Methomyl (BioDeep_00000002183)

   

human metabolite Endogenous


代谢物信息卡片


(E)-[(methyl-C-hydroxycarbonimidoyl)oxy][1-(methylsulfanyl)ethylidene]amine

化学式: C5H10N2O2S (162.046296)
中文名称: 灭多威农药纯度标准物质
谱图信息: 最多检出来源 Viridiplantae(plant) 93.33%

分子结构信息

SMILES: C/C(=N\OC(=O)NC)SC
InChI: InChI=1S/C5H10N2O2S/c1-4(10-3)7-9-5(8)6-2/h1-3H3,(H,6,8)

描述信息

D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
Methomyl is an Agricultural insecticide and nematocid
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2942
CONFIDENCE standard compound; INTERNAL_ID 2619
D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals

同义名列表

54 个代谢物同义名

(E)-[(methyl-C-hydroxycarbonimidoyl)oxy][1-(methylsulfanyl)ethylidene]amine; Methyl (1E)-N-([(methylamino)carbonyl]oxy)ethanimidothioate; Methyl N-[[(methylamino)carbonyl]oxy]ethanimidothioate, 9ci; N-((Methylcarbamoyl)oxy)thioacetimidic acid methyl ester; N-[(Methylcarbamoyl)oxy]thioacetimidic acid methyl ester; S-Methyl N-[[(methylamino)carbonyl]oxy]ethanimidothioate; Acetimidothioic acid, methyl-, N-(methylcarbamoyl) ester; N-[[(Methylamino)carbonyl]oxy]-2-(methylthio)ethanimine; Methyl N-(((methylamino)carbonyl)oxy)ethanimidothioate; 2-Methylthio-propionaldehyd-O-(methylcarbamoyl)-oxim; methyl (1E)-N-(methylcarbamoyloxy)ethanimidothioate; 2-Methylthio-acetaldehyd-O-(methylcarbamoyl)-oxime; 2-Methylthio-acetaldehyd-O-(methylcarbamoyl)-oxim; 1-(Methylthio)acetaldehyde O-methylcarbamoyloxime; Methyl O-(methylcarbamoyl)thiolacethohydroxamate; Methyl O-(methylcarbamoyl)thiolacetohydroxamate; Methyl N-((methylcarbamoyl)oxy)thioacetimidate; Methyl N-(methylcarbamoyloxy)ethanimidothioate; Methyl O-(methylcarbamyl)thiolacetohydroxamate; S-Methyl N-(methylcarbamoyloxy)thioacetimidate; Methyl N-[(methylcarbamoyl)oxy]thioacetimidate; 1-(Methylthio)ethylideneamino methylcarbamate; 3-Thiabutan-2-one, O-(methylcarbamoyl)oxime; Thiobutan-2-one, O-(methylcarbamoyl)oxime; Du pont insecticide 1179; Sorex golden fly bait; Methomyl (lannate); Insecticide 1,179; Methomyl lannate; Insecticide 1179; Du pont 1179; Methomyl 5g; Dupont 1179; 20, Lannate; Lannate(R); Lannate LV; Lannate 20; Lannate LB; Nu-bait II; Lannabait; Lanox 216; Lannate L; Methomex; LANOX 90; Methavin; Memilene; methomyl; Mesomile; Lannate; Metomil; Flytek; Kipsin; Nudrin; Lanox



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shimei Pang, Ziqiu Lin, Wen-Juan Chen, Shao-Fang Chen, Yaohua Huang, Qiqi Lei, Pankaj Bhatt, Sandhya Mishra, Shaohua Chen, Huishan Wang. High-efficiency degradation of methomyl by the novel bacterial consortium MF0904: Performance, structural analysis, metabolic pathways, and environmental bioremediation. Journal of hazardous materials. 2023 Mar; 452(?):131287. doi: 10.1016/j.jhazmat.2023.131287. [PMID: 37003005]
  • Wenhong Li, Lu Lv, Yanhua Wang, Yu-Cheng Zhu. Mixture effects of thiamethoxam and seven pesticides with different modes of action on honey bees (Aplis mellifera). Scientific reports. 2023 Feb; 13(1):2679. doi: 10.1038/s41598-023-29837-w. [PMID: 36792894]
  • Junjun Feng, Haiyun Jiang, Jing Wang, Zhengyi Jing, Fan Zhang, Tianyu Tan, Feng He, Lihua Jiang, Haiqin Li, Shimin Chang, Tengfei Li. [Simultaneous determination of 40 plant growth regulators, fungicides, insecticides, and antibiotics in bean sprouts by QuEChERS-high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2022 Sep; 40(9):843-853. doi: 10.3724/sp.j.1123.2021.12028. [PMID: 36156631]
  • Rufus Isaacs, Steven Van Timmeren, Brian E Gress, Frank G Zalom, Fatemeh Ganjisaffar, Kelly A Hamby, Margaret T Lewis, Oscar E Liburd, Nupur Sarkar, Cesar Rodriguez-Saona, Robert Holdcraft, Hannah J Burrack, Aurora Toennisson, Francis Drummond, Nathan Spaulding, Srinivas Lanka, Ashfaq Sial. Monitoring of Spotted-Wing Drosophila (Diptera: Drosophilidae) Resistance Status Using a RAPID Method for Assessing Insecticide Sensitivity Across the United States. Journal of economic entomology. 2022 08; 115(4):1046-1053. doi: 10.1093/jee/toac021. [PMID: 35296902]
  • Kahina Chabane, M'hammed Amine Khene, Faiza Zaida, Lynda Ainouz, Jean Giaimis, Saâdia Mameri, Ahsene Baz. Subacute and subchronic methomyl exposure induced toxic effects on intestines via oxidative stress in male albino rats: biochemical and histopathological study. Drug and chemical toxicology. 2022 Mar; 45(2):523-536. doi: 10.1080/01480545.2020.1727496. [PMID: 32063051]
  • Yoshikazu Yamagishi, Hirotaro Iwase, Yasumitsu Ogra. Post-Mortem Changes of Methomyl in Blood with Hemoglobin. Chemical research in toxicology. 2021 01; 34(1):161-168. doi: 10.1021/acs.chemrestox.0c00472. [PMID: 33405899]
  • Thanawat Kaewmaroeng, Klintean Wunnapuk, Manoch Chockjamsai, Korawan Sringarm, Surat Hongsibsong. Simple Colorimetric Method for Cholinesterase-inhibitor Screening in Gastric Content by Using Phytoesterase Enzyme from Kidney Bean. Pakistan journal of biological sciences : PJBS. 2020 Jan; 23(7):904-910. doi: 10.3923/pjbs.2020.904.910. [PMID: 32700837]
  • Amin Abdou Seleem. Induction of hyperpigmentation and heat shock protein 70 response to the toxicity of methomyl insecticide during the organ development of the Arabian toad, Bufo arabicus (Heyden,1827). Journal of histotechnology. 2019 09; 42(3):104-115. doi: 10.1080/01478885.2019.1619653. [PMID: 31492089]
  • S D Nusair, A N Joukhan, Ah Bani Rashaid, A M Rababa'h. Methomyl induced effect on fortilin and S100A1 in serum and cardiac tissue: Potential biomarkers of toxicity. Human & experimental toxicology. 2019 Mar; 38(3):371-377. doi: 10.1177/0960327118814153. [PMID: 30472887]
  • Shi Chen, Mohammed Esmail Abdalla Elzaki, Chaohui Ding, Zheng-Fang Li, Jie Wang, Ren-Sen Zeng, Yuan-Yuan Song. Plant allelochemicals affect tolerance of polyphagous lepidopteran pest Helicoverpa armigera (Hübner) against insecticides. Pesticide biochemistry and physiology. 2019 Feb; 154(?):32-38. doi: 10.1016/j.pestbp.2018.12.009. [PMID: 30765054]
  • J Weng, B Cai, J Chen, B Chen, H Wu, C Wen, F Sun, L Hu, C Chen, X Wang, Z Wang. Metabolic changes in methomyl poisoned rats treated by vitamin E. Human & experimental toxicology. 2018 Apr; 37(4):390-398. doi: 10.1177/0960327117705428. [PMID: 28425351]
  • R S Silva, L P Arcanjo, J R S Soares, D O Ferreira, J E Serrão, J C Martins, Á H Costa, M C Picanço. Insecticide toxicity to the borer Neoleucinodes elegantalis (Guenée) (Lepidoptera: Crambidae): developmental and egg-laying effects. Neotropical entomology. 2018 Apr; 47(2):318-325. doi: 10.1007/s13744-017-0553-8. [PMID: 28822099]
  • Shun-Long Meng, Li-Ping Qiu, Geng-Dong Hu, Li-Min Fan, Chao Song, Yao Zheng, Wei Wu, Jian-Hong Qu, Dan-Dan Li, Jia-Zhang Chen, Pao Xu. Effect of methomyl on sex steroid hormone and vitellogenin levels in serum of male tilapia (Oreochromis niloticus) and recovery pattern. Environmental toxicology. 2017 Jul; 32(7):1869-1877. doi: 10.1002/tox.22409. [PMID: 28251797]
  • Xiang Wei, Yiou Pan, Xuecheng Xin, Chao Zheng, Xiwu Gao, Jinghui Xi, Qingli Shang. Cross-resistance pattern and basis of resistance in a thiamethoxam-resistant strain of Aphis gossypii Glover. Pesticide biochemistry and physiology. 2017 May; 138(?):91-96. doi: 10.1016/j.pestbp.2017.03.007. [PMID: 28456311]
  • Yuka Kawakami, Chiaki Fuke, Maki Fukasawa, Kenji Ninomiya, Yoko Ihama, Tetsuji Miyazaki. An experimental study of postmortem decomposition of methomyl in blood. Legal medicine (Tokyo, Japan). 2017 Mar; 25(?):36-42. doi: 10.1016/j.legalmed.2017.01.001. [PMID: 28457508]
  • Yongqiang Liu, Yu Gao, Gemei Liang, Yanhui Lu. Chlorantraniliprole as a candidate pesticide used in combination with the attracticides for lepidopteran moths. PloS one. 2017; 12(6):e0180255. doi: 10.1371/journal.pone.0180255. [PMID: 28658277]
  • ShunLong Meng, LiPing Qiu, GengDong Hu, LiMin Fan, Chao Song, Yao Zheng, Wei Wu, JianHong Qu, DanDan Li, JiaZhang Chen, Pao Xu. Effects of methomyl on steroidogenic gene transcription of the hypothalamic-pituitary-gonad-liver axis in male tilapia. Chemosphere. 2016 Dec; 165(?):152-162. doi: 10.1016/j.chemosphere.2016.09.024. [PMID: 27643660]
  • Rafael Valencia-Quintana, Sandra Gómez-Arroyo, Juana Sánchez-Alarcón, Mirta Milić, José Luis Gómez Olivares, Stefan M Waliszewski, Josefina Cortés-Eslava, Rafael Villalobos-Pietrini, María Elena Calderón-Segura. Assessment of genotoxicity of Lannate-90® and its plant and animal metabolites in human lymphocyte cultures. Arhiv za higijenu rada i toksikologiju. 2016 Jun; 67(2):116-25. doi: 10.1515/aiht-2016-67-2763. [PMID: 27331299]
  • Mauro C Wesseling, Lisa Wagner-Britz, Duc Bach Nguyen, Salome Asanidze, Judy Mutua, Nagla Mohamed, Benjamin Hanf, Mehrdad Ghashghaeinia, Lars Kaestner, Ingolf Bernhardt. Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 39(5):1941-1954. doi: 10.1159/000447891. [PMID: 27771709]
  • Shun-Long Meng, Jian-Hong Qu, Li-Min Fan, Li-Ping Qiu, Jia-Zhang Chen, Pao Xu. Responses of glutathione-related antioxidant defense system in serum of Nile tilapia (Oreochromis niloticus) exposed to sublethal concentration of methomyl and recovery pattern. Environmental toxicology. 2015 Apr; 30(4):483-9. doi: 10.1002/tox.21925. [PMID: 24273132]
  • Assia Djeffal, Mahfoud Messarah, Amel Boumendjel, Lilia Kadeche, Abdelfattah El Feki. Protective effects of vitamin C and selenium supplementation on methomyl-induced tissue oxidative stress in adult rats. Toxicology and industrial health. 2015 Jan; 31(1):31-43. doi: 10.1177/0748233712468020. [PMID: 23222694]
  • Ahmed F El-Aswad, Mohamed E I Badawy. Inhibition kinetics of acid and alkaline phosphatases by atrazine and methomyl pesticides. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2015; 50(7):484-91. doi: 10.1080/03601234.2015.1018759. [PMID: 25996812]
  • Fatma El-Demerdash, Youssef Dewer, Reda H ElMazoudy, Azza A Attia. Kidney antioxidant status, biochemical parameters and histopathological changes induced by methomyl in CD-1 mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2013 Sep; 65(6):897-901. doi: 10.1016/j.etp.2013.01.002. [PMID: 23375192]
  • Juliano R Farias, Ervandil C Costa, Jerson V C Guedes, Alessandro P Arbage, Armando B Neto, Mauricio Bigolin, Felipe F Pinto. Managing the sugarcane borer, Diatraea saccharalis, and corn earworm, Helicoverpa zea, using Bt corn and insecticide treatments. Journal of insect science (Online). 2013; 13(?):109. doi: 10.1673/031.013.10901. [PMID: 24735131]
  • Shun Long Meng, Geng Dong Hu, Li Ping Qiu, Chao Song, Li Min Fan, Jia Zhang Chen, Pao Xu. Effects of chronic exposure of methomyl on the antioxidant system in kidney of Nile tilapia (Oreochromis niloticus) and recovery pattern. Journal of toxicology and environmental health. Part A. 2013; 76(15):937-43. doi: 10.1080/15287394.2013.825893. [PMID: 24156696]
  • H W Gil, J R Hong, H Y Song, S Y Hong. A case of methanol intoxication caused by methomyl pesticide ingestion. Human & experimental toxicology. 2012 Dec; 31(12):1299-302. doi: 10.1177/0960327112459532. [PMID: 23023026]
  • Sheng-Yin Wang, Xian-Hong Zhou, An-Sheng Zhang, Li-Li Li, Xing-Yuan Men, Si-Cong Zhang, Yong-Jie Liu, Yi Yu. [Resistance mechanisms and cross-resistance of phoxim-resistant Frankliniella occidentalis Pergande population]. Ying yong sheng tai xue bao = The journal of applied ecology. 2012 Jul; 23(7):1933-9. doi: . [PMID: 23173470]
  • Ali Al-Sarar, Hamdy Hussein, Yasser Abobakr, Alaa Bayoumi. Molluscicidal activity of methomyl and cardenolide extracts from Calotropis procera and Adenium arabicum against the land snail Monacha cantiana. Molecules (Basel, Switzerland). 2012 May; 17(5):5310-8. doi: 10.3390/molecules17055310. [PMID: 22565481]
  • Fatma El-Demerdash, Azza A Attia, Reda H Elmazoudy. Biochemical and histopathological changes induced by different time intervals of methomyl treatment in mice liver. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2012; 47(12):1948-54. doi: 10.1080/03601234.2012.676513. [PMID: 22755542]
  • Charlotte N Legind, Coleen M Kennedy, Arno Rein, Nathan Snyder, Stefan Trapp. Dynamic plant uptake model applied for drip irrigation of an insecticide to pepper fruit plants. Pest management science. 2011 May; 67(5):521-7. doi: 10.1002/ps.2087. [PMID: 21472970]
  • M A Shalaby, H Y El Zorba, Reem M Ziada. Reproductive toxicity of methomyl insecticide in male rats and protective effect of folic acid. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Nov; 48(11):3221-6. doi: 10.1016/j.fct.2010.08.027. [PMID: 20813150]
  • Yu-Hui Hu, Chen-Chang Yang, Juo-Fang Deng, Ming-Ling Wu. Methomyl-alphamethrin poisoning presented with cholinergic crisis, cortical blindness, and delayed peripheral neuropathy. Clinical toxicology (Philadelphia, Pa.). 2010 Oct; 48(8):859-62. doi: 10.3109/15563650.2010.522581. [PMID: 20923394]
  • Md Wasim Aktar, Dwaipayan Sengupta, Samsul Alam, Ashim Chowdhury. Risk assessment and chemical decontamination of an oxime carbamate insecticide (methomyl) from eggplant, Solanum melongena L. Environmental monitoring and assessment. 2010 Sep; 168(1-4):657-68. doi: 10.1007/s10661-009-1141-0. [PMID: 19757122]
  • David Villar, Dubel Balvin, Carlos Giraldo, Miguel Motas, Marta Olivera. Plasma and brain cholinesterase in methomyl-intoxicated free-ranging pigeons (Columba livia f. domestica). Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2010 Mar; 22(2):313-5. doi: 10.1177/104063871002200229. [PMID: 20224101]
  • Sameeh A Mansour, Abdel-Tawab H Mossa, Tarek M Heikal. Effects of methomyl on lipid peroxidation and antioxidant enzymes in rat erythrocytes: in vitro studies. Toxicology and industrial health. 2009 Sep; 25(8):557-63. doi: 10.1177/0748233709349829. [PMID: 19825863]
  • Amina E Essawy, Nabila E Abdelmeguied, Mohamed A Radwan, Sherifa S Hamed, Amira E Hegazy. Neuropathological effect of carbamate molluscicides on the land snail, Eobania vermiculata. Cell biology and toxicology. 2009 Jun; 25(3):275-90. doi: 10.1007/s10565-008-9077-7. [PMID: 18470629]
  • Pitchaya Mungkornasawakul, Sukanda Chaiyong, Thanapat Sastraruji, Araya Jatisatienr, Chaiwat Jatisatienr, Stephen G Pyne, Alison T Ung, John Korth, Wilford Lie. Alkaloids from the roots of Stemona aphylla. Journal of natural products. 2009 May; 72(5):848-51. doi: 10.1021/np900030y. [PMID: 19374387]
  • Yuko Ito, Tomomi Goto, Sadaji Yamada, Tsutomu Ohno, Hiroshi Matsumoto, Hisao Oka, Yoichiro Ito. Rapid determination of carbamate pesticides in food using dual counter-current chromatography directly interfaced with mass spectrometry. Journal of chromatography. A. 2008 Apr; 1187(1-2):53-7. doi: 10.1016/j.chroma.2008.01.078. [PMID: 18295222]
  • Guillaume Hoizey, Frédéric Canas, Laurent Binet, Matthieu L Kaltenbach, Gérard Jeunehomme, Marie-Hélène Bernard, Denis Lamiable. Thiodicarb and methomyl tissue distribution in a fatal multiple compounds poisoning. Journal of forensic sciences. 2008 Mar; 53(2):499-502. doi: 10.1111/j.1556-4029.2008.00676.x. [PMID: 18366586]
  • Dharm Paul Garg, Ravi Kiran, Anil K Bansal, Anshoo Malhotra, Devinder K Dhawan. Role of vitamin E in mitigating methomyl induced acute toxicity in blood of male Wistar rats. Drug and chemical toxicology. 2008; 31(4):487-99. doi: 10.1080/01480540802390775. [PMID: 18850358]
  • Yuko Ito, Tomomi Goto, Sadaji Yamada, Hiroshi Matsumoto, Hisao Oka, Nobuyuki Takahashi, Hiroyuki Nakazawa, Hisamitsu Nagase, Yoichiro Ito. Application of dual counter-current chromatography for rapid sample preparation of N-methylcarbamate pesticides in vegetable oil and citrus fruit. Journal of chromatography. A. 2006 Mar; 1108(1):20-5. doi: 10.1016/j.chroma.2005.12.070. [PMID: 16445929]
  • E Bruce, S Korpalski, D Johnson, D Klonne, W Nagel, L Holden, B Lange. Effect of dislodging techniques on foliar residue determination for agricultural crops. Archives of environmental contamination and toxicology. 2006 Jan; 50(1):138-43. doi: 10.1007/s00244-005-7041-6. [PMID: 16385393]
  • Om Ali Y El-Khawaga. Role of selenium on antioxidant capacity in methomyl-treated mice. Journal of physiology and biochemistry. 2005 Dec; 61(4):501-6. doi: 10.1007/bf03168375. [PMID: 16669347]
  • Keiko Kudo, Yoshihiro Hida, Akinori Zaitsu, Hiromasa Inoue, Akiko Tsuji, Tomomi Ishida, Noriaki Ikeda. A case of poisoning in a man who drank a nutrition supplement containing methomyl, a carbamate pesticide. Fukuoka igaku zasshi = Hukuoka acta medica. 2005 Jul; 96(7):305-10. doi: . [PMID: 16173456]
  • Fumio Moriya, Yoshiaki Hashimoto. A fatal poisoning caused by methomyl and nicotine. Forensic science international. 2005 May; 149(2-3):167-70. doi: 10.1016/j.forsciint.2004.06.013. [PMID: 15749358]
  • Stefan Korpalski, Eric Bruce, Larry Holden, Dennis Klonne. Dislodgeable foliar residues are lognormally distributed for agricultural re-entry studies. Journal of exposure analysis and environmental epidemiology. 2005 Mar; 15(2):160-3. doi: 10.1038/sj.jea.7500383. [PMID: 15454947]
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