Didanosine (BioDeep_00000002366)

 

Secondary id: BioDeep_00000408801

human metabolite blood metabolite


代谢物信息卡片


9-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

化学式: C10H12N4O3 (236.0909362)
中文名称: 2,3-二脱氧肌苷
谱图信息: 最多检出来源 Homo sapiens(urine) 13.9%

分子结构信息

SMILES: C1CC(OC1CO)N2C=NC3=C2N=CNC3=O
InChI: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1

描述信息

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. [PubChem]
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C254 - Anti-Infective Agent > C281 - Antiviral Agent
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3135
Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV[1][2][3].

同义名列表

22 个代谢物同义名

9-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one; 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one; 9-((2R,5S)-5-(Hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one; 9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol; Bristol-myers squibb brand OF didanosine; Bristol myers squibb brand OF didanosine; Bristol-myers brand OF didanosine; Bristol myers brand OF didanosine; 2,3-Dideoxyinosine; 2,3 Dideoxyinosine; DdI (antiviral); Dideoxyinosine; ABBR ddi; MLS003373937; Didanosinum; Didanosina; Didanosine; Videx; DdIno; DDI; 2',3'-Dideoxyinosine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Julie Høgh, Malene Hove-Skovsgaard, Marco Gelpi, Anne Marie Reimer Jensen, Jan Gerstoft, Thomas Benfield, Heidi Storgaard, Susanne Dam Nielsen. Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency. BMC infectious diseases. 2022 May; 22(1):503. doi: 10.1186/s12879-022-07485-1. [PMID: 35643429]
  • Marco Gelpi, Andreas Dehlbæk Knudsen, Karoline Brostrup Larsen, Amanda Mocroft, Anne-Mette Lebech, Birgitte Lindegaard, Jens Lundgren, Klaus Fuglsang Kofoed, Susanne Dam Nielsen. Long-lasting alterations in adipose tissue density and adiponectin production in people living with HIV after thymidine analogues exposure. BMC infectious diseases. 2019 Aug; 19(1):708. doi: 10.1186/s12879-019-4347-y. [PMID: 31399063]
  • Nongodo Firmin Kaboré, Armel Poda, Jacques Zoungrana, Ollo Da, Laura Ciaffi, Aoua Semdé, Issouf Yaméogo, Adrien B Sawadogo, Eric Delaporte, Nicolas Meda, Sophie Limou, Amandine Cournil. Chronic kidney disease and HIV in the era of antiretroviral treatment: findings from a 10-year cohort study in a west African setting. BMC nephrology. 2019 05; 20(1):155. doi: 10.1186/s12882-019-1335-9. [PMID: 31064340]
  • Hongxiang Chen, Gang Wang, Lanzhen Sun, Huicong Zhang, Mengchi Sun, Jin Sun, Lei Shang, Cong Luo. Regulating the alky chain length of fatty acid-didanosine prodrugs and evaluating its role in albumin binding. Drug delivery and translational research. 2018 02; 8(1):21-31. doi: 10.1007/s13346-017-0428-x. [PMID: 28944416]
  • Aylin B Unsal, Aviva S Mattingly, Sara E Jones, Julia B Purdy, James C Reynolds, Jeffrey B Kopp, Rohan Hazra, Colleen M Hadigan. Effect of Antiretroviral Therapy on Bone and Renal Health in Young Adults Infected With HIV in Early Life. The Journal of clinical endocrinology and metabolism. 2017 08; 102(8):2896-2904. doi: 10.1210/jc.2017-00197. [PMID: 28531309]
  • Opass Putcharoen, Lalita Wattanachanya, Jiratchaya Sophonphan, Sarawut Siwamogsatham, Vorapot Sapsirisavat, Sivaporn Gatechompol, Supalak Phonphithak, Stephen J Kerr, Pairoj Chattranukulchai, Yingyos Avihingsanon, Kiat Ruxrungtham, Anchalee Avihingsanon. New-onset diabetes in HIV-treated adults: predictors, long-term renal and cardiovascular outcomes. AIDS (London, England). 2017 07; 31(11):1535-1543. doi: 10.1097/qad.0000000000001496. [PMID: 28398958]
  • Alexander N Geisman, Vladimir T Valuev-Elliston, Alexander A Ozerov, Anastasia L Khandazhinskaya, Alexander O Chizhov, Sergey N Kochetkov, Christophe Pannecouque, Lieve Naesens, Katherine L Seley-Radtke, Mikhail S Novikov. 1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus. Bioorganic & medicinal chemistry. 2016 06; 24(11):2476-85. doi: 10.1016/j.bmc.2016.04.010. [PMID: 27112451]
  • Karanam Anandan Suresh, Venkata Subbaiah C Kadiam, Thaslim S K Basha, Naga Raju Chamarti, Suresh M Kumar, Rajendra Wudayagiri, Lokanatha Valluru. Synthesis and Antiviral Activity of Novel Phosphorylated Derivatives of Didanosine Against Newcastle Disease Virus in Chicken. Archiv der Pharmazie. 2016 Jun; 349(6):442-55. doi: 10.1002/ardp.201600038. [PMID: 27128998]
  • Noris Pavia-Ruz, Magdel Rossouw, Xavier Sáez-Llorens, Torsak Bunupuradah, Mathew Taylor, Rong Yang, Heather Sevinsky, Mark Krystal, Max Lataillade, Daniel Seekins, Sophie Biguenet. Efavirenz Capsule Sprinkle and Liquid Formulations With Didanosine and Emtricitabine in HIV-1-infected Infants and Children 3 Months to 6 Years of Age: Study AI266-922. The Pediatric infectious disease journal. 2015 Dec; 34(12):1355-60. doi: 10.1097/inf.0000000000000913. [PMID: 26379163]
  • Xu Lan, Lei Mingdao, Guo Huilin, Gan Wei, Hu Lvjiang, Zhou Yan, Li Gang. Simultaneous determination of 2',3'-dideoxyinosine and the active metabolite, 2',3'-dideoxyadenosine-5'-triphosphate in human peripheral-blood mononuclear cell by HPLC-MS/MS and the application to cell pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Oct; 1002(?):337-42. doi: 10.1016/j.jchromb.2015.08.039. [PMID: 26350426]
  • Rupak Shivakoti, Nikhil Gupte, Wei-Teng Yang, Noluthando Mwelase, Cecilia Kanyama, Alice M Tang, Sandy Pillay, Wadzanai Samaneka, Cynthia Riviere, Sima Berendes, Javier R Lama, Sandra W Cardoso, Patcharaphan Sugandhavesa, Richard D Semba, Parul Christian, Thomas B Campbell, Amita Gupta. Pre-antiretroviral therapy serum selenium concentrations predict WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy. Nutrients. 2014 Nov; 6(11):5061-78. doi: 10.3390/nu6115061. [PMID: 25401501]
  • Keishiro Yajima, Tomoko Uehira, Hiroshi Otera, Yusuke Koizumi, Dai Watanabe, Yoshinori Kodama, Noriyoshi Kuzushita, Yasuharu Nishida, Eiji Mita, Masayuki Mano, Takuma Shirasaka. A case of non-cirrhotic portal hypertension associated with anti-retroviral therapy in a Japanese patient with human immunodeficiency virus infection. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2014 Sep; 20(9):582-5. doi: 10.1016/j.jiac.2014.06.005. [PMID: 25034388]
  • Louis-Félix Nothias-Scaglia, Pascal Retailleau, Julien Paolini, Christophe Pannecouque, Johan Neyts, Vincent Dumontet, Fanny Roussi, Pieter Leyssen, Jean Costa, Marc Litaudon. Jatrophane diterpenes as inhibitors of chikungunya virus replication: structure-activity relationship and discovery of a potent lead. Journal of natural products. 2014 Jun; 77(6):1505-12. doi: 10.1021/np500271u. [PMID: 24926807]
  • Elsabé Jones, Elizabeth Ojewole, Rahul Kalhapure, Thirumala Govender. In vitro comparative evaluation of monolayered multipolymeric films embedded with didanosine-loaded solid lipid nanoparticles: a potential buccal drug delivery system for ARV therapy. Drug development and industrial pharmacy. 2014 May; 40(5):669-79. doi: 10.3109/03639045.2014.892957. [PMID: 24576267]
  • Hervé Hillaireau, Nathalie Dereuddre-Bosquet, Rym Skanji, Fawzia Bekkara-Aounallah, Joachim Caron, Sinda Lepêtre, Sébastien Argote, Laurent Bauduin, Rahima Yousfi, Christine Rogez-Kreuz, Didier Desmaële, Bernard Rousseau, Ruxandra Gref, Karine Andrieux, Pascal Clayette, Patrick Couvreur. Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies. Biomaterials. 2013 Jul; 34(20):4831-8. doi: 10.1016/j.biomaterials.2013.03.022. [PMID: 23562054]
  • Linda Barlow-Mosha, Allison Ross Eckard, Grace A McComsey, Philippa M Musoke. Metabolic complications and treatment of perinatally HIV-infected children and adolescents. Journal of the International AIDS Society. 2013 Jun; 16(?):18600. doi: 10.7448/ias.16.1.18600. [PMID: 23782481]
  • H Hien, N Meda, S Diagbouga, E Zoure, S Yaméogo, H Tamboura, J Somé, A Ouiminga, F Rouet, A Drabo, A Hien, J Nicolas, H Chappuy, P Van de Perre, P Msellati, B Nacro. 24-Month adherence, tolerance and efficacy of once-a-day antiretroviral therapy with didanosine, lamivudine, and efavirenz in African HIV-1 infected children: ANRS 12103/12167. African health sciences. 2013 Jun; 13(2):287-94. doi: 10.4314/ahs.v13i2.13. [PMID: 24235926]
  • Eugenia Vispo, Muge Cevik, Juergen K Rockstroh, Pablo Barreiro, Mark Nelson, Andrew Scourfield, Christoph Boesecke, Jan-Christian Wasmuth, Vincent Soriano. Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013 Apr; 56(8):1117-22. doi: 10.1093/cid/cit001. [PMID: 23315321]
  • Naïm Bouazza, Jean-Marc Tréluyer, Philippe Msellati, Philippe Van de Perre, Serge Diagbouga, Boubacar Nacro, Hervé Hien, Emmanuelle Zoure, François Rouet, Adama Ouiminga, Stephane Blanche, Déborah Hirt, Saik Urien. A novel pharmacokinetic approach to predict virologic failure in HIV-1-infected paediatric patients. AIDS (London, England). 2013 Mar; 27(5):761-8. doi: 10.1097/qad.0b013e32835caad1. [PMID: 23719348]
  • N N Guimarães, C J Silva, H H R de Andrade, R R Dihl, M Lehmann, K S Cunha. Comparative analysis of genetic toxicity of antiretroviral combinations in somatic cells of Drosophila melanogaster. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Mar; 53(?):299-309. doi: 10.1016/j.fct.2012.12.005. [PMID: 23261680]
  • T C S Martin, A Scourfield, N Rockwood, N K Martin, N Patel, M Nelson, B G Gazzard. Pancreatic insufficiency in patients with HIV infection: role of didanosine questioned. HIV medicine. 2013 Mar; 14(3):161-6. doi: 10.1111/j.1468-1293.2012.01047.x. [PMID: 22994793]
  • T Suárez-Zarracina, E Valle-Garay, J Collazos, A H Montes, V Cárcaba, J A Carton, V Asensi. Didanosine (ddI) associates with increased liver fibrosis in adult HIV-HCV coinfected patients. Journal of viral hepatitis. 2012 Oct; 19(10):685-93. doi: 10.1111/j.1365-2893.2012.01596.x. [PMID: 22967099]
  • Didier Desmaële, Ruxandra Gref, Patrick Couvreur. Squalenoylation: a generic platform for nanoparticular drug delivery. Journal of controlled release : official journal of the Controlled Release Society. 2012 Jul; 161(2):609-18. doi: 10.1016/j.jconrel.2011.07.038. [PMID: 21840355]
  • Laia Tolosa, Sandra Pinto, M Teresa Donato, Agustín Lahoz, José V Castell, J Enrique O'Connor, M José Gómez-Lechón. Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs. Toxicological sciences : an official journal of the Society of Toxicology. 2012 May; 127(1):187-98. doi: 10.1093/toxsci/kfs083. [PMID: 22331495]
  • Kasongo Wa Kasongo, Rainer H Müller, Roderick B Walker. The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients. Pharmaceutical development and technology. 2012 May; 17(3):353-62. doi: 10.3109/10837450.2010.542163. [PMID: 21241166]
  • Alberto Diez-Torrubia, Silvia Cabrera, Anne-Marie Lambeir, Jan Balzarini, María-José Camarasa, Sonsoles Velázquez. Dipeptidyl peptidase IV (DPPIV/CD26)-based prodrugs of hydroxy-containing drugs. ChemMedChem. 2012 Apr; 7(4):618-28. doi: 10.1002/cmdc.201100504. [PMID: 22307932]
  • Raveen Parboosing, Glenn E M Maguire, Patrick Govender, Hendrik G Kruger. Nanotechnology and the treatment of HIV infection. Viruses. 2012 04; 4(4):488-520. doi: 10.3390/v4040488. [PMID: 22590683]
  • Johannes Vermehren, Annika Vermehren, Axel Mueller, Amina Carlebach, Thomas Lutz, Peter Gute, Gaby Knecht, Christoph Sarrazin, Mireen Friedrich-Rust, Nicole Forestier, Thierry Poynard, Stefan Zeuzem, Eva Herrmann, Wolf Peter Hofmann. Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers. BMC gastroenterology. 2012 Mar; 12(?):27. doi: 10.1186/1471-230x-12-27. [PMID: 22453133]
  • Elizabeth Ojewole, Irene Mackraj, Kamil Akhundov, Josias Hamman, Alvaro Viljoen, Eugene Olivier, James Wesley-Smith, Thirumala Govender. Investigating the effect of Aloe vera gel on the buccal permeability of didanosine. Planta medica. 2012 Mar; 78(4):354-61. doi: 10.1055/s-0031-1280431. [PMID: 22161764]
  • Enrico Girardi, Paola Scognamiglio, Claudio Angeletti, Andrea Gori, Dora Buonfrate, Massimo Arlotti, Giovanni Mazzarello, Antonella Castagna, Massimo Andreoni, Antonella d'Arminio Monforte, Andrea Antinori, Giuseppe Ippolito. Determinants of access to experimental antiretroviral drugs in an Italian cohort of patients with HIV: a multilevel analysis. BMC health services research. 2012 Feb; 12(?):38. doi: 10.1186/1472-6963-12-38. [PMID: 22336471]
  • Giuseppe Pontrelli, Nicola Cotugno, Donato Amodio, Paola Zangari, Hyppolite K Tchidjou, Stefania Baldassari, Paolo Palma, Stefania Bernardi. Renal function in HIV-infected children and adolescents treated with tenofovir disoproxil fumarate and protease inhibitors. BMC infectious diseases. 2012 Jan; 12(?):18. doi: 10.1186/1471-2334-12-18. [PMID: 22269183]
  • Marilia Rita Pinzone, Michelino Di Rosa, Bruno Cacopardo, Giuseppe Nunnari. HIV RNA suppression and immune restoration: can we do better?. Clinical & developmental immunology. 2012; 2012(?):515962. doi: 10.1155/2012/515962. [PMID: 22489250]
  • Julie H Levison, Catherine Orrell, Sébastien Gallien, Daniel R Kuritzkes, Naishin Fu, Elena Losina, Kenneth A Freedberg, Robin Wood. Virologic failure of protease inhibitor-based second-line antiretroviral therapy without resistance in a large HIV treatment program in South Africa. PloS one. 2012; 7(3):e32144. doi: 10.1371/journal.pone.0032144. [PMID: 22427821]
  • Bernhard Setzer, Ulrich A Walker. Antiretroviral nucleoside analogues suppress antibody synthesis in human B-lymphocytes. Antiviral therapy. 2012; 17(4):729-35. doi: 10.3851/imp2086. [PMID: 22414568]
  • Robert Balikuddembe, Joshua Kayiwa, David Musoke, Muhammad Ntale, Steven Baveewo, Paul Waako, Celestino Obua. Plasma drug level validates self-reported adherence but predicts limited specificity for nonadherence to antiretroviral therapy. ISRN pharmacology. 2012; 2012(?):274978. doi: 10.5402/2012/274978. [PMID: 22530137]
  • Thomas Aschacher, Sandra Sampl, Lisa Käser, David Bernhard, Andreas Spittler, Klaus Holzmann, Michael Bergmann. The combined use of known antiviral reverse transcriptase inhibitors AZT and DDI induce anticancer effects at low concentrations. Neoplasia (New York, N.Y.). 2012 Jan; 14(1):44-53. doi: 10.1593/neo.11426. [PMID: 22355273]
  • Slim Fourati, Isabelle Malet, Carolin A Guenzel, Cathia Soulie, Priscilla Maidou-Peindara, Laurence Morand-Joubert, Marc Wirden, Sophie Sayon, Gilles Peytavin, Anne Simon, Christine Katlama, Serge Benichou, Vincent Calvez, Anne-Geneviève Marcelin. E17A mutation in HIV-1 Vpr confers resistance to didanosine in association with thymidine analog mutations. Antiviral research. 2012 Jan; 93(1):167-74. doi: 10.1016/j.antiviral.2011.11.008. [PMID: 22138483]
  • Patrícia Severino, Tatiana Andreani, Ana Sofia Macedo, Joana F Fangueiro, Maria Helena A Santana, Amélia M Silva, Eliana B Souto. Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. Journal of drug delivery. 2012; 2012(?):750891. doi: 10.1155/2012/750891. [PMID: 22175030]
  • Kasongo Wa Kasongo, Jana Pardeike, Rainer H Müller, Roderick B Walker. Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers. Journal of pharmaceutical sciences. 2011 Dec; 100(12):5185-96. doi: 10.1002/jps.22711. [PMID: 22020815]
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  • Andrea Costantini, Katia Marinelli, Giulia Biagioni, Alessia Monachetti, Monica L Ferreri, Luca Butini, Maria Montroni, Aldo Manzin, Patrizia Bagnarelli. Molecular analysis of hepatitis B virus (HBV) in an HIV co-infected patient with reactivation of occult HBV infection following discontinuation of lamivudine-including antiretroviral therapy. BMC infectious diseases. 2011 Nov; 11(?):310. doi: 10.1186/1471-2334-11-310. [PMID: 22054111]
  • Thomas A Rasmussen, Martin Tolstrup, Jesper Melchjorsen, Christian A Frederiksen, Ulla S Nielsen, Bente L Langdahl, Lars Østergaard, Alex L Laursen. Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy. BMC infectious diseases. 2011 Oct; 11(?):267. doi: 10.1186/1471-2334-11-267. [PMID: 21970555]
  • Kasongo Wa Kasongo, Mirko Jansch, Rainer H Müller, Roderick B Walker. Evaluation of the in vitro differential protein adsorption patterns of didanosine-loaded nanostructured lipid carriers (NLCs) for potential targeting to the brain. Journal of liposome research. 2011 Sep; 21(3):245-54. doi: 10.3109/08982104.2010.539186. [PMID: 21174528]
  • Rym Skanji, Karine Andrieux, Muriel Lalanne, Joachim Caron, Claudie Bourgaux, Jéril Degrouard, François Brisset, Claire Gueutin, Hélène Chacun, Nathalie Dereuddre-Bosquet, Angelo Paci, Gilles Vassal, Laurent Bauduin, Sébastien Garcia-Argote, Bernard Rousseau, Pascal Clayette, Didier Desmaële, Patrick Couvreur. A new nanomedicine based on didanosine glycerolipidic prodrug enhances the long term accumulation of drug in a HIV sanctuary. International journal of pharmaceutics. 2011 Jul; 414(1-2):285-97. doi: 10.1016/j.ijpharm.2011.05.005. [PMID: 21596125]
  • Laurence Ahoua, Gunar Guenther, Christine Rouzioux, Loretxu Pinoges, Paul Anguzu, Anne-Marie Taburet, Suna Balkan, David M Olson, Charles Olaro, Mar Pujades-Rodríguez. Immunovirological response to combined antiretroviral therapy and drug resistance patterns in children: 1- and 2-year outcomes in rural Uganda. BMC pediatrics. 2011 Jul; 11(?):67. doi: 10.1186/1471-2431-11-67. [PMID: 21791095]
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