Hydroxyzine (BioDeep_00000002003)

 

Secondary id: BioDeep_00000408996

human metabolite blood metabolite


代谢物信息卡片


2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol

化学式: C21H27ClN2O2 (374.1761)
中文名称: 羟嗪-d8
谱图信息: 最多检出来源 Homo sapiens(blood) 50.74%

分子结构信息

SMILES: c1ccc(cc1)C(c1ccc(cc1)Cl)N1CCN(CC1)CCOCCO
InChI: InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2

描述信息

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8146; ORIGINAL_PRECURSOR_SCAN_NO 8142
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8167; ORIGINAL_PRECURSOR_SCAN_NO 8166
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8152; ORIGINAL_PRECURSOR_SCAN_NO 8147
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8169; ORIGINAL_PRECURSOR_SCAN_NO 8167
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8128; ORIGINAL_PRECURSOR_SCAN_NO 8124
CONFIDENCE standard compound; INTERNAL_ID 1306; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8120; ORIGINAL_PRECURSOR_SCAN_NO 8118
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BB - Diphenylmethane derivatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder[1].

同义名列表

24 个代谢物同义名

2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol; 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol; Hydroxyzine dihydrochloride; hydroxyzine hydrochloride; Pamoate, hydroxyzine; Hydroxyzine pamoate; Hydroxyzine base; Hydroxizinum; Hydroxyzinum; Idrossizina; Hydroxyzyne; Hidroxizina; hydroxyzine; Hydroxycine; Hydroxizine; Hydroxyzin; Hychotine; Hydroxine; Orgatrax; Vistaril; Atarax; Durrax; Marex; Hydroxyzine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, ABL1, ACE, ALB, ANXA5, EP300
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 1 HTN1
Nucleus 3 ABL1, ALB, EP300
cytosol 5 ABL1, ALB, ANXA5, EP300, HRH1
dendrite 2 ABL1, HRH1
nuclear body 1 ABL1
centrosome 1 ALB
nucleoplasm 2 ABL1, EP300
Cell membrane 7 ABCB1, ACE, C5AR1, HRH1, HTR3A, KCNH2, MAG
Cleavage furrow 1 HTR3A
Multi-pass membrane protein 6 ABCB1, C5AR1, CACNA1I, HRH1, HTR3A, KCNH2
Synapse 3 HRH1, HTR3A, TAC1
cell surface 2 ABCB1, KCNH2
glutamatergic synapse 1 ABL1
Golgi apparatus 1 ALB
Golgi membrane 1 INS
growth cone 1 ABL1
neuronal cell body 2 ABL1, TAC1
postsynapse 2 ABL1, HTR3A
sarcolemma 1 ANXA5
Lysosome 2 ACE, SMPD1
endosome 2 ACE, SMPD1
plasma membrane 13 ABCB1, ABL1, ACE, C5AR1, CACNA1I, HRH1, HTR3A, IFNLR1, IGHE, KCNH2, MAG, PRSS27, SMPD1
Membrane 9 ABCB1, ACE, ANXA5, CACNA1I, HTR3A, IFNLR1, KCNH2, MAG, SMPD1
apical plasma membrane 1 ABCB1
axon 1 TAC1
basolateral plasma membrane 1 C5AR1
extracellular exosome 5 ABCB1, ACE, ALB, ANXA5, SMPD1
endoplasmic reticulum 2 ALB, HTN1
extracellular space 6 ACE, ALB, IGHE, INS, SMPD1, TAC1
lysosomal lumen 1 SMPD1
perinuclear region of cytoplasm 2 ABL1, KCNH2
mitochondrion 2 ABL1, HTN1
protein-containing complex 2 ABL1, ALB
postsynaptic density 1 ABL1
Single-pass type I membrane protein 4 ACE, IFNLR1, IGHE, MAG
Secreted 4 ACE, ALB, INS, SMPD1
extracellular region 9 ACE, ALB, ANXA5, HTN1, IGHE, INS, PRSS27, SMPD1, TAC1
Single-pass membrane protein 1 MAG
anchoring junction 1 ALB
transcription regulator complex 1 EP300
nuclear membrane 1 ABL1
external side of plasma membrane 2 ACE, ANXA5
actin cytoskeleton 1 ABL1
cytoplasmic vesicle 1 C5AR1
nucleolus 1 ABL1
apical part of cell 1 C5AR1
postsynaptic membrane 1 HTR3A
Apical cell membrane 1 ABCB1
Membrane raft 1 MAG
focal adhesion 1 ANXA5
collagen-containing extracellular matrix 1 ANXA5
Postsynaptic cell membrane 1 HTR3A
ruffle 1 ABL1
Zymogen granule membrane 1 ANXA5
neuron projection 1 HTR3A
ciliary basal body 1 ALB
chromatin 1 EP300
IgE immunoglobulin complex 1 IGHE
Chromosome 1 EP300
centriole 1 ALB
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 1 ALB
sperm midpiece 1 ACE
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
Lipid droplet 1 SMPD1
monoatomic ion channel complex 1 KCNH2
myelin sheath 1 MAG
basal plasma membrane 1 ACE
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 1 KCNH2
secretory granule lumen 1 INS
secretory granule membrane 1 C5AR1
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
paranode region of axon 1 MAG
Schmidt-Lanterman incisure 1 MAG
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
vesicle membrane 1 ANXA5
histone acetyltransferase complex 1 EP300
protein-DNA complex 1 EP300
external side of apical plasma membrane 1 ABCB1
[Isoform 3]: Cell membrane 1 IGHE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
compact myelin 1 MAG
myelin sheath adaxonal region 1 MAG
lamellar body 1 SMPD1
endothelial microparticle 1 ANXA5
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Sphingomyelin phosphodiesterase, processed form]: Secreted, extracellular space 1 SMPD1
endolysosome 1 SMPD1
mesaxon 1 MAG
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Stuart W Paine, Mohammed Aldurdunji, Alix Garth-Greeves, Tessa Muir, Pamela R Hincks. Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. Journal of veterinary pharmacology and therapeutics. 2022 Jan; 45(1):46-53. doi: 10.1111/jvp.13010. [PMID: 34469007]
  • Yu Ri Woo, Seok Hoon Moon, Jeesuk Yu, Sang Hyun Cho. Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model. Nutrients. 2021 Dec; 14(1):. doi: 10.3390/nu14010133. [PMID: 35011005]
  • Dalia Farag A El-Telbany, Rania Farag A El-Telbany, Sherin Zakaria, Kawkab A Ahmed, Yasmin A El-Feky. Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification technique for transdermal delivery. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Nov; 143(?):112130. doi: 10.1016/j.biopha.2021.112130. [PMID: 34560549]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • S Mohammadi Kebar, A Sharghi, M Ghorghani, S Hoseininia. Comparison of gabapentin and hydroxyzine in the treatment of pruritus in patients on dialysis. Clinical and experimental dermatology. 2020 Oct; 45(7):866-871. doi: 10.1111/ced.14270. [PMID: 32363638]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Heather K Knych, Daniel Weiner, Stacy Steinmetz, Katherine Flynn, Daniel S McKemie. Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics. 2019 Nov; 42(6):617-623. doi: 10.1111/jvp.12808. [PMID: 31490561]
  • Pedro Rafael da Silva, Laís Cristina Santana Sena, Rubens Pedro Lorena Silva, Danielle Cristine Almeida Silva de Santana, Fernando José Malagueño de Santana. Determination of cocaine adulterants in human urine by dispersive liquid-liquid microextraction and high-performance liquid chromatography. Analytical and bioanalytical chemistry. 2019 Jun; 411(16):3447-3461. doi: 10.1007/s00216-019-01797-z. [PMID: 31123783]
  • Laura L Giusto, Patricia M Zahner, Daniel A Shoskes. An evaluation of the pharmacotherapy for interstitial cystitis. Expert opinion on pharmacotherapy. 2018 07; 19(10):1097-1108. doi: 10.1080/14656566.2018.1491968. [PMID: 29972328]
  • NULL. Good Night's Sleep Gone Wrong. AORN journal. 2017 10; 106(4):360-331. doi: 10.1016/j.aorn.2017.07.001. [PMID: 28958323]
  • Soren Snitker, Rebecca M Doerfler, Elsayed Z Soliman, Rajat Deo, Wendy L St Peter, Susan Kramlik, Michael J Fischer, Sankar Navaneethan, Patrice Delafontaine, Bernard G Jaar, Akinlolu Ojo, Gail K Makos, Anne Slaven, Matthew R Weir, Min Zhan, Jeffrey C Fink. Association of QT-Prolonging Medication Use in CKD with Electrocardiographic Manifestations. Clinical journal of the American Society of Nephrology : CJASN. 2017 09; 12(9):1409-1417. doi: 10.2215/cjn.12991216. [PMID: 28793999]
  • Selvakumar Kanthiah, Valliappan Kannappan. D-Optimal mixture design optimization of an HPLC method for simultaneous determination of commonly used antihistaminic parent molecules and their active metabolites in human serum and urine. Biomedical chromatography : BMC. 2017 Aug; 31(8):. doi: 10.1002/bmc.3932. [PMID: 28058761]
  • Yuuki Sandhu, Katsutoshi Ando, Hidenori Takekawa, Haruhi Takagi, Michihiro Hirama, Kenji Kido, Kazuhisa Takahashi. Safety of Bronchoscopy for Patients Undergoing Hemodialysis. Respiratory investigation. 2017 03; 55(2):173-175. doi: 10.1016/j.resinv.2016.10.007. [PMID: 28274534]
  • Tadiboyina Sirisha, Bannimath Gurupadayya, Bharath Kumar Inturi, Madhusudhan Purohit. Enantioselective UFLC Determination of Hydroxyzine Enantiomers and Application to a Pharmacokinetic Study in Rabbits. Journal of chromatographic science. 2016 Nov; 54(10):1806-1812. doi: 10.1093/chromsci/bmw141. [PMID: 27621133]
  • Shanshan He, Jingbo Xiao, Andrés E Dulcey, Billy Lin, Adam Rolt, Zongyi Hu, Xin Hu, Amy Q Wang, Xin Xu, Noel Southall, Marc Ferrer, Wei Zheng, T Jake Liang, Juan J Marugan. Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. Journal of medicinal chemistry. 2016 Feb; 59(3):841-53. doi: 10.1021/acs.jmedchem.5b00752. [PMID: 26599718]
  • Iain M McIntyre, Amber Trochta, Ray D Gary, Alina Storey, Jennifer Corneal, Bethann Schaber. A Fatality Related to Two Novel Hallucinogenic Compounds: 4-Methoxyphencyclidine and 4-Hydroxy-N-methyl-N-ethyltryptamine. Journal of analytical toxicology. 2015 Nov; 39(9):751-5. doi: 10.1093/jat/bkv089. [PMID: 26265285]
  • Samaneh Nakhaee, Ahmad Nasiri, Yadollah Waghei, Jamileh Morshedi. Comparison of Avena sativa, vinegar, and hydroxyzine for uremic pruritus of hemodialysis patients: a crossover randomized clinical trial. Iranian journal of kidney diseases. 2015 Jul; 9(4):316-22. doi: . [PMID: 26174460]
  • Evelyn Pawlik, Hellmut Mahler, Benno Hartung, Gerd Plässer, Thomas Daldrup. Drug-related death: adulterants from cocaine preparations in lung tissue and blood. Forensic science international. 2015 Apr; 249(?):294-303. doi: 10.1016/j.forsciint.2015.02.006. [PMID: 25747329]
  • Jessica L Knittel, Shawn P Vorce, Barry Levine, Rhome L Hughes, Thomas Z Bosy. Multidrug toxicity involving sumatriptan. Journal of analytical toxicology. 2015 Jan; 39(1):75-9. doi: 10.1093/jat/bku120. [PMID: 25324526]
  • Magí Farré, Clara Pérez-Mañá, Esther Papaseit, Esther Menoyo, Marta Pérez, Soraya Martin, Santiago Bullich, Santiago Rojas, José-Raúl Herance, Carlos Trampal, Luis Labeaga, Román Valiente. Bilastine vs. hydroxyzine: occupation of brain histamine H1 -receptors evaluated by positron emission tomography in healthy volunteers. British journal of clinical pharmacology. 2014 Nov; 78(5):970-80. doi: 10.1111/bcp.12421. [PMID: 24833043]
  • S Veraldi, E Cuka, C Francia, M C Persico. Scabies acquired in Chinese massage centers. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia. 2014 Oct; 149(5):627-8. doi: ". [PMID: 25213389]
  • Szymon Dziomba, Michał Biernacki, Ilona Olędzka, Elżbieta Skrzydlewska, Tomasz Bączek, Piotr Kowalski. Repetitive injection field-amplified sample stacking for cationic compounds determination. Talanta. 2014 Jul; 125(?):1-6. doi: 10.1016/j.talanta.2014.02.045. [PMID: 24840407]
  • María Pilar Vicente Sánchez, Diego Macías Saint-Gerons, César de la Fuente Honrubia, Diana González Bermejo, Dolores Montero Corominas, Ferrán Catalá-López. [Trends of use of anxiolytics and hypnotics in Spain from 2000 to 2011]. Revista espanola de salud publica. 2013 May; 87(3):247-55. doi: 10.4321/s1135-57272013000300004. [PMID: 23892676]
  • Giovanni Mistraletti, Elena S Mantovani, Paolo Cadringher, Barbara Cerri, Davide Corbella, Michele Umbrello, Stefania Anania, Elisa Andrighi, Serena Barello, Alessandra Di Carlo, Federica Martinetti, Paolo Formenti, Paolo Spanu, Gaetano Iapichino. Enteral vs. intravenous ICU sedation management: study protocol for a randomized controlled trial. Trials. 2013 Apr; 14(?):92. doi: 10.1186/1745-6215-14-92. [PMID: 23551983]
  • Alfredo Carlo Altamura, Donatella Moliterno, Silvia Paletta, Michele Maffini, Massimo Carlo Mauri, Silvio Bareggi. Understanding the pharmacokinetics of anxiolytic drugs. Expert opinion on drug metabolism & toxicology. 2013 Apr; 9(4):423-40. doi: 10.1517/17425255.2013.759209. [PMID: 23330992]
  • Cristina Lopez-Peig, Xavier Mundet, Bartomeu Casabella, Jose Luis del Val, David Lacasta, Eduard Diogene. Analysis of benzodiazepine withdrawal program managed by primary care nurses in Spain. BMC research notes. 2012 Dec; 5(?):684. doi: 10.1186/1756-0500-5-684. [PMID: 23237104]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Saeed Nojavan, Arezoo Moharami, Ali Reza Fakhari. Two-step liquid phase microextraction combined with capillary electrophoresis: a new approach to simultaneous determination of basic and zwitterionic compounds. Journal of separation science. 2012 Aug; 35(15):1959-66. doi: 10.1002/jssc.201200229. [PMID: 22753354]
  • R Salgado, R Marques, J P Noronha, G Carvalho, A Oehmen, M A M Reis. Assessing the removal of pharmaceuticals and personal care products in a full-scale activated sludge plant. Environmental science and pollution research international. 2012 Jun; 19(5):1818-27. doi: 10.1007/s11356-011-0693-z. [PMID: 22207237]
  • Antony Citterio-Quentin, Eric Seidel, Laurence Ramuz, François Parant, Mustapha Moulsma. LSD screening in urine performed by CEDIA® LSD assay: positive interference with sertraline. Journal of analytical toxicology. 2012 May; 36(4):289-90. doi: 10.1093/jat/bks031. [PMID: 22511703]
  • Walter Ling, Steven Shoptaw, Maureen Hillhouse, Michelle A Bholat, Charles Charuvastra, Keith Heinzerling, David Chim, Jeffrey Annon, Patrick T Dowling, Geetha Doraimani. Double-blind placebo-controlled evaluation of the PROMETA™ protocol for methamphetamine dependence. Addiction (Abingdon, England). 2012 Feb; 107(2):361-9. doi: 10.1111/j.1360-0443.2011.03619.x. [PMID: 22082089]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • John Stevens-Garmon, Jörg E Drewes, Stuart J Khan, James A McDonald, Eric R V Dickenson. Sorption of emerging trace organic compounds onto wastewater sludge solids. Water research. 2011 May; 45(11):3417-26. doi: 10.1016/j.watres.2011.03.056. [PMID: 21536314]
  • Saeed Nojavan, Ali Reza Fakhari. Chiral separation and quantitation of cetirizine and hydroxyzine by maltodextrin-mediated CE in human plasma: effect of zwitterionic property of cetirizine on enantioseparation. Electrophoresis. 2011 Mar; 32(6-7):764-71. doi: 10.1002/elps.201000607. [PMID: 21328396]
  • Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller, Hinnerk Boriss. Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals. 2011 Feb; 39(2):312-21. doi: 10.1124/dmd.110.036095. [PMID: 21071520]
  • Patrick L West, B Zane Horowitz. Delayed recrudescence to toxic salicylate concentrations after salsalate overdose. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2010 Jun; 6(2):150-4. doi: 10.1007/s13181-010-0070-1. [PMID: 20405267]
  • Amitava Dasgupta, Gertie Tso, Myrtle Johnson, Loretta Chow. Hydroxyzine and cetirizine interfere with the PENTINA carbamazepine assay but not with the ADVIA CENTEUR carbamazepine assay. Therapeutic drug monitoring. 2010 Feb; 32(1):112-5. doi: 10.1097/ftd.0b013e3181c6b0dc. [PMID: 20040899]
  • Daniele Torchia, Maria Miteva, Shasa Hu, Carlos Cohen, Paolo Romanelli. Papuloerythroderma 2009: two new cases and systematic review of the worldwide literature 25 years after its identification by Ofuji et al. Dermatology (Basel, Switzerland). 2010; 220(4):311-20. doi: 10.1159/000301915. [PMID: 20339287]
  • Annette Petersen, Harold C Schott. Effects of dexamethasone and hydroxyzine treatment on intradermal testing and allergen-specific IgE serum testing results in horses. Veterinary dermatology. 2009 Oct; 20(5-6):615-22. doi: 10.1111/j.1365-3164.2009.00837.x. [PMID: 20178502]
  • Devang R Doshi, Miles M Weinberger. Experience with cyclosporine in children with chronic idiopathic urticaria. Pediatric dermatology. 2009 Jul; 26(4):409-13. doi: 10.1111/j.1525-1470.2009.00869.x. [PMID: 19689515]
  • Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry. 2009 Mar; 52(6):1693-700. doi: 10.1021/jm801441s. [PMID: 19256501]
  • Jason Sea, Joel M H Teichman. Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment. Drugs. 2009; 69(3):279-96. doi: 10.2165/00003495-200969030-00004. [PMID: 19275272]
  • Petra Bizikova, Mark G Papich, Thierry Olivry. Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs. Veterinary dermatology. 2008 Dec; 19(6):348-57. doi: 10.1111/j.1365-3164.2008.00697.x. [PMID: 18980631]
  • A M Beltagi, O M Abdallah, M M Ghoneim. Development of a voltammetric procedure for assay of the antihistamine drug hydroxyzine at a glassy carbon electrode: Quantification and pharmacokinetic studies. Talanta. 2008 Jan; 74(4):851-9. doi: 10.1016/j.talanta.2007.07.009. [PMID: 18371719]
  • Chen Chen. Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Current medicinal chemistry. 2008; 15(21):2173-91. doi: 10.2174/092986708785747625. [PMID: 18781943]
  • Sherin Farouk Hammad, Mokhtar Mohamed Mabrouk, Ahmed Habib, Hamed Elfatatry, Naoya Kishikawa, Kenichiro Nakashima, Naotaka Kuroda. Precolumn fluorescence labeling method for simultaneous determination of hydroxyzine and cetirizine in human serum. Biomedical chromatography : BMC. 2007 Oct; 21(10):1030-5. doi: 10.1002/bmc.848. [PMID: 17516468]
  • Harold C Urschel, Larry L Hanselka, Irin Gromov, Lenae White, Michael Baron. Open-label study of a proprietary treatment program targeting type A gamma-aminobutyric acid receptor dysregulation in methamphetamine dependence. Mayo Clinic proceedings. 2007 Oct; 82(10):1170-8. doi: 10.4065/82.10.1170. [PMID: 17908523]
  • María Amparo Martínez-Gómez, Rosa M Villanueva-Camañas, Salvador Sagrado, María José Medina-Hernández. Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE. Electrophoresis. 2007 Aug; 28(15):2635-43. doi: 10.1002/elps.200600742. [PMID: 17605150]
  • Laurent Spahr, Alessandra Coeytaux, Emiliano Giostra, Antoine Hadengue, Jean-Marie Annoni. Histamine H1 blocker hydroxyzine improves sleep in patients with cirrhosis and minimal hepatic encephalopathy: a randomized controlled pilot trial. The American journal of gastroenterology. 2007 Apr; 102(4):744-53. doi: 10.1111/j.1572-0241.2006.01028.x. [PMID: 17222324]
  • Amitava Dasgupta, Alice Wells, Pradip Datta. False-positive serum tricyclic antidepressant concentrations using fluorescence polarization immunoassay due to the presence of hydroxyzine and cetirizine. Therapeutic drug monitoring. 2007 Feb; 29(1):134-9. doi: NULL. [PMID: 17333576]
  • Pradip Datta, Amitava Dasgupta. Turbidimetric carbamazepine immunoassay on the ADVIA 1650 and 2400 analyzers is free from interference of antihistamine drugs hydroxyzine and cetirizine. Journal of clinical laboratory analysis. 2007; 21(3):188-92. doi: 10.1002/jcla.20176. [PMID: 17506478]
  • Amitava Dasgupta, Alice Wells, Pradip Datta. False-positive serum tricyclic antidepressant concentrations using fluorescence polarization immunoassay due to the presence of hydroxyzine and cetirizine. Therapeutic drug monitoring. 2006 Oct; 28(5):662-7. doi: 10.1097/01.ftd.0000246767.12872.5b. [PMID: 17038882]
  • Luciana de Matos Alves Pinto, Sônia Valéria Pinheiro Malheiros, Antônio Carlos Senges Lino, Eneida de Paula, Maria Angélica Perillo. Hydroxyzine, promethazine and thioridazine interaction with phospholipid monomolecular layers at the air-water interface. Biophysical chemistry. 2006 Feb; 119(3):247-55. doi: 10.1016/j.bpc.2005.09.006. [PMID: 16233945]
  • J O'Sullivan, M I O'Sullivan, K E Tipton, G Davey. Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine. Journal of neural transmission. Supplementum. 2006; ?(71):105-12. doi: 10.1007/978-3-211-33328-0_12. [PMID: 17447421]
  • Manuel J Barbanoj, Consuelo García-Gea, Rosa Antonijoan, Iñaki Izquierdo, Ester Donado, Iñaki Pérez, Anna Solans, Francesc Jané. Evaluation of the cognitive, psychomotor and pharmacokinetic profiles of rupatadine, hydroxyzine and cetirizine, in combination with alcohol, in healthy volunteers. Human psychopharmacology. 2006 Jan; 21(1):13-26. doi: 10.1002/hup.741. [PMID: 16389668]
  • Raphaël Serreau, Meriem Komiha, Florence Blanc, François Guillot, Evelyne Jacqz-Aigrain. Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy. Reproductive toxicology (Elmsford, N.Y.). 2005 Nov; 20(4):573-4. doi: 10.1016/j.reprotox.2005.03.005. [PMID: 16199350]
  • M A Kutlubaev, R R Farkhutdinov, L R Akhmadeeva, A F Mufazalov. Free radical oxidation in rat brain during chronic stress and pharmacological regulation of this process. Bulletin of experimental biology and medicine. 2005 Oct; 140(4):416-8. doi: 10.1007/s10517-005-0507-8. [PMID: 16671569]
  • François Parant, Mustapha Moulsma, Marie Claude Gagnieu, Gisèle Lardet. Hydroxyzine and metabolites as a source of interference in carbamazepine particle-enhanced turbidimetric inhibition immunoassay (PETINIA). Therapeutic drug monitoring. 2005 Aug; 27(4):457-62. doi: 10.1097/01.ftd.0000160718.88822.20. [PMID: 16044102]
  • Vijay Zawar. Pityriasis rosea-like eruptions due to mustard oil application. Indian journal of dermatology, venereology and leprology. 2005 Jul; 71(4):282-4. doi: 10.4103/0378-6323.16625. [PMID: 16394442]
  • A M Marsland, S Soundararajan, K Joseph, A P Kaplan. Effects of calcineurin inhibitors on an in vitro assay for chronic urticaria. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2005 May; 35(5):554-9. doi: 10.1111/j.1365-2222.2005.02242.x. [PMID: 15898974]
  • Abeer A W Elzainy, Xiaochen Gu, F Estelle R Simons, Keith J Simons. Hydroxyzine- and cetirizine-loaded liposomes: effect of duration of thin film hydration, freeze-thawing, and changing buffer pH on encapsulation and stability. Drug development and industrial pharmacy. 2005 Mar; 31(3):281-91. doi: 10.1081/ddc-52070. [PMID: 15830724]
  • Fabienne Péhourcq. A simple high-performance liquid chromatographic method for detection of hydroxyzine in human plasma after overdose. Journal of pharmacological and toxicological methods. 2004 Jul; 50(1):41-4. doi: 10.1016/j.vascn.2004.01.001. [PMID: 15233966]
  • Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry. 2004 Mar; 47(7):1783-8. doi: 10.1021/jm0309001. [PMID: 15027870]
  • Abeer A W Elzainy, Xiaochen Gu, F Estelle R Simons, Keith J Simons. Hydroxyzine from topical phospholipid liposomal formulations: evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model. AAPS pharmSci. 2003 Nov; 5(4):E28. doi: 10.1208/ps050428. [PMID: 15198516]
  • Joseph W Polli, Todd M Baughman, Joan E Humphreys, Kelly H Jordan, Angela L Mote, Jo A Salisbury, Timothy K Tippin, Cosette J Serabjit-Singh. P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine. Journal of pharmaceutical sciences. 2003 Oct; 92(10):2082-9. doi: 10.1002/jps.10453. [PMID: 14502547]
  • G R Sant, K J Propert, P M Hanno, D Burks, D Culkin, A C Diokno, C Hardy, J R Landis, R Mayer, R Madigan, E M Messing, K Peters, T C Theoharides, J Warren, A J Wein, W Steers, J W Kusek, L M Nyberg. A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis. The Journal of urology. 2003 Sep; 170(3):810-5. doi: 10.1097/01.ju.0000083020.06212.3d. [PMID: 12913705]
  • F Orhan, B E Sekerel. Beef allergy: a review of 12 cases. Allergy. 2003 Feb; 58(2):127-31. doi: 10.1034/j.1398-9995.2003.00021.x. [PMID: 12622743]
  • John H Tegzes, Sean D Smarick, Birgit Puschner. Coma and apnea in a dog with hydroxyzine toxicosis. Veterinary and human toxicology. 2002 Feb; 44(1):24-6. doi: NULL. [PMID: 11824769]
  • G Plember van Balen, G Caron, G Ermondi, A Pagliara, T Grandi, G Bouchard, R Fruttero, P A Carrupt, B Testa. Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems. Pharmaceutical research. 2001 May; 18(5):694-701. doi: 10.1023/a:1011049830615. [PMID: 11465428]
  • M Boussofara, D Bracco, P Ravussin. Comparison of the effects of clonidine and hydroxyzine on haemodynamic and catecholamine reactions to microlaryngoscopy. European journal of anaesthesiology. 2001 Feb; 18(2):75-8. doi: 10.1046/j.1365-2346.2001.00782.x. [PMID: 11270028]
  • K Sade, I Dotan, Y Levo. [Systemic mastocytosis]. Harefuah. 2000 Sep; 139(5-6):202-6, 245. doi: NULL. [PMID: 11062953]
  • B C Channu, H N Kalpana, G B Eregowda, C Dass, P J Houghton, K N Thimmaiah. Interaction of substituted phenoxazine chemosensitizers with bovine serum albumin. Journal of pharmaceutical and biomedical analysis. 1999 Dec; 21(4):775-85. doi: 10.1016/s0731-7085(99)00187-9. [PMID: 10701943]
  • P Hans, J F Brichant, P Y Dewandre, J D Born, M Lamy. Effects of two calculated plasma sufentanil concentrations on the hemodynamic and bispectral index responses to Mayfield head holder application. Journal of neurosurgical anesthesiology. 1999 Apr; 11(2):81-5. doi: 10.1097/00008506-199904000-00002. [PMID: 10213433]
  • T Beppu, M Ogawa, T Yamanaka, H Egami, C Ohara, Y Masuda, S Kudo, M Kuramoto, K Doi, T Matsuda. [Clinical evaluation of Azasetron Hydrochloride: a new selective 5-HT3 receptor antagonist--antiemetic profile and plasma concentration in transcatheter arterial chemoembolization using CDDP for unresectable hepatocellular carcinoma]. Gan to kagaku ryoho. Cancer & chemotherapy. 1998 Jul; 25(8):1197-202. doi: NULL. [PMID: 9679583]
  • A Pagliara, B Testa, P A Carrupt, P Jolliet, C Morin, D Morin, S Urien, J P Tillement, J P Rihoux. Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist. Journal of medicinal chemistry. 1998 Mar; 41(6):853-63. doi: 10.1021/jm9704311. [PMID: 9526560]
  • B P Kennedy, S K Mahata, D T O'Connor, M G Ziegler. Mechanism of cardiovascular actions of the chromogranin A fragment catestatin in vivo. Peptides. 1998; 19(7):1241-8. doi: 10.1016/s0196-9781(98)00086-2. [PMID: 9786174]
  • P Hans, E Coussaert, F Cantraine, P Y Dewandre, J F Brichant, M Grevesse, M Lamy. Effects of target-controlled anesthesia with propofol and sufentanil on the hemodynamic response to Mayfield head holder application. Acta anaesthesiologica Belgica. 1998; 49(1):7-11. doi: NULL. [PMID: 9627732]
  • K J Chou, M D Donovan. Distribution of antihistamines into the CSF following intranasal delivery. Biopharmaceutics & drug disposition. 1997 May; 18(4):335-46. doi: 10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w. [PMID: 9158881]
  • P Hans, J F Brichant, F Pieron, P Pieyns, J D Born, M Lamy. Elevated plasma alpha 1-acid glycoprotein levels: lack of connection to resistance to vecuronium blockade induced by anticonvulsant therapy. Journal of neurosurgical anesthesiology. 1997 Jan; 9(1):3-7. doi: NULL. [PMID: 9016432]
  • F E Simons, G L Sussman, K J Simons. Effect of the H2-antagonist cimetidine on the pharmacokinetics and pharmacodynamics of the H1-antagonists hydroxyzine and cetirizine in patients with chronic urticaria. The Journal of allergy and clinical immunology. 1995 Mar; 95(3):685-93. doi: 10.1016/s0091-6749(95)70173-7. [PMID: 7897151]
  • F E Simons, H E Murray, K J Simons. Quantitation of H1-receptor antagonists in skin and serum. The Journal of allergy and clinical immunology. 1995 Mar; 95(3):759-64. doi: 10.1016/s0091-6749(95)70183-4. [PMID: 7897161]
  • X Chen, F E Simons, K J Simons. Effect of the H2-receptor antagonist cimetidine, on the pharmacokinetics and pharmacodynamics of the H1-receptor antagonists hydroxyzine and cetirizine in rabbits. Pharmaceutical research. 1994 Feb; 11(2):295-300. doi: 10.1023/a:1018971828065. [PMID: 8165191]
  • D F Bajorin, P B Chapman, G Y Wong, B V Cody, C Cordon-Cardo, L Dantes, M A Templeton, D Scheinberg, H F Oettgen, A N Houghton. Treatment with high dose mouse monoclonal (anti-GD3) antibody R24 in patients with metastatic melanoma. Melanoma research. 1992 Dec; 2(5-6):355-62. doi: 10.1097/00008390-199212000-00009. [PMID: 1292783]
  • G W Canonica, G Pesce, S Ruffoni, S Buscaglia, F Boero, G Jing, J P Rihoux, G Ciprandi. Cetirizine does not influence the immune response. Annals of allergy. 1992 Mar; 68(3):251-4. doi: . [PMID: 1347675]
  • N A Soter. Treatment of urticaria and angioedema: low-sedating H1-type antihistamines. Journal of the American Academy of Dermatology. 1991 Jun; 24(6 Pt 2):1084-7. doi: 10.1016/0190-9622(91)70161-t. [PMID: 1677011]
  • M T Rosseel, R A Lefebvre. Determination of cetirizine in human urine by high-performance liquid chromatography. Journal of chromatography. 1991 Apr; 565(1-2):504-10. doi: 10.1016/0378-4347(91)80417-b. [PMID: 1678748]
  • G Merlin, L Lepoittevin, A Turcant, J Mylonas, J F Cavellat. [Responsibility of psychotropic drugs in road accidents]. Presse medicale (Paris, France : 1983). 1991 Mar; 20(9):409-12. doi: NULL. [PMID: 1826775]
  • P J Coulie, L Ghys, J P Rihoux. Inhibitory effects of orally or sublingually administered cetirizine on histamine-induced weals and flares and their correlation with cetirizine plasma concentrations. The Journal of international medical research. 1991 Mar; 19(2):174-9. doi: 10.1177/030006059101900213. [PMID: 1677903]
  • G Occelli, M Raucoules, F Philip, P Lapalus, M Candito, D Grimaud. [Changes in plasma histamine and catecholamines levels after injection of chymopapain in chemonucleolysis]. Annales francaises d'anesthesie et de reanimation. 1991; 10(6):516-21. doi: 10.1016/s0750-7658(05)80287-4. [PMID: 1785700]
  • G M Walsh, R Moqbel, A Hartnell, A B Kay. Effects of cetirizine on human eosinophil and neutrophil activation in vitro. International archives of allergy and applied immunology. 1991; 95(2-3):158-62. doi: 10.1159/000235422. [PMID: 1682275]
  • S Levander, M Ståhle-Bäckdahl, O Hägermark. Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine. European journal of clinical pharmacology. 1991; 41(5):435-9. doi: 10.1007/bf00626365. [PMID: 1684750]
  • L Juhlin. Cetirizine in the treatment of chronic urticaria. Clinical therapeutics. 1991 Jan; 13(1):81-6. doi: NULL. [PMID: 1827614]
  • P Kintz, B Godelar, P Mangin. Gas chromatographic identification and quantification of hydroxyzine: application in a fatal self-poisoning. Forensic science international. 1990 Dec; 48(2):139-43. doi: 10.1016/0379-0738(90)90106-9. [PMID: 2283137]
  • J K Woodward. Pharmacology of antihistamines. The Journal of allergy and clinical immunology. 1990 Oct; 86(4 Pt 2):606-12. doi: 10.1016/s0091-6749(05)80224-6. [PMID: 1977782]
  • H Gong, D P Tashkin, B Dauphinee, B Djahed, T C Wu. Effects of oral cetirizine, a selective H1 antagonist, on allergen- and exercise-induced bronchoconstriction in subjects with asthma. The Journal of allergy and clinical immunology. 1990 Mar; 85(3):632-41. doi: 10.1016/0091-6749(90)90104-c. [PMID: 1968919]
  • L Juhlin, J P Rihoux. Effect of cetirizine on cutaneous reactions to PAF, kallikrein and serum in patients with chronic urticaria. Acta dermato-venereologica. 1990; 70(2):151-3. doi: 102340/0001555570151153. [PMID: 1969202]
  • W M Awni, J Yeh, C E Halstenson, J A Opsahl, M Chung, G R Matzke. Effect of haemodialysis on the pharmacokinetics of cetirizine. European journal of clinical pharmacology. 1990; 38(1):67-9. doi: 10.1007/bf00314806. [PMID: 1970299]
  • W T Watson, K J Simons, X Y Chen, F E Simons. Cetirizine: a pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis. The Journal of allergy and clinical immunology. 1989 Oct; 84(4 Pt 1):457-64. doi: 10.1016/0091-6749(89)90358-8. [PMID: 2571627]