Phenmetrazine (BioDeep_00000002086)

 

Secondary id: BioDeep_00000406246

human metabolite Endogenous blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


Hydrochloride, phenmetrazine

化学式: C11H15NO (177.1154)
中文名称: 芬美曲秦, 吩甲嗪
谱图信息: 最多检出来源 Homo sapiens(blood) 10.89%

分子结构信息

SMILES: CC1C(c2ccccc2)OCCN1
InChI: InChI=1S/C11H15NO/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3

描述信息

Phenmetrazine is only found in individuals that have used or taken this drug. It is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. [PubChem]Phenmetrazine is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron leading to an increase in the release of these monoamines into the extraneuronal space. Dopamine integrates incoming sensory stimuli, initiates and controls fine movement (nigro-neostriatal pathway), controls emotional behavior (midbrain mesolimbic-forebrain system) and controls hypothalamic-pituitary endocrine system (tubero-infundibular system). It is this latter effect on the tubero-infundibular systm that seems to lead to reduced food intake. Phenmetrazine also acts as a monoamine oxidase inhibitor.
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants

同义名列表

14 个代谢物同义名

Hydrochloride, phenmetrazine; Phenmetrazine hydrochloride; 2-Phenyl-3-methylmorpholine; 3-Methyl-2-phenylmorpholine; Dexphenmetrazine; phenmetrazine; Phenmetraline; Defenmetrazin; Oxazimedrine; Fenmetrazin; USAF ge-1; Preludin; Phenmetrazine; Phenmetrazine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 MAPK3, SLC6A3
Nucleus 1 MAPK3
cytosol 1 MAPK3
dendrite 1 GRM2
nucleoplasm 1 MAPK3
Cell membrane 5 GPRC5A, GRM2, GRM3, SLC29A4, SLC6A3
Cell projection, axon 1 SLC6A3
Multi-pass membrane protein 5 GPRC5A, GRM2, GRM3, SLC29A4, SLC6A3
Synapse 2 GRM2, NPS
cell surface 1 SLC6A3
glutamatergic synapse 3 GRM2, GRM3, MAPK3
Golgi apparatus 1 MAPK3
Golgi membrane 1 INS
neuronal cell body 1 SLC6A3
presynaptic membrane 3 GRM2, GRM3, SLC6A3
Presynapse 1 SLC29A4
plasma membrane 7 GCG, GPRC5A, GRM2, GRM3, MAPK3, SLC29A4, SLC6A3
Membrane 4 GRM2, GRM3, SLC29A4, SLC6A3
apical plasma membrane 1 SLC29A4
axon 3 GRM2, GRM3, SLC6A3
basolateral plasma membrane 1 SLC29A4
caveola 1 MAPK3
extracellular exosome 1 GPRC5A
extracellular space 2 GCG, INS
mitochondrion 1 MAPK3
intracellular membrane-bounded organelle 1 GPRC5A
postsynaptic density 1 GRM3
Secreted 2 GCG, INS
extracellular region 3 GCG, INS, NPS
neuronal cell body membrane 1 SLC6A3
dendritic spine 1 GRM3
nucleolus 1 GPRC5A
Early endosome 1 MAPK3
vesicle 1 GPRC5A
postsynaptic membrane 3 GRM2, GRM3, SLC6A3
Apical cell membrane 1 SLC29A4
Membrane raft 1 SLC6A3
Cell junction, focal adhesion 1 MAPK3
focal adhesion 1 MAPK3
flotillin complex 1 SLC6A3
Late endosome 1 MAPK3
receptor complex 1 GPRC5A
Cell projection, neuron projection 1 SLC6A3
neuron projection 1 SLC6A3
cytoskeleton 1 MAPK3
nuclear envelope 1 MAPK3
endosome lumen 1 INS
Membrane, caveola 1 MAPK3
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 1 GRM2
pseudopodium 1 MAPK3
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 GCG, INS, MAPK3
axon terminus 1 SLC6A3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
dopaminergic synapse 1 SLC6A3
astrocyte projection 2 GRM2, GRM3
[Glucagon-like peptide 1]: Secreted 1 GCG


文献列表

  • Sabrina Lehmann, Alissa Sczyslo, Judith Froch-Cortis, Markus Alexander Rothschild, Mario Thevis, Hilke Andresen-Streichert, Katja Mercer-Chalmers-Bender. Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine. Forensic science international. 2019 Oct; 303(?):109959. doi: 10.1016/j.forsciint.2019.109959. [PMID: 31546164]
  • Christina Grumann, Kerstin Henkel, Alexander Stratford, Maren Hermanns-Clausen, Torsten Passie, Simon D Brandt, Volker Auwärter. Validation of an LC-MS/MS method for the quantitative analysis of 1P-LSD and its tentative metabolite LSD in fortified urine and serum samples including stability tests for 1P-LSD under different storage conditions. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):270-276. doi: 10.1016/j.jpba.2019.05.062. [PMID: 31181490]
  • Christina Grumann, Laura M Huppertz, Philippe Bisel, Verena Angerer, Volker Auwärter. Method validation and preliminary pharmacokinetic studies on the new designer stimulant 3-fluorophenmetrazine (3-FPM). Drug testing and analysis. 2019 Jul; 11(7):1009-1017. doi: 10.1002/dta.2577. [PMID: 30784204]
  • Gavin McLaughlin, Michael H Baumann, Pierce V Kavanagh, Noreen Morris, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Gary Hessman, Folker Westphal, Donna Walther, Simon D Brandt. Synthesis, analytical characterization, and monoamine transporter activity of the new psychoactive substance 4-methylphenmetrazine (4-MPM), with differentiation from its ortho- and meta- positional isomers. Drug testing and analysis. 2018 Sep; 10(9):1404-1416. doi: 10.1002/dta.2396. [PMID: 29673128]
  • Felix P Mayer, Nadine V Burchardt, Ann M Decker, John S Partilla, Yang Li, Gavin McLaughlin, Pierce V Kavanagh, Walter Sandtner, Bruce E Blough, Simon D Brandt, Michael H Baumann, Harald H Sitte. Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family. Neuropharmacology. 2018 05; 134(Pt A):149-157. doi: 10.1016/j.neuropharm.2017.10.006. [PMID: 28988906]
  • Matilda Bäckberg, Jenny Westerbergh, Olof Beck, Anders Helander. Adverse events related to the new psychoactive substance 3-fluorophenmetrazine - results from the Swedish STRIDA project. Clinical toxicology (Philadelphia, Pa.). 2016 Nov; 54(9):819-825. doi: 10.1080/15563650.2016.1211288. [PMID: 27491700]
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  • Ernesto Solis, Julie A Suyama, Matthew F Lazenka, Louis J DeFelice, S Stevens Negus, Bruce E Blough, Matthew L Banks. Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters. Scientific reports. 2016 08; 6(?):31385. doi: 10.1038/srep31385. [PMID: 27514281]
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