID: 32415948]
Søren T Knudsen, Mark E Cooper. Renal protection: What have we learnt from ADVANCE about kidney disease in type 2 diabetes?. Diabetes, obesity & metabolism. 2020 04; 22 Suppl 2(?):12-18. doi: 10.1111/dom.13917. [PMID: 31729127]
Yuxiu Gu, Hualin Cai, Jianjun Guo, Xiaomei Huang, Heng Yang, Yamin Yin, Xun Tan, Binbin He, Xiaomeng Zhou, Xia Liu, Wei Wei, Bikui Zhang. A UPLC-MS/MS method for quantification of perindopril and perindoprilat and applied in a bioequivalence study for their pharmacokinetic parameter measurement . International journal of clinical pharmacology and therapeutics. 2020 Feb; 58(2):103-111. doi: 10.5414/cp203593. [PMID: 31845865]
Catherine Leggett, Ei Mon Phyo Lwin, Usha Ritchie, Yunmei Song, Jacobus P Gerber, Sean Turner, William M Hague, Michael Stark, Richard Upton, Sanjay Garg. Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study. Drug design, development and therapy. 2020; 14(?):961-967. doi: 10.2147/dddt.s239704. [PMID: 32184565]
Sahar S Abd El-Rahman, Hany M Fayed. Targeting AngII/AT1R signaling pathway by perindopril inhibits ongoing liver fibrosis in rat. Journal of tissue engineering and regenerative medicine. 2019 12; 13(12):2131-2141. doi: 10.1002/term.2940. [PMID: 31348596]
Hae Rin Kim, Woo Kyoung Kim, Ae Wha Ha. Effects of Phytochemicals on Blood Pressure and Neuroprotection Mediated Via Brain Renin-Angiotensin System. Nutrients. 2019 Nov; 11(11):. doi: 10.3390/nu11112761. [PMID: 31739443]
Attila Simon, Csaba András Dézsi. Treatment of Hypertensive and Hypercholesterolaemic Patients with the Triple Fixed Combination of Atorvastatin, Perindopril and Amlodipine: The Results of the CORAL Study. Advances in therapy. 2019 08; 36(8):2010-2020. doi: 10.1007/s12325-019-01002-8. [PMID: 31183780]
Umit Yuksek, Levent Cerit, Nihan Kahya Eren, Oktay Ergene. The effect of perindopril on echocardiographic parameters, NYHA functional class and serum NT-proBNP values in patients with diastolic heart failure. Cardiovascular journal of Africa. 2019 Jul; 30(4):222-227. doi: 10.5830/cvja-2019-022. [PMID: 31140540]
Peng Lin, Haiyong Li, Tianhua Yu, Yuanyuan Liu. The Effect of Angiotensin-Converting Enzyme Gene Polymorphisms on the Clinical Efficacy of Perindopril Prescribed for Acute Myocardial Infarction in Chinese Han Patients. Genetic testing and molecular biomarkers. 2019 May; 23(5):316-324. doi: 10.1089/gtmb.2018.0232. [PMID: 30942616]
Agustin J Ramirez, Maria J Sanchez, Ramiro A Sanchez. Diabetic patients with essential hypertension treated with amlodipine: blood pressure and arterial stiffness effects of canagliflozin or perindopril. Journal of hypertension. 2019 03; 37(3):636-642. doi: 10.1097/hjh.0000000000001907. [PMID: 30113526]
Valentina Buda, Minodora Andor, Carmen Cristescu, Mirela Cleopatra Tomescu, Danina M Muntean, Dana Emilia Bâibâță, Diana Aurora Bordejevic, Corina Danciu, Olivia Dalleur, Dorina Coricovac, Zorin Crainiceanu, Anca Tudor, Ionut Ledeti, Lucian Petrescu. Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril. Drug design, development and therapy. 2019; 13(?):3515-3526. doi: 10.2147/dddt.s218428. [PMID: 31631975]
Valentina Buda, Minodora Andor, Dana Emilia Baibata, Ramona Cozlac, Gabriela Radu, Dorina Coricovac, Corina Danciu, Ionut Ledeti, Adelina Cheveresan, Cristian Nica, Paul Tuduce, Mirela Cleopatra Tomescu. Decreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril. Drug design, development and therapy. 2019; 13(?):1915-1925. doi: 10.2147/dddt.s186378. [PMID: 31239642]
Toshiaki Ohkuma, Min Jun, Anthony Rodgers, Mark E Cooper, Paul Glasziou, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Michel Marre, Bruce Neal, Vlado Perkovic, Neil Poulter, Bryan Williams, Sophia Zoungas, John Chalmers, Mark Woodward. Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus. Hypertension (Dallas, Tex. : 1979). 2019 01; 73(1):84-91. doi: 10.1161/hypertensionaha.118.12060. [PMID: 30571562]
John S Sampalis, Eliofotisti Psaradellis, Melissa Stutz, Jenaya Rickard, Emmanouil Rampakakis. Post Hoc Analysis of the CONFIDENCE II, PROTECT I, SHAKE THE HABIT I and SHAKE THE HABIT II Observational Studies in Mild to Moderate Hypertensive Patients Treated with Perindopril and Atorvastatin Concomitantly. Drugs in R&D. 2018 Dec; 18(4):283-293. doi: 10.1007/s40268-018-0255-7. [PMID: 30448890]
Abdel-Gawad S Shalkami, Mohamed I A Hassan, Ahmed A Abd El-Ghany. Perindopril regulates the inflammatory mediators, NF-κB/TNF-α/IL-6, and apoptosis in cisplatin-induced renal dysfunction. Naunyn-Schmiedeberg's archives of pharmacology. 2018 11; 391(11):1247-1255. doi: 10.1007/s00210-018-1550-0. [PMID: 30066022]
Ann Bugeja, Paula Blanco, Edward G Clark, Manish M Sood. Sickle cell disease: a case report of renal amyloidosis. BMC nephrology. 2018 10; 19(1):256. doi: 10.1186/s12882-018-1047-6. [PMID: 30305036]
Bernard I Lévy, Stefano Taddei. Vascular legacy beyond blood pressure control: benefits of perindopril/indapamide combination in hypertensive patients with diabetes. Current medical research and opinion. 2018 09; 34(9):1557-1570. doi: 10.1080/03007995.2018.1425674. [PMID: 29307229]
Andrzej Madej, Józefa Dąbek, Michał Majewski, Justyna Szuta. Effect of perindopril and bisoprolol on IL-2, INF-γ, hs-CRP and T-cell stimulation and correlations with blood pressure in mild and moderate hypertension. International journal of clinical pharmacology and therapeutics. 2018 Sep; 56(9):393-399. doi: 10.5414/cp203249. [PMID: 29809132]
Csaba András Dézsi. Treatment with triple combination of atorvastatin, perindopril, and amlodipine in patients with stable coronary artery disease: A subgroup analysis from the PAPA-CAD study. The Journal of international medical research. 2018 May; 46(5):1902-1909. doi: 10.1177/0300060518760158. [PMID: 29557300]
Sigrid C van Steen, Mark Woodward, John Chalmers, Qiang Li, Michel Marre, Mark E Cooper, Pavel Hamet, Giuseppe Mancia, Stephen Colagiuri, Bryan Williams, Diederick E Grobbee, J Hans DeVries. Haemoglobin glycation index and risk for diabetes-related complications in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Diabetologia. 2018 04; 61(4):780-789. doi: 10.1007/s00125-017-4539-1. [PMID: 29308539]
Emilia Staniszewska-Slezak, Ewelina Wiercigroch, Andrzej Fedorowicz, Elżbieta Buczek, Lukasz Mateuszuk, Malgorzata Baranska, Stefan Chlopicki, Kamilla Malek. A possible Fourier transform infrared-based plasma fingerprint of angiotensin-converting enzyme inhibitor-induced reversal of endothelial dysfunction in diabetic mice. Journal of biophotonics. 2018 02; 11(2):. doi: 10.1002/jbio.201700044. [PMID: 28700133]
Takanori Yasu, Akiko Mutoh, Hiroshi Wada, Mayumi Kobayashi, Yuji Kikuchi, Shinichi Momomura, Shinichiro Ueda. Renin-Angiotensin System Inhibitors Can Prevent Intravenous Lipid Infusion-Induced Myocardial Microvascular Dysfunction and Leukocyte Activation. Circulation journal : official journal of the Japanese Circulation Society. 2018 01; 82(2):494-501. doi: 10.1253/circj.cj-17-0809. [PMID: 28954968]
Kamel Mohammedi, John Chalmers, William Herrington, Qiang Li, Giuseppe Mancia, Michel Marre, Neil Poulter, Anthony Rodgers, Bryan Williams, Vlado Perkovic, Josef Coresh, Mark Woodward. Associations between body mass index and the risk of renal events in patients with type 2 diabetes. Nutrition & diabetes. 2018 01; 8(1):7. doi: 10.1038/s41387-017-0012-y. [PMID: 29343817]
Emmy Luu, Kevin B Ita, Matthew J Morra, Inna E Popova. The Influence of Microneedles on the Percutaneous Penetration of Selected Antihypertensive Agents: Diltiazem Hydrochloride and Perindopril Erbumine. Current drug delivery. 2018; 15(10):1449-1458. doi: 10.2174/1567201815666180730125941. [PMID: 30058488]
Wojciech Gilowski, Robert Krysiak, Bogdan Marek, Bogusław Okopień. The effect of short-term perindopril and telmisartan treatment on circulating levels of anti-inflammatory cytokines in hypertensive patients. Endokrynologia Polska. 2018; 69(6):667-674. doi: 10.5603/ep.a2018.0068. [PMID: 30259507]
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