Methylthiouracil (BioDeep_00000002157)

 

Secondary id: BioDeep_00001867815

human metabolite blood metabolite


代谢物信息卡片


6-Methyl-2-sulphanylidene-1H-pyrimidin-4-one

化学式: C5H6N2OS (142.0200826)
中文名称: 甲硫尿嘧啶
谱图信息: 最多检出来源 Viridiplantae(plant) 98.08%

分子结构信息

SMILES: CC1=CC(=O)NC(=S)N1
InChI: InChI=1S/C5H6N2OS/c1-3-2-4(8)7-5(9)6-3/h2H,1H3,(H2,6,7,8,9)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 1235; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1149; ORIGINAL_PRECURSOR_SCAN_NO 1146
CONFIDENCE standard compound; INTERNAL_ID 1235; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1156; ORIGINAL_PRECURSOR_SCAN_NO 1153
CONFIDENCE standard compound; INTERNAL_ID 1235; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1126; ORIGINAL_PRECURSOR_SCAN_NO 1124
CONFIDENCE standard compound; INTERNAL_ID 1235; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1143; ORIGINAL_PRECURSOR_SCAN_NO 1141
CONFIDENCE standard compound; INTERNAL_ID 1235; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1165; ORIGINAL_PRECURSOR_SCAN_NO 1163
CONFIDENCE standard compound; INTERNAL_ID 1235; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 1155; ORIGINAL_PRECURSOR_SCAN_NO 1154
H - Systemic hormonal preparations, excl. sex hormones and insulins > H03 - Thyroid therapy > H03B - Antithyroid preparations > H03BA - Thiouracils
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D013956 - Antithyroid Agents
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist > C885 - Antithyroid Agent
CONFIDENCE standard compound; INTERNAL_ID 1164
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.

同义名列表

8 个代谢物同义名

6-Methyl-2-sulphanylidene-1H-pyrimidin-4-one; 6-Methyl-2-sulphanylpyrimidin-4-ol; 6-methyl-2-sulfanylpyrimidin-4-ol; 6-Methyl-2-thiouracil; methyl thiouracil; methylthiouracil; Thimecil; MTU



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sebastian Witek, Barbara Wozniak, Iwona Matraszek-Zuchowska, Andrzej Posyniak. Analysis of thyreostats in bovine feces using ultra high performance liquid chromatography with tandem mass spectrometry. Journal of separation science. 2018 Mar; 41(5):1083-1090. doi: 10.1002/jssc.201701069. [PMID: 29266785]
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  • Liqun Ren, Naifeng Liu, Hong Zhi, Yingjuan Li, Yanzhi Li, Rining Tang, Zulong Sheng. Vasculoprotective effects of rosiglitazone through modulating renin-angiotensin system in vivo and vitro. Cardiovascular diabetology. 2011 Jan; 10(?):10. doi: 10.1186/1475-2840-10-10. [PMID: 21269478]
  • Margarita S Chernov'yants, Andrey O Dolinkin, Anatoly V Chernyshev, Evgeniy V Khohlov, Elizaveta G Golovanova. Interaction of antithyroid drugs with bovine serum albumin: electrophoretic and fluorimetric study. Journal of pharmaceutical sciences. 2010 Mar; 99(3):1567-73. doi: 10.1002/jps.21915. [PMID: 19774650]
  • Krishna P Bhabak, Govindasamy Mugesh. Antithyroid drugs and their analogues protect against peroxynitrite-mediated protein tyrosine nitration--a mechanistic study. Chemistry (Weinheim an der Bergstrasse, Germany). 2010 Jan; 16(4):1175-85. doi: 10.1002/chem.200902145. [PMID: 20029917]
  • Yue Wei, Zhu-Jun Zhang, Yan-Tu Zhang, Yong-Hua Sun. Determination of propylthiouracil and methylthiouracil in human serum using high-performance liquid chromatography with chemiluminescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jul; 854(1-2):239-44. doi: 10.1016/j.jchromb.2007.04.028. [PMID: 17521973]
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  • A Heeremans, A Ermens, K K De Wasch, C Van Peteghem, H F De Brabander. Elimination profile of methylthiouracil in cows after oral administration. The Analyst. 1998 Dec; 123(12):2629-32. doi: 10.1039/a805113e. [PMID: 10435313]
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