m-chlorophenylpiperazine (m-CPP) (BioDeep_00000002142)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


1-(3-Chlorophenyl)piperazine monohydrochloride

化学式: C10H13ClN2 (196.0767)
中文名称: 1-(3-氯苯基)哌嗪, 4-氟苯胺
谱图信息: 最多检出来源 Homo sapiens(blood) 39.02%

分子结构信息

SMILES: c1c(Cl)cccc1N1CCNCC1
InChI: InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2

描述信息

m-chlorophenylpiperazine (m-CPP) is a metabolite of trazodone. Trazodone (also sold under the brand names Desyrel, Oleptro, Beneficat, Deprax, Desirel, Molipaxin, Thombran, Trazorel, Trialodine, Trittico, and Mesyrel) is an antidepressant of the serotonin antagonist and reuptake inhibitor (SARI) class. It is a phenylpiperazine compound. Trazodone also has anxiolytic and hypnotic effects. Trazodone has considerably fewer prominent anticholinergic and sexual side effects than most of the tricyclic antidepressants (TCAs). (Wikipedia)
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
CONFIDENCE Parent Substance with Reference Standard (Level 1); INTERNAL_ID 1300
EAWAG_UCHEM_ID 2818; CONFIDENCE standard compound
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2818

同义名列表

19 个代谢物同义名

1-(3-Chlorophenyl)piperazine monohydrochloride; 1-(3-Chlorophenyl)piperazine dihydrochloride; Piperazine, 1-(3-chlorophenyl)- (m-CPP); m-chlorophenylpiperazine (m-CPP); Dihydrochloro phenyl piperazine; 1-(m-Chlorophenyl)piperazine; 1-(3-Chlorophenyl)piperazine; Meta-chlorophenylpiperazine; 3-Chlorophenyl piperazine; 3-Chlorophenylpiperazine; m-Chlorophenylpiperazine; OCP_197.0840_11.1; 1-3-CPP; (m-CPP); m-CPP; MCPP; m-Chlorophenylpiperazine; 4-Fluoroaniline; 4-Fluoroaniline



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ADRA1A, CYP2D6, CYP3A4, HTR2B, POMC
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 4 CYP1A2, CYP2D6, CYP3A4, DRD1
Nucleus 3 ADRA1A, DRD1, FOS
cytosol 2 ADRA1A, FOS
dendrite 7 DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C
nucleoplasm 3 ADRA1A, FOS, HTR2B
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 12 ADRA1A, ADRB3, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR3A, SLC6A4
Cleavage furrow 1 HTR3A
Cell projection, axon 1 HTR2A
Multi-pass membrane protein 12 ADRA1A, ADRB3, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR3A, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 8 CRH, DRD2, HTR1A, HTR1D, HTR2B, HTR2C, HTR3A, SLC6A4
dendritic shaft 1 HTR2A
glutamatergic synapse 3 DRD1, DRD2, HTR2A
Golgi membrane 1 DRD2
neuronal cell body 1 HTR2A
postsynapse 1 HTR3A
presynaptic membrane 5 DRD1, DRD2, HTR1B, HTR2A, SLC6A4
Presynapse 2 HTR2A, SLC6A4
acrosomal vesicle 1 DRD2
plasma membrane 13 ADRA1A, ADRB3, DRD1, DRD2, GCG, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR3A, SLC6A4
synaptic vesicle membrane 1 DRD2
Membrane 4 CYP2D6, CYP3A4, HTR3A, SLC6A4
axon 3 CCK, DRD2, HTR2A
caveola 2 ADRA1A, HTR2A
endoplasmic reticulum 3 CYP2D6, FOS, HTR1B
extracellular space 4 CCK, CRH, GCG, POMC
mitochondrion 1 CYP2D6
intracellular membrane-bounded organelle 4 ADRA1A, CYP1A2, CYP2D6, CYP3A4
Microsome membrane 3 CYP1A2, CYP2D6, CYP3A4
Secreted 4 CCK, CRH, GCG, POMC
extracellular region 4 CCK, CRH, GCG, POMC
Single-pass membrane protein 1 CYP2D6
ciliary membrane 2 DRD1, DRD2
Nucleus membrane 1 ADRA1A
nuclear membrane 1 ADRA1A
varicosity 1 CRH
dendritic spine 2 DRD1, DRD2
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, DRD2
cytoplasmic vesicle 1 HTR2A
postsynaptic membrane 5 DRD1, DRD2, HTR2A, HTR3A, SLC6A4
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
GABA-ergic synapse 2 DRD1, DRD2
Cell projection, dendritic spine 1 DRD1
secretory granule 1 POMC
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 1 HTR3A
receptor complex 1 ADRB3
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 HTR3A, SLC6A4
cilium 2 DRD1, DRD2
chromatin 1 FOS
non-motile cilium 2 DRD1, DRD2
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
sperm flagellum 1 DRD2
Endomembrane system 1 SLC6A4
Membrane, caveola 2 ADRA1A, HTR2A
cell body fiber 1 HTR2A
Cell projection, dendrite 3 DRD1, HTR1A, HTR2A
secretory granule lumen 2 GCG, POMC
endoplasmic reticulum lumen 1 GCG
nuclear matrix 1 FOS
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
neurofilament 1 HTR2A
calyx of Held 1 HTR1B
Synapse, synaptosome 1 HTR2B
protein-DNA complex 1 FOS
dopaminergic synapse 1 DRD2
Cell projection, cilium membrane 1 DRD1
transcription factor AP-1 complex 1 FOS
[Glucagon-like peptide 1]: Secreted 1 GCG
G protein-coupled receptor complex 2 DRD1, DRD2
G protein-coupled serotonin receptor complex 4 HTR1B, HTR2A, HTR2B, HTR2C
serotonergic synapse 2 HTR1B, SLC6A4


文献列表

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