Ropivacaine (BioDeep_00000002024)
Secondary id: BioDeep_00000406012
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
化学式: C17H26N2O (274.2045)
中文名称: 罗哌卡因
谱图信息:
最多检出来源 Homo sapiens(general) 31.72%
分子结构信息
SMILES: CCCN1CCCCC1C(=O)Nc1c(C)cccc1C
InChI: InChI=1S/C17H26N2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20)
描述信息
Ropivacaine is only found in individuals that have used or taken this drug. It is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer. Ropivacaine hydrochloride is commonly marketed by AstraZeneca under the trade name Naropin. [Wikipedia]Local anesthetics such as Ropivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Specifically, they block the sodium-channel and decrease chances of depolarization and consequent action potentials. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BB - Amides
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
23 个代谢物同义名
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; (-)-1-Propyl-2,6-dimethyl-2-piperidylcarboxyanilide; Ropivacaine monohydrochloride, (S)-isomer; L-N-N-Propylpipecolic acid-2,6-xylidide; (S)-(-)-1-Propyl-2,6-pipecoloxylidide; L-N-N-Propylpipecolate-2,6-xylidide; (-)-1-Propyl-2,6-pipecoloxylidide; 1 Propyl 2,6 pipecoloxylidide; Ropivacaine monohydrochloride; 1-Propyl-2,6-pipecoloxylidide; Ropivacaine hydrochloride; rac-Ropivacaine; S-Ropivacaine; Ropivacainum; Ropivacaina; Ropivacaine; Naropeine; LEA 103; Naropin; LEA-103; Ropivacaine; Ropivacaine
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:60802
- ChEBI: CHEBI:8890
- KEGG: C07532
- KEGGdrug: D08490
- PubChem: 175805
- PubChem: 71273
- HMDB: HMDB0014441
- Metlin: METLIN2374
- DrugBank: DB00296
- ChEMBL: CHEMBL1077896
- Wikipedia: Ropivacaine
- MeSH: Ropivacaine
- chemspider: 153165
- CAS: 684647-62-9
- CAS: 84057-95-4
- CAS: 98626-61-0
- PMhub: MS000001698
- PubChem: 9735
- NIKKAJI: J33.095G
- KNApSAcK: 8890
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tao Kang, Jiwei Tao, Xuetao Wang, Yu Liu, Dan Jin. Epidural ropivacaine versus bupivacaine for cesarean sections: a system review and meta-analysis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2024 Dec; 37(1):2313356. doi:
10.1080/14767058.2024.2313356. [PMID: 38342577] - Minghao Liu, Xuezi Chen, Dan Guo. Effect of epidural dexmedetomidine in single-dose combined with ropivacaine for cesarean section.
BMC anesthesiology.
2024 Apr; 24(1):134. doi:
10.1186/s12871-024-02519-4. [PMID: 38589819] - Yingjun Zhang, Chaopeng Ou, Xiaolin Luo, Yinqian Kang, Li Jiang, Shaoyong Wu, Handong Ouyang. Effectiveness of acupuncture for postoperative gastrointestinal recovery in patients undergoing thoracoscopic surgery: a prospective randomized controlled study.
Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2024 Feb; 42(1):14-22. doi:
10.1177/09645284231202807. [PMID: 37800350] - Ji-Jie Feng, Jian-Jun Xu, Ke Wang, Jia Zhou, Tong-Yu Chen. [Retrospective cohort study on application of acupuncture-aided anesthesia technique to patients undergoing thoracoscopic lobectomy].
Zhen ci yan jiu = Acupuncture research.
2023 Sep; 48(9):946-50. doi:
10.13702/j.1000-0607.20220733. [PMID: 37730266] - Jing Feng, Ping Xia, Feifei Pu. Safety and efficacy of topical ropivacaine injection for relieving postoperative pain of spinal tuberculosis: A randomized clinical trial.
Asian journal of surgery.
2023 04; 46(4):1645-1646. doi:
10.1016/j.asjsur.2022.09.105. [PMID: 36202705] - Mingxu Zhao, Shasha Zhu, Ding Zhang, Chang Zhou, Zhilai Yang, Chunhui Wang, Xuesheng Liu, Jiqian Zhang. Long-lasting postoperative analgesia with local anesthetic-loaded hydrogels prevent tumor recurrence via enhancing CD8+T cell infiltration.
Journal of nanobiotechnology.
2023 Feb; 21(1):50. doi:
10.1186/s12951-023-01803-8. [PMID: 36765361] - Matilde Zaballos, Ignacio Fernández, Arturo Melone, Lucía Rodríguez, Olalla Varela, Sergio García, Oscar Quintela, Elena Vazquez, María José Anadón, Jesús Almendral. Sodium bicarbonate reverts electrophysiologic cardiotoxicity of ropivacaine faster than lipid emulsions in a porcine model.
Basic & clinical pharmacology & toxicology.
2023 Feb; 132(2):211-222. doi:
10.1111/bcpt.13822. [PMID: 36479999] - Xin Ye, Yi-Feng Ren, Yu-Cheng Hu, Shi-Yan Tan, Hua Jiang, Long-Fei Zhang, Wei Shi, Yu-Ting Wang. Dexamethasone Does Not Provide Additional Clinical Analgesia Effect to Local Wound Infiltration: A Comprehensive Systematic Review and Meta-Analysis.
Advances in wound care.
2023 01; 12(1):1-14. doi:
10.1089/wound.2021.0163. [PMID: 35081741] - Wei Zhang, Chunzhao Li, Chunmei Zhao, Nan Ji, Fang Luo. Pre-incisional infiltration with ropivacaine plus dexamethasone palmitate emulsion for postoperative pain in patients undergoing craniotomy: study protocol for a prospective, randomized controlled trial.
Trials.
2022 Dec; 23(1):996. doi:
10.1186/s13063-022-06936-z. [PMID: 36510271] - Shu Yuan, Jun Chen, Shuo Feng, Min Li, Yingui Sun, Yuzhen Liu. Combination anesthetic therapy: co-delivery of ropivacaine and meloxicam using transcriptional transactivator peptide modified nanostructured lipid carriers in vitro and in vivo.
Drug delivery.
2022 Dec; 29(1):263-269. doi:
10.1080/10717544.2021.2023695. [PMID: 35014916] - C Philip Larson, Kevin Youssefzadeh, Jane S Moon. The Bupivacaine Story: A Tribute to George A. Albright, MD (1931-2020).
Anesthesia and analgesia.
2022 11; 135(5):1115-1119. doi:
10.1213/ane.0000000000006161. [PMID: 35924832] - Lin Zeng, Juan Liu, Tianyao Zhang, Yusong Liu, Lumiu Liao, Xuelian Chen, Shuhua Dong. Study on the protective mechanism of dexmedetomidine on the liver of perioperative diabetic patients: A randomized controlled trial.
Medicine.
2022 Oct; 101(41):e30899. doi:
10.1097/md.0000000000030899. [PMID: 36254014] - Chenran Wang, Shen Sun, Jing Jiao, Xinhua Yu, Shaoqiang Huang. Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Fundamental & clinical pharmacology.
2022 Oct; 36(5):811-817. doi:
10.1111/fcp.12778. [PMID: 35373856] - Wojciech Gola, Szymon Bialka, Marek Zajac, Hanna Misiolek. Cardiac Arrest after Small Doses Ropivacaine: Local Anesthetic Systemic Toxicity in the Course of Continuous Femoral Nerve Blockade.
International journal of environmental research and public health.
2022 09; 19(19):. doi:
10.3390/ijerph191912223. [PMID: 36231524] - Matilde Zaballos, Ignacio Fernández, Lucia Rodríguez, Sergio García, Olalla Varela, Oscar Quintela, María-José Anadón, Jesús Almendral. Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity.
Clinical toxicology (Philadelphia, Pa.).
2022 08; 60(8):902-911. doi:
10.1080/15563650.2022.2080075. [PMID: 35658706] - Peng Zou, Xiaoping Zhang, Rui Zhang, Jun-Song Yang, Lei Chu, Xiang-Fu Wang, Jian-Min Wei, Xin Chai, Yuan-Ting Zhao, Bo Liao. The feasibility and safety of cocktail treatment of triple anti-inflammatory agents loaded with gelatin sponge promotes early recovery after posterior percutaneous endoscopic cervical discectomy.
Journal of orthopaedic surgery and research.
2022 May; 17(1):290. doi:
10.1186/s13018-022-03178-2. [PMID: 35619183] - Shen Sun, Yaojun Lu, Fubo Tian, Shaoqiang Huang. Ropivacaine with intraspinal administration alleviates preeclampsia-induced kidney injury via glycocalyx /alpha 7 nicotinic acetylcholine receptor pathway.
Bioengineered.
2022 05; 13(5):13131-13140. doi:
10.1080/21655979.2022.2080365. [PMID: 35635041] - Xiubin Chen, Yueqi Zhang, Xiu Ni, Zhiqiang Liu. Effects of labour analgesia with different concentrations of ropivacaine on maternal body temperature and inflammatory factor: A randomised controlled study.
Anaesthesia, critical care & pain medicine.
2022 04; 41(2):101030. doi:
10.1016/j.accpm.2022.101030. [PMID: 35123105] - Hanmei Li, Qi Tang, Yao Wang, Mao Li, Yannan Wang, Hong Zhu, Fang Geng, Di Wu, Lianxin Peng, Gang Zhao, Liang Zou, Sanjun Shi. Injectable thermosensitive lipo-hydrogels loaded with ropivacaine for prolonging local anesthesia.
International journal of pharmaceutics.
2022 Jan; 611(?):121291. doi:
10.1016/j.ijpharm.2021.121291. [PMID: 34780929] - Seong-Ho Ok, Dawon Kang, Soo Hee Lee, Hyun-Jin Kim, Seung Hyun Ahn, Ju-Tae Sohn. Lipid emulsions attenuate the inhibition of carnitine acylcarnitine translocase induced by toxic doses of local anesthetics in rat cardiomyoblasts.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211065978. doi:
10.1177/09603271211065978. [PMID: 35135371] - Ryan C Dregalla, Yvette Uribe, Marko Bodor. Effect of local anesthetics on platelet physiology and function.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2021 Dec; 39(12):2744-2754. doi:
10.1002/jor.25019. [PMID: 33694196] - Juan Morgaz, David F Latorre, Juan M Serrano-Rodríguez, María M Granados, Juan M Domínguez, J Andrés Fernández-Sarmiento, Setefilla Quiros-Carmona, Rocío Navarrete-Calvo. Preperitoneal ropivacaine infusion versus epidural ropivacaine-morphine for postoperative analgesia in dogs undergoing ovariohysterectomy: a randomized clinical trial.
Veterinary anaesthesia and analgesia.
2021 Nov; 48(6):935-942. doi:
10.1016/j.vaa.2021.04.009. [PMID: 34561181] - D Viderman, B Ben-David, A Sarria-Santamera. Analysis of bupivacaine and ropivacaine-related cardiac arrests in regional anesthesia: A systematic review of case reports.
Revista espanola de anestesiologia y reanimacion.
2021 Oct; 68(8):472-483. doi:
10.1016/j.redare.2020.10.005. [PMID: 34538765] - Bruno A Zanfini, Matteo Biancone, Marco Famele, Stefano Catarci, Roberta Lavalle, Luciano Frassanito, Alessandra Piersanti, Cristina Olivieri, Antonio Lanzone, Rosa Draisci, Gaetano Draisci. Comparison of ropivacaine plasma concentration after posterior Quadratus Lumborum Block in Cesarean Section with ropivacaine with epinephrine vs. plane.
Minerva anestesiologica.
2021 09; 87(9):979-986. doi:
10.23736/s0375-9393.21.15354-4. [PMID: 33938678] - Ji-Yeon Bang, Sugeun Nam, Chang-Soon Hwang, Eun-Kyung Lee, Byung-Moon Choi. Population pharmacokinetic analysis of ropivacaine extended-release from a temperature-responsive hydrogel in rats.
Clinical and experimental pharmacology & physiology.
2021 06; 48(6):932-937. doi:
10.1111/1440-1681.13492. [PMID: 33686702] - Vincent Marolf, Keila K Ida, Danuta Siluk, Wiktoria Struck-Lewicka, Michał J Markuszewski, Charlotte Sandersen. Effects of perineural administration of ropivacaine combined with perineural or intravenous administration of dexmedetomidine for sciatic and saphenous nerve blocks in dogs.
American journal of veterinary research.
2021 Jun; 82(6):449-458. doi:
10.2460/ajvr.82.6.449. [PMID: 34032477] - Xingfeng Sun, Qun Zhou, Min Zhou, Rong Cao, Zuolei Chen, Songjiang Tang, Shaoqiang Huang. The Effect of Epidural Nalbuphine Combined With Ropivacaine on Epidural Analgesia During Labor: A Multicenter, Randomized, Double-blind, Controlled Study.
The Clinical journal of pain.
2021 06; 37(6):437-442. doi:
10.1097/ajp.0000000000000928. [PMID: 33758132] - Montiel Jiménez-Fuertes, Dolores C García-Olmo, Sara Puy, Marc Beisani, Francisca Planells, Alba Boldó, Jaime Ruiz-Tovar, Manuel Durán, Damián García-Olmo. Effects of negative-pressure therapy with and without ropivacaine instillation in the early evolution of severe peritonitis in pigs.
European journal of trauma and emergency surgery : official publication of the European Trauma Society.
2021 Apr; 47(2):597-606. doi:
10.1007/s00068-019-01244-9. [PMID: 31641785] - Kirill Gromov, Stanislas Grassin-Delyle, Nicolai B Foss, Lars Møller Pedersen, Christian S Nielsen, Elodie Lamy, Anders Troelsen, Saik Urien, Henrik Husted. Population pharmacokinetics of ropivacaine used for local infiltration anaesthesia during primary total unilateral and simultaneous bilateral knee arthroplasty.
British journal of anaesthesia.
2021 04; 126(4):872-880. doi:
10.1016/j.bja.2020.11.038. [PMID: 33455802] - Hongfei Chen, Zhousheng Jin, Fangfang Xia, Zhijian Fu. Bupivacaine inhibits a small conductance calcium-activated potassium type 2 channel in human embryonic kidney 293 cells.
BMC pharmacology & toxicology.
2021 03; 22(1):15. doi:
10.1186/s40360-021-00481-2. [PMID: 33712065] - Yifeng Ren, Hong Liu, Yuting Wang, Xi Fu, Fengming You. Efficacy of Nalbuphine as an Adjuvant to Ropivacaine in Ultrasound-guided Supraclavicular Brachial Block: A Prospective Randomized Controlled Study.
The Clinical journal of pain.
2021 02; 37(2):158-159. doi:
10.1097/ajp.0000000000000899. [PMID: 33165020] - Yi Han, Xiaoyuan Chen, Panpan Mi, Yunzhao Ji, Xiangan Meng, Pengbo Han, Jingyi Zhang. Different Concentrations of Ropivacaine under Ultrasound Guidance on Quadratus Lumbar Muscle Nerve Block in Elderly Patients with Hip Replacement.
BioMed research international.
2021; 2021(?):9911352. doi:
10.1155/2021/9911352. [PMID: 34977251] - Min Liang, Yijiao Chen, Wenchao Zhu, Dachun Zhou. Efficacy and safety of different doses of ropivacaine for laparoscopy-assisted infiltration analgesia in patients undergoing laparoscopic cholecystectomy: A prospective randomized control trial.
Medicine.
2020 Nov; 99(46):e22540. doi:
10.1097/md.0000000000022540. [PMID: 33181643] - Haikou Yang, Wei Fan, Yong Yang, Jing Zhou, Hao Zhang, Jian Sun, Bo Wang. Application of dexmedetomidine combined with ropivacaine in axillary brachial plexus block in children and its effect on inflammatory factors.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 Jul; 66(5):73-79. doi:
10.14715/cmb/2020.66.5.14. [PMID: 33040817] - Jung-Taek Hwang, Ji Su Jang, Jae Jun Lee, Dong-Keun Song, Han Na Lee, Do-Young Kim, Sang-Soo Lee, Sung Mi Hwang, Yong-Been Kim, Sanghyeon Lee. Dexmedetomidine combined with interscalene brachial plexus block has a synergistic effect on relieving postoperative pain after arthroscopic rotator cuff repair.
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA.
2020 Jul; 28(7):2343-2353. doi:
10.1007/s00167-019-05799-3. [PMID: 31773201] - Steve Coppens, Steffen Rex, Steffen Fieuws, Arne Neyrinck, Andre D'Hoore, Geertrui Dewinter. Transmuscular quadratus lumborum (TQL) block for laparoscopic colorectal surgery: study protocol for a double-blind, prospective randomized placebo-controlled trial.
Trials.
2020 Jun; 21(1):581. doi:
10.1186/s13063-020-04525-6. [PMID: 32586361] - Ronggang Zhu, Tingting Du, Hongzhu Gao. Effects of dezocine and ropivacaine infiltration anesthesia on cellular immune function indicators, anesthesia recovery time and pain factors in patients with open liver resection.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 Jun; 66(3):149-154. doi:
. [PMID: 32538762] - Yar L Yeap, John W Wolfe, Elizabeth Kroepfl, Jonathan Fridell, John A Powelson. Transversus abdominis plane (TAP) block for laparoscopic live donor nephrectomy: Continuous catheter infusion provides no additional analgesic benefit over single-injection ropivacaine.
Clinical transplantation.
2020 06; 34(6):e13861. doi:
10.1111/ctr.13861. [PMID: 32198963] - Elodie Lamy, Fanta Fall, Lisa Boigne, Kirill Gromov, Nicolas Fabresse, Stanislas Grassin-Delyle. Validation according to European and American regulatory agencies guidelines of an LC-MS/MS method for the quantification of free and total ropivacaine in human plasma.
Clinical chemistry and laboratory medicine.
2020 04; 58(5):701-708. doi:
10.1515/cclm-2018-1298. [PMID: 30939109] - Jun Zhang, Tieshuai Liu, Haiyan Zhou, Yue Fei, Xin Yu. The Safety and Efficacy of Ultrasound-Guided Bilateral Dual Transversus Abdominis Plane (BD-TAP) Block in ERAS Program of Laparoscopic Hepatectomy: A Prospective, Randomized, Controlled, Blinded, Clinical Study.
Drug design, development and therapy.
2020; 14(?):2889-2898. doi:
10.2147/dddt.s255385. [PMID: 32764887] - Xiang-Hong Lu, Xiao-Lan Chang, Si-Lan Liu, Jing-Ya Xu, Xiao-Jun Gou. Ultrasound-Guided Inactivation of Trigger Points Combined with Muscle Fascia Stripping by Liquid Knife in Treatment of Postherpetic Neuralgia Complicated with Abdominal Myofascial Pain Syndrome: A Prospective and Controlled Clinical Study.
Pain research & management.
2020; 2020(?):4298509. doi:
10.1155/2020/4298509. [PMID: 32509046] - Hai-Yan Zhang, Xiao-Juan Jiang, Qi Li, Xiao-Hong Tang, Tao Zhu. Single-Injection Ultrasound-Guided Thoracic Paravertebral Block versus Local Anesthetic Infiltration in Peritoneal Dialysis Catheter Surgeries: A Randomized Controlled Trial.
Blood purification.
2020; 49(4):426-433. doi:
10.1159/000505259. [PMID: 31927549] - Meng Yin, Zhong-Hua Li, Chen Wang, Ying Li, Hong Zhang, Hui-Bo Du, Zhen-Ao Zhao, Chun-Yu Niu, Zi-Gang Zhao. Stellate Ganglion Blockade repairs Intestinal Mucosal Barrier through suppression of Endoplasmic Reticulum Stress following Hemorrhagic Shock.
International journal of medical sciences.
2020; 17(14):2147-2154. doi:
10.7150/ijms.47662. [PMID: 32922175] - Jing Zhang, Xue-Rong Lin, Yu-Ping Zhang, Li-Min Zhang, Hui-Bo Du, Li-Na Jiang, Zi-Gang Zhao, Chun-Yu Niu. Blockade of Stellate Ganglion Remediates Hemorrhagic Shock-Induced Intestinal Barrier Dysfunction.
The Journal of surgical research.
2019 12; 244(?):69-76. doi:
10.1016/j.jss.2019.06.007. [PMID: 31279996] - Thomas Rössel, Christopher Uhlig, Jörg Pietsch, Stefan Ludwig, Thea Koch, Torsten Richter, Peter Markus Spieth, Stephan Kersting. Effects of regional anesthesia techniques on local anesthetic plasma levels and complications in carotid surgery: a randomized controlled pilot trial.
BMC anesthesiology.
2019 11; 19(1):218. doi:
10.1186/s12871-019-0890-8. [PMID: 31771512] - Mao-Jun Li, Bin-Xiu Wei, Qiu-Xia Deng, Xin Liu, Xiao-Dong Zhu, Ying Zhang. [Effect of preemptive electroacupuncture on pain reactions in primiparous parturients during vaginal delivery].
Zhen ci yan jiu = Acupuncture research.
2019 Oct; 44(10):752-6. doi:
10.13702/j.1000-0607.180873. [PMID: 31657166] - Zhaojun Qin, Chunyan Xiang, Hongbo Li, Tingting Liu, Leyun Zhan, Zhengyuan Xia, Min Zhang, Jianping Lai. The impact of dexmedetomidine added to ropivicaine for transversus abdominis plane block on stress response in laparoscopic surgery: a randomized controlled trial.
BMC anesthesiology.
2019 10; 19(1):181. doi:
10.1186/s12871-019-0859-7. [PMID: 31604428] - Jane Hayden, Anil Gupta, Sven-Egron Thörn, Pontus Thulin, Linda Block, Jonatan Oras. Does intraperitoneal ropivacaine reduce postoperative inflammation? A prospective, double-blind, placebo-controlled pilot study.
Acta anaesthesiologica Scandinavica.
2019 09; 63(8):1048-1054. doi:
10.1111/aas.13410. [PMID: 31206591] - Rakesh V Sondekoppam, Vishal Uppal, Jonathan Brookes, Sugantha Ganapathy. Bilateral Thoracic Paravertebral Blocks Compared to Thoracic Epidural Analgesia After Midline Laparotomy: A Pragmatic Noninferiority Clinical Trial.
Anesthesia and analgesia.
2019 09; 129(3):855-863. doi:
10.1213/ane.0000000000004219. [PMID: 31425230] - Carolina C Rennó, Juliana Z B Papini, Cintia Maria Saia Cereda, Elizabeth Martinez, Victor Angelo Montalli, Eneida de Paula, José Pedrazzoli Júnior, Silvana Aparecida Calafatti, Giovana Radomille Tofoli. Preclinical Evaluation of Ropivacaine in 2 Liposomal Modified Systems.
Anesthesia and analgesia.
2019 08; 129(2):387-396. doi:
10.1213/ane.0000000000003837. [PMID: 30303863] - Zairong Tang, Cheng Zhang, Zhifei Xu, Feng Jin, Dongliang Liang. Observation of single spinal anesthesia by 25G needle puncture through a lateral crypt for hip surgery in elderly patients.
Medicine.
2019 Jul; 98(27):e16334. doi:
10.1097/md.0000000000016334. [PMID: 31277184] - Qin Fang, Yong-le Li, Ming-Yang Cai, Wei Huang, Chao Yuan, Xiang-Nan Chen. [Efficacy of Ropivacaine injection at acupoints for labor analgesia and its effect on breastfeeding and serum prolactin].
Zhen ci yan jiu = Acupuncture research.
2019 Jun; 44(6):434-8. doi:
10.13702/j.1000-0607.190009. [PMID: 31368267] - Tatsuo Maeyashiki, Jae-Hwi Jang, Florian Janker, Yoshito Yamada, Ilhan Inci, Walter Weder, Tobias Piegeler, Wolfgang Jungraithmayr. The Amide Local Anesthetic Ropivacaine Attenuates Acute Rejection After Allogeneic Mouse Lung Transplantation.
Lung.
2019 04; 197(2):217-226. doi:
10.1007/s00408-019-00197-5. [PMID: 30739218] - Milan Patel, Andreia Z Chignalia, Ayman Isbatan, Nikhil Bommakanti, Randal O Dull. Ropivacaine inhibits pressure-induced lung endothelial hyperpermeability in models of acute hypertension.
Life sciences.
2019 Apr; 222(?):22-28. doi:
10.1016/j.lfs.2019.02.053. [PMID: 30822427] - Jennifer M Crawford, John A Loadsman, Kenny Xf Yang, Peter Ca Kam. Adding low concentrations of clonidine to ropivacaine for transversus abdominis plane blocks does not reduce plasma ropivacaine levels, suggesting a lack of vasoconstrictor effect.
Anaesthesia and intensive care.
2019 Mar; 47(2):134-140. doi:
10.1177/0310057x19838731. [PMID: 31070463] - Purnima Narasimhan, Lokesh Kashyap, V K Mohan, Mahesh Kumar Arora, Dilip Shende, Maddur Srinivas, Seema Kashyap, Sayan Nath, Puneet Khanna. Comparison of caudal epidural block with paravertebral block for renal surgeries in pediatric patients: A prospective randomised, blinded clinical trial.
Journal of clinical anesthesia.
2019 Feb; 52(?):105-110. doi:
10.1016/j.jclinane.2018.09.007. [PMID: 30243061] - Singh Mathuria Kaushal-Deep, Mehershree Lodhi, Afzal Anees, Shehtaj Khan, Mohammad Amanullah Khan. Randomised prospective study of using intraoperative, intraincisional and intraperitoneal ropivacaine for the early discharge of post-laparoscopic cholecystectomy patients as a day case in a cost-effective way in government setup of low-income and middle-income countries: Opening new horizons.
Postgraduate medical journal.
2019 Feb; 95(1120):78-84. doi:
10.1136/postgradmedj-2018-135662. [PMID: 31015318] - Yanbing Wang, Jian Cheng, Liu Yang, Jingjing Wang, Hao Liu, Zhongzhu Lv. Ropivacaine for Intercostal Nerve Block Improves Early Postoperative Cognitive Dysfunction in Patients Following Thoracotomy for Esophageal Cancer.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Jan; 25(?):460-465. doi:
10.12659/msm.912328. [PMID: 30647402] - Yongjian Yang, Dahai Qiu, Yajun Liu, Lei Chao. Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer.
Drug design, development and therapy.
2019; 13(?):3307-3319. doi:
10.2147/dddt.s211443. [PMID: 31571832] - Aimei Li, Feng Yang, Jiaying Xin, Xuebo Bai. An efficient and long-acting local anesthetic: ropivacaine-loaded lipid-polymer hybrid nanoparticles for the control of pain.
International journal of nanomedicine.
2019; 14(?):913-920. doi:
10.2147/ijn.s190164. [PMID: 30774342] - Hao-Wen Kao, Yi-Yu Lin, Walter J Gwathney, Keelung Hong. Formulation and evaluation of multilamellar vesicles ropivacaine in pain management.
International journal of nanomedicine.
2019; 14(?):7891-7901. doi:
10.2147/ijn.s215952. [PMID: 31632006] - Xiqing Zhao, Yue Gao, Xuemei Tang, Wei Lei, Yang Yang, Fanglin Yu, Yan Liu, Meiyan Yang, Yuli Wang, Wei Gong, Zhiping Li, ChunSheng Gao, Xingguo Mei. Development and Evaluation of Ropivacaine Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres with Low Burst Release.
Current drug delivery.
2019; 16(6):490-499. doi:
10.2174/1567201816666190528122137. [PMID: 31132975] - Sietske M K Bakker, Maaike G E Fenten, Daan J Touw, Bart J F van den Bemt, Petra J C Heesterbeek, Gert-Jan Scheffer, Rudolf Stienstra. Pharmacokinetics of 400 mg Locally Infiltrated Ropivacaine After Total Knee Arthroplasty Without Perioperative Tourniquet Use.
Regional anesthesia and pain medicine.
2018 Oct; 43(7):699-704. doi:
10.1097/aap.0000000000000816. [PMID: 29905628] - Mazaher Ahmadi, Mohammad Mahdi Moein, Tayyebeh Madrakian, Abbas Afkhami, Soleiman Bahar, Mohamed Abdel-Rehim. Reduced graphene oxide as an efficient sorbent in microextraction by packed sorbent: Determination of local anesthetics in human plasma and saliva samples utilizing liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):177-182. doi:
10.1016/j.jchromb.2018.07.036. [PMID: 30077098] - Zoubir Djerada, Catherine Feliu, Yoann Cazaubon, Faouzi Smati, Philippe Gomis, Dominique Guerrot, Beny Charbit, Olivier Fernandes, Jean-Marc Malinovsky. Population Pharmacokinetic-Pharmacodynamic Modeling of Ropivacaine in Spinal Anesthesia.
Clinical pharmacokinetics.
2018 09; 57(9):1135-1147. doi:
10.1007/s40262-017-0617-2. [PMID: 29236228] - Mark C Kendall. Re: Choi et al.: Effect of Intercostal Nerve Block and Nephrostomy Tract Infiltration With Ropivacaine on Postoperative Pain Control After Tubeless Percutaneous Nephrolithotomy: A Prospective, Randomized, and Case-controlled Trial (Urology 2018;114:49-55).
Urology.
2018 09; 119(?):162. doi:
10.1016/j.urology.2018.05.038. [PMID: 29908217] - Wei Dai, Yao Lu, Jia Liu, Lili Tang, Bin Mei, Xuesheng Liu. Ultrasound-guided left lateral transversus abdominis plane block combined with rectus sheath block in peritoneal dialysis catheter placement.
Journal of anesthesia.
2018 08; 32(4):645-648. doi:
10.1007/s00540-018-2528-2. [PMID: 29978298] - Manakamana Khanal, Shalini V Gohil, Emmanuel Kuyinu, Ho-Man Kan, Brittany E Knight, Kyle M Baumbauer, Kevin W-H Lo, Joseph Walker, Cato T Laurencin, Lakshmi S Nair. Injectable nanocomposite analgesic delivery system for musculoskeletal pain management.
Acta biomaterialia.
2018 07; 74(?):280-290. doi:
10.1016/j.actbio.2018.05.038. [PMID: 29803784] - Zi Li, Xiao Hong Tang, Qi Li, Wen-Juan Zhang, Tian Tao, Tao Zhu. Ultrasound-Guided Oblique Sub-Costal Transversus Abdominis Plane Block as the Principal Anesthesia Technique in Peritoneal Dialysis Catheter Implantation and Plasma Ropivacaine Concentration Evaluation in ESRD Patients: A Prospective, Randomized, Double-Blinded, Controlled Trial.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2018 May; 38(3):192-199. doi:
10.3747/pdi.2017.00222. [PMID: 29848599] - E Muszyńska, E Hanus-Fajerska, K Ciarkowska. Studies on lead and cadmium toxicity in Dianthus carthusianorum calamine ecotype cultivated in vitro.
Plant biology (Stuttgart, Germany).
2018 May; 20(3):474-482. doi:
10.1111/plb.12712. [PMID: 29450951] - Reuben J Miller, Andrew J Cameron, Julian Dimech, Robert J Orec, Nicholas J Lightfoot. Plasma Ropivacaine Concentrations Following Local Infiltration Analgesia in Total Knee Arthroplasty: A Pharmacokinetic Study to Determine Safety Following Fixed-Dose Administration.
Regional anesthesia and pain medicine.
2018 May; 43(4):347-351. doi:
10.1097/aap.0000000000000727. [PMID: 29369957] - Xiang-Nan Chen, Shi-Hui Yang, Hui-Rui Lin, Ning-Ning Chen, Chen-Lu Su, Wei Huang. [Efficacy of ropivacaine injection at acupoints for labor analgesia and its effect on cortisol level in parturients].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2018 Apr; 38(4):502-504. doi:
NULL. [PMID: 29735455] - J Tang, S Y Zhang, F J Lu, W H Qin, Y S Shi. [The application of combining low dose naloxone with ropivacaine in supraclavicular brachial plexus block].
Zhonghua yi xue za zhi.
2017 Dec; 97(48):3787-3791. doi:
10.3760/cma.j.issn.0376-2491.2017.48.007. [PMID: 29325337] - Masashi Yoshimoto, Takashi Horiguchi, Tetsu Kimura, Toshiaki Nishikawa. Recovery From Ropivacaine-Induced or Levobupivacaine-Induced Cardiac Arrest in Rats: Comparison of Lipid Emulsion Effects.
Anesthesia and analgesia.
2017 11; 125(5):1496-1502. doi:
10.1213/ane.0000000000002435. [PMID: 28877036] - Joo-Hyun Jun, Gaab-Soo Kim, Jeong Jin Lee, Justin S Ko, Sung Joo Kim, Pil Hyun Jeon. Comparison of intrathecal morphine and surgical-site infusion of ropivacaine as adjuncts to intravenous patient-controlled analgesia in living-donor kidney transplant recipients.
Singapore medical journal.
2017 Nov; 58(11):666-673. doi:
10.11622/smedj.2017077. [PMID: 28805236] - Jing-Xian Sun, Ke-Yun Bai, Yan-Feng Liu, Gang Du, Zhi-Hao Fu, Hao Zhang, Jin-Huan Yang, Ben Wang, Xiu-Yu Wang, Bin Jin. Effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy.
World journal of gastroenterology.
2017 Sep; 23(36):6733-6740. doi:
10.3748/wjg.v23.i36.6733. [PMID: 29085218] - Zhi Yuen Beh, Mohd Shahnaz Hasan. Ultrasound-guided costoclavicular approach infraclavicular brachial plexus block for vascular access surgery.
The journal of vascular access.
2017 Sep; 18(5):e57-e61. doi:
10.5301/jva.5000720. [PMID: 28478621] - ". Corrections: Lipid rescue for treatment of delayed systemic ropivacaine toxicity from a continuous thoracic paravertebral block.
BMJ case reports.
2017 08; 2017(?):. doi:
10.1136/bcr-2016-215071corr1. [PMID: 27302637] - Matthias Desmet, Kris Vermeylen, Imré Van Herreweghe, Laurence Carlier, Filiep Soetens, Stijn Lambrecht, Kathleen Croes, Hans Pottel, Marc Van de Velde. A Longitudinal Supra-Inguinal Fascia Iliaca Compartment Block Reduces Morphine Consumption After Total Hip Arthroplasty.
Regional anesthesia and pain medicine.
2017 May; 42(3):327-333. doi:
10.1097/aap.0000000000000543. [PMID: 28059869] - Takahiro Tamura, Shoichi Mori, Atsushi Mori, Masahiko Ando, Shuichi Yokota, Yasuyuki Shibata, Kimitoshi Nishiwaki. A randomized controlled trial comparing paravertebral block via the surgical field with thoracic epidural block using ropivacaine for post-thoracotomy pain relief.
Journal of anesthesia.
2017 Apr; 31(2):263-270. doi:
10.1007/s00540-017-2307-5. [PMID: 28116506] - M G E Fenten, S M K Bakker, D J Touw, B J F van den Bemt, G J Scheffer, P J C Heesterbeek, R Stienstra. Pharmacokinetics of 400 mg ropivacaine after periarticular local infiltration analgesia for total knee arthroplasty.
Acta anaesthesiologica Scandinavica.
2017 Mar; 61(3):338-345. doi:
10.1111/aas.12849. [PMID: 28066882] - Quehua Luo, Weifeng Yao, HaiHua Shu, Ming Zhong. Double-injection technique assisted by a nerve stimulator for ultrasound-guided supraclavicular brachial plexus block results in better distal sensory-motor block: A randomised controlled trial.
European journal of anaesthesiology.
2017 03; 34(3):127-134. doi:
10.1097/eja.0000000000000542. [PMID: 27798452] - Vedat Eljezi, Etienne Imhoff, Daniel Bourdeaux, Bruno Pereira, Mehdi Farhat, Pierre Schoeffler, Kasra Azarnoush, Christian Dualé. Bilateral sternal infusion of ropivacaine and length of stay in ICU after cardiac surgery with increased respiratory risk: A randomised controlled trial.
European journal of anaesthesiology.
2017 Feb; 34(2):56-65. doi:
10.1097/eja.0000000000000564. [PMID: 27977439] - Massimo Allegri, Martina Ornaghi, Catherine E Ferland, Dario Bugada, Yash Meghani, Serena Calcinati, Manuela De Gregori, Federica Lovisari, Krishnaprabha Radhakrishnan, Maria Cusato, Stefano Scalia Catenacci, Marta Somaini, Guido Fanelli, Pablo Ingelmo. Peritoneal Nebulization of Ropivacaine during Laparoscopic Cholecystectomy: Dose Finding and Pharmacokinetic Study.
Pain research & management.
2017; 2017(?):4260702. doi:
10.1155/2017/4260702. [PMID: 28316464] - Xavier Capdevila, Sebastien Moulard, Christian Plasse, Jean-Luc Peshaud, Nicolas Molinari, Christophe Dadure, Sophie Bringuier. Effectiveness of Epidural Analgesia, Continuous Surgical Site Analgesia, and Patient-Controlled Analgesic Morphine for Postoperative Pain Management and Hyperalgesia, Rehabilitation, and Health-Related Quality of Life After Open Nephrectomy: A Prospective, Randomized, Controlled Study.
Anesthesia and analgesia.
2017 01; 124(1):336-345. doi:
10.1213/ane.0000000000001688. [PMID: 27918333] - Camila Morais Gonçalves da Silva, Michelle Franz-Montan, Cíntia Elisabeth Gomez Limia, Lígia Nunes de Morais Ribeiro, Mário Antônio Braga, Viviane Aparecida Guilherme, Camila Batista da Silva, Bruna Renata Casadei, Cíntia Maria Saia Cereda, Eneida de Paula. Encapsulation of ropivacaine in a combined (donor-acceptor, ionic-gradient) liposomal system promotes extended anesthesia time.
PloS one.
2017; 12(10):e0185828. doi:
10.1371/journal.pone.0185828. [PMID: 28982145] - Maya Keplinger, Peter Marhofer, Wolfgang Klug, Birgit Reiter, Thomas Stimpfl, Stephan C Kettner, Lena Korf, Markus Zeitlinger, Daniela Marhofer, Lydia Triffterer. Feasibility and pharmacokinetics of caudal blockade in children and adolescents with 30-50 kg of body weight.
Paediatric anaesthesia.
2016 Nov; 26(11):1053-1059. doi:
10.1111/pan.12972. [PMID: 27397645] - Yukitoshi Niiyama, Takatoshi Yotsuyanagi, Michiaki Yamakage. Continuous wound infiltration with 0.2\% ropivacaine versus a single intercostal nerve block with 0.75\% ropivacaine for postoperative pain management after reconstructive surgery for microtia.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS.
2016 Oct; 69(10):1445-9. doi:
10.1016/j.bjps.2016.05.009. [PMID: 27350268] - Akito Tsukinaga, Tomoya Irie, Kazuhiro Uchimoto, Tetsuya Miyashita, Takahisa Goto. [A Case of Combined Spinal-Epidural Anesthesia for Cesarean Section in a Patient with Right Heart Failure due to Supravalvular Pulmonary Stenosis after Jatene Operation].
Masui. The Japanese journal of anesthesiology.
2016 10; 65(10):1031-1033. doi:
NULL. [PMID: 30358281] - A M-H Ho, M K Karmakar, S K Ng, S Wan, C S H Ng, R H L Wong, S K C Chan, G M Joynt. Local anaesthetic toxicity after bilateral thoracic paravertebral block in patients undergoing coronary artery bypass surgery.
Anaesthesia and intensive care.
2016 09; 44(5):615-9. doi:
10.1177/0310057x1604400502. [PMID: 27608346] - Pauline Dureau, Beny Charbit, Nathalie Nicolas, Dan Benhamou, Jean-Xavier Mazoit. Effect of Intralipid® on the Dose of Ropivacaine or Levobupivacaine Tolerated by Volunteers: A Clinical and Pharmacokinetic Study.
Anesthesiology.
2016 09; 125(3):474-83. doi:
10.1097/aln.0000000000001230. [PMID: 27404223] - Huaijiang Wang, Liandi Li, Chengshi Xu, Xiangdong Qu, Zhijun Qu, Geng Wang. The efficacy of simultaneous bilateral axillary brachial plexus block under the guidance of neurostimulator or ultrasound: a prospective study.
Journal of anesthesia.
2016 08; 30(4):596-602. doi:
10.1007/s00540-016-2193-2. [PMID: 27255448] - Matthias Flury, Dominik Rickenbacher, Hans-Kaspar Schwyzer, Christian Jung, Marco M Schneider, Katharina Stahnke, Jörg Goldhahn, Laurent Audigé. Does Pure Platelet-Rich Plasma Affect Postoperative Clinical Outcomes After Arthroscopic Rotator Cuff Repair? A Randomized Controlled Trial.
The American journal of sports medicine.
2016 Aug; 44(8):2136-46. doi:
10.1177/0363546516645518. [PMID: 27184542] - C Stoetzer, T Doll, T Stueber, C Herzog, F Echtermeyer, F Greulich, C Rudat, A Kispert, F Wegner, A Leffler. Tetrodotoxin-sensitive α-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics.
Naunyn-Schmiedeberg's archives of pharmacology.
2016 Jun; 389(6):625-36. doi:
10.1007/s00210-016-1231-9. [PMID: 27000037] - Elyad M Davidson, Simon Haroutounian, Leonid Kagan, Michael Naveh, Arnon Aharon, Yehuda Ginosar. A Novel Proliposomal Ropivacaine Oil: Pharmacokinetic-Pharmacodynamic Studies After Subcutaneous Administration in Pigs.
Anesthesia and analgesia.
2016 May; 122(5):1663-72. doi:
10.1213/ane.0000000000001200. [PMID: 27057797] - Yehuda Ginosar, Simon Haroutounian, Leonid Kagan, Michael Naveh, Arnon Aharon, Elyad M Davidson. Proliposomal Ropivacaine Oil: Pharmacokinetic and Pharmacodynamic Data After Subcutaneous Administration in Volunteers.
Anesthesia and analgesia.
2016 May; 122(5):1673-80. doi:
10.1213/ane.0000000000001217. [PMID: 27057798] - C Adami, D Casoni, F Noussitou, U Rytz, C Spadavecchia. Addition of magnesium sulphate to ropivacaine for spinal analgesia in dogs undergoing tibial plateau levelling osteotomy.
Veterinary journal (London, England : 1997).
2016 Mar; 209(?):163-8. doi:
10.1016/j.tvjl.2015.11.017. [PMID: 26831174] - Lisa K Mouzi, Olivia Adams, Germaine Cuff, Elaan Lukasiewicz, Elise Champeil, Arthur Atchabahian. Plasma concentrations of ropivacaine following ultrasound-guided or nerve-stimulator-guided femoral nerve block: A prospective randomised study.
Anaesthesia, critical care & pain medicine.
2016 Feb; 35(1):45-48. doi:
10.1016/j.accpm.2015.08.002. [PMID: 26681523] - Zi Wang, Haizhen Huang, Shaozhong Yang, Shanshan Huang, Jingxuan Guo, Qi Tang, Feng Qi. Long-term effect of ropivacaine nanoparticles for sciatic nerve block on postoperative pain in rats.
International journal of nanomedicine.
2016; 11(?):2081-90. doi:
10.2147/ijn.s101563. [PMID: 27274236]
