Mepyramine (BioDeep_00000002045)

   

human metabolite blood metabolite


代谢物信息卡片


N-[(4-Methoxyphenyl)methyl]-n,n-dimethyl-N-2-pyridinyl-1,2-ethanediamine

化学式: C17H23N3O (285.1841)
中文名称: 美吡拉敏
谱图信息: 最多检出来源 Homo sapiens(blood) 5%

分子结构信息

SMILES: CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2
InChI: InChI=1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3

描述信息

Mepyramine (also known as pyrilamine) is a first generation antihistamine, targeting the H1 receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It is used in over-the-counter combination products for colds and menstrual symptoms.
D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3006
D018926 - Anti-Allergic Agents

同义名列表

18 个代谢物同义名

N-[(4-Methoxyphenyl)methyl]-n,n-dimethyl-N-2-pyridinyl-1,2-ethanediamine; N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine; N-(p-Methoxybenzyl)-n,n-dimethyl-N-(alpha-pyridyl)ethylenediamine; N,n-dimethyl-N-(p-methoxybenzyl)-N-(2-pyridyl)ethylenediamine; N-(p-Methoxybenzyl)-n,n-dimethyl-N-(α-pyridyl)ethylenediamine; N-(p-Methoxybenzyl)-n,n-dimethyl-N-(a-pyridyl)ethylenediamine; Boots brand OF mepyramine maleate; Boots bite and sting relief; Maleate, mepyramine; Maleate, pyrilamine; Pyrilamine maleate; Mepyramine maleate; Pyranisamine; pyrilamine; Mepyramine; Anthisan; Kriptin; Mepyramine



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALOX5, CA1, CYP2D6, HDC, ITPR3, SLC22A5, SLC9A1
Peripheral membrane protein 1 ALOX5
Endoplasmic reticulum membrane 2 CYP2D6, ITPR3
Nucleus 3 FOS, HDC, PLCZ1
cytosol 9 ALOX5, CA1, FOS, HDC, HRH1, PLCZ1, PRKCQ, SLC22A5, SST
dendrite 3 HRH1, HRH2, HRH3
nucleoplasm 5 ALOX5, FOS, ITPR3, PLCZ1, SLC9A1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 6 CYSLTR2, HRH1, HRH2, HRH3, SLC22A5, SLC9A1
lamellipodium 1 SLC9A1
Multi-pass membrane protein 8 CACNA1I, CYSLTR2, HRH1, HRH2, HRH3, ITPR3, SLC22A5, SLC9A1
Synapse 4 HRH1, HRH2, HRH3, TAC1
cell surface 1 SLC9A1
neuronal cell body 3 ITPR3, SST, TAC1
Cytoplasm, cytosol 1 ALOX5
Presynapse 1 HRH3
plasma membrane 11 CACNA1I, CYSLTR2, HRH1, HRH2, HRH3, IGHE, ITPR3, KNG1, PRKCQ, SLC22A5, SLC9A1
Membrane 6 CACNA1I, CYP2D6, HDC, ITPR3, SLC22A5, SLC9A1
apical plasma membrane 2 SLC22A5, SLC9A1
axon 1 TAC1
basolateral plasma membrane 1 SLC9A1
brush border 1 ITPR3
extracellular exosome 4 CA1, KNG1, SLC22A5, SLC9A1
endoplasmic reticulum 4 CYP2D6, FOS, ITPR3, SLC22A5
extracellular space 6 ALOX5, GAST, IGHE, KNG1, SST, TAC1
perinuclear region of cytoplasm 3 ALOX5, PLCZ1, SLC9A1
intercalated disc 1 SLC9A1
mitochondrion 2 CYP2D6, SLC9A1
intracellular membrane-bounded organelle 1 CYP2D6
Microsome membrane 1 CYP2D6
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 IGHE
Secreted 2 GAST, SST
extracellular region 6 ALOX5, GAST, IGHE, KNG1, SST, TAC1
Single-pass membrane protein 1 CYP2D6
centriolar satellite 1 PRKCQ
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
T-tubule 1 SLC9A1
nucleolus 2 ITPR3, PLCZ1
apical part of cell 1 ITPR3
Apical cell membrane 1 SLC22A5
Cytoplasm, perinuclear region 2 ALOX5, PLCZ1
Membrane raft 1 SLC9A1
focal adhesion 1 SLC9A1
GABA-ergic synapse 1 SST
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 KNG1
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
chromatin 1 FOS
IgE immunoglobulin complex 1 IGHE
Secreted, extracellular space 1 KNG1
brush border membrane 1 SLC22A5
blood microparticle 1 KNG1
Basolateral cell membrane 1 SLC9A1
[Isoform 2]: Cell membrane 1 IGHE
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
basal plasma membrane 1 SLC22A5
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
secretory granule membrane 1 ITPR3
endoplasmic reticulum lumen 1 KNG1
nuclear matrix 2 ALOX5, FOS
platelet alpha granule lumen 1 KNG1
voltage-gated calcium channel complex 1 CACNA1I
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 SST
aggresome 1 PRKCQ
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
platelet dense tubular network membrane 1 ITPR3
Basal cell membrane 1 SLC22A5
protein-DNA complex 1 FOS
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
[Isoform 3]: Endoplasmic reticulum 1 SLC22A5
[Isoform 3]: Cell membrane 1 IGHE
transcription factor AP-1 complex 1 FOS
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
transport vesicle membrane 1 ITPR3
sperm head 1 PLCZ1
Nucleus intermembrane space 1 ALOX5
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
cation-transporting ATPase complex 1 SLC9A1


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