Hydroxyzine (BioDeep_00000002003)

 

Secondary id: BioDeep_00000408996

human metabolite blood metabolite


代谢物信息卡片


2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol

化学式: C21H27ClN2O2 (374.1760952)
中文名称: 羟嗪-d8
谱图信息: 最多检出来源 Homo sapiens(blood) 10.47%

分子结构信息

SMILES: c1ccc(cc1)C(c1ccc(cc1)Cl)N1CCN(CC1)CCOCCO
InChI: InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2

描述信息

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8146; ORIGINAL_PRECURSOR_SCAN_NO 8142
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8167; ORIGINAL_PRECURSOR_SCAN_NO 8166
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8152; ORIGINAL_PRECURSOR_SCAN_NO 8147
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8169; ORIGINAL_PRECURSOR_SCAN_NO 8167
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8128; ORIGINAL_PRECURSOR_SCAN_NO 8124
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8120; ORIGINAL_PRECURSOR_SCAN_NO 8118
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BB - Diphenylmethane derivatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder[1].

同义名列表

24 个代谢物同义名

2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol; 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol; Hydroxyzine dihydrochloride; hydroxyzine hydrochloride; Pamoate, hydroxyzine; Hydroxyzine pamoate; Hydroxyzine base; Hydroxizinum; Hydroxyzinum; Idrossizina; Hydroxyzyne; Hidroxizina; hydroxyzine; Hydroxycine; Hydroxizine; Hydroxyzin; Hychotine; Hydroxine; Orgatrax; Vistaril; Atarax; Durrax; Marex; Hydroxyzine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Stuart W Paine, Mohammed Aldurdunji, Alix Garth-Greeves, Tessa Muir, Pamela R Hincks. Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. Journal of veterinary pharmacology and therapeutics. 2022 Jan; 45(1):46-53. doi: 10.1111/jvp.13010. [PMID: 34469007]
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  • S Mohammadi Kebar, A Sharghi, M Ghorghani, S Hoseininia. Comparison of gabapentin and hydroxyzine in the treatment of pruritus in patients on dialysis. Clinical and experimental dermatology. 2020 Oct; 45(7):866-871. doi: 10.1111/ced.14270. [PMID: 32363638]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Heather K Knych, Daniel Weiner, Stacy Steinmetz, Katherine Flynn, Daniel S McKemie. Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics. 2019 Nov; 42(6):617-623. doi: 10.1111/jvp.12808. [PMID: 31490561]
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  • María Pilar Vicente Sánchez, Diego Macías Saint-Gerons, César de la Fuente Honrubia, Diana González Bermejo, Dolores Montero Corominas, Ferrán Catalá-López. [Trends of use of anxiolytics and hypnotics in Spain from 2000 to 2011]. Revista espanola de salud publica. 2013 May; 87(3):247-55. doi: 10.4321/s1135-57272013000300004. [PMID: 23892676]
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  • Cristina Lopez-Peig, Xavier Mundet, Bartomeu Casabella, Jose Luis del Val, David Lacasta, Eduard Diogene. Analysis of benzodiazepine withdrawal program managed by primary care nurses in Spain. BMC research notes. 2012 Dec; 5(?):684. doi: 10.1186/1756-0500-5-684. [PMID: 23237104]
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  • Saeed Nojavan, Arezoo Moharami, Ali Reza Fakhari. Two-step liquid phase microextraction combined with capillary electrophoresis: a new approach to simultaneous determination of basic and zwitterionic compounds. Journal of separation science. 2012 Aug; 35(15):1959-66. doi: 10.1002/jssc.201200229. [PMID: 22753354]
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  • John Stevens-Garmon, Jörg E Drewes, Stuart J Khan, James A McDonald, Eric R V Dickenson. Sorption of emerging trace organic compounds onto wastewater sludge solids. Water research. 2011 May; 45(11):3417-26. doi: 10.1016/j.watres.2011.03.056. [PMID: 21536314]
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  • Daniele Torchia, Maria Miteva, Shasa Hu, Carlos Cohen, Paolo Romanelli. Papuloerythroderma 2009: two new cases and systematic review of the worldwide literature 25 years after its identification by Ofuji et al. Dermatology (Basel, Switzerland). 2010; 220(4):311-20. doi: 10.1159/000301915. [PMID: 20339287]
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